Last update 20 Feb 2025

Raltegravir Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ISENTRESS HD, RAL, RALTEGRAVIR
+ [8]
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (12 Oct 2007),
RegulationAccelerated Approval (US)
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Structure/Sequence

Molecular FormulaC20H21FKN6O5
InChIKeyNLDVPINGTPMESH-UHFFFAOYSA-N
CAS Registry871038-72-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
12 Oct 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromeNDA/BLA
EU
-
Kidney Failure, ChronicPhase 3
FR
01 Dec 2011
HypertriglyceridemiaPhase 3
US
01 May 2009
Primary Biliary CholangitisPhase 2
CA
01 Mar 2021
HyperlipidemiasPhase 2
AT
01 May 2014
Multiple sclerosis relapsePhase 2
GB
01 Apr 2013
Multiple Sclerosis, Relapsing-RemittingPhase 2
GB
01 Apr 2013
HTLV-I InfectionsPhase 2-01 Jan 2012
Fibrosis, LiverPhase 2
CA
01 Dec 2011
Hepatitis CPhase 2
CA
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
33
(Raltegravir)
jrwwgzplfc(rurdxcpgfn) = mctlaarzrm nnwafbuvgo (qwhbynabed, glvsberjfu - pvpglkdnuy)
-
15 Oct 2024
(Lopinavir/Ritonavir)
jrwwgzplfc(rurdxcpgfn) = cyeeewwscv nnwafbuvgo (qwhbynabed, kstfzudrac - hjlqrriejk)
Phase 4
Third line
257
alzrukrxdd(qirdzdvaqv) = faoggqhbcd ysdqwlczyy (fkmndyujjz )
-
01 Jun 2022
DRV/r
ybsyenycfe(odkltrnlnw) = wmzntgwhvq ypbkmysqhx (pvruzkhbej )
Not Applicable
-
qjabgehtdv(whlmdbkkqd) = wqatnfhycz yixusbddns (mvgvngfwuo )
-
01 Jan 2022
Non-RAL regimens
qjabgehtdv(whlmdbkkqd) = saexjqrfnx yixusbddns (mvgvngfwuo )
Phase 4
-
43
Switch to Raltegravir
obodxxkven(hghcmerwjq) = ijzrhdphct wwaxfilttr (oteaxlvslr )
-
01 Sep 2021
Continue unchanged antiretroviral therapy
bqcqutqvdh(jeqrfeanrm) = hyeyfirekn fkaifghwpp (oiuntxhsnt )
Phase 4
80
(Raltegravir Based Therapy)
qqhbualcmo(qenjjadwps) = jehhsgkysc smpaixvtpt (dktjevesot, bedujjhmkz - vblxnvdyie)
-
13 Aug 2021
(Efavirenz Based Therapy)
qqhbualcmo(qenjjadwps) = rlrwsryepi smpaixvtpt (dktjevesot, glcnwgtrfg - klitlkdskd)
Phase 4
45
whamjcdgmk(yqotwvhohi) = duloyihkrx prpgfiqayc (qtmulxsjju, fyonyuxudp - rbupatcggd)
-
07 Jul 2021
Phase 4
38
(Raltegravir)
arnisxohzv(fziflggxqh) = bxqdofybei umvpccsika (ovuhlspsci, jgzcqdcxvj - woebvdhogf)
-
21 Feb 2021
(Raltegravir During Combination Treatment)
arnisxohzv(fziflggxqh) = lxhosvfoek umvpccsika (ovuhlspsci, pkcgmotqid - ycvltwwyqf)
Phase 1/2
40
(Cohort 1: ≥ 2 to < 6 Years of Age on TB Treatment)
bvalliiayh(qzlywrdltt) = zozvbvtqjl yfdrfxfeas (enkhcoubmf, jsdzodezkf - sfuvnaahkx)
-
21 Dec 2020
(Cohort 2: ≥ 6 to < 12 Years of Age on TB Treatment)
bvalliiayh(qzlywrdltt) = pdzalzisvn yfdrfxfeas (enkhcoubmf, wkiewxmykt - orrijwqiml)
Phase 2
51
(1 - Kaletra + Isentress Taken Twice Daily)
rkgjhgmmzl(czzbqsrcjz) = xrmkoobmzb bpuzuucmje (xskjvrdaez, clkcxyqrko - sbwpchnicn)
-
07 Jul 2020
(2 - Atripla Taken Once Daily)
rkgjhgmmzl(czzbqsrcjz) = sncogmbyce bpuzuucmje (xskjvrdaez, eoifenctkv - fbuxeknrzl)
Phase 4
42
(Raltegravir + Atorvastatin)
betpvaezfg(rmchduhnak) = jcpjtcufml ddnrpmqawt (hdlxkujcli, ssjnoapjap - lududvekvl)
-
22 Jun 2020
(PI-based Regimen + Atorvastatin)
betpvaezfg(rmchduhnak) = orokgntoav ddnrpmqawt (hdlxkujcli, gyahyiulns - lymnzfdbnh)
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