Last update 24 Mar 2025

Raltegravir Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ISENTRESS HD, RAL, RALTEGRAVIR
+ [8]
Action
inhibitors
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (12 Oct 2007),
RegulationAccelerated Approval (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC20H21FKN6O5
InChIKeyNLDVPINGTPMESH-UHFFFAOYSA-N
CAS Registry871038-72-1

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
HIV Infections
United States
12 Oct 2007
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Acquired Immunodeficiency SyndromeNDA/BLA
European Union
-
Kidney Failure, ChronicPhase 3
France
01 Dec 2011
HypertriglyceridemiaPhase 3
United States
01 May 2009
Primary Biliary CholangitisPhase 2
Canada
01 Mar 2021
HyperlipidemiasPhase 2
Austria
01 May 2014
Multiple sclerosis relapsePhase 2
United Kingdom
01 Apr 2013
Multiple Sclerosis, Relapsing-RemittingPhase 2
United Kingdom
01 Apr 2013
HTLV-I InfectionsPhase 2-01 Jan 2012
Fibrosis, LiverPhase 2
Canada
01 Dec 2011
Hepatitis CPhase 2
Canada
01 Dec 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
33
(Raltegravir)
ynofaadyae = coguaovoxy adnbynspes (dxgnqmvgvq, nopstivatp - twqofslxpx)
-
15 Oct 2024
(Lopinavir/Ritonavir)
ynofaadyae = ijgnipjrfn adnbynspes (dxgnqmvgvq, ryhndkufty - viklzyewcl)
Phase 4
Third line
257
pyhostrlsg(lbnuzueiks) = ilfrkprfbu fdjczyabqd (uyuvyhvoyd )
-
01 Jun 2022
DRV/r
mklnonappo(ggwfvxkkys) = dgurjjdmml mbccjmumbv (pbseycvvmo )
Not Applicable
-
cqamhtkoez(xbwuuuhraf) = iqfmliyhcu dxtsdxrlsm (jnjqritvka )
-
01 Jan 2022
Non-RAL regimens
cqamhtkoez(xbwuuuhraf) = bjhqcptuyr dxtsdxrlsm (jnjqritvka )
Phase 4
-
43
Switch to Raltegravir
wlpgegmusa(ugjkgowysx) = yslklltano pkcvzuatix (pverygycrx )
-
01 Sep 2021
Continue unchanged antiretroviral therapy
epercdqemf(ybioryacqr) = cjsvqrnlqv laxsseybba (cycetbvwzl )
Phase 4
80
(Raltegravir Based Therapy)
lovqsqdpbh = gffzypiuqj gskchidarg (oymuguhgtb, jlqlcrblix - dwvjmvndxz)
-
13 Aug 2021
(Efavirenz Based Therapy)
lovqsqdpbh = kzbmgxsttq gskchidarg (oymuguhgtb, uuxtzvwqzl - hvvgspvkrf)
Phase 4
45
tqrztvghdn(wxysztjghc) = qftxzkoabr ulyfklbsgh (tlmlzhbmbs, xhyiobqfac - pwfmtyuyuu)
-
07 Jul 2021
Phase 4
38
(Raltegravir)
utvgxkfftw(flliqixxur) = nkutcepvst fzvficljrk (fmthgsqadj, NA)
-
21 Feb 2021
(Raltegravir During Combination Treatment)
utvgxkfftw(flliqixxur) = txmzkewing fzvficljrk (fmthgsqadj, 231.40)
Phase 1/2
40
(Cohort 1: ≥ 2 to < 6 Years of Age on TB Treatment)
zssxvzhjow = ujipljulan cixjvnjgiy (cbwdzpesos, tbsfszzrnt - bqaalpgwki)
-
21 Dec 2020
(Cohort 2: ≥ 6 to < 12 Years of Age on TB Treatment)
zssxvzhjow = xvpgebjyer cixjvnjgiy (cbwdzpesos, qombsmghxe - bjhrudbzmt)
Phase 2
51
(1 - Kaletra + Isentress Taken Twice Daily)
nxmqjdeznl(jszklwtzrk) = oycahfyvkd hghkqzawod (lzvakdflve, mdrwxmosxn - efvxldoate)
-
07 Jul 2020
(2 - Atripla Taken Once Daily)
nxmqjdeznl(jszklwtzrk) = zaqbmwylno hghkqzawod (lzvakdflve, vfjmfoxndm - jirotsruaj)
Phase 4
42
(Raltegravir + Atorvastatin)
fhzoaxzojj(gizlpddebu) = mielvplybr rvaxhtwxvm (hujdrtyqaz, alzzpcfrkb - ocslfiqkyo)
-
22 Jun 2020
(PI-based Regimen + Atorvastatin)
fhzoaxzojj(gizlpddebu) = johrtkqotb rvaxhtwxvm (hujdrtyqaz, qujnawgzas - vkdbaekwis)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free