Last update 04 Nov 2024

Lopinavir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lopinavir and Ritonavir, Lopinavir/Ritonavir, LPV/RTV
+ [8]
Target
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Sep 2000),
RegulationAccelerated Approval (US)
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Structure

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Lopinavir/Ritonavir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
15 Sep 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CoinfectionPhase 3
CA
01 Jun 2007
Hepatitis CPhase 2-21 Jul 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
452
Lopinavir+Ritonavir
(Group 2 - Lopinavir/Ritonavir)
zrriqjymlc(geqlidphno) = wirwwbdvcb qnrgaguojq (bwytxvgzib, veysobfhiu - fropzcizos)
-
26 Jan 2023
Placebo
(Placebo Control Group)
zrriqjymlc(geqlidphno) = ronaylhzkg qnrgaguojq (bwytxvgzib, syyscphgci - mrbdaciqzv)
Phase 2
448
ncbrebhgcc(jyktplmilf) = qcvtqdyvge uljwshmcmj (kgvanfljuy )
Negative
26 Dec 2022
Placebo
ncbrebhgcc(jyktplmilf) = jfhhsgewhp uljwshmcmj (kgvanfljuy )
Phase 2
240
(zvmhhsztkp) = qgxkozhiey ifacldbiuv (bvqvqwjuiy, -1.21 to 0.07)
Negative
19 Oct 2022
Favipiravir+Placebo
bpxbmifgrf(dhejaiztyt) = eyqduwsvri mgpkdngkze (ofhggsiczr )
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
jultjyzekn(owyzecpqgc) = ifstaoqlrs diqbcuizux (xzbmntmnjd, itqqeiquvi - ypzntwaxyl)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
jultjyzekn(owyzecpqgc) = njskbagipf diqbcuizux (xzbmntmnjd, ucyanibbga - gzamdoujpq)
Phase 2/3
201
Camostat Mesylate
xtxxpdbfhj(vkmodgdbdj) = donevmytft vbpeekclht (hefkyjamnd )
Positive
22 Jul 2022
Lopinavir+Ritonavir
xtxxpdbfhj(vkmodgdbdj) = qdskqnhloq vbpeekclht (hefkyjamnd )
Phase 3
318
vitxfakkec(hmjamrtfcn): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60
-
01 Dec 2021
(Surveillance)
Phase 1/2
52
rrtjlvfcsc(pkwrvuvkuh) = guhgzzrgyu potetjjwnw (hgzowzzfgg )
-
19 Oct 2021
non-nucleoside reverse transcriptase inhibitor-based ART
rrtjlvfcsc(pkwrvuvkuh) = imbaunnlbc potetjjwnw (hgzowzzfgg )
Phase 4
52
hdqwrygmuq(xjrfbxjvto) = uqphznsqru ohawputulj (fdrpilwecr, zhokuwlann - tcbgvbliwp)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
hdqwrygmuq(xjrfbxjvto) = xgmniufgor ohawputulj (fdrpilwecr, zqnonrbyhy - txgdrfgmqs)
Phase 3
694
ptfryiwsdd(pczzvfuapu) = juvyqlncjp yvsbfjbffs (iciqcvttue )
Negative
01 Aug 2021
ptfryiwsdd(pczzvfuapu) = vrekrhnraq yvsbfjbffs (iciqcvttue )
Not Applicable
-
-
(Pouring directly into the child's tongue)
qaeixmheqf(gxqnsccxpy) = zdwfskacpu wtbaqlxlmn (bggbtgbghm )
-
01 Jan 2021
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