Drug Type Small molecule drug |
Synonyms Lopinavir and Ritonavir, Lopinavir/Ritonavir, LPV/RTV + [8] |
Target |
Mechanism HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (15 Sep 2000), |
RegulationAccelerated Approval (US) |
Molecular FormulaC37H48N4O5 |
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N |
CAS Registry192725-17-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Lopinavir/Ritonavir | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HIV Infections | US | 15 Sep 2000 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Coinfection | Phase 3 | CA | 01 Jun 2007 | |
Hepatitis C | Phase 2 | - | 21 Jul 2005 |
Phase 2 | 452 | Lopinavir+Ritonavir (Group 2 - Lopinavir/Ritonavir) | zrriqjymlc(geqlidphno) = wirwwbdvcb qnrgaguojq (bwytxvgzib, veysobfhiu - fropzcizos) View more | - | 26 Jan 2023 | ||
Placebo (Placebo Control Group) | zrriqjymlc(geqlidphno) = ronaylhzkg qnrgaguojq (bwytxvgzib, syyscphgci - mrbdaciqzv) View more | ||||||
Phase 2 | 448 | ncbrebhgcc(jyktplmilf) = qcvtqdyvge uljwshmcmj (kgvanfljuy ) | Negative | 26 Dec 2022 | |||
Placebo | ncbrebhgcc(jyktplmilf) = jfhhsgewhp uljwshmcmj (kgvanfljuy ) | ||||||
Phase 2 | 240 | (zvmhhsztkp) = qgxkozhiey ifacldbiuv (bvqvqwjuiy, -1.21 to 0.07) | Negative | 19 Oct 2022 | |||
Favipiravir+Placebo | bpxbmifgrf(dhejaiztyt) = eyqduwsvri mgpkdngkze (ofhggsiczr ) | ||||||
Phase 2/3 | 289 | (Ascorbic Acid and Folic Acid) | jultjyzekn(owyzecpqgc) = ifstaoqlrs diqbcuizux (xzbmntmnjd, itqqeiquvi - ypzntwaxyl) View more | - | 08 Aug 2022 | ||
(Hydroxychloroquine and Folic Acid) | jultjyzekn(owyzecpqgc) = njskbagipf diqbcuizux (xzbmntmnjd, ucyanibbga - gzamdoujpq) View more | ||||||
Phase 2/3 | 201 | Camostat Mesylate | xtxxpdbfhj(vkmodgdbdj) = donevmytft vbpeekclht (hefkyjamnd ) View more | Positive | 22 Jul 2022 | ||
Lopinavir+Ritonavir | xtxxpdbfhj(vkmodgdbdj) = qdskqnhloq vbpeekclht (hefkyjamnd ) View more | ||||||
Phase 3 | 318 | vitxfakkec(hmjamrtfcn): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60 | - | 01 Dec 2021 | |||
(Surveillance) | |||||||
Phase 1/2 | 52 | rrtjlvfcsc(pkwrvuvkuh) = guhgzzrgyu potetjjwnw (hgzowzzfgg ) | - | 19 Oct 2021 | |||
non-nucleoside reverse transcriptase inhibitor-based ART | rrtjlvfcsc(pkwrvuvkuh) = imbaunnlbc potetjjwnw (hgzowzzfgg ) | ||||||
Phase 4 | 52 | (Severe Malnutrition) | hdqwrygmuq(xjrfbxjvto) = uqphznsqru ohawputulj (fdrpilwecr, zhokuwlann - tcbgvbliwp) View more | - | 12 Aug 2021 | ||
(Normal Nutrition/Mild Malnutrition) | hdqwrygmuq(xjrfbxjvto) = xgmniufgor ohawputulj (fdrpilwecr, zqnonrbyhy - txgdrfgmqs) View more | ||||||
Phase 3 | 694 | ptfryiwsdd(pczzvfuapu) = juvyqlncjp yvsbfjbffs (iciqcvttue ) | Negative | 01 Aug 2021 | |||
ptfryiwsdd(pczzvfuapu) = vrekrhnraq yvsbfjbffs (iciqcvttue ) | |||||||
Not Applicable | - | - | (Pouring directly into the child's tongue) | qaeixmheqf(gxqnsccxpy) = zdwfskacpu wtbaqlxlmn (bggbtgbghm ) | - | 01 Jan 2021 |