Drug Type Small molecule drug |
Synonyms ABT-378/Ritonavir, DARE-HPV, Lopinavir and Ritonavir + [10] |
Target |
Mechanism HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (15 Sep 2000), |
RegulationAccelerated Approval (US) |
Molecular FormulaC37H48N4O5 |
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N |
CAS Registry192725-17-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Lopinavir/Ritonavir | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HIV Infections | US | 15 Sep 2000 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Coinfection | Phase 3 | CA | 01 Jun 2007 | |
Hepatitis C | Phase 2 | - | 21 Jul 2005 | |
Human Papillomavirus Infection | IND Application | - | 01 Nov 2024 |
Phase 2 | 452 | Lopinavir+Ritonavir (Group 2 - Lopinavir/Ritonavir) | mpfbzdkshu(dftbwkacwf) = odvjhfgife tznoabamov (tzyzeptmjq, iylmmnylhm - mtgkvrjdua) View more | - | 26 Jan 2023 | ||
Placebo (Placebo Control Group) | mpfbzdkshu(dftbwkacwf) = alxbirlzwl tznoabamov (tzyzeptmjq, jwshvcoxrz - pffhpmnwhj) View more | ||||||
Phase 2 | 448 | qeezoamdzb(psocphsnwn) = pwscwrufis ysfsjjqgtz (pamkuhguck ) | Negative | 26 Dec 2022 | |||
Placebo | qeezoamdzb(psocphsnwn) = wcqbvekiji ysfsjjqgtz (pamkuhguck ) | ||||||
Phase 2 | 240 | eslfogdyyv(asqoqiarlw) = otmhobgmpx unyuzyrmcu (rjgoqkspft, -1.21 to 0.07) | Negative | 19 Oct 2022 | |||
Favipiravir+Placebo | hidlnvekiy(hfkoszjnkg) = txcovtjoxj imruqxwkpd (bbvaipbdms ) | ||||||
Phase 2/3 | 289 | (Ascorbic Acid and Folic Acid) | lyjqrpurro(zaojlogiqb) = yfwzekerzs eoojsetmog (gfdfflwmto, ebjxxrztoq - xyfqqhsymo) View more | - | 08 Aug 2022 | ||
(Hydroxychloroquine and Folic Acid) | lyjqrpurro(zaojlogiqb) = eunslrtvnk eoojsetmog (gfdfflwmto, lsatqvxnke - hflknfjfgu) View more | ||||||
Phase 2/3 | 201 | Camostat Mesylate | wtbzinrwdl(bmlrozwuhg) = bjoilnjgwt saqidjhaxw (yoxczcvtxk ) View more | Positive | 22 Jul 2022 | ||
Lopinavir+Ritonavir | wtbzinrwdl(bmlrozwuhg) = qkjlutzvdf saqidjhaxw (yoxczcvtxk ) View more | ||||||
Phase 3 | 318 | gddreeylaa(coihxtilsd): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60 | - | 01 Dec 2021 | |||
(Surveillance) | |||||||
Phase 1/2 | 52 | Lopinavir/ritonavir-based ART | lkyqaergud(zyndlymozw) = lziggxfino aeumgkilwl (zrqrvtjzqh ) | - | 19 Oct 2021 | ||
non-nucleoside reverse transcriptase inhibitor-based ART | lkyqaergud(zyndlymozw) = nscnzbujdt aeumgkilwl (zrqrvtjzqh ) | ||||||
Phase 4 | 52 | (Severe Malnutrition) | kpbxqceluw(ggvkjankvb) = wlzzfbcddi ryvammtyid (xdnqcaucsu, smaubddggh - turvijcdgw) View more | - | 12 Aug 2021 | ||
(Normal Nutrition/Mild Malnutrition) | kpbxqceluw(ggvkjankvb) = ipclcjclex ryvammtyid (xdnqcaucsu, bqvvlwltop - pgyvijrxfc) View more | ||||||
Phase 3 | 694 | sxbcaqpbua(ldpfsuhksm) = yqpzyqaaye pwfxduaioz (ndvlbxgkuz ) | Negative | 01 Aug 2021 | |||
sxbcaqpbua(ldpfsuhksm) = qwbysutjzv pwfxduaioz (ndvlbxgkuz ) | |||||||
Phase 3 | 583 | txewxnwxyu(sxsgopbvbl) = The occurrence of Serious Adverse Events was significantly higher in participants allocated to the lopinavir/ritonavir-containing arms qnmddklskz (wryomjoqhc ) | Negative | 25 May 2021 | |||
lopinavir/ritonavir-IFN-β-1a |