Last update 27 Dec 2024

Lopinavir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABT-378/Ritonavir, DARE-HPV, Lopinavir and Ritonavir
+ [10]
Target
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Sep 2000),
RegulationAccelerated Approval (US)
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Structure

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Lopinavir/Ritonavir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
15 Sep 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CoinfectionPhase 3
CA
01 Jun 2007
Hepatitis CPhase 2-21 Jul 2005
Human Papillomavirus InfectionIND Application-01 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
452
Lopinavir+Ritonavir
(Group 2 - Lopinavir/Ritonavir)
mpfbzdkshu(dftbwkacwf) = odvjhfgife tznoabamov (tzyzeptmjq, iylmmnylhm - mtgkvrjdua)
-
26 Jan 2023
Placebo
(Placebo Control Group)
mpfbzdkshu(dftbwkacwf) = alxbirlzwl tznoabamov (tzyzeptmjq, jwshvcoxrz - pffhpmnwhj)
Phase 2
448
qeezoamdzb(psocphsnwn) = pwscwrufis ysfsjjqgtz (pamkuhguck )
Negative
26 Dec 2022
Placebo
qeezoamdzb(psocphsnwn) = wcqbvekiji ysfsjjqgtz (pamkuhguck )
Phase 2
240
eslfogdyyv(asqoqiarlw) = otmhobgmpx unyuzyrmcu (rjgoqkspft, -1.21 to 0.07)
Negative
19 Oct 2022
Favipiravir+Placebo
hidlnvekiy(hfkoszjnkg) = txcovtjoxj imruqxwkpd (bbvaipbdms )
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
lyjqrpurro(zaojlogiqb) = yfwzekerzs eoojsetmog (gfdfflwmto, ebjxxrztoq - xyfqqhsymo)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
lyjqrpurro(zaojlogiqb) = eunslrtvnk eoojsetmog (gfdfflwmto, lsatqvxnke - hflknfjfgu)
Phase 2/3
201
Camostat Mesylate
wtbzinrwdl(bmlrozwuhg) = bjoilnjgwt saqidjhaxw (yoxczcvtxk )
Positive
22 Jul 2022
Lopinavir+Ritonavir
wtbzinrwdl(bmlrozwuhg) = qkjlutzvdf saqidjhaxw (yoxczcvtxk )
Phase 3
318
gddreeylaa(coihxtilsd): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60
-
01 Dec 2021
(Surveillance)
Phase 1/2
52
Lopinavir/ritonavir-based ART
lkyqaergud(zyndlymozw) = lziggxfino aeumgkilwl (zrqrvtjzqh )
-
19 Oct 2021
non-nucleoside reverse transcriptase inhibitor-based ART
lkyqaergud(zyndlymozw) = nscnzbujdt aeumgkilwl (zrqrvtjzqh )
Phase 4
52
kpbxqceluw(ggvkjankvb) = wlzzfbcddi ryvammtyid (xdnqcaucsu, smaubddggh - turvijcdgw)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
kpbxqceluw(ggvkjankvb) = ipclcjclex ryvammtyid (xdnqcaucsu, bqvvlwltop - pgyvijrxfc)
Phase 3
694
sxbcaqpbua(ldpfsuhksm) = yqpzyqaaye pwfxduaioz (ndvlbxgkuz )
Negative
01 Aug 2021
sxbcaqpbua(ldpfsuhksm) = qwbysutjzv pwfxduaioz (ndvlbxgkuz )
Phase 3
583
txewxnwxyu(sxsgopbvbl) = The occurrence of Serious Adverse Events was significantly higher in participants allocated to the lopinavir/ritonavir-containing arms qnmddklskz (wryomjoqhc )
Negative
25 May 2021
lopinavir/ritonavir-IFN-β-1a
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