Last update 21 Nov 2024

Lamivudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine, (-)-2'-Deoxy-3'-thiacytidine, 2',3'-Dideoxy-3'-thiacytidine
+ [31]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Nov 1995),
RegulationOrphan Drug (JP), Priority Review (CN), Accelerated Approval (US)
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Structure

Molecular FormulaC8H11N3O3S
InChIKeyJTEGQNOMFQHVDC-NKWVEPMBSA-N
CAS Registry134678-17-4

External Link

KEGGWikiATCDrug Bank
D00353Lamivudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis B
JP
22 Sep 2000
Hepatitis B, Chronic
EU
29 Jul 1999
Hepatitis B, Chronic
IS
29 Jul 1999
Hepatitis B, Chronic
LI
29 Jul 1999
Hepatitis B, Chronic
NO
29 Jul 1999
HIV Infections
US
17 Nov 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LymphomaDiscovery
US
01 Dec 2015
HIV InfectionsDiscovery
PR
31 Aug 2001
Hepatitis B, ChronicDiscovery
US
08 Dec 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
xhdyhtimdy(crilhbkdcf) = bcvwvksobo tqbmugaymu (fogqbivneg )
Positive
01 Jun 2024
tenofovir + Emtricitabine or Lamivudine + Lopinavir + ritonavir
(ehwbjwkbdm) = hstcvubcxg rfwlnrgxcu (dtfbpavvxn, 47 - 66)
Not Applicable
-
6
Abacavir-based regimen
ussqlzsjdf(oudcknynws) = svcgvnpzrh glmbjeekzd (bqgnduthni )
Positive
01 Apr 2024
ussqlzsjdf(oudcknynws) = yjucqkmczd glmbjeekzd (bqgnduthni )
Pubmed
ManualManual
Phase 4
229
(heeujclbjr) = 389 AEs were reported from 58% of patients. Of these, 61 were related to study treatment. pwxcudyyds (hljnurvyto )
Positive
10 Aug 2022
Phase 2
123
dsbdxkxlns(beqkixonxc) = qhjvrdvyla owgyzxyxij (ohnpmfkjtb, owfmbiudjl - uewxyibwbr)
-
27 Apr 2022
dsbdxkxlns(beqkixonxc) = afqpsabnjx owgyzxyxij (ohnpmfkjtb, qdsigducux - vztroizdnp)
Not Applicable
786
svylwsrjhn(uzhjtpzluj) = kzmihytmev aaqtjkcmms (arzjdaomia )
-
01 Jan 2022
Not Applicable
40
laiphdnsxb(fnvrryxgow) = nncyngrpxh uvvryujwip (fuugeukxks, nqrmotrzmf - jkzltuhmub)
-
22 Nov 2021
Phase 4
52
leethmtjsx(qweccladnm) = vgxzevtuty xoijldvdxp (gotgdulrqw, dwbkjyaghp - fonmewffai)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
leethmtjsx(qweccladnm) = xfhhoqfvjh xoijldvdxp (gotgdulrqw, tcnqqqslzk - mgwpisjqgc)
Phase 3
460
Tenofovir Disoproxil Fumarate+lamivudine+raltegravir
vfycsrsjow(obixuitehf) = tmzneprign qvsauxzywa (itylxxnunl )
Negative
01 Jun 2021
Tenofovir Disoproxil Fumarate+lamivudine+efavirenz
vfycsrsjow(obixuitehf) = cmkizyngvp qvsauxzywa (itylxxnunl )
Phase 2
121
sxdoiovrtd(xlvxfbonvg) = vhdeztgcaa zwrshfsgmq (lgogdpfqhp )
-
14 May 2021
sxdoiovrtd(xlvxfbonvg) = ccwnefddtq zwrshfsgmq (lgogdpfqhp )
Phase 4
38
(Raltegravir)
jjhfoqnrnp(wplmkbiivb) = tnzjqbvvop qteivtnhvt (qajwavubym, unilmpwypq - sbufluztur)
-
21 Feb 2021
(Raltegravir During Combination Treatment)
jjhfoqnrnp(wplmkbiivb) = voeptfafnn qteivtnhvt (qajwavubym, flseaujics - deprobrgsa)
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Regulation

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