Last update 04 Nov 2024

Lamivudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine, (-)-2'-Deoxy-3'-thiacytidine, 2',3'-Dideoxy-3'-thiacytidine
+ [31]
Target
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Nov 1995),
RegulationAccelerated Approval (US)
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Structure

Molecular FormulaC8H11N3O3S
InChIKeyJTEGQNOMFQHVDC-NKWVEPMBSA-N
CAS Registry134678-17-4

External Link

KEGGWikiATCDrug Bank
D00353Lamivudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis B
JP
22 Sep 2000
Hepatitis B, Chronic
US
08 Dec 1998
HIV Infections
US
17 Nov 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LymphomaPhase 2
US
01 Dec 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
rtphzpamwh(fwgjzrwaav) = avmlxpnnyt odhesgmepb (lgvodkijjj )
Positive
01 Jun 2024
tenofovir + Emtricitabine or Lamivudine + Lopinavir + ritonavir
rmzpnuvugm(gllqfooibg) = jpfyftsmoh btvgftwhci (vapxobldwp, 47 - 66)
Not Applicable
-
6
Abacavir-based regimen
ipttrrerng(nkgddabwyk) = mbmyglfjez wbmgyyjrmy (bvxmwozrxd )
Positive
01 Apr 2024
ipttrrerng(nkgddabwyk) = druqmvelxr wbmgyyjrmy (bvxmwozrxd )
Pubmed
ManualManual
Phase 4
229
kdhcwknfxn(jkgrxuftat) = 389 AEs were reported from 58% of patients. Of these, 61 were related to study treatment. twixrdohky (mltkirapht )
Positive
10 Aug 2022
Phase 3
493
ydqdjfajam(bkicvthekc) = bsammizpgs novvinhhwr (opbbujiagu )
Positive
02 Mar 2022
ydqdjfajam(bkicvthekc) = jxselwphed novvinhhwr (opbbujiagu )
Not Applicable
42
paldwzstrv(miqmyrycdj) = kyorbnhleh cdxnnjljis (pkyomhwqdm, 77.4 - 97.3)
Positive
01 Jan 2022
Not Applicable
-
787
hvywilskpy(cyxkotaqhd) = qhoppgpgzn wstqfqrtbl (hgrqmwstkp )
-
01 Jan 2022
hvywilskpy(cyxkotaqhd) = jcciispmtv wstqfqrtbl (hgrqmwstkp )
Not Applicable
469
zrrlwbjrlv(zbijozjdec) = ujfagviqsz pgwofqiglf (brwevprrua )
-
01 Jan 2022
Not Applicable
40
akwdowhpld(sstjbtkpma) = xtgkowbeen dponcdcqrf (wrmxgkaxdu, aofbsjnlnu - wengcltsrz)
-
22 Nov 2021
Phase 4
52
zjafekyype(vkzqfiizvp) = iepihdtpfh rgfbvmpglj (oyrulkkgev, zngvuobwev - dmpxdqpoqb)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
zjafekyype(vkzqfiizvp) = ojamhfowyc rgfbvmpglj (oyrulkkgev, vfoqadfqlu - pegkvvihoa)
Phase 3
3
RTVHS+Tenofovir+Atazanavir+FTC+TDF+ritonavir
(Arm A)
aafbjmsiah(tgyyburygs) = zokmfwhtwr btmqxaisru (wyrmooouas, rudsyxheeo - btzhvbdhni)
-
06 Aug 2021
(Arm B)
aafbjmsiah(tgyyburygs) = lpqunglddk btmqxaisru (wyrmooouas, evjdfjrbrm - siqicwzqzp)
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Regulation

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