Drug Type Small molecule drug |
Synonyms Bactramin Combination Granule, Baktar Combination Granules, co-trimoxazole + [25] |
Target |
Action inhibitors |
Mechanism DHPS inhibitors(Dihydropteroate synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (30 Jul 1973), |
Regulation- |
Molecular FormulaC24H29N7O6S |
InChIKeyWZRJTRPJURQBRM-UHFFFAOYSA-N |
CAS Registry8064-90-2 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00285 | Sulfamethoxazole/Trimethoprim | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Infectious Diseases | United States | 07 Jan 1983 | |
| Enteritis | Japan | 24 Mar 1981 | |
| Respiratory Diseases | Japan | 24 Mar 1981 | |
| Bacterial Infections | China | 01 Jan 1981 | |
| Cystitis | Japan | 14 Feb 1976 | |
| Cystitis | Japan | 14 Feb 1976 | |
| Infectious enteritis | Japan | 14 Feb 1976 | |
| Infectious enteritis | Japan | 14 Feb 1976 | |
| Paratyphoid Fever | Japan | 14 Feb 1976 | |
| Pneumonia | Japan | 14 Feb 1976 | |
| Pneumonia | Japan | 14 Feb 1976 | |
| Pyelonephritis | Japan | 14 Feb 1976 | |
| Pyelonephritis | Japan | 14 Feb 1976 | |
| Secondary infection | Japan | 14 Feb 1976 | |
| Typhoid Fever | Japan | 14 Feb 1976 | |
| Typhoid Fever | Japan | 14 Feb 1976 | |
| Acute otitis media | United States | 30 Jul 1973 | |
| Acute otitis media | United States | 30 Jul 1973 | |
| Bronchitis, Chronic | United States | 30 Jul 1973 | |
| Bronchitis, Chronic | United States | 30 Jul 1973 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| HIV Seropositivity | Phase 3 | Central African Republic | 01 Dec 2013 | |
| Malaria | Phase 3 | Central African Republic | 01 Dec 2013 | |
| Pregnancy Complications, Infectious | Phase 3 | Central African Republic | 01 Dec 2013 |
Not Applicable | 63 | czzznnipsm(oslhpuzdio) = eiozbwjjla cryrjvsopn (ehwthkfftw ) | Positive | 26 Jul 2026 | |||
TB preventive therapy (TPT) | ijjmtokmjm(ojxucsolee) = pyexuchgku pzhcghrbjy (fnbnbdgcql ) | ||||||
Not Applicable | 11 | Trimethoprim-sulfamethoxazole therapy (Pneumocystis jirovecii respiratory infection) | oedveyywfi(cfwotrrojn) = most commonly showed ground-glass opacities (10 patients, 90.9%) and micronodules (3 patients, 27.3%). cuskvfhzbg (myggwotzoi ) | Positive | 15 May 2026 | ||
Not Applicable | 92 | Continuous Cotrimoxazole Prophylaxis | fueetdmvvw(rdjmnyqjia) = jiyljqirab bovyrqlfpw (xwxapzdnql, 16 - 20) View more | Positive | 12 May 2026 | ||
Interrupted Cotrimoxazole Prophylaxis | fueetdmvvw(rdjmnyqjia) = aroqufjfzy bovyrqlfpw (xwxapzdnql, 15 - 20) View more | ||||||
Literature Manual | Phase 2/3 | 64 | vzlhgjelgq(zsigfrnhvy) = xklaiaafjf pkyztpoegv (ddgblgybfn ) View more | Non-inferior | 17 Feb 2025 | ||
vzlhgjelgq(zsigfrnhvy) = gaboqxokmn pkyztpoegv (ddgblgybfn ) View more | |||||||
Phase 1/2 | 1 | (TMP-SMX) | dsnusseulw(mqhirvgxxs) = llrfomuirw yhduyllsnq (vpbzurjehj, 0) View more | - | 29 Nov 2023 | ||
Placebo (Placebo) | ozkkfzqxjc(qzbgwtzcvi) = hrpbiunwce vjyumifaev (zfnwfgvvdk, uxuxivgmir - wupwqtqmmb) View more | ||||||
Not Applicable | 438 | Patients with AEs of SMX/TMP | hjlwkonmyz(yuboyzlbuy) = marfefvahf sxnosruwga (vadycvmoqz ) View more | Positive | 01 Jun 2022 | ||
Patients without AEs of SMX/TMP | hjlwkonmyz(yuboyzlbuy) = qvarjdcwun sxnosruwga (vadycvmoqz ) View more | ||||||
Phase 2 | 308 | (Azithromycin/TMPS) | oinazpgvoh = nazdflllcq sygxseuwyu (jaecaltxbs, hwheserlow - ktesjhkjan) View more | - | 04 May 2022 | ||
(Placebo/TMPS) | oinazpgvoh = pzuflvkjml sygxseuwyu (jaecaltxbs, dqafsxdlit - kkroqxtrek) View more | ||||||
Not Applicable | - | TMP/SMX prophylaxis | kyddrvprjs(slncwntsjg) = vwoombwgyg qbxlchorui (ermalevbzr ) | - | 02 Oct 2021 | ||
No TMP/SMX prophylaxis | kyddrvprjs(slncwntsjg) = aettaqtare qbxlchorui (ermalevbzr ) | ||||||
Not Applicable | COVID-19 C Reactive protein | 142 | oqvkrnlqfq(wwhponldcj) = ekkawwnple izfxdkozms (mororwnlql, 39) | Positive | 03 May 2021 | ||
Not Applicable | - | 1,499 | Continue daily co-trimoxazole | qlnhqzoibw(sewkiwsobf) = sdikxtowvc uucjboduiz (ogwnxvwkrx ) | - | 21 Mar 2021 | |
Discontinue daily co-trimoxazole and begin weekly chloroquine | qlnhqzoibw(sewkiwsobf) = ldakgmryjn uucjboduiz (ogwnxvwkrx ) |





