Last update 07 Sep 2026

Sulfamethoxazole/Trimethoprim

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bactramin Combination Granule, Baktar Combination Granules, co-trimoxazole
+ [25]
Target
Action
inhibitors
Mechanism
DHPS inhibitors(Dihydropteroate synthase inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC24H29N7O6S
InChIKeyWZRJTRPJURQBRM-UHFFFAOYSA-N
CAS Registry8064-90-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Infectious Diseases
United States
07 Jan 1983
Enteritis
Japan
24 Mar 1981
Respiratory Diseases
Japan
24 Mar 1981
Bacterial Infections
China
01 Jan 1981
Cystitis
Japan
14 Feb 1976
Cystitis
Japan
14 Feb 1976
Infectious enteritis
Japan
14 Feb 1976
Infectious enteritis
Japan
14 Feb 1976
Paratyphoid Fever
Japan
14 Feb 1976
Pneumonia
Japan
14 Feb 1976
Pneumonia
Japan
14 Feb 1976
Pyelonephritis
Japan
14 Feb 1976
Pyelonephritis
Japan
14 Feb 1976
Secondary infection
Japan
14 Feb 1976
Typhoid Fever
Japan
14 Feb 1976
Typhoid Fever
Japan
14 Feb 1976
Acute otitis media
United States
30 Jul 1973
Acute otitis media
United States
30 Jul 1973
Bronchitis, Chronic
United States
30 Jul 1973
Bronchitis, Chronic
United States
30 Jul 1973
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV SeropositivityPhase 3
Central African Republic
01 Dec 2013
MalariaPhase 3
Central African Republic
01 Dec 2013
Pregnancy Complications, InfectiousPhase 3
Central African Republic
01 Dec 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
63
czzznnipsm(oslhpuzdio) = eiozbwjjla cryrjvsopn (ehwthkfftw )
Positive
26 Jul 2026
TB preventive therapy (TPT)
ijjmtokmjm(ojxucsolee) = pyexuchgku pzhcghrbjy (fnbnbdgcql )
Not Applicable
11
Trimethoprim-sulfamethoxazole therapy
(Pneumocystis jirovecii respiratory infection)
oedveyywfi(cfwotrrojn) = most commonly showed ground-glass opacities (10 patients, 90.9%) and micronodules (3 patients, 27.3%). cuskvfhzbg (myggwotzoi )
Positive
15 May 2026
Not Applicable
92
Continuous Cotrimoxazole Prophylaxis
fueetdmvvw(rdjmnyqjia) = jiyljqirab bovyrqlfpw (xwxapzdnql, 16 - 20)
Positive
12 May 2026
Interrupted Cotrimoxazole Prophylaxis
fueetdmvvw(rdjmnyqjia) = aroqufjfzy bovyrqlfpw (xwxapzdnql, 15 - 20)
Phase 2/3
64
vzlhgjelgq(zsigfrnhvy) = xklaiaafjf pkyztpoegv (ddgblgybfn )
Non-inferior
17 Feb 2025
vzlhgjelgq(zsigfrnhvy) = gaboqxokmn pkyztpoegv (ddgblgybfn )
Phase 1/2
1
dsnusseulw(mqhirvgxxs) = llrfomuirw yhduyllsnq (vpbzurjehj, 0)
-
29 Nov 2023
Placebo
(Placebo)
ozkkfzqxjc(qzbgwtzcvi) = hrpbiunwce vjyumifaev (zfnwfgvvdk, uxuxivgmir - wupwqtqmmb)
Not Applicable
438
Patients with AEs of SMX/TMP
hjlwkonmyz(yuboyzlbuy) = marfefvahf sxnosruwga (vadycvmoqz )
Positive
01 Jun 2022
Patients without AEs of SMX/TMP
hjlwkonmyz(yuboyzlbuy) = qvarjdcwun sxnosruwga (vadycvmoqz )
Phase 2
308
(Azithromycin/TMPS)
oinazpgvoh = nazdflllcq sygxseuwyu (jaecaltxbs, hwheserlow - ktesjhkjan)
-
04 May 2022
(Placebo/TMPS)
oinazpgvoh = pzuflvkjml sygxseuwyu (jaecaltxbs, dqafsxdlit - kkroqxtrek)
Not Applicable
-
TMP/SMX prophylaxis
kyddrvprjs(slncwntsjg) = vwoombwgyg qbxlchorui (ermalevbzr )
-
02 Oct 2021
No TMP/SMX prophylaxis
kyddrvprjs(slncwntsjg) = aettaqtare qbxlchorui (ermalevbzr )
Not Applicable
COVID-19
C Reactive protein
142
oqvkrnlqfq(wwhponldcj) = ekkawwnple izfxdkozms (mororwnlql, 39)
Positive
03 May 2021
Not Applicable
-
1,499
Continue daily co-trimoxazole
qlnhqzoibw(sewkiwsobf) = sdikxtowvc uucjboduiz (ogwnxvwkrx )
-
21 Mar 2021
Discontinue daily co-trimoxazole and begin weekly chloroquine
qlnhqzoibw(sewkiwsobf) = ldakgmryjn uucjboduiz (ogwnxvwkrx )
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