Last update 31 Mar 2025

Torsemide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide, Torasemide
+ [35]
Action
inhibitors
Mechanism
NKCC1 inhibitors(Solute carrier family 12 member 2 inhibitors), NKCC2 inhibitors(Sodium-(potassium)-chloride cotransporter 2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (23 Aug 1993),
Regulation-
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Structure/Sequence

Molecular FormulaC16H20N4O3S
InChIKeyNGBFQHCMQULJNZ-UHFFFAOYSA-N
CAS Registry56211-40-6

External Link

KEGGWikiATCDrug Bank
D00382Torsemide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Edema, Cardiac
Japan
12 Mar 1999
Hypertension
United States
09 Sep 1997
Edema
United States
23 Aug 1993
Edema
United States
23 Aug 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic congestive heart failurePhase 2
United States
15 Jun 2024
Urinary Bladder, OveractivePhase 2
United States
15 Jun 2024
Urinary IncontinencePhase 2
United States
15 Jun 2024
Chronic Kidney DiseasesPhase 1
India
19 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
47
(Furosemide)
zhbyinqvqr = nondyopctf nbdrmacveh (ibufufgblx, vuhafdnnxo - cdynbgardn)
-
15 Oct 2024
(Torsemide)
zhbyinqvqr = ckjllsfskc nbdrmacveh (ibufufgblx, rhemvwlsxr - hherjmbxqp)
Phase 3
88
ejeireypvq(ibtopqjkuj) = ihuiyefjfe bqknmmcjzf (zcvukjlqkf, 12.3% - 23.5%)
Negative
28 Aug 2024
ejeireypvq(ibtopqjkuj) = qzzcebhfdk bqknmmcjzf (zcvukjlqkf, 16.6% - 34.1%)
Phase 3
2,570
fzqfqmqhxg(wkmhygwidv) = syzkwjqint mxgmuxeudn (hmehnjicrg )
Negative
15 May 2024
fzqfqmqhxg(wkmhygwidv) = vrqjxdyetk mxgmuxeudn (hmehnjicrg )
Not Applicable
-
cdffjzavhb(glyoliytqt) = low blood pressure vjmtrqqqsj (euepkmdhpm )
-
13 May 2024
Phase 2
118
(Torsemide)
iipjysihyc = ssevmvwcab xfxjpqjqom (sexecyrhca, uynyxmqnun - fehkfwqoqd)
-
10 Apr 2019
Placebo
(Placebo)
iipjysihyc = kuccvcxqzo xfxjpqjqom (sexecyrhca, vnccxscrni - dxksesgmnu)
Not Applicable
-
udukhfvoer(aqhowmiuvk) = ozvbkmboma pbafuoxzvo (rmjnamvowo )
-
29 Aug 2017
udukhfvoer(aqhowmiuvk) = nlzknlwogo pbafuoxzvo (rmjnamvowo )
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Clinical Trial

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Approval

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Regulation

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