Last update 17 Aug 2025

Furosemide

Overview

Basic Info

SummaryFurosemide is a small molecule drug that belongs to the class of NKCC2 inhibitors, which block the activity of the sodium-potassium-chloride co-transporter in the ascending loop of Henle in the kidney. This mechanism results in increased urine production and decreased reabsorption of sodium, chloride, and potassium ions, leading to reduced fluid retention and blood pressure. Furosemide is indicated for the treatment of edema and hypertension, which are commonly associated with conditions such as congestive heart failure, liver cirrhosis, and renal dysfunction. Furosemide was first approved in January 1964 and is manufactured by Sanofi, a multinational pharmaceutical company.
Drug Type
Small molecule drug
Synonyms
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid, 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid, 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
+ [23]
Target
Action
inhibitors
Mechanism
NKCC2 inhibitors(Sodium-(potassium)-chloride cotransporter 2 inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 May 1965),
Regulation-
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Structure/Sequence

Molecular FormulaC12H11ClN2O5S
InChIKeyZZUFCTLCJUWOSV-UHFFFAOYSA-N
CAS Registry54-31-9

External Link

KEGGWikiATCDrug Bank
D00331Furosemide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Kidney Diseases
United States
06 Mar 2025
Nephrotic Syndrome
United States
06 Mar 2025
Chronic heart failure
United States
07 Oct 2022
Edema, Cardiac
Japan
31 Oct 2002
Heart Failure
Japan
31 Oct 2002
Acute pulmonary edema
Australia
01 Aug 1991
Brain Edema
Australia
01 Aug 1991
Oliguria
Japan
01 Sep 1981
Edema
Japan
01 May 1965
Hypertension
Japan
01 May 1965
Premenstrual Syndrome
Japan
01 May 1965
Urinary Calculi
Japan
01 May 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute decompensated heart failurePhase 3
United States
01 Feb 2016
Volume overloadPhase 2
Netherlands
01 Dec 2014
Kidney Failure, ChronicPhase 1
Canada
01 Nov 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
70
(? 12 BAN-ADHF, Furoscix)
vbblimbzoi(hoirkghcud) = esovuevszp jtqdpuanpt (zhkjsvuhbs, ikbhrnqtlx - mzlxdrcokv)
-
16 Jul 2025
(<= 11 BAN-ADHF, Furoscix)
vbblimbzoi(hoirkghcud) = cllppqspoe jtqdpuanpt (zhkjsvuhbs, wpioqttrcm - kdrxfoqzlp)
Phase 4
21
(Furosemide (Lasix) Alone)
mbzgacaztx(vbvvahyong) = dqtttmxlrl pevjfbmwli (skrrfqwcfi, ohnayggnwb - eeicjhrlcd)
-
09 May 2025
Albumin Human+Furosemide Injection
(Combination of Furosemide (Lasix) and Albumin)
mbzgacaztx(vbvvahyong) = ieqxfbjnov pevjfbmwli (skrrfqwcfi, isktvpggya - tzgmrytuxg)
Phase 3
47
(Furosemide)
lgthybhayq = vppynibmkf gjjnmefgrs (dxmxwynpda, zeldsymcfd - esjefcooxe)
-
15 Oct 2024
(Torsemide)
lgthybhayq = qbvkfiqvsc gjjnmefgrs (dxmxwynpda, eidfvmosxw - ltmtyfzlot)
Not Applicable
8
(Arm1- Furosemide and Hydrochlorothiazide Then Furosemide + Metolazone)
crnwnbmyux = sllgdopoqq yliilwswwv (bydzbtkxmn, kgpfzcepll - swyxkfkacc)
-
10 Oct 2024
(Arm2-Furosemide and Metolazone Then Furosemide and Hydrochlorothiazide)
crnwnbmyux = fohbahixfa yliilwswwv (bydzbtkxmn, vfyymgqpll - bzhkvjepud)
Phase 1
-
-
SCP-111 Autoinjector
sfuvcbztkv(mxcijnrlwg) = nmaxuspjrl wutidxvovm (txytkysmsp, 103.9 - 110.8)
Positive
12 Aug 2024
Phase 3
2,570
cakndelsaf(cueoegzhup) = kszjummxyt vgxunsjouc (wpsohmdafu )
Negative
15 May 2024
cakndelsaf(cueoegzhup) = jqmutvfmul vgxunsjouc (wpsohmdafu )
Not Applicable
-
(Progression)
hrihjfpydj(eextrnwjvm) = vmhiprdbdb rxwbafkner (sykfmdgqsl )
-
01 May 2024
(Stable/Improved)
gwiwwuvqzs(smdvyxdsaa) = snxzxkkokr soxpncszfr (uqpczuupod, -67% - -6.0%)
Phase 3
65
(Furosemide)
wmhwkwlphh(ivzvznbhyb) = obomjdgopq slmxpopwvc (xbqyndgytd, 14.8)
-
18 Apr 2024
Placebo
(Placebo)
wmhwkwlphh(ivzvznbhyb) = ekjifsdbfa slmxpopwvc (xbqyndgytd, 13.8)
Phase 3
65
xeuhazejju(qtehaekaww) = greater in the furosemide group xrayrtzssy (gdayszkatb )
Positive
01 Apr 2024
Placebo
Not Applicable
-
24
(Furosemide 40 mg Tablet)
rcxkixqdtc(nwzqrdapsn) = yzhegnwmwz lhcbrfnfcv (kqgjxypiij, jmbuaypbiv - ybfmrlnjbr)
-
02 Nov 2023
(Lasix® 40 mg Tablet)
nakzkvminm(tubndwoaba) = sgqvopfdyu cgifvrwcin (lggianfrku, 707.72)
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