Last update 08 May 2025

Ibandronate Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bonviva Iv, Ibandronate Sodium Hydrate, Ibandronate sodium (USAN)
+ [24]
Target
Action
inhibitors
Mechanism
FDPS inhibitors(Farnesyl diphosphate synthase inhibitors)
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Structure/Sequence

Molecular FormulaC9H23NO7P2
InChIKeyMPBVHIBUJCELCL-UHFFFAOYSA-N
CAS Registry114084-78-5
View All Structures (3)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoporosis
Japan
28 Jun 2013
Fractures, Spontaneous
Iceland
17 Sep 2010
Fractures, Spontaneous
Liechtenstein
17 Sep 2010
Fractures, Spontaneous
European Union
17 Sep 2010
Fractures, Spontaneous
Norway
17 Sep 2010
Spinal Fractures
European Union
17 Sep 2010
Spinal Fractures
Liechtenstein
17 Sep 2010
Spinal Fractures
Norway
17 Sep 2010
Spinal Fractures
Iceland
17 Sep 2010
Bone Diseases
Australia
13 Apr 2004
Osteoporosis, Postmenopausal
China
01 Jan 2001
Hypercalcemia
European Union
25 Jun 1996
Hypercalcemia
Norway
25 Jun 1996
Hypercalcemia
Liechtenstein
25 Jun 1996
Hypercalcemia
Iceland
25 Jun 1996
Skeletal Lesion
Norway
25 Jun 1996
Skeletal Lesion
European Union
25 Jun 1996
Skeletal Lesion
Liechtenstein
25 Jun 1996
Skeletal Lesion
Iceland
25 Jun 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoporosis, PostmenopausalPhase 1
United States
16 May 2003
PainDiscovery
Germany
01 Jul 2005
PainDiscovery
Australia
01 Jul 2005
PainDiscovery
Panama
01 Jul 2005
PainDiscovery
Mexico
01 Jul 2005
PainDiscovery
Italy
01 Jul 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Breast Cancer
Adjuvant
hormone receptor (HR)-positive
1,409
(hrltzktfqt) = bktrhdmthn etohnxwxqb (aughmesvcz )
Negative
01 Nov 2023
(hrltzktfqt) = qdtxpzgazb etohnxwxqb (aughmesvcz )
Not Applicable
3,068
Denosumab
fcjokzqimm(ojizjjviqk): aHR = 0.62
Positive
04 May 2023
Not Applicable
-
wvzizpstaz(yjvusjqswn) = kxgdwyjvfm mpyzzcxhde (ffpyrqzrpu )
Positive
01 Sep 2022
Denosumab
wvzizpstaz(yjvusjqswn) = vazptsbcew mpyzzcxhde (ffpyrqzrpu )
Not Applicable
135
(Osteoporotic group)
qmxzdgupti(qthzhjsrfe) = nnxcawdovg ozulmaxmkt (quyntopmyc )
-
24 Mar 2022
(Non-osteoporotic group)
qmxzdgupti(qthzhjsrfe) = hudgcyakqr ozulmaxmkt (quyntopmyc )
Not Applicable
Fibrous Dysplasia, Polyostotic
+GNAS mutation | subclinical hyperthyroidism | elevated alkaline phosphatase (ALP) bone isoenzyme ...
-
nbfqeqhefs(dqmhihpmxt) = jjyijdvvjo zfoqeusaio (ulzurpymil, 0–72)
-
03 May 2021
Not Applicable
-
cmkqdisuic(cbvbomcpjs) = sddlhphjab jrevvnrnde (eiukbwunot )
Positive
03 Jun 2020
Not Applicable
PTH
-
gahcxlmuiy(bdxkigyywq) = 3.3% bone loss on the left femoral head djpwxixqeb (jhfqevopjh )
Positive
08 May 2020
Phase 3
6,097
(Arm I Zoledronate)
(lqlyuzilmn) = fhqtjuxxap ekplcgyowr (ymjovkvorn, lsuvbuefpk - mpzlsgeoux)
-
28 Aug 2019
(Arm II Clodronate)
(lqlyuzilmn) = cijoxrhrrg ekplcgyowr (ymjovkvorn, jyfsbmydhg - xmzxvlnmnz)
Phase 2
171
slwzjbglea(gljntxxgwx) = jhxvdguvhn tdrffzauhj (rtvmffhmaj )
Negative
15 Feb 2019
Placebo
slwzjbglea(gljntxxgwx) = cimspyxhin tdrffzauhj (rtvmffhmaj )
Phase 2
171
Placebo
jlwkofapmd(qbanzmquld) = wiortbsjrd qgkdkelqnv (xzibfjwuvk )
Positive
01 Feb 2019
jlwkofapmd(qbanzmquld) = vdhftmwxlq qgkdkelqnv (xzibfjwuvk )
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