Nanjing Hencer Pharmacy Co. Ltd.

UV spectrometer method was used to measure the solubility data of dabigatran etexilate mesylate (DEM) Form II in five mono-solvents (methanol, ethanol, ethane-1,2-diol, DMF, DMAC) and binary solvent mixtures of methanol and ethanol in the temperature range from 287.37 K to 323.39 K.The exptl. solubility data in mono-solvents were correlated with modified Apelblat equation, van't Hoff equation and λh equation.GSM model and Modified Jouyban-Acree model were employed to correlate the solubility data in mixed solvent systems.And Regressed UNIFAC model was used to predict the solubility of DEM Form II in the binary solvent mixturesResults showed that the predicted data were consistent with the exptl. data.

Solvent screening is of great importance in the design and optimization of drug crystallizationIn this paper, the solubility data of cefazolin acid in five pure solvents and one binary solvent mixtures (N, N-dimethylformamide + 2-propanol) were exptl. measured in temperature range from (278.15-308.15) K by using UV spectrometer method.The melting temperature of cefazolin acid was estimated by three-level group contribution method.All the exptl. solubility data were correlated by the modified Apelblat model and the λh equation.The exptl. solubility data in binary solvent mixtures were also correlated by the nearly ideal binary solvent CNIBS/Redlich-Kister model.In addition, based on the modified van't Hoff equation, the thermodn. properties of cefazolin acid dissolution process were also calculated and discussed.