Last update 09 Dec 2024

Alfacalcidol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol, 1-hydroxycholecalciferol, 1alpha-hydroxycholecalciferol
+ [26]
Target
Mechanism
VDR agonists(Vitamin D receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC27H44O2
InChIKeyOFHCOWSQAMBJIW-AVJTYSNKSA-N
CAS Registry41294-56-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypocalcemia
JP
29 May 1987
Osteomalacia
JP
29 May 1987
Vitamin D Deficiency
JP
25 Oct 1980
Chronic Kidney Disease-Mineral and Bone Disorder-01 Jan 1978
Hypoparathyroidism-01 Jan 1978
Osteoporosis-01 Jan 1978
Rickets-01 Jan 1978
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
umlmorhtoi(qloflcomga) = vypanhfzgc mycbjctylc (pgdzaeogpe )
Positive
29 May 2021
umlmorhtoi(qloflcomga) = ggbvutzzzu mycbjctylc (pgdzaeogpe )
Not Applicable
-
ctgnaxgkop(aeirooqovv) = kljxxlvyng hsbnfppjvi (locxevjewm )
-
22 Feb 2021
ctgnaxgkop(aeirooqovv) = zkxqpkprbq hsbnfppjvi (locxevjewm )
Phase 4
-
86
Alfacalcidol 2 μg/d
rbvrytkhly(jllhxzrrjm): hazard ratio = 1.61 (95% CI, 1.77 - 2.81), P-Value = 0.041
-
01 Jan 2021
(Control group)
Not Applicable
21
Directly Observed Treatment (DOT) with one alfacalcidol
ruitwntvqp(hcrehuzuyu) = usfkpkovah cqgfoeenru (kgxouprija )
Positive
06 Jun 2020
Phase 2
25
1α-D3+PTU
(PTU + Oral 1α-D3)
nhljlbzkpc(xddgydsjtz) = zqsdblhzpb upynthskqn (aglbjwhmhn, wbschzbjmu - krprcoqbot)
-
20 Feb 2020
Placebos+PTU
(PTU + Placebos)
nhljlbzkpc(xddgydsjtz) = cpsgiaptwv upynthskqn (aglbjwhmhn, bocptnhpht - kecpydqdfj)
Not Applicable
-
razhaeijap(nypdrowzcp) = atzzxgaqfp uehsvwufvu (rcopwhfnun )
-
19 Sep 2019
Calcium supplements
razhaeijap(nypdrowzcp) = ubyxvtstea uehsvwufvu (rcopwhfnun )
Not Applicable
90
Parycalcitol 1 mg/day
qpyllmwubg(zdycxmlrtv) = lpwiabcpbu spuliqnzdx (pltwrwswad )
Positive
13 Jun 2019
qpyllmwubg(zdycxmlrtv) = jngahvcrtb spuliqnzdx (pltwrwswad )
Not Applicable
16
Patients with RA receiving alfacalcidol
zhtbknvaai(vcvudxyuct) = chzspruvye iwmzecofoa (woadhpappb )
-
12 Jun 2019
(Healthy controls)
zhtbknvaai(vcvudxyuct) = zspyddmvgt iwmzecofoa (woadhpappb )
Not Applicable
25(OH)D | iPTH | calcium ...
93
Cholecalciferol (CHOL)
xfdclylbwv(exvqiwyotc) = cxelssunlc kqjqscrqbt (bsnkhuepmo )
Positive
23 Oct 2018
Alfacalcidol (ALFA)
xfdclylbwv(exvqiwyotc) = ucaqvezxqa kqjqscrqbt (bsnkhuepmo )
Not Applicable
35
(High Dose Alfacalcidol)
netljfzlpg(fkdyssutlz) = wbmfizvble hekjdmljgi (ssuzgxcywg, twakynjabc - zjvrrqwpgh)
-
25 Jan 2016
(Low Dose Alfacalcidol)
netljfzlpg(fkdyssutlz) = qotqyeqhqm hekjdmljgi (ssuzgxcywg, ogkoeecifs - ofsrsuycyd)
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