This prospective randomized double-blinded controlled study will be conducted to evaluate the effect of adding calcitonin to bupivacaine in thoracic paravertebral block for patients undergoing thoracotomy.

Start Date28 Mar 2024

Sponsor / Collaborator

Tanta University

IRCT20220523054971N1 / RecruitingPhase 3IIT

Evaluation of response to calcitonin treatment in patients with frozen shoulder in selected hospitals of Islamic Azad University of Medical Sciences, Tehran in 2022

Start Date19 Dec 2021

Sponsor / Collaborator

Islamic Azad University

100 Clinical Results associated with Calcitonin Salmon

100 Translational Medicine associated with Calcitonin Salmon

100 Patents (Medical) associated with Calcitonin Salmon

1,322

Literatures (Medical) associated with Calcitonin Salmon

01 Jan 2025·DIABETES OBESITY & METABOLISM

Diabetic Charcot neuroarthropathy: A threat to both limb and life

Review

Author: Bell, David S. H. ; Jerkins, Terri

Abstract:

Diabetic Charcot neuroarthropathy (DCN), first described in 1936, occurs in less than 1% of diabetic patients, but in those diabetic subjects with distal symmetrical polyneuropathy, the overall incidence increases to 30% and the risk is even greater in those with type 1 diabetes. Factors that precipitate DCN are trauma, ischaemia due to arterio‐venous shunting, increased osteoclastic activity and inflammation. DCN usually presents with a painless swollen foot and/or ankle which is ‘hot to the touch’. These clinical findings are soon followed by characteristic magnetic resonance imaging (MRI) abnormalities and later X‐ray changes. The joints that are most typically involved in chronological order are the tarsometatarsals followed by the naviculocuniform, sub‐tarsal, talonavicular and metatarsal and tarsophalangeal. The cornerstone of therapy is prolonged (3–12 months) offloading with immobilization. Bisphosphonates may possibly accelerate recovery, whereas other unproven possible therapies include rhPTH, 1–34, calcitonin and methylprednisolone, which are not only ineffective but in some cases may also prolong the time to healing. Denosumab is potentially an efficacious, if unproven, therapy to accelerate healing. The risk of amputation is high and increases in the presence of a foot ulcer. DCN is associated with manifestations of autonomic neuropathy, including cardiac denervation, so that the risks of a cardiac event and heart failure are increased with DCN. Mortality is also increased with DCN, especially in the presence of a foot ulcer. To avoid the recurrence of DCN and especially to lower the risk of the recurrence of a foot ulcer recurrence reconstructive, surgery may be needed.

01 Dec 2024·PEPTIDES

Modulation of amylin and calcitonin receptor activation by hybrid peptides

Article

Author: Lee, Sangmin

Calcitonin peptide hormone controls calcium homeostasis by activating the calcitonin receptor. When the calcitonin receptor forms a complex with an accessory protein, the complex functions as the receptors for another peptide hormone amylin. The amylin receptors are the drug target for diabetes and obesity treatment. Since human amylin can produce aggregates, rat amylin that does not form aggregates has been commonly used for research. Interestingly, calcitonin originated from salmons was reported to interact with human amylin receptors with higher affinity/potency than endogenous rat amylin. Here, the peptide hybrid was made of a rat amylin N-terminal fragment and a salmon calcitonin C-terminal fragment. This novel hybrid peptide showed higher potency for human amylin receptor 1/2 activation by 6- to 8-fold than endogenous rat amylin. To further examine the role of the peptide C-terminal fragment in receptor activation, another hybrid peptide was made where salmon calcitonin N-terminal 21 amino acids were fused with rat amylin C-terminal 11 amino acids. The rat amylin C-terminal fragment was previously reported to have relatively low affinity for calcitonin receptor extracellular domain. As expected, this calcitonin-amylin hybrid peptide decreased the potency for calcitonin receptor activation by 3-fold compared to salmon calcitonin. The hybrid strategy used in this study significantly changed the peptide potency for amylin and calcitonin receptor activation. These results provide insight into the role of peptide C-terminal fragments in modulating amylin and calcitonin receptor activation.

27 Nov 2024·BIOSCIENCE REPORTS

Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities

Review

Author: Suar, Mrutyunjay ; Das, Aleena ; Reddy, K Sony

Abstract:

Human malaria, caused by Plasmodium parasites, is a fatal disease that disrupts the host’s physiological balance and affects the neuroendocrine system. This review explores how malaria influences and is influenced by hormones. Malaria activates the Hypothalamus-Pituitary-Adrenal axis, leading to increased cortisol, aldosterone, and epinephrine. Cortisol, while reducing inflammation, aids parasite survival, whereas epinephrine helps manage hypoglycemia. The Hypothalamus-Pituitary-Gonad and Hypothalamus-Pituitary-Thyroid axes are also impacted, resulting in lower sex and thyroid hormone levels. Malaria disrupts the renin-angiotensin-aldosterone system (RAAS), causing higher angiotensin-II and aldosterone levels, contributing to edema, hyponatremia and hypertension. Malaria-induced anemia is exacerbated by increased hepcidin, which impairs iron absorption, reducing both iron availability for the parasite and red blood cell formation, despite elevated erythropoietin. Hypoglycemia is common due to decreased glucose production and hyperinsulinemia, although some cases show hyperglycemia due to stress hormones and inflammation. Hypocalcemia, and hypophosphatemia are associated with low Vitamin D3 and parathyroid hormone but high calcitonin. Hormones such as DHEA, melatonin, PTH, Vitamin D3, hepcidin, progesterone, and erythropoietin protects against malaria. Furthermore, synthetic analogs, receptor agonists and antagonists or mimics of hormones like DHEA, melatonin, serotonin, PTH, vitamin D3, estrogen, progesterone, angiotensin, and somatostatin are being explored as potential antimalarial treatments or adjunct therapies. Additionally, hormones like leptin and PCT are being studied as probable markers of malaria infection.

News (Medical) associated with Calcitonin Salmon

24 Jun 2022

·www.biospace.com

Global Osteoporosis Therapeutics Market Stands At A Valuation Of US$ 12.7 Bn Currently, Predicted To Reach US$ 14.2 Bn By The End Of 2026.

The U.S. Accounts for a Substantial Market Share Of 41% in the Global Osteoporosis Therapeutics Industry Landscape. “Rising aging population will drive demand for osteoporosis treatment as old people are more at risk of osteoporosis,” says a Fact.MR analyst Fact.MR – A Market Research and Competitive Intelligence Provider: Demand for osteoporosis therapeutics is anticipated to increase at a CAGR of 2.9% from 2022 to 2026, as per this new analysis by Fact.MR, a market research and competitive intelligence provider. The osteoporosis therapeutics market is projected to surge to a valuation of US$ 14.2 Bn by the end of 2026. Osteoporosis is a medical condition that weakens the bones and makes them brittle. This condition is highly prevalent in old people, and since the aging population is increasing across the world at a significant pace, this will be a prime driver for market expansion. Increasing sedentary lifestyle, poor eating habits, and rising awareness of osteoporosis are other factors that will guide osteoporosis therapeutics market growth through the coming years. However, lack of diagnosis of osteoporosis and longer time taken by regulatory authorities to approve osteoporosis drugs are expected to constrain osteoporosis therapeutics market potential through 2026. Want A Detailed Understanding of Osteoporosis Therapeutics Market? Request for a Sample Here Osteoporosis drug manufacturers are focusing on launching new drugs and commercializing them to ensure maximum market penetration. In April 2022, Pfenex Inc., a biotechnology company, announced the commercialization of the Teriparatide Injection by its commercialization partner Alvogen in the United States. This will be used for postmenopausal women suffering from osteoporosis and other applications as well. Key Takeaways from Market Study In 2022, the global osteoporosis therapeutics market stands at a net value of US$ 12.7 Bn. The osteoporosis therapeutics market is projected to expand at a CAGR of 2.9% from 2022 to 2026, and reach US$ 14.2 Bn by the end of 2026. Increasing aging population and rising prevalence of osteoporosis are major factors driving market growth. Longer approval times and lack of diagnostic equipment are expected to hamper osteoporosis therapeutics market potential to some extent through 2026. In 2022, the U.S. osteoporosis therapeutics market accounts for around 41% of the global market share. The market for osteoporosis therapeutics in China is predicted to rise at a CAGR of 5.4% from 2022 to 2026. To gain in-depth insights on Osteoporosis Therapeutics Market Report, request methodology at Competitive Landscape: Osteoporosis drug manufacturers are increasing their investments in the research and development of novel drugs to fast-track new launches. Osteoporosis treatment injections are gaining popularity and market players are trying to launch these to advance their revenue potential in the global market. In October 2021, Entera Bio, a leading biotechnology company, posted crucial data for its oral osteoporosis drug formulation trial that is in its mid-stage. The company moved ahead to phase 3 registration of this study. Key Segments Covered in Osteoporosis Therapeutics Industry Research Osteoporosis Therapeutics Market by Drug Class : Bisphosphonates Selective Estrogen Inhibitor Modulators (SERM) Parathyroid Hormone Therapies Calcitonin Rank Ligand Inhibitors Osteoporosis Therapeutics Market by Route of Administration : Oral Osteoporosis Therapeutics Injectable Osteoporosis Therapeutics Other Routes of Administration Osteoporosis Therapeutics Market by Region : North America Osteoporosis Therapeutics Market Latin America Osteoporosis Therapeutics Market Europe Osteoporosis Therapeutics Market East Asia Osteoporosis Therapeutics Market South Asia & Oceania Osteoporosis Therapeutics Market Mea Osteoporosis Therapeutics Market Get Customization on this Osteoporosis Therapeutics Market Report for Specific Research Solutions at Winning Strategy Osteoporosis drug manufacturers are investing in research and development to create novel drugs and expand their product portfolios. They are also focusing on expanding their business scope through increasing awareness of osteoporosis across the world. Osteoporosis drug suppliers are adopting various strategies to boost their revenue generation potential and strengthen their market presence across regions. Developed economies are expected to be highly lucrative markets for osteoporosis drug suppliers. More Valuable Insights on Offer Fact.MR, in its new offering, presents an unbiased analysis of the global osteoporosis therapeutics market, presenting historical demand data (2017-2021) and forecast statistics for the period of 2022-2026. The study divulges essential insights on the market on the basis of drug class (bisphosphonates, selective estrogen inhibitor modulators (SERM), parathyroid hormone therapies, calcitonin, rank ligand inhibitors) and route of administration (oral, injectables, other routes of administration), across six major regions (North America, Latin America, Europe, East Asia, South Asia & Oceania, and the Middle East & Africa). Fact.MR’s Domain Knowledge in Healthcare Our healthcare consulting team guides organizations at each step of their business strategy by helping you understand how the latest influencers account for operational and strategic transformation in the healthcare sector. Our expertise in recognizing the challenges and trends impacting the global healthcare industry provides indispensable insights and support - encasing a strategic perspective that helps you identify critical issues and devise appropriate solutions. Check out more studies related to Healthcare Industry, conducted by Fact.MR: Hyperbaric Oxygen Therapy Devices Market - Hyperbaric Oxygen Therapy (HBOT) Devices Market Analysis by Product (Monoplace, Multiplace HBOT Devices), by Application (Wound Healing, Decompression Sickness, Infection Treatment, Gas Embolism), by Region - Global Forecast 2021-2028 Portable Isolation Room Market - Portable Isolation Room Market Analysis by Product (Portable Isolation Rooms, Portable Isolation Pods), by Occupancy (Single Occupancy Portable Isolation Rooms, Multiple Occupancy Portable Isolation Rooms), by Sales Channel, by Region - Global Forecast 2022-2032 Heart Valve Devices Market - Heart Valve Devices Market Analysis by Type (Mechanical Heart Valves, Biological Heart Valve, Transcatheter Valves), by End User (Hospitals, Ambulatory Surgical Centers), by Region - Global Forecast 2022-2032 Laboratory Information Management System Market - Laboratory Information Management System Market Analysis by Component (Software, Services), by Deployment Model (On-premise, Web-based, Web-Hosted Laboratory Information Management System), by End-User, by Region - Global Forecast 2022-2032 Skincare Devices Market - Skincare Devices Market Analysis by Product (Diagnostic Devices [Dermatoscopes, Microscopes, Biopsy Devices], Treatment Devices [Light Therapy Devices, Electrosurgical Equipment, Liposuction Devices, Cryotherapy Devices]), by Application, by End Use & Regional Forecast 2022-2032 Basin, Bowl and Cup Market - Basin, Bowl and Cup Market Analysis by Type (Basin, Bowl, Cup), by Material Type (Plastic (Polypropylene), Stainless steel), by End-user, Global Forecast 2022-2032 Endoscopy Operative Devices Market - Endoscopy Operative Devices Market Analysis by Product Type (Energy Systems, Access Devices, Suction & Irrigation Systems, Hand Instruments, Snares), by Application (Laparoscopy, Arthroscopy, Bronchoscopy, Mediastinoscopy), by Region - Global Forecast 2022-2032 Generic Injectables Market - Generic Injectables Market by Product Type (Large Molecule Injectables, mAb Generic Injectables, Insulin Generic Injectables), by Application (Oncology, Cardiology), by Container Type (Vials, Ampoules Premix, Prefilled syringes) by Region - Global insights 2022-2032 Antibody Drug Conjugates Contract Market - Antibody Drug Conjugates(ADC) Contract Market by Condition Type (Myeloma, Lymphoma, Breast Cancer, Other Condition Types), Application Type (Cleavable Linker, Non-cleavable Linker), and By Region - Global Research 2022 to 2032 Drainage Bottles Market - Drainage Bottles Market Analysis by Application (Chest Drainage, Accel Evacuated, Peritoneal Drainage, Urostomy, Wound Drainage), End-use (Hospitals and Clinics, Homecare, Nursing Facilities) and by Region- 2022 to 2032 About Us: Market research and consulting agency with a difference! That’s why 80% of Fortune 1,000 companies trust us for making their most critical decisions. While our experienced consultants employ the latest technologies to extract hard-to-find insights, we believe our USP is the trust clients have on our expertise. Spanning a wide range – from automotive & industry 4.0 to healthcare & retail, our coverage is expansive, but we ensure even the most niche categories are analyzed. Our sales offices in United States and Dublin, Ireland. Headquarter based in Dubai, UAE. Reach out to us with your goals, and we’ll be an able research partner. Contact: Mahendra Singh US Sales Office: 11140 Rockville Pike Suite 400 Rockville, MD 20852 Email: sales@factmr.com Tel: +1 (628) 251-158

AntibodyADC

24 Nov 2016

·www.bioportfolio.com

Hybio Pharmaceutical Co., Ltd. 300199 Financial and Strategic SWOT Analysis Review Prices from USD $300

Summary Hybio Pharmaceutical Co., Ltd. Hybio is a biopharmaceutical company that develops polypeptide drugs. The company manufactures and develops peptide finished dosage products and peptide active pharmaceutical ingredients. Its finished dosage products include desmopressin for injection, terlipressin for injection, sodium ozagrel for injection, oxytocin for injection, omeprazole sodium for injection,and others. Hybio provides active pharmaceutical ingredients such as abarelix, calcitonin, copaxone, antide, desmopression, alarelin, bivalirudin, desirudin, elecatonin, fertirelin, ganadorelin, histrelin, leuprorelin, vapreotide and haxapeptide. The company conducts research and development to advance its products. Hybio is headquartered in Shenzhen, China. This comprehensive SWOT profile of Hybio Pharmaceutical Co., Ltd. provides you an indepth strategic analysis of the company's businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company's key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better. This company report forms part of GlobalData's Profile on Demand' service, covering over 50,000 of the world's leading companies. Once purchased, GlobalData's highly qualified team of company analysts will comprehensively research and author a full financial and strategic analysis of Hybio Pharmaceutical Co., Ltd. including a detailed SWOT analysis, and deliver this direct to you in pdf format within two business days. excluding weekends. The profile contains critical company information including*, x000D x000D Business description A detailed description of the company's operations and business divisions.x000D Corporate strategy Analyst's summarization of the company's business strategy.x000D SWOT Analysis A detailed analysis of the company's strengths, weakness, opportunities and threats.x000D Company history Progression of key events associated with the company.x000D Major products and services A list of major products, services and brands of the company.x000D Key competitors A list of key competitors to the company.x000D Key employees A list of the key executives of the company.x000D Executive biographies A brief summary of the executives' employment history.x000D Key operational heads A list of personnel heading key departments/functions.x000D Important locations and subsidiaries A list and contact details of key locations and subsidiaries of the company.x000D Key manufacturing facilities A list of key manufacturing facilities of the company.x000D Detailed financial ratios for the past five years The latest financial ratios derived from the annual financial statements published by the company with 5 years history.x000D Interim ratios for the last five interim periods The latest financial ratios derived from the quarterly/semiannual financial statements published by the company for 5 interims history.x000D x000D Note*: Some sections may be missing if data is unavailable for the company. Key benefits of buying this profile include,x000D x000D You get detailed information about the company and its operations to identify potential customers and suppliers.x000D The profile analyzes the company's business structure, operations, major products and services, prospects, locations and subsidiaries, key executives and their biographies and key competitors.x000D x000D Understand and respond to your competitors' business structure and strategies, and capitalize on their weaknesses. Stay up to date on the major developments affecting the company.x000D The company's core strengths and weaknesses and areas of development or decline are analyzed and presented in the profile objectively. Recent developments in the company covered in the profile help you track important events. x000D x000D Equip yourself with information that enables you to sharpen your strategies and transform your operations profitably.x000D Opportunities that the company can explore and exploit are sized up and its growth potential assessed in the profile. Competitive and/or technological threats are highlighted.x000D x000D Scout for potential investments and acquisition targets, with detailed insight into the companies' strategic, financial and operational performance.x000D Financial ratio presented for major public companies in the profile include the revenue trends, profitability, growth, margins and returns, liquidity and leverage, financial position and efficiency ratios.x000D x000D Gain key insights into the company for academic or business research.x000D Key elements such as SWOT analysis, corporate strategy and financial ratios and charts are incorporated in the profile to assist your academic or business research needs.

Financial StatementAcquisition

100 Deals associated with Calcitonin Salmon

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	H05BA01	DB00017

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bone Diseases, Metabolic	US	Upsher-Smith Laboratories LLC	12 Aug 2005
Hypercalcemia	US	Mylan Ireland Ltd.	03 Jul 1986
Osteitis Deformans	US	Mylan Ireland Ltd.	03 Jul 1986
Osteoporosis, Postmenopausal	US	Mylan Ireland Ltd.	03 Jul 1986

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00478335 (CTgov)	Not Applicable	Diabetes Insipidus, Nephrogenic	4	Placebo+sildenafil+indomethacin+hydrochlorothiazide+calcitonin+amiloride (Experimental First Then Standard)	osdhrwzmii(ebdjwidxza) = ltemjhenwh tblyypntbr (tkgjzxlbba, diyinryatz - tgmwjcwwol) View more	-	12 Feb 2018
				Placebo+sildenafil+indomethacin+hydrochlorothiazide+calcitonin+amiloride (Standard First Then Experimental)	osdhrwzmii(ebdjwidxza) = sxycphvgff tblyypntbr (tkgjzxlbba, whsfflphnp - kxdscucwvm) View more
NCT01292187 (CTgov)	Phase 2	Osteoporosis, Postmenopausal \| Fractures, Bone	129	Calcitonin (Oral Calcitonin Tablets)	efntnadunz(jregtisvbg) = pirbblrula ipfqkldwbv (sgdirtnaal, qwujixyiec - facuenorwe)	-	12 Sep 2014
				Placebo (Oral Placebo Tablets)	efntnadunz(jregtisvbg) = qguknzplcb ipfqkldwbv (sgdirtnaal, nfvhdkfoas - ghtxadzbgc) View more
EULAR2014	Not Applicable	Osteoporosis	134	Alfacalcidol	fnxbknefhj(giwhhvhbvm) = zkijzhxyhy usrstldsyb (anioqlmvjz )	-	11 Jun 2014
				Calcitonin	(opmreqhhfb) = wziebdmapl opgfqrnnzp (uhfwerzjge ) View more
SFN2007	Not Applicable	-	-	Calcitonin	tycfqniscs(tuzgutmweg) = vnxicyymhr qhgmvcntdp (kbfkmdewlr, 1.8)	-	05 Nov 2007
EULAR2001	Not Applicable	Juvenile Idiopathic Arthritis	16	Calcitonin and Calcium	mjfaxutrgo(heplrkjryo) = nzhctrllys zirjdjndtt (oncjynbqhv )	-	13 Jun 2001
				Calcium	mjfaxutrgo(heplrkjryo) = xfsljopvif zirjdjndtt (oncjynbqhv )

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