Adnexal torsion is the rotation of the ovary around its vascular axis resulting, in the absence of treatment, ischemia that can lead to peritonitis by necrosis or impaired fertility. It is a gynecological emergency affecting 3% of women of childbearing age, including from adolescence, and requires surgical treatment as soon as possible, classically within 6 hours.
The symptomatology of adnexal torsion is dominated by pelvic pain of sudden onset and variable intensity, an aspecific sign that does not allow a diagnosis of certainty. There are no biological markers and, in the context of the emergency, the only imaging examination available is pelvic ultrasound associated with a Doppler flow analysis but with a low and variable diagnostic performance depending on the studies (sensitivity variable from 46 to 73%).
There are currently no tests that can provide a diagnosis of certainty. Only surgical exploration, carried out at the discretion of the practitioner on the basis of a bundle of arguments, can confirm or refute the diagnosis. However, this management strategy leads to the realization of emergency surgical interventions wrongly since 3 out of 10 women will finally not have an adnexal torsion (PMSI data from participating centers: 30 to 45% false positives).
Contrast ultrasound is a technique that uses a strict intravascular product to assess the vascularization of the ovary and offers a high diagnostic performance in the context of adnexal torsion. Indeed, a retrospective study, published in 2021, reports a sensitivity of 94% and a specificity of 100%. The preliminary results of our pilot study (AGATA APJC 2019, Dr Bertholdt, NCT04522219) also go in this direction with a sensitivity of 100%, a specificity of 86% and a negative predictive value of 100% (data being published).
The COVARIAN project, second stage of the AGATA project, aims to demonstrate that the addition of a contrast evaluation to standard ultrasound in the diagnostic strategy in case of suspicion of adnexal torsion improves the health of women by reducing the rate of wrongly surgery, that is, without proven torsion.
COVARIAN will be the first prospective multicenter randomized study evaluating the direct benefit for women of using ultrasound contrast evaluation in the management strategy in case of suspicion of adnexal torsion.

Start Date01 Jan 2025

Sponsor / Collaborator

Centre Hospitalier Regional de Nancy

NCT06693752 / Not yet recruitingPhase 2IIT

Pilot Study of Improved Diagnosis and Monitoring of Hydrocephalus in Neonates and Infants Using Contrast-Enhanced Ultrasound

Hydrocephalus affects up to 2 out of every 500 births and results in long-term disability in up to 78% of those affected. The standard treatment of hydrocephalus is cerebrospinal fluid (CSF) diversion via placement of an invasive ventricular shunt to relieve elevated intracranial pressure (ICP). The clinical decision for CSF diversion is based on the ventricular size and clinical symptoms which are not robust indicators of brain health in neonatal hydrocephalus. The purpose of this study is to assess the safety and feasibility of performing brain contrast-enhanced ultrasound (CEUS) in neonates and infants with diagnosed and/or suspected hydrocephalus.

Start Date14 Nov 2024

Sponsor / Collaborator

The Children's Hospital of Philadelphia

NCT06497959 / Not yet recruitingPhase 3IIT

Contribution of Contrast-Enhanced Ultrasound (CES) in the Fetal-placental Circulation Study

Preeclampsia and intrauterine growth restriction (IUGR) are two principal complications of pregnancy. These diseases are related to placental dysfunction nevertheless knowledge of its pathophysiological mechanisms remains inadequate.
No etiological treatment for these pathologies is available. Inducing birth is the only way to prevent the occurrence of these complications (such as fetal death in utero.
Therefore, a better understanding of placental vascularization under pathological and physiological conditions is necessary. This placental vascularization evolves throughout gestation. Histological studies have improved our knowledge of placental vascular pathologies; however, these are ex vivo data that only provide an incomplete reflection of placental function. In vivo placental studies are therefore essential to understand the mechanisms of placental perfusion. Currently, these studies are limited because the available tools (such as placental Doppler) do not allow for the separate study of maternal placental flow from fetal flow. However, histological evidence clearly establishes maternal placental vascular involvement in IUGR. It would therefore be interesting to study maternal and fetal placental vascularization separately. The development of new in vivo imaging exploration techniques will help to better understand placental pathologies.
In obstetrics, CES would offer the opportunity to study in vivo placental vascularization in a segmented manner (maternal versus fetal side independently) since the microbubbles do not cross the placental barrier. Animal studies show no toxic effects on fetal development nor any crossing of the placental barrier. In humans, the innovative use of this contrast agent has allowed for a better understanding of placental vascularization in the first trimester of pregnancy.

Start Date02 Sep 2024

Sponsor / Collaborator

Centre Hospitalier Regional de Nancy

100 Clinical Results associated with Sulfur Hexafluoride Lipid-Type A Microspheres

100 Translational Medicine associated with Sulfur Hexafluoride Lipid-Type A Microspheres

100 Patents (Medical) associated with Sulfur Hexafluoride Lipid-Type A Microspheres

1,427

Literatures (Medical) associated with Sulfur Hexafluoride Lipid-Type A Microspheres

01 Jan 2025·ULTRASOUND IN MEDICINE AND BIOLOGY

Ultrasound and Microbubble-Induced Reduction of Functional Vasculature Depends on the Microbubble, Tumor Type and Time After Treatment

Article

Author: Bjørkøy, Astrid ; Snipstad, Sofie ; Einen, Caroline ; Fernandez, Jessica Lage ; Mühlenpfordt, Melina ; Årseth, Charlotte ; Davies, Catharina de Lange ; Kastellet, Andrea Berge ; Kurbatskaya, Anna ; Berg, Sigrid

OBJECTIVE:

Ultrasound in combination with microbubbles can enhance accumulation and improve the distribution of various therapeutic agents in tumor tissue, leading to improved efficacy. Understanding the impact of treatment on the tumor microenvironment, concurrently with how microenvironment attributes affect treatment outcome, will be important for selecting appropriate patient cohorts in future clinical trials. The main aim of this work was to investigate the influence of ultrasound and microbubbles on the functional vasculature of cancer tissue.

METHODS:

Four different tumor models in mice (bone, pancreatic, breast and colon cancer) were characterized with respect to vascular parameters using contrast-enhanced ultrasound imaging. The effect of treatment with microbubbles and ultrasound was then investigated using immunohistochemistry and confocal microscopy, quantifying the total amount of vasculature and fraction of functional vessels. Two different microbubbles were used, the clinical contrast agent SonoVue and the large bubbles generated by Acoustic Cluster Therapy (ACT), tailored for therapeutic purposes.

RESULTS:

The colon cancer model displayed slower flow but a higher vascular volume than the other models. The pancreatic model showed the fastest flow but also the lowest vascular volume. Ultrasound and SonoVue transiently reduced the amount of functional vasculature in breast and colon tumors immediately after treatment. No reduction was observed for ACT, likely due to shorter ultrasound pulses and lower pressures applied.

CONCLUSION:

Variation between tumor models due to tissue characteristics emphasizes the importance of evaluating treatment suitability in the specific tissue of interest, as altered perfusion could have a large impact on drug delivery and therapeutic outcome.

01 Jan 2025·ULTRASOUND IN MEDICINE AND BIOLOGY

Evaluation of Renal Masses Using Contrast-Enhanced Ultrasound with Sonovue and Sonazoid

Article

Author: Chen, Peng ; Guo, Gang ; Zhu, Run ; Qin, Chi ; Wang, Hua ; Zhang, Haixiang ; Gao, Yongyan

OBJECTIVE:

To explore the differences between SonoVue and Sonazoid contrast-enhanced ultrasound (CEUS) in evaluating enhancement features of renal masses and determine the diagnostic value of CEUS in clear cell renal cell carcinoma (ccRCC).

METHODS:

A total of 57 eligible patients were enrolled and divided into the ccRCC, papillary renal cell carcinoma (pRCC), non-ccRCC and non-pRCC malignancy groups, and benign mass groups based on their postsurgical histopathologic diagnosis. The enhancement features of renal masses following SonoVue and Sonazoid CEUS in each group were analyzed. Diagnostic efficiencies of SonoVue and Sonazoid CEUS for ccRCC and non-ccRCC were determined.

RESULTS:

There were no significant differences in the enhancement features of renal masses with SonoVue and Sonazoid imaging in the four groups (p > .05). Both SonoVue CEUS and Sonazoid CEUS showed good diagnostic performance for the differential diagnosis of ccRCC and non-ccRCC, with sensitivities of 88.6% and 85.7%, specificities of 76.5% and 88.2%, accuracies of 84.6% and 86.5%, positive predictive values of 88.6% and 93.8%, and negative predictive values of 76.5% and 75%, respectively. There were no statistically significant differences in any of the diagnostic performance indices between the two methods (p > .05).

CONCLUSION:

The CEUS features of SonoVue and Sonazoid in evaluating renal masses were similar in the vascular phase. Both SonoVue and Sonazoid CEUS showed good diagnostic performance for the differential diagnosis of ccRCC and non-ccRCC.

01 Dec 2024·ULTRASOUND IN MEDICINE AND BIOLOGY

A Comparative Study of SonoVue and Sonazoid for Contrast-Enhanced Ultrasound CT/MRI Fusion Guidance During Radiofrequency Ablation of Poorly Visualized Hepatic Malignancies: A Prospective Intra-Individual Analysis

Article

Author: Kim, Jae Hyun ; Kim, HeeSoo ; Lee, Jeong Min

PURPOSE:

This study aimed to evaluate the effectiveness of two contrast agents, SonoVue (SV) and Sonazoid (SZ), by comparing them intra-individually in contrast-enhanced ultrasound (CEUS)-CT/MRI fusion imaging (FI) to improve the visibility of inconspicuous liver malignancies on B-mode sonography for guiding percutaneous radiofrequency ablation (RFA). Additionally, the radiologists' preference between SonoVue- CT/MRI FI (SV-FI) and Sonazoid-CT/MRI FI (SZ-FI) was determined.

METHODS:

This prospective study enrolled 23 patients with inconspicuous hepatic malignancies (≤ 3 cm) on B-mode US who underwent both SV-FI and SZ-FI for RFA guidance. The patients underwent real-time CEUS FI with CT/MRI on the same day, utilizing both SV and SZ with at least 15-min intervals. Tumor visibility and radiologists' preferences were assessed and graded using a 4-point scale during the dynamic phases of both SV-FI and SZ-FI and the Kupffer phase of SZ-FI.

RESULTS:

The tumor visibility scores obtained from CEUS-CT/MRI FI were significantly better than those obtained from US-FI. Indeed, SV-FI and SZ-FI demonstrated comparable visibility scores when corresponding phases were compared (p > 0.05). However, the Kupffer phase images of SZ-FI displayed superior visibility scores (3.70 ± 0.56 vs. 2.96 ± 0.88; p = 0.002) than the late vascular phase images of SV-FI. The radiologists favored SZ-FI in many cases, exhibiting moderate inter-observer agreement (Kappa value = 0.587; 95% CI, 0.403-0.772).

CONCLUSION:

Although CEUS-CT/MRI FI with either SV or SZ substantially improved the visibility of inconspicuous tumors on US-CT/MRI FI, radiologists preferred SZ to SV to guide the RFA procedure.

News (Medical) associated with Sulfur Hexafluoride Lipid-Type A Microspheres

27 Feb 2023

·www.sciencedaily.com

New superacid converts harmful compounds into sustainable chemicals

Researchers have succeeded in producing very special catalysts, known as 'Lewis superacids', which can be used to break strong chemical bonds and speed up reactions. The production of these substances has, until now, proven extremely difficult. The chemists' discovery enables non-biodegradable fluorinated hydrocarbons, similar to Teflon, and possibly even climate-damaging greenhouse gases, such as sulphur hexafluoride, to be converted back into sustainable chemicals. Researchers at Paderborn University have succeeded in producing very special catalysts, known as "Lewis superacids," which can be used to break strong chemical bonds and speed up reactions. The production of these substances has, until now, proven extremely difficult. The chemists' discovery enables non-biodegradable fluorinated hydrocarbons, similar to Teflon, and possibly even climate-damaging greenhouse gases, such as sulphur hexafluoride, to be converted back into sustainable chemicals. The researchers have now published their results in the journal Angewandte Chemie (Applied Chemistry). "Lewis acids" are compounds that add electron pairs. Because of this ability, they are often used to speed up chemical reactions. Lewis superacids are stronger than antimony pentafluoride -- the strongest Lewis acid -- and can break even the toughest bonds. Professor Jan Paradies from the Department of Chemistry at Paderborn University explains: "For strong bonds, you need highly reactive reagents, i.e. substances that are extremely reactive." The new catalyst can split, for example, carbon-fluorine or sulphur-fluorine bonds, which are particularly robust. "Intrinsically, these Lewis superacids are incredibly reactive, which makes them difficult to produce and use. Using a trick, we managed to produce such molecules and use them in catalytic reactions. This makes it possible to, for example, activate and further convert virtually inert, i.e. less reactive, carbon-fluorine or sulphur-fluorine bonds," says Paradies. The researchers in the Department of Chemistry have joined forces in the Center for Sustainable Systems Design (CSSD), which bundles interdisciplinary basic research in the field of sustainability at Paderborn University. The complementary scientific interests of the groups involved form the nucleus for new approaches in the development of sustainable systems. The centre wants to leverage this capacity to contribute to the sustainable use of resources. This and related topics are also covered in Paderborn within the framework of its "Sustainable Chemistry" master's programme.

21 Feb 2023

·www.biospace.com

Enhanced Ultrasound Superior to MRI for Diagnosing Certain Liver and Kidney Tumors, According to New Studies

CHICAGO--(BUSINESS WIRE)-- Contrast-enhanced ultrasound (CEUS) is more accurate and reliable than MRI for examining certain liver and kidney nodules, according to two new studies published in the Journal of Ultrasound in Medicine (JUM) and highlighted by the International Contrast Ultrasound Society (ICUS). “We found that CEUS is a better and less expensive first-step evaluation for newly-discovered liver nodules,” said Dr. Stephanie Wilson, principal investigator of the liver CEUS study, which followed 196 patients at the University of Calgary for two years. Dr. Wilson is a clinical professor of radiology and gastroenterology at the University of Calgary and Co-President of ICUS. “CEUS found malignant or pre-malignant diagnoses that would likely have been missed or delayed if we had not used CEUS in these patients,” according to Dr. Wilson. “In addition, CEUS quickly and reliably identified benign lesions and pseudo-lesions, sparing these patients the costs and risks associated with unnecessary downstream testing and procedures,” she added. This study shows that CEUS scans are at least equivalent if not superior to MRI for evaluating these liver lesions, and CEUS should be the first investigation for nodules found on surveillance for liver cancer, according to Dr. Wilson. She called upon the American Association for the Study of Liver Diseases (AASLD) to include CEUS in its liver imaging guidelines, along with MRI and CT. Meanwhile, an Ohio team reviewed clinical data over a 10 year period to assess the accuracy of CEUS diagnoses of benign kidney nodules in 341 patients. Their blinded analysis found that none of the CEUS diagnoses changed during that period. “Our data confirm that when CEUS determines a kidney mass is benign, the mass is benign and no further follow up is needed -- sparing the patient from unnecessary downstream tests, anxiety and costs,” according to Dr. Richard G. Barr, the lead author of the kidney CEUS study. Dr. Barr is a professor of radiology at the Northeast Ohio Medical University and treasurer of ICUS. CEUS is a non-invasive imaging tool that is safely and routinely used worldwide to help identify and characterize cancers, diagnose heart and vascular disease, monitor chronic gastro-intestinal diseases and monitor therapy. Ultrasound contrast agents are administered intravenously to enhance the images produced by ultrasound scans, allowing for visualization of abnormal microvascular blood flow patterns in real time. “It is important to remember that ultrasound contrast agents do not contain iodinated dye and do not harm the kidneys, making CEUS the examination of choice for patients with renal insufficiency,” according to Dr. Barr. “In addition, CEUS allows for improved visualization of enhancement patterns in real time, the thin slice thickness of CEUS allows for evaluation of small nodules, multiplanar imaging allows for improved visualization and confirmation of enhancement, and multiple doses may be used during the same examination to provide an opportunity to image the lesion thoroughly,” Dr. Barr said. Since kidney masses are often found on imaging for other indications, CEUS offers an essential imaging option because it is safe, accurate, low-cost, radiation-free and can help these patients avoid additional unnecessary tests and surgery, he added. “Further, due to radiation exposure associated with CT, we believe CT should not be used as the first line imaging modality for assessing cystic lesions that are most probably benign in character,” Dr. Barr said, citing the FDA’s recent white paper addressing unnecessary radiation exposure from medical imaging. Many urologists are now also finding that CEUS is essential for diagnosing indeterminate kidney masses. “If CEUS shows concern for malignancy of renal masses, we have complete confidence in proceeding with treatment; and if CEUS confirms a lesion to be benign our Urology group feels equally assured that it is safe to follow such lesions over time and to forego treatment,” said Dr. Daniel Ricchiuti, a urologist in Boardman, Ohio. The Canadian liver study represents the first prospective comparison of CEUS and contrast-enhanced MRI for assessment of newly-discovered liver nodules, according to Dr. Wilson. She said her study showed that CEUS offers superior sensitivity when compared to MRI (81% vs 64%) for the diagnosis of malignancy, without compromising specificity (92% vs. 93%). In addition, CEUS was more likely than MRI to reproduce and characterize the nodule found on screening (97% vs. 78.5%). Nonetheless, MRI remains an essential tool for managing patients with malignant tumors, particularly for staging these tumors prior to treatment, according to Dr. Wilson. Four ultrasound contrast agents are available in various countries around the world: Sonovue (Lumason in the USA), manufactured and sold by Bracco; Definity (Luminity in Europe), manufactured and sold by Lantheus; and Optison and Sonazoid, manufactured and sold by GE Healthcare. ABOUT ICUS: The International Contrast Ultrasound Society (ICUS) is a non-profit medical society dedicated to advancing the medically appropriate use of contrast enhanced ultrasound (CEUS) to improve patient care and outcomes. ICUS offers free membership, CME-accredited webinars, newsletters, a comprehensive CEUS website and new mobile app, “ICUS Connect.” To join ICUS and learn more about CEUS, please visit .

Radiation Therapy

24 Nov 2022

·www.prnewswire.com

A "Rheumatoid Arthritis" clinical study conducted by China Medical University Hospital (CMUH) was published on the American Association of Immunologist.

The study also won 2022 Future Technology Award in Taiwan. TAICHUNG,Taiwan, Nov. 24, 2022 /PRNewswire/ -- A clinical study to explore the influence of BR1 on rheumatoid arthritis conducted by Professor Gregory J. Tsai from China Medical University Hospital (CMUH) in Taiwan was published at a meeting of the American Association of Immunologist (AAI), a top medical society in the US. Continue Reading Figure: In 2022, Professor Gregory J. Tsay published a clinical study to explore the influence of BR1 on rheumatoid arthritis at a meeting of the American Association of Immunologists (AAI), a top medical society in US. In the study, Dr. Gregory J. Tsay explained that rheumatoid arthritis belongs to a kind of autoimmune disease with chronic inflammation and deteriorating issues and impacts 0.5-1% of the population, Most patients are female and around 40 years old. The prevalence of arthritis in the US and China exceeds 50 million and 100 million people, respectively. The number of patients continue to grow every year. Patients usually feel joint pain, swelling, and stiffness. In particular, Dr. Gregory J. Tsay stated that many studies have indicated that rheumatoid arthritis is closely correlated with periodontal disease. The major pathogen of periodontal disease is Porphyromonas gingivalis, which generates many toxic factors, including gingipains, with many domains like RgpA (arginine gingipain) and Kpg (lysine gingipain). Therefore, the R&D team led by Dr. Gregory J. Tsay planned to determine a section of peptides for rheumatoid arthritis diagnosis in the pathogen of periodontal disease. This innovative serological target-based test has been developed as a diagnostic kit with ELISA (Anti-BR1 IgG ELISA Kit) for clinical diagnosis. The diagnosis of rheumatoid arthritis primarily relies on two serological tests of "rheumatoid factor (RF)" and "antibody against citrullinated protein antigens (ACPA)," but no less than 30% of rheumatoid arthritis patients have negative RF or ACPA tests. Since no single test can confirm the diagnosis of rheumatoid arthritis, physicians need to combine patients' signs and symptoms, joint examination, x-rays, blood tests, etc. to rule out the diagnosis. However, physicians may be unable to prescribe the reimbursed treatments for the patients if their diagnostic test scores do not meet the criteria. Therefore, a more innovative biological labeling marker is required to improve the sensitivity of the tests and assess the treatment responses to relieve disease conditions and move toward additional treatments. In a recent case at China Medical University Hospital, Ms. Huang, a 37-year-old woman, began frequently experiencing joint redness, swelling, and pain since she was 18 years old. When she woke up in the morning, she would feel body stiffness, swelling in both knees swelling, and difficulty standing up; even her daily walking would be influenced. Because her father had a history of gout, she went to a hospital to seek help at 21 years old and was diagnosed with gout by the doctor. Afterward, she started to control her diet and undergo treatment with medication. However, she did not feel any better. By the time she was 23 years old, she visited the OPD of a well-known top physician of the Rheumatology and Immunology specialty, Professor Gregory J. Tsay. (Dr. Gregory J. Tsay) checked the patient and made an initial diagnosis ruled as rheumatoid arthritis, but both her rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) tests showed negative and were unable to confirm the diagnosis. Therefore, Dr. Gregory J. Tsay's team began studying a new test for rheumatoid arthritis, which is abbreviated as the "anti-BR1 antibody test." After Ms. Huang's anti-BR1 serum test, her test results showed positive and confirmed the rheumatoid arthritis diagnosis. Ms. Huang was treated with new anti-rheumatoid drugs, including disease-modifying anti-rheumatic drugs (DMARD) and biological disease-modifying anti-rheumatic drugs (bDMARD); her joint swelling disappeared quickly, and she recovered a normal life. Currently, she maintains her treatment, and this research achievement won the honor of the 2022 Future Technology Award in Taiwan. Precisely guided by "anti-BR1 antibody test," China Medical University Hospital (CMUH) found a method to increase 60% rheumatoid arthritis serum anti body positive rate to 80% Dr. Gregory J. Tsay and his R&D team identified a critical section of peptides (BR1) by exploring the correlation between periodontal disease and rheumatoid arthritis to be applied to the diagnosis of rheumatoid arthritis. Through the ELISA approach, the plasma BR1 autoimmune antibody can be applied to help confirm a rheumatoid arthritis diagnosis. The team identified 76 (54.3%) rheumatoid arthritis patients with positive BR1 antibody among 140 patients with rheumatoid arthritis. One-half of the patients with negative RF and ACPA were found to have positive anti-BR1, improving the positive rate of those two traditional tests from 66.3% to 87.1%. The accuracy of the BR1 antibody test kit may elevate the sensitivity of clinical diagnosis for rheumatoid arthritis. Dr. Gregory J. Tsay further explained that the kit is expected to be the third regular test for rheumatoid arthritis diagnosis to achieve the goal of early diagnosis for subsequent early treatment; then patients can get relief from pain and improve their quality of life. SOURCE China Medical University Hospital

Clinical ResultAACR

100 Deals associated with Sulfur Hexafluoride Lipid-Type A Microspheres

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KEGG	Wiki	ATC	Drug Bank
-	Sulfur Hexafluoride Lipid-Type A Microspheres	V08DA05	DB11104

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Vesico-Ureteral Reflux	US	Bracco Diagnostics, Inc.	22 Dec 2016
Cerebrovascular Disorders	CN	Bracco SpA	18 Nov 2014
Liver Diseases	US	Bracco Diagnostics, Inc.	10 Oct 2014
Cardiovascular Diseases	EU	Bracco International BV	26 Mar 2001
Cardiovascular Diseases	IS	Bracco International BV	26 Mar 2001
Cardiovascular Diseases	LI	Bracco International BV	26 Mar 2001
Cardiovascular Diseases	NO	Bracco International BV	26 Mar 2001
Contrast agents	EU	Bracco International BV	26 Mar 2001
Contrast agents	IS	Bracco International BV	26 Mar 2001
Contrast agents	LI	Bracco International BV	26 Mar 2001
Contrast agents	NO	Bracco International BV	26 Mar 2001

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Heart Diseases	Phase 3	US	Bracco Diagnostics, Inc.	01 Oct 2015
Coronary Artery Disease	Phase 3	US	Bracco Diagnostics, Inc.	24 Sep 2015
Coronary Artery Disease	Phase 3	CA	Bracco Diagnostics, Inc.	24 Sep 2015
Coronary Artery Disease	Phase 3	DE	Bracco Diagnostics, Inc.	24 Sep 2015
Coronary Artery Disease	Phase 3	IT	Bracco Diagnostics, Inc.	24 Sep 2015
Liver Cancer	Phase 3	US	Bracco Diagnostics, Inc.	01 Jun 2010
Visible Lesion	Phase 3	US	Bracco Diagnostics, Inc.	01 Jun 2010
Hypertension, Pulmonary	Phase 2	US	Bracco Diagnostics, Inc.	01 Apr 2011

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03821376 (CTgov)	Phase 4	Kidney Neoplasms	12	Lumason	oqteuxiirr(derddbeqmn) = urpipwikcv huqcfpvmlv (hzfkbpwbeb, lkacllghyg - fxclepyxos) View more	-	10 Oct 2024
NCT04569799 (CTgov)	Phase 4	Hepatocellular Carcinoma	26	Lumason	qhcqrhiezi(pfbngzuobj) = khhyvlxxlx xdevlmpwyt (obmohbqzmq, pbtrrgjxwy - uaxlzoetdv) View more	-	02 Nov 2023
NCT03687502 (CTgov)	Phase 2	Appendicitis	37	Sulfur hexafluoride lipid-type A microspheres	vxmidnlqza(ydoqmvgprn) = tzffnlnpjt sjsjrvvqmc (pxwjtdwtya, lxwphogjam - ggxsvxffvb) View more	-	01 Dec 2022
NCT03235180 (CTgov)	Phase 4	Crohn Disease	9	Magnetic Resonance Enterography (MRE)+Sulfur Hexafluoride	zoaoesebkh(ardhxlrpxn) = nixfejkqwd kdryrxoxuq (pricgkkokt, dgbugehixk - htdxyndqzc) View more	-	10 Nov 2021
PROSPECTIVE INTRA-INDIVIDUAL COMPARISON (ILCA2020)	Not Applicable	-	-	SULFUR HEXAFLUORIDE (Perfluorobutane (C4F10))	qwwcynzosn(datuchxoyl) = nkqywvweul zgxrnvqepb (coqeytpnws ) View more	Positive	11 Sep 2020
ESC2020	Not Applicable	-	100	Perfluoropropane contrast	maymwxrfnq(qtiilrpttt) = odgjmchhbn ylimqanuwq (altpbdtkuo ) View more	-	29 Aug 2020
ESC2020	Not Applicable	-	100	Sulphur hexafluoride contrast	maymwxrfnq(qtiilrpttt) = pmcczzyydv ylimqanuwq (altpbdtkuo ) View more	-	29 Aug 2020
ERS2019	Not Applicable	Asthma	-	SF6	pshllldnzg(lvcafzgwli) = jbnngzwrnj ovrjzjxoez (uwrflxubkv )	Positive	28 Sep 2019
ERS2019	Not Applicable	Asthma	-	SF6	pshllldnzg(lvcafzgwli) = cymqhjbprd ovrjzjxoez (uwrflxubkv )	Positive	28 Sep 2019
NCT03040323 (CTgov)	Phase 4	Liver Diseases	83	Lumason 60.7Mg Powder for Injection (Biopsy With Lumason)	grcthmmzvf(qwrmafehop) = mcqqczywyu nggsfpdncw (xnmpvgsynv, mcbhpfqubo - uhdtatmscm) View more	-	24 Jul 2019
NCT03040323 (CTgov)	Phase 4	Liver Diseases	83	Placebos (Biopsy With Placebos)	grcthmmzvf(qwrmafehop) = qwulmhynte nggsfpdncw (xnmpvgsynv, xpvottlztm - vqblejmlyl) View more	-	24 Jul 2019
2019 ARVO Annual Meeting (ARVO2019)	Not Applicable	-	88	20% sulfur hexafluoride (SF6) gas	zhlvsvjkec(kujfmltxzu) = ouozruednu kndmgecvst (qvfiylmnuu ) View more	Positive	01 Jul 2019
2019 ARVO Annual Meeting (ARVO2019)	Not Applicable	-	88	20% sulfur hexafluoride (SF6) gas (Air)	zhlvsvjkec(kujfmltxzu) = gngascvcnt kndmgecvst (qvfiylmnuu ) View more	Positive	01 Jul 2019
NCT02786810 (CTgov)	Phase 2	Kidney Diseases \| Urinary Tract Infections \| Vesico-Ureteral Reflux	10	Sulfur hexafluoride type-a lipid microspheres	mgexlfpjoj(gqetrhrzfl) = amfhqyywsj tvfrgkdegb (faccwnmgia, mimyxuwcnd - oszgjeepvb) View more	-	04 Apr 2018

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