The purpose of this study is to evaluate the effects of L-carnitine on symptomatic improvement, oxidative stress, and inflammation in mild to moderate knee osteoarthritis patients.

Start Date01 May 2025

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

NCT03994874

/ RecruitingPhase 1/2

Peritoneal Ultrafiltration in Cardio Renal Syndrome to Prevent Heart Failure Exacerbation.

Randomized, controlled, unblinded, adaptive design clinical trial to evaluate the safety and efficacy of PolyCore (Polydextrin, L-Carnitine, D-xylitol) peritoneal ultrafiltration (PUF) in patients with heart failure and reduced ejection fraction (HFrEF).

Start Date16 Apr 2025

Sponsor / Collaborator

Iperboreal Pharma Srl

NCT06564909

/ Not yet recruitingPhase 2IIT

Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

The study aims is to evaluate the efficacy and tolerability of L-Carnitine on biomarkers of myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI by the assessment of nitrotyrosine as an oxidative stress marker and Matrix metallopeptidase-2 (MMP-2) as a cardiac fibrosis marker

Start Date01 Feb 2025

Sponsor / Collaborator

Ain Shams University

100 Clinical Results associated with Levocarnitine

100 Translational Medicine associated with Levocarnitine

100 Patents (Medical) associated with Levocarnitine

15,293

Literatures (Medical) associated with Levocarnitine

31 Dec 2025·GYNECOLOGICAL ENDOCRINOLOGY

Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol

Article

Author: Rusce, Maria Laura ; Spelta, Eleonora ; Battipaglia, Christian ; Genazzani, Alessandro D. ; Foschi, Martina ; Kostrzak, Anna ; Szeliga, Anna ; Meczekalski, Blazej ; Semprini, Elisa ; Aio, Claudia

OBJECTIVE:

To evaluate the effects of a combination of carnitines, L-arginine, L-cysteine and myo-inositol on metabolic and reproductive parameters in PCOS overweight/obese patients.

METHODS:

This was a retrospective study analyzing information of a group of PCOS (n = 25) overweight/obesity patients, not requiring hormonal treatment, selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Modena, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). The hepatic insulin extraction index was also calculated.

RESULTS:

The mix of complementary substances significantly improved metabolic parameters, homeostatic model assessment for insulin resistance index values and gonadotropin plasma levels. Glucose, C-peptide and insulin response to OGTT was significantly reduced as well as the hepatic insulin extraction index.

CONCLUSION:

The administration of a combination of carnitines, L-arginine, L-cysteine and myoinositol improved gonadotropin plasma levels and insulin sensitivity in overweight/obese PCOS patients and restored hepatic clearance of insulin as demonstrated by the decreased hepatic insulin extraction index.

31 Dec 2025·Journal of Pharmaceutical Policy and Practice

Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado

Article

Author: Saseen, Joseph J. ; Dardouri, Mouna ; Nair, Kavita V. ; Moore, Gina D. ; DiStefano, Michael J.

Background:

High prices and other access barriers have contributed to the rise of a market for compounded glucagon-like peptide-1 receptor agonists for weight loss in the United States. This market has not been systematically studied. We conducted a pilot study to assess the prevalence, characteristics, and advertising content of direct-to-consumer providers of compounded glucagon-like peptide-1 products for weight loss in Colorado.

Methods:

We conducted a cross-sectional study of websites advertising compounded glucagon-like peptide-1 products for weight loss in Colorado. Websites were identified using Google searches focused on census-defined statistical areas. Searches were conducted between March 21 and April 12, 2024. Data collected from websites included physical addresses, business type, highest reported staff credential, advertised glucagon-like peptide-1 products, whether businesses referred to Food and Drug Administration approval when describing products, and whether businesses referred to products as 'generic'.

Results:

We identified 93 business websites advertising compounded glucagon-like peptide-1 products for weight loss corresponding to 188 physical locations throughout Colorado. Most businesses were self-categorized as medical/health spas (33/93) or weight loss services (26/93). Advertised products included semaglutide (92/93), tirzepatide (40/93), liraglutide (2/93), and retatrutide (1/93). Advertised combination products included B vitamins (8/93), levocarnitine (1/93), mannitol (1/93), BPC-157 (1/93), and glycine (1/93). Seven websites advertised oral formulations. Additionally, 41/93 websites referred to Food and Drug Administration approval in their descriptions of compounded products and 5/93 referred to products as 'generic'.

Conclusion:

This study identified several instances of unapproved glucagon-like peptide-1 products being compounded and advertised in Colorado. Additionally, 1 product was advertised as compounded with BPC-157, a substance determined by the Food and Drug Administration to be unsafe for compounding. This study also identified numerous examples of misleading claims regarding the regulatory status of compounded glucagon-like peptide-1 products. Regulatory action is needed to ensure the benefits of compounded GLP-1 products outweigh the risks.

31 Dec 2025·Gut Microbes

Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition

Article

Author: Wang, Jin-Town ; Lo, Yi-Ling ; Kuo, Han-Chun ; Kao, Hsien-Li ; Hsu, Chia-Lang ; Yen, Jeffrey J Y ; Sheen, Lee-Yan ; Chen, Yi-Hsun ; Hsu, Cheng-Chih ; Liao, Yu-Chieh ; Panyod, Suraphan ; Lo, I-Hsuan ; Chiu, Tina H T ; Kuo, Ching-Hua ; Zou, Hsin-Bai ; Yang, Yu-Tang ; Chuang, Hsiao-Li ; Chiu, Jian-Ying ; Wu, Ming-Shiang ; Wu, Wei-Kai ; Chiu, Han-Mo

Gut microbial metabolism of L-carnitine, which leads to the production of detrimental trimethylamine N-oxide (TMAO), offers a plausible link between red meat consumption and cardiovascular risks. Several microbial genes, including cntA/B, the cai operon, and the recently identified gbu gene cluster, have been implicated in the conversion of dietary L-carnitine into TMA(O). However, the key microbial genes and associated gut microbes involved in this pathway have not been fully explored. Utilizing the oral carnitine challenge test (OCCT), which specifically measures TMAO production from L-carnitine intake and identifies TMAO producer phenotypes, we compared the abundance of microbial genes between low- and high-TMAO producers across three independent cohorts. Our findings consistently revealed that the gbu gene cluster, rather than cntA/B or the cai operon, was significantly enriched in high-TMAO producers. We further analyzed 292 paired multi-omic datasets from OCCT and shotgun metagenomic sequencing, which demonstrated a significant positive correlation between the abundance of fecal gbu genes and L-carnitine-induced TMAO production, with gbuB showing the strongest correlation. Interestingly, these fecal gbu genes were found to increase with L-carnitine supplementation and decrease with a plant-based diet. Notably, we verified a previously uncultured gbu-containing bacterium, JAGTTR01 sp018223385, as the major contributor to TMA formation in the human gut. We isolated these gbu-containing gut microbes and confirmed their role in TMA/TMAO production using anaerobic incubation and a gnotobiotic mouse model. Using an in-house collection of gbu-containing isolates, we developed a qPCR-based method to quantify fecal gbuB and validated its correlation with L-carnitine-mediated TMAO production as measured by OCCT. Overall, these findings suggest that gbu-containing gut microbes are crucial for TMAO increases following L-carnitine intake and may serve as biomarkers or targets for personalized nutrition.

News (Medical) associated with Levocarnitine

15 Dec 2024

·www.accesswire.com

Best Legal Steroids: Effective Bodybuilding Steroid Alternatives for Muscle Growth

Closest thing to real steroids to use for cutting and bulking in the bodybuilding industry SAN FRANCISCO, CA / ACCESSWIRE / December 15, 2024 / For many years, professional and amateur bodybuilders have been drawn to the allure of steroids for muscle growth and strength gains, a trend observed by experienced trainers working closely with athletes over decades.But the risks of anabolic androgenic steroids-legal issues, severe side effects, and long-term damage to your health-just aren't worth it. That's why I've turned my attention to legal steroid alternatives.Legal alternatives to Dianabol and Trenbolone, for example, are designed to give you the same benefits as traditional oral and injectable steroids-more muscle, more strength, and more endurance-but without the downsides.The best part? They're legal and available to buy online in the USA.In this guide, I'll take you through the best bodybuilding steroid alternatives that not only deliver amazing results but also support your overall health and performance. Whether you want to bulk up, get lean, or enhance your athleticism, these legal steroid alternatives have you covered.Best Legal Steroids for Sale Online - IntroHere are the most effective and popular muscle building supplements and legal substitutes to traditional anabolic steroids for sale online in the USA.D-Bal Max (Dianabol)Tren-Max (Trenbolone)Crazy Bulk Stacks (4 x combo)Testo Prime (Testosterone)The listed brands and products can be ordered online and have long money back guarantees. Free delivery to the United States, Canada, UK and Australia.Top-Rated Legal Steroids for Bodybuilding:Here is a more in depth explanation of the most effective steroids for sale that are legally available to buy in the USA. Each product is from a reputable manufacturer and can be ordered directly, which passes on savings and ease of communication with customer service.#1 - D-Bal Max - Legal Dianabol SteroidCLICK to view D-Bal Max price, special offers and availabilityAs someone with years of experience in bodybuilding and training both men and women to achieve massive muscle gains, I've used and experimented with countless steroids and supplements.But when it comes to legal alternatives that can produce similar results to anabolic steroids, D-Bal Max is the most effective.D-Bal Max is designed to replicate the muscle-building power of Dianabol, one of the most famous anabolic steroids.Like other legal steroid alternatives, D-Bal Max falls under the category of dietary supplements and is subject to different regulatory standards compared to anabolic steroids.What makes it the top choice is its ability to deliver massive lean muscle growth without the dangerous side effects associated with steroids.I've had clients who wanted to bulk up quickly but were hesitant to use illegal anabolic steroids, and D-Bal Max has consistently provided them with the results they were looking for.What sets D-Bal Max apart is its powerful blend of ingredients that work synergistically to boost muscle size, strength, and endurance.It contains a combination of natural compounds like Pro BCAA Complex, 20-Hydroxyecdysterone, and a Whey Protein Complex, which together enhance protein synthesis, increase nitrogen retention, and improve energy levels.These are the same mechanisms through which Dianabol works, but D-Bal Max does it safely and legally.I've personally seen the transformation in individuals who've used D-Bal Max as part of their training regimen.Their muscles become fuller and stronger, their recovery times are shortened, and they're able to push harder in the gym.The results are not just superficial; they're substantial and sustainable, making D-Bal Max an ideal choice for anyone serious about increased muscle and bodybuilding.If you're looking to get big quickly and want a legal, safe alternative to Dianabol, D-Bal Max is the best option on the market. It delivers powerful results without the risks, and that's why I recommend it to all my clients.#2 - Tren-Max - Legal TrenboloneCLICK for promotions and price on legal Trenbolone - Tren-MaxTrenbolone is another steroid that I've used, and it's similar to Dianabol in that both are incredibly effective for rapid muscle growth and strength gains. However, Trenbolone takes it a step further by offering lean muscle gains without the water retention that often comes with Dbol.When I was looking for a legal alternative that could deliver similar results to Trenbolone, I came across Tren-Max from CrazyBulk, and I have to say, it's the best Trenbolone substitute legally available to buy in the USA.Tren-Max is designed to replicate the powerful anabolic effects of Trenbolone, but without the harsh side effects. Tren-Max is a legal alternative to performance enhancing drugs like Trenbolone, providing similar benefits without the legal and health risks. What makes Tren-Max so effective is its ability to boost muscle mass, strength, and conditioning all at once.It works by increasing nitrogen retention and red blood cell production, which are the same pathways that make Trenbolone so potent. The difference is, Tren-Max does this naturally and legally.Some of the guys I have trained who wanted the muscle density and vascularity that Trenbolone provides, didn't want to risk the severe side effects like "Tren cough," night sweats, or cardiovascular strain. Tren max has been the perfect solution for them.It's packed with natural ingredients like Beta-Sitosterol, Samento Inner Bark, Nettle Leaf Extract, and Pepsin, which together promote serious muscle growth, enhanced fat loss, and improved physical conditioning.The results I've seen with Tren-Max are impressive. My clients have experienced significant gains in muscle hardness and strength, similar to what you'd expect from a Trenbolone cycle, but without the risks associated with steroids.The strength gains are real, and the muscle definition is far more pronounced, giving that chiseled, gym-hardened look.If you're aiming to get ripped and build solid, lean muscle mass while staying on the right side of the law, Tren-Max from CrazyBulk is the way to go.It's a must have for anyone serious about achieving a powerful, shredded physique without compromising their health.#3 - Bulking Stack - Steroid Stack ComboCLICK for details and availability on CRAZY BULK Bulking StackIf you're training someone who's looking for quick and rapid muscle gains, the CrazyBulk Bulking Stack is a combination I strongly recommend.This stack contains the top legal alternatives to some of the most powerful and popular anabolic steroids: Dianabol (Dbol), Trenbolone (Tren), Deca-Durabolin (Deca), and Testosterone. Together, these legal supplements create the ultimate combination for anyone serious about packing on muscle mass fast.The CrazyBulk Bulking Stack is designed to mimic the effects of traditional bulking steroids without the dangerous side effects. The stack includes:D-Bal (Dianabol alternative): Known for rapid muscle and strength gains, D-Bal boosts protein synthesis and nitrogen retention, which are crucial for building muscle mass.Tren-Max (Trenbolone alternative): Tren-Max promotes lean muscle gains, enhanced fat loss, and increased vascularity, giving you that hard, defined look while still packing on size.Deca-max (Deca-Durabolin alternative): Deca-Max supports joint health and boosts collagen synthesis, which is essential for heavy lifting. It also enhances muscle endurance and recovery, allowing for more intense, longer workouts.Testo-Max (Testosterone alternative): Testo-Max powers the entire stack by naturally increasing testosterone levels, which is the key hormone for muscle growth, strength, and overall performance.While the stack does not include human growth hormone, it provides a comprehensive approach to muscle building and performance enhancement.When combined, these four supplements work synergistically to create an anabolic environment in your body that promotes rapid muscle growth, increased strength, and faster recovery times.The stack is perfect for pushing past plateaus and achieving the kind of muscle mass that's typically only possible with steroids, but without the legal risks or harmful side effects.If you're training someone who wants to see dramatic results quickly, the CrazyBulk Bulking Stack is an unbeatable option. It's a safe, legal, and highly effective way to achieve massive muscle gains in a short amount of time, making it the ultimate choice for serious bodybuilders and athletes.#4 - Testo Prime - Legit Testosterone BoosterCLICK to get pricing and discount deals on TestoPrime - Legal TestosteroneIf you're aiming to get ripped and build solid, lean muscle mass while staying on the right side of the law, Tren Max from CrazyBulk is the way to go.It's a game-changer for anyone serious about achieving a powerful, shredded physique without compromising their health.But let me tell you, no matter how effective your stack is, it's going to fall short if your testosterone levels aren't where they need to be. That's where TestoPrime comes into play.This is hands down the best natural testosterone booster I've come across, and it's something I recommend to everyone, whether they're just starting out or they're seasoned lifters looking to break through a plateau.TestoPrime is packed with proven ingredients that naturally elevate your testosterone levels, which is crucial for muscle growth, fat loss, and overall performance.As someone who has experimented with various T-boosters over the years, I can honestly say that TestoPrime delivers results you can feel. The increased energy, improved mood, and enhanced strength are all game-changers in the gym.There were men and women who I have worked with who were struggling with low energy, slow recovery, and just not seeing the muscle gains they were working so hard for.After adding TestoPrime to their regimen, the difference was night and day. Their strength shot up, their recovery times shortened, and they started packing on lean muscle much faster.It's also great for keeping your natural testosterone levels high when you're cycling off other supplements, ensuring that you maintain the gains you've worked so hard for.TestoPrime isn't just about boosting testosterone; it's about optimizing your entire performance. It helps burn stubborn fat, enhances mental clarity, and gives you the edge you need to dominate every workout.If you're serious about taking your training to the next level, TestoPrime is an absolute must-have in your supplement arsenal.#5 - Testol 140 - Legally Available Rad 140RAD 140, also known as Testolone, isn't an anabolic steroid, but it's a powerful SARM (Selective Androgen Receptor Modulator) that's gained a lot of attention in the bodybuilding community for its ability to mimic the effects of traditional steroids without some of the harsh side effects.It's known for delivering impressive muscle gains, enhanced strength, and improved physical conditioning. But if you're looking for a legal and safe alternative that gives you similar results, Testol 140 from CrazyBulk is the way to go.Testol 140 is designed to replicate the incredible muscle-building and fat-burning effects of RAD 140, but with a formula that's 100% natural and legal.One of the things I love about Testol 140 is that it provides the same kind of lean, hard muscle gains that you'd expect from a SARM like RAD 140, but without the risks associated with SARMs, such as potential liver toxicity or hormonal imbalances.I've had clients who were skeptical about legal alternatives, especially when they'd heard so much hype around RAD 140.But after incorporating Testol 140 into their training program, they quickly saw why this SARM is one the most effective legal steroid alternatives for targeted muscle growth. The muscle gains are substantial, and the fat loss is real, helping them achieve that shredded, lean look that's so hard to get naturally. Plus, Testol 140 also boosts energy levels and stamina, allowing you to push harder in your workouts and recover faster afterward.What really sets Testol 140 apart is that it's safe, effective, and doesn't mess with your hormones like some of the harsher substances out there.It's ideal for anyone who wants to experience the benefits of RAD 140-such as increased muscle mass, strength, and endurance-without the legal risks or side effects.If you're serious about building a lean, strong physique naturally, Testol 140 is a smart choice that delivers on its promises.What are Legal Steroids and How Do They Work as Performance Enhancing Drugs?Legal steroids (also known as steroid alternatives) are supplements that mimic the muscle building effects of anabolic steroids but without the side effects.Unlike taking anabolic steroids, which can lead to severe health risks, legal steroids offer a safer alternative for muscle growth and performance enhancement.They work by boosting the body's natural functions such as protein synthesis and nitrogen retention which are needed for muscle growth and strength.Unlike regular anabolic steroids, legal steroids do not have synthetic hormones or harmful substances so it's a safer steroid option for anyone who wants to build muscle and perform better.Benefits of Legal Steroids for Muscle MassLegal steroids is a safer and faster way to build muscle and strength without the risks of anabolic steroids.They help in building lean muscle while losing fat so you get a more defined and athletic body. These supplements also boost athletic performance and endurance so it's a favorite among bodybuilders and athletes.Plus legal steroids don't need post-cycle therapy (PCT) and are generally easier to use than regular anabolic steroids.How to Choose the Legal Steroid Alternative for YouWhen choosing a legal steroid alternative for your needs you need to consider a few things to make sure you get it right.First identify your goals-muscle mass, endurance or fat loss-and choose a product that fits. Look for products with natural ingredients and from companies that have a good safety and effectiveness record.Also read reviews and stay up to date with the latest science. As of 2024 several studies have proven certain natural ingredients in legal steroids and you can make a more educated decision. Always do your research to make sure the product you choose is safe and effective. And always consult with a doctor before starting any new supplement regimen to tailor the product to your needs and health.Safety and Side Effects of Anabolic Steroid UseLegal steroids are generally safe and don't have the same severe side effects as anabolic steroids but you can still experience mild side effects.These can be stomach upset, headaches or allergic reactions depending on your individual sensitivity to certain ingredients. The latest 2024 research confirms that these side effects are rare and mild especially when you follow the recommended dosage.To minimize the risk you need to follow the recommended dosage and consult with a doctor if you experience any adverse effects.Natural Ingredients and Their BenefitsD-Aspartic Acid: A natural amino acid that increases testosterone production which is needed for muscle growth and strength. 2024 research confirms it helps with muscle mass in athletes.Panax Ginseng: A natural herb that improves athletic performance and endurance. 2024 research shows it increases energy and reduces fatigue during intense workouts.L-Carnitine: An amino acid involved in fat metabolism and muscle growth. 2024 science proves it helps with fat loss and preserves lean muscle mass.Tyrosine: An amino acid that helps with muscle growth and recovery. It increases mental focus and reduces stress which can impact workout performance and recovery time.Can Women Use Legal Steroid Alternatives?Yes, women can use steroid alternatives to build muscle, lose fat and support overall fitness goals. But you must use steroids like Anavar for example, that are specifically designed for women to avoid virilization (development of male characteristics).Many legal steroid alternatives on the market are designed for women, powerful but balanced formulas that support lean muscle growth and fat loss without hormonal imbalance. Always follow the recommended dosage and consult with a doctor before starting any supplement to make sure it's aligned with your health and fitness goals.Are Steroid Substitutes Legal in the USA?Yes, steroid substitutes are 100% legal in the United States and available to buy online and in stores. These alternatives are made from natural ingredients and do not contain synthetic compounds found in androgenic anabolic steroids, so they are safe and legal to use.But you must choose products from reputable companies that are transparent with their ingredients and manufacturing process. Follow the recommended dosage to ensure safety and effectiveness.Before-After Results of the Best Steroid SubstitutesD-Bal MAX: Users get massive muscle gain and strength after using D-Bal MAX. It's praised for mimicking the effects of Dianabol without the side effects, so it's a top choice for those who want to bulk up fast and safely.CrazyBulk Bulking Stack: This stack combines several legal steroid substitutes and users get impressive muscle gain, strength and overall athletic performance. It's perfect for those who are under intense training and want to maximize their muscle building potential.TestoPrime: TestoPrime is highly recommended for its ability to boost testosterone levels naturally and users get massive muscle gain, strength and fat loss. Users also get more energy and faster recovery, so it's a top choice for those who want to transform their body.How to Choose the Best Over the Counter Steroid SubstitutesWhen choosing the best over the counter steroid substitutes, prioritize products made from natural ingredients and from reputable companies. Start by reading reviews and research the product to make sure it has a good safety and effectiveness record.Look for legal steroids online that are tested and backed by science or positive user reviews. And always consult with a doctor before starting any new supplement to ensure you're healthy and not taking any medications. This way you can choose the right and effective steroid alternative for your needs.Summary - Legal Steroid Alternatives and Dietary Supplements for SaleSo there you have it, legal steroid alternatives are a powerful and safe way to increase muscle growth, strength and athletic performance without the risks of anabolic steroids. These products like D-Bal MAX, CrazyBulk Bulking Stack and TestoPrime deliver impressive results by using natural ingredients that are scientifically backed and tailored to your goals.Whether you want to bulk up, lose fat or just overall physical conditioning these legal steroid alternatives are the solution. They are legal, available and designed to help you peak performance safely. Just remember, the key to success with any supplement is to choose products from reputable companies, follow the dosage and consult with a doctor to make sure they are suitable for your individual health and fitness goals.FAQWhere to buy steroids online?You can buy steroids online but in many countries including the US it's illegal to buy without a prescription. However you can buy legal steroid alternatives which are safe and work from reputable websites like CrazyBulk which specializes in natural supplements that mimic the effects of anabolic steroids.What's the best natural steroid for lean mass?The best natural supplement for lean mass is often considered to be a product like TestoPrime which boosts testosterone levels naturally and supports muscle growth and fat loss. Another popular one is Trenorol from CrazyBulk which mimics the effects of Trenbolone and gives lean muscle gains without water retention.Is buying steroids online legal?In many countries including the US it's illegal to buy anabolic steroids online without a prescription. However buying legal steroid alternatives which are made from natural ingredients and don't contain synthetic hormones is legal and can be done through online retailers.What are the safest steroid alternatives online?The safest steroid alternatives are those made from natural ingredients and sold by reputable companies. Products like D-Bal MAX, Trenorol and TestoPrime are popular ones that mimic the effects of anabolic steroids but are legal and safe to use. They are available to buy online.Can women use legal steroid alternatives?Yes women can use legal steroid alternatives but make sure to choose products designed for women to avoid side effects. Products like CrazyBulk's Anvarol and Winsol are popular for women who want to build lean muscle and burn fat safely.How do I know I'm buying safe and legal steroid alternatives online?To make sure you're buying safe and legal steroid alternatives, buy from well known companies with good reviews and transparent ingredient lists. Look for products made from natural ingredients and tested for safety and effectiveness. Consult with a healthcare professional before starting any new supplement.Top Natural Steroids for Muscle GrowthFor those seeking muscle growth without the risks associated with anabolic steroids, natural alternatives are a safer and effective option. Here are some of the top natural steroids for muscle growth:Creatine: Found naturally in foods like fish and meat, creatine helps increase muscle strength and endurance, making it a popular choice among athletes.Ashwagandha: This herb, used in Ayurvedic medicine, is known for its ability to promote muscle growth and enhance strength.Tribulus Terrestris: A plant extract that boosts testosterone levels, Tribulus Terrestris supports muscle growth and overall physical performance.D-Aspartic Acid (DAA): An amino acid that increases testosterone levels, DAA is essential for promoting muscle growth and strength.Vitamin D: An essential nutrient, Vitamin D plays a crucial role in muscle growth and strength, supporting overall health and performance.These natural supplements provide a safer alternative to anabolic steroids, helping to build muscle mass and improve strength without the associated health risks.Herbal Supplements for Muscle GrowthIn addition to natural steroids, several herbal supplements can aid in muscle growth and overall fitness. Here are some effective options:Ginseng: Known for its energy-boosting properties, ginseng helps increase endurance and enhance athletic performance.Fenugreek: This herb is known to increase testosterone levels, promoting muscle growth and strength.Safed Musli: Used in traditional Indian medicine, Safed Musli supports muscle growth and enhances physical strength.5-Alpha-Hydroxy-Laxogenin: A plant extract that promotes muscle growth and strength, 5-alpha-hydroxy-laxogenin is a popular choice among bodybuilders.While these herbal supplements can significantly aid muscle growth, they should be used alongside a healthy diet and regular exercise for the best results. Always consult with a healthcare professional before starting any new supplement to ensure it aligns with your health and fitness goals.Understanding Anabolic SteroidsAnabolic steroids are synthetic hormones designed to mimic the effects of the male sex hormone testosterone. These substances are widely used to promote muscle growth, increase strength, and enhance athletic performance. Available in various forms such as oral tablets, injectable solutions, and creams, anabolic steroids work by increasing protein synthesis, which helps build muscle mass and repair damaged tissues.However, anabolic steroids are classified as controlled substances due to their high potential for misuse and abuse. Using anabolic steroids without a medical prescription is illegal and can lead to severe health consequences. Many athletes and bodybuilders misuse anabolic steroids to gain a competitive edge, but this practice can result in significant health problems, including liver damage, high blood pressure, and cardiovascular disease. The risks associated with anabolic androgenic steroid use far outweigh the benefits, making it crucial to consider safer alternatives.Risks of Anabolic Steroid MisuseMisusing anabolic steroids can lead to a range of serious health problems, including:Liver Damage and Liver Cancer: Anabolic steroids can cause severe liver damage, leading to conditions such as liver cancer.High Blood Pressure and Cardiovascular Disease: Steroid use can raise blood pressure, increasing the risk of cardiovascular diseases, including heart attacks and strokes.Aggressive Behavior and Mood Swings: Known as "roid rage," anabolic steroids can cause significant changes in mood and behavior.Acne and Skin Problems: Steroid use can exacerbate skin conditions, leading to severe acne and other skin issues.Hair Loss and Male Pattern Baldness: Anabolic steroids can accelerate hair loss and contribute to male pattern baldness.Gynecomastia: The development of breast tissue in men, a condition known as gynecomastia, can occur with steroid misuse.Infertility and Sexual Dysfunction: Long-term use of anabolic steroids can lead to infertility and other sexual health issues.Additionally, long-term use of anabolic steroids can lead to dependence and addiction. When individuals stop using anabolic steroids, they may experience withdrawal symptoms such as depression, anxiety, and insomnia. The potential for these severe health risks underscores the importance of avoiding anabolic steroid misuse.Contact InformationTony StevensLabmeeting[email protected]4152229090SOURCE: Labmeeting

12 Nov 2024

·www.prnewswire.com

2024 Tsingke High-Impact Literature Compilation - Gene Synthesis

BEIJING, Nov. 12, 2024 /PRNewswire/ -- Tsingke has delivered high-quality biotechnology services and products to nearly 300,000 users globally. The number of high-level academic papers published using Tsingke's products and services has grown steadily year after year, continuously driving the advancement of life science research. We have selected two high-impact papers, published in prestigious journals, spanning a range of fields from gene function research to immunotherapy. Compilation of High-Impact Literature 1. Title: Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition DOI: 10.1126/science.adk8838 Journal: Science Impact Factor: 56.9 Summary: This study shows that crop yield potential is limited by inherent trade-offs between grain size and number. While brassinosteroids (BRs) promote grain enlargement, their role in regulating grain number has been unclear. By analyzing a cluster-type rice germplasm, the researchers found that activating the BR metabolic gene BRASSINOSTEROID-DEFICIENT DWARF3 (BRD3) significantly increases grain number. A molecular pathway was established where the BR signal inhibitor GSK3/SHAGGY-LIKE KINASE2 phosphorylates and stabilizes the OsMADS1 transcription factor, which targets the TERMINAL FLOWER1-like gene RICE CENTRORADIALIS2. Tissue-specific activation of BRD3 in secondary branch meristems enhances panicle branching, reduces the negative impact on grain size, and improves grain yield. The study demonstrates the powerful role of tissue-specific hormone manipulation in overcoming trait trade-offs and unlocking rice yield potential. 2. Title: Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer DOI: 10.1038/s41392-024-01772-w Journal: Signal Transduction and Targeted Therapy Impact Factor: 39.3 Summary: Despite the success of immune checkpoint therapies, resistance and relapse remain common in lung cancer. Cancer stem cells (CSCs) are an important factor in immune therapy resistance. Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, has shown synergistic effects with immunotherapy. This study shows that the key rate-limiting enzyme CPT1A in fatty acid oxidation, together with L-carnitine from tumor-associated macrophages, drives ferroptosis resistance and CD8+ T cell dysfunction in lung cancer. Mechanistically, CPT1A inhibits the ubiquitination and degradation of c-Myc, which transcriptionally activates CPT1A expression. The CPT1A/c-Myc positive feedback loop enhances the NRF2/GPX4 system and reduces the quantity of phospholipid polyunsaturated fatty acids, boosting cellular antioxidant capacity and suppressing ferroptosis in CSCs. Importantly, targeting CPT1A enhances anti-tumor immunity and ferroptosis in immune checkpoint blockade therapy in tumor-bearing mice. These results present a metabolic vulnerability-targeting approach to improve lung cancer immunotherapy efficacy. Tsynth™ Gene Synthesis Tsingke is built on a foundation of advanced gene synthesis technology, supported by a gene-smart molecular splitting and assembly platform that enhances accuracy and success rates. Leveraging years of expertise in life sciences, bioinformatics, and computer science, Tsingke has pioneered cutting-edge codon optimization techniques. At the same time, the company utilizes the propeller system (TSINGKE HELIXTECH), an integrated full-cycle management system that combines customer service, production management, and lean management. By employing AI algorithms, it effectively links raw materials, equipment, and processes, powering intelligent production lines and precise gene detection quality control techniques. This enables Tsingke to provide low-cost, high-efficiency, and high-quality gene synthesis services, meeting the needs of researchers in fields such as life science research, biopharmaceuticals, biological breeding, biomanufacturing, and gene storage. For more high-impact papers utilizing Tsingke's products and services, visit our website to explore how our solutions are helping advance research worldwide. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

ImmunotherapyGene Therapy

28 Oct 2024

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Cocrystal Health Industry Announces Launch of Best in Class Bioabsorption and Stability Cocrystallized Lutein and Curcumin Technologies

Patented and clinically verified nutraceutical actives outperform current branded offerings and offer a powerful solution for supplement product potency concerns. LAS VEGAS, Oct. 28, 2024 /PRNewswire/ -- At the Supplyside West tradeshow this week representatives from Cocrystal Health Industry are announcing the launch of the Cocrystal Lutein and Curcumin powder actives. Backed by 60 global patents and near 100 published papers, the company leverages their proprietary and clean cocrystallization platform to produce actives with dramatically improved bioabsorption, stability and functionality relative to existing offerings. These launches build on their existing cocrystallized ingredient portfolio which includes Ubiquinol CoQ10, Hydroxytyrosol and Alpha Tocopherol Vitamin E. Continue Reading Cocrystal Curcumin Powder Cocrystal Lutein Powder Lutein is well demonstrated in clinical research to support eye health, though traditional lutein ingredients have poor bioabsorption, solubility, and stability, as the ingredient is easily oxidized. Powered by Cocrystal Health Industry's clean, vegan and non-GMO cocrystallization process, Cocrystal Lutein now provides a powerful solution to address these concerns. In 3rd party testing, Cocrystal Lutein demonstrated over 6 times greater bioabsorption and 3 times better solubility compared to current marketed lutein. In a head-to-head capsule stability study, the cocrystal advantage is even more dramatic. Cocrystal Lutein maintained over 99% of potency in capsules after 30 days, while current marketed lutein maintained less than 2% of its original potency. In addition to performance advantages, the cocrystal technology offers a significant cost savings relative to well known branded lutein. While well researched to support a range of benefits including joint and cognitive health, marketed curcumin extracts are similarly limited by very poor bioavailability. Patented Cocrystal Curcumin featuring L-Carnitine as a ligand has been shown in studies to offer over 10X greater bioabsorption in comparison to current marketed curcumin. And while there are several enhanced bioavailability curcumin materials available, in a head-to-head study Cocrystal Curcumin showed significantly better bioabsorption even relative to an existing enhanced offer. Alex Mei, PhD, Cocrystal Health Industry's Founder & CEO commented, "We are thrilled to expand our portfolio and introduce powerful new solutions in our Cocrystal Lutein & Curcumin technologies. Our proprietary platform solves for multiple nutrition brand concerns – providing meaningful differentiation and unparalleled benefit performance to their consumers, while ensuring sustained potency against label claim. As the global leader in cocrystallized active ingredients, we're proud to offer these transformative solutions." To learn more manufacturers and formulators can reach out to [email protected]. About Cocrystal Health Industry: Backed by 60 global patents and near 100 published papers, Cocrystal Health Industry introduces cocrystal powder technologies as unprecedented solutions for poor stability and low bioavailability ingredients. With demonstrated best in class bioavailability and superior in-formula stability, our actives also feature pure nature integrity, improved solubility, dissolution, melting point and flowability versus existing offerings. Beyond their superior performance, Cocrystal actives typically offer a cost advantage relative to other branded ingredients. The company's growing portfolio includes Cocrystal Ubiquinol, Hydroxytyrosol, Alpha Tocopherol, Rutin and now Lutein and Curcumin. For more information visit . Media Contact: Jeff Avila 305-632-1733 [email protected] SOURCE Cocrystal Health Industry WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

100 Deals associated with Levocarnitine

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KEGG	Wiki	ATC	Drug Bank
D02176	Levocarnitine	A16AA01	DB00583

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Kidney Diseases	Italy	Alfasigma SpA	18 May 2015
Shock, Septic	Italy	Alfasigma SpA	18 May 2015
Cardiovascular Diseases	China	Leadiant Biosciences, Inc.	31 Dec 1999
Metabolism, Inborn Errors	Ireland	Shire Pharmaceutical Development Ltd.	23 Oct 1996
Carnitine palmitoyltransferase deficiency	Netherlands	Sigma-Tau Industrie Farmaceutiche Riunite SpA	03 Feb 1986
Systemic Carnitine Deficiency	United States	Leadiant Biosciences, Inc.	27 Dec 1985

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Inflammation	Phase 3	Egypt	Tanta University	05 Mar 2023
Pain	Phase 3	Egypt	Tanta University	05 Mar 2023
Rheumatoid Arthritis	Phase 3	Egypt	Tanta University	05 Mar 2023
Moderate persistent asthma	Phase 3	Egypt	Tanta University	08 Aug 2022
Persistent asthma	Phase 3	Egypt	Tanta University	08 Aug 2022
Beta-Thalassemia	Phase 3	Egypt	Tanta University	08 Jul 2022
Refractory heart failure	Phase 3	China	Lee's Pharmaceutical Holdings Ltd.	01 Jan 2011
HMN (Hereditary Motor Neuropathy) Proximal Type I	Phase 2	United States	Leadiant Biosciences, Inc.	01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type I	Phase 2	Canada	Leadiant Biosciences, Inc.	01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type I	Phase 2	Germany	Leadiant Biosciences, Inc.	01 Apr 2008

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ISN WCN2024	Not Applicable	L-carnitine \| levocarnitine	284	L-carnitine supplementation	ajeqcnydyx(vknfeuvkko) = wimqntqjep qflxybwvaq (atwgxzbedh, -10.29 to 4.13) View more	Negative	01 Apr 2024
NCT05083637 (Pubmed \| J Nutr)	Not Applicable	Malnutrition Myeloperoxidase \| Neopterin \| alpha-1-antitrypsin ... View more	98	L-carnitine syrup (100 mg/kg/d)	yyryfjwoyg(dehuoidwqj) = adrxnjshka yppmbwvfyh (lppcxlbyyc, -556.58 to 249.91)	Negative	01 Mar 2024
AASLD2023	Not Applicable	Hepatic Encephalopathy \| Hyperammonemia	-	Oral L-Carnitine	xwvjqxbtln(dhpuiokomg) = wsvnouitcv htojzirdjz (vgexhageof ) View more	-	10 Nov 2023
ATS2023	Not Applicable	Brain Diseases	-	Valproate	vkaiogjfqr(lsartgatcb) = hemodynamic instability, metabolic derangements, encephalopathy, and cerebral edema that can progress to coma and death faybmrtjoo (rgsqndofay ) View more	-	21 May 2023
ESMO2022	Not Applicable	Head and Neck Neoplasms	150	L-carnitine 500mg	uutowrloxr(wckupigvux) = svocgjcdmo eqslzypzeb (bwadfzyuwo )	-	10 Sep 2022
ESMO2022	Not Applicable	Head and Neck Neoplasms	150	L-carnitine (Control)	uutowrloxr(wckupigvux) = tbndaykzeu eqslzypzeb (bwadfzyuwo )	-	10 Sep 2022
NCT01783041 (CTgov)	Phase 2/3	Systemic Carnitine Deficiency \| Obstetric Labor, Premature \| Neurodevelopmental Disorders	144	5% dextrose (5% Dextrose)	tonqdkvrep(tewccutlhn) = ezyplhnchr axaklhertd (momqmwbkpu, 3.5) View more	-	08 Mar 2022
NCT01783041 (CTgov)	Phase 2/3		144	L-carnitine (L-carnitine)	tonqdkvrep(tewccutlhn) = mbkpgygrgp axaklhertd (momqmwbkpu, 3.3) View more	-	08 Mar 2022
ESC2021	Not Applicable	Burns, Electric KCNH2-N588K	-	L-Carnitine	cslsbeyguk(qmdrcexwzh) = qrjzznblka xdfrkfjhwq (pgycevzdib ) View more	-	29 Aug 2021
ESC2021	Not Applicable	Burns, Electric KCNH2-N588K	-	L-Carnitine	cslsbeyguk(qmdrcexwzh) = yyncsoxsgc xdfrkfjhwq (pgycevzdib )	-	29 Aug 2021
NCT03426722 (Pubmed \| Invest New Drugs)	Phase 3	Gastrointestinal Stromal Tumors First line	42	L-carnitine	uogjefqeww(qprcmhitxv) = sztaabdbwk jkxspnjgzp (lwqxllysfn ) View more	-	01 Apr 2020
IC 172 (ASN2019)	Not Applicable	Hodgkin's Lymphoma Maintenance	172	Intravenous L-Carnitine (LC) 1000 mg	norteoqwqz(wqdqqbuakt) = lvrbblvlud oaifkjfetq (dliitdmdzl )	Positive	05 Nov 2019
ASN2019	Not Applicable	Peritoneal dialysis complication serum free carnitine (FC) \| acyl-carnitine (AC) \| urinary L-FABP ... View more	24	L-carnitine supplementation (750 mg/day)	ucnqgonoyt(kgrhilujyz) = rhhlbpnpmv qjgjxkvsya (xaxgyzxgto ) View more	Positive	05 Nov 2019
ASN2019	Not Applicable		24	L-Carnitine (Control)	ucnqgonoyt(kgrhilujyz) = ngebhjfonb qjgjxkvsya (xaxgyzxgto ) View more	Positive	05 Nov 2019

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