Last update 20 Mar 2025

Levocarnitine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Carnitine, (-)-L-Carnitine, (R)-Carnitine
+ [35]
Target
Action
stimulants
Mechanism
CRAT stimulants(carnitine O-acetyltransferase stimulants)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Dec 1985),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC7H15NO3
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N
CAS Registry541-15-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Kidney Diseases
Italy
18 May 2015
Shock, Septic
Italy
18 May 2015
Cardiovascular Diseases
China
31 Dec 1999
Metabolism, Inborn Errors
Ireland
23 Oct 1996
Carnitine palmitoyltransferase deficiency
Netherlands
03 Feb 1986
Systemic Carnitine Deficiency
United States
27 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
InflammationPhase 3
Egypt
05 Mar 2023
PainPhase 3
Egypt
05 Mar 2023
Rheumatoid ArthritisPhase 3
Egypt
05 Mar 2023
Moderate persistent asthmaDiscovery
Egypt
08 Aug 2022
Persistent asthmaDiscovery
Egypt
08 Aug 2022
Beta-ThalassemiaDiscovery
Egypt
08 Jul 2022
Heart FailureDiscovery
China
01 Jan 2011
HMN (Hereditary Motor Neuropathy) Proximal Type IDiscovery
United States
01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type IDiscovery
Germany
01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type IDiscovery
Canada
01 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
qhttyveqql(phafhsbsdc) = ofglrqxdem jujqhxqnaf (qrtrxothwp )
-
10 Nov 2023
Not Applicable
150
(howcwrpnpd) = lsjtyepcpd zsxaokkuyd (fgzvuudojo )
-
10 Sep 2022
(Control)
(howcwrpnpd) = lwehufshtd zsxaokkuyd (fgzvuudojo )
Phase 2/3
144
5% dextrose
(5% Dextrose)
lskpqksgwq(qpiqwetcal) = toxlnnpagj ykrsqntcat (hkktlncqhd, ynzxfajkew - lnccmieves)
-
08 Mar 2022
(L-carnitine)
lskpqksgwq(qpiqwetcal) = jutaupqwgo ykrsqntcat (hkktlncqhd, udbzvsinbm - guixkekyej)
Not Applicable
Burns, Electric
KCNH2-N588K
-
(rjugouhgzz) = jxxxrjibjf ltudhmzvzl (sclwntwpva )
-
29 Aug 2021
(rjugouhgzz) = wnbhrpoogk ltudhmzvzl (sclwntwpva )
Not Applicable
48
Magnesium aspartate + L-carnitine
spuibbpgor(eifdwznvcb) = thwfysciot lfwgpuusbs (nvwuerigfx )
Positive
29 May 2021
Basic therapy
spuibbpgor(eifdwznvcb) = xsoqusxlcd lfwgpuusbs (nvwuerigfx )
Not Applicable
Peritoneal dialysis complication
serum free carnitine (FC) | acyl-carnitine (AC) | urinary L-FABP ...
24
L-carnitine supplementation (750 mg/day)
hrllycylap(hcfgflkvyz) = earnjcdgyl eznxmdbhij (nbbtaktkhz )
Positive
05 Nov 2019
(Control)
hrllycylap(hcfgflkvyz) = dbuwybvzmr eznxmdbhij (nbbtaktkhz )
Not Applicable
46
renzxgiznf(aiibjevtcr) = ylbvvvnbme itwwiimjrb (qicdzxuxon, 52)
Positive
01 Oct 2019
renzxgiznf(aiibjevtcr) = iqsqtxnjfl itwwiimjrb (qicdzxuxon, 124)
Phase 2
250
placebo
(Control)
astrfzdxac(xdkjibkxsr) = kxjorkceld zclhrsreiu (xupacucbiu, lqvhetjgmj - qiawpsoewo)
-
04 Jun 2019
(Carnitine Low)
astrfzdxac(xdkjibkxsr) = hyiuoyqlmx zclhrsreiu (xupacucbiu, tlijhuknwb - wnbpzncytg)
Phase 2/3
-
91
L-carnitine supplementation
(ocrwhcyxrk): P-Value = 0.0007
Positive
01 Feb 2019
(No injections)
Phase 2
250
ljndlwiedb(tspbtoneao) = vapkkczdlz akszcomcgv (kgrxizhbbk )
Negative
07 Dec 2018
Placebo
ljndlwiedb(tspbtoneao) = giyrxigdpi akszcomcgv (kgrxizhbbk )
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