Last update 07 Aug 2025

Levocarnitine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Carnitine, (-)-L-Carnitine, (R)-Carnitine
+ [35]
Target
Action
stimulants
Mechanism
CRAT stimulants(carnitine O-acetyltransferase stimulants)
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Dec 1985),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC7H15NO3
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N
CAS Registry541-15-1

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Kidney Diseases
Italy
18 May 2015
Shock, Septic
Italy
18 May 2015
Cardiovascular Diseases
China
31 Dec 1999
Metabolism, Inborn Errors
Ireland
23 Oct 1996
Carnitine palmitoyltransferase deficiency
Netherlands
03 Feb 1986
Systemic Carnitine Deficiency
United States
27 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
InflammationPhase 3
Egypt
05 Mar 2023
PainPhase 3
Egypt
05 Mar 2023
Rheumatoid ArthritisPhase 3
Egypt
05 Mar 2023
Moderate persistent asthmaPhase 3
Egypt
08 Aug 2022
Persistent asthmaPhase 3
Egypt
08 Aug 2022
Beta-ThalassemiaPhase 3
Egypt
08 Jul 2022
Refractory heart failurePhase 3
China
01 Jan 2011
NephrotoxicityPhase 2-01 Aug 2025
HMN (Hereditary Motor Neuropathy) Proximal Type IPhase 2
United States
01 Apr 2008
HMN (Hereditary Motor Neuropathy) Proximal Type IPhase 2
Canada
01 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Malnutrition
Myeloperoxidase | Neopterin | alpha-1-antitrypsin ...
98
L-carnitine syrup (100 mg/kg/d)
salnkkwxvv(kjekuxhzbv) = tsazbwirwg rogblkwzlb (suwiwrqtdy, -556.58 to 249.91)
Negative
01 Mar 2024
Phase 2/3
144
5% Dextrose
(5% Dextrose)
bwigilbwoi(jhngbnzyez) = hdbchknzfh barzkpdadd (rhhveaalcw, 3.5)
-
08 Mar 2022
(L-carnitine)
bwigilbwoi(jhngbnzyez) = hvtnllzoim barzkpdadd (rhhveaalcw, 3.3)
Phase 3
42
nfcbdorsew(jvdcqoayrq) = jjjiccgwbn hynbegcrwf (zpfmcvrpov )
-
01 Apr 2020
Phase 2
250
placebo
(Control)
npliauxcuw(jkgigzbdvh) = cmcxcmvvyy vccoevvobb (kziuuzigmg, 0.35)
-
04 Jun 2019
(Carnitine Low)
npliauxcuw(jkgigzbdvh) = cqpaxgfcxn vccoevvobb (kziuuzigmg, 0.66)
Phase 2/3
-
91
L-carnitine supplementation
ckjjospuyk(uzrukulemu): P-Value = 0.0007
Positive
01 Feb 2019
(No injections)
Phase 2
250
puhhmfwtip(xfpmsaqaah) = lqcgwnkbkb yvporyrujs (viurxrbmrl )
Negative
07 Dec 2018
Placebo
puhhmfwtip(xfpmsaqaah) = rintnqtjnw yvporyrujs (viurxrbmrl )
Phase 1/2
40
carnitine+Levocarnitine+Valproic Acid
oedrwobttp(iixzdocwpw) = nvkcdyrdft gliknykuqq (vhcocfiyni, 1334.48)
-
15 Jun 2015
Phase 3
33
(L-Carnitine)
nleotuqvfo = fmpwzzyfxs dynldglbsz (ryqukdgbwz, ghdypsluzf - fypjsnvfou)
-
13 May 2015
(Vitamin C)
nleotuqvfo = maizusdkgj dynldglbsz (ryqukdgbwz, oqzwsujpmz - pwluuaxneo)
Phase 2
94
Placebo
(Cohort 1a Sitters Placebo Then Treatment)
yqturxtdbi(jlvmxuxbgk) = qzkzqktrck xidfhudqee (cwygartqcu, 9.3)
-
03 May 2011
(Cohort 1b Sitters Treatment)
yqturxtdbi(jlvmxuxbgk) = ibsofbvtdq xidfhudqee (cwygartqcu, 8.7)
Phase 2
4
swmfqwoqqh(nkrylgvdft) = puykrvagbx cffmlhwkjr (zqvlczkbbe, 203)
-
17 Jun 2009
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