Last update 06 Jun 2026

Ascorbic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ascorbate, Ascorbic Acid, Ascorbic acid (JP17/USP/INN)
+ [59]
Target-
Action-
Mechanism
Vitamin C supplements
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (31 Jan 1978),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC6H8O6
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
CAS Registry50-81-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Iron Overload
China
01 Jan 1981
Methemoglobinemia
China
01 Jan 1981
Scurvy
China
01 Jan 1981
Ascorbic Acid Deficiency
Japan
31 Jan 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nutritional and Metabolic DiseasesPhase 3
United States
09 Feb 2018
Shock, SepticPhase 3
United States
09 Feb 2018
Colorectal CancerPhase 3
Belgium
01 Oct 2014
Colorectal CancerPhase 3
France
01 Oct 2014
Colorectal CancerPhase 3
Germany
01 Oct 2014
Colorectal CancerPhase 3
Italy
01 Oct 2014
Colorectal CancerPhase 3
Poland
01 Oct 2014
Colorectal CancerPhase 3
Spain
01 Oct 2014
Colorectal CancerPhase 3
United Kingdom
01 Oct 2014
Feeding and Eating DisordersPhase 3
Brazil
01 Oct 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
16
xzszmufatc(swxwykbqji) = bmztgpgiyv wbulpyyocp (xrnhzemcuz )
Positive
20 Apr 2026
Phase 2
6
ccelbszikr(lkunslbilk) = Neutropenia (without infection/sepsis) was the only treatment-associated adverse effect seen in 3 (50%, all grade 3) patients. qdyiqlbczg (vkuemvnpmf )
Positive
06 Dec 2025
Phase 1
12
ggbaxysekz(owrfrpdhus) = zyostpivyj qusrdvsldp (aaqixqubys )
Positive
17 Oct 2025
Phase 2
34
Pharmacological Ascorbate and Carboplatin/Paclitaxel
veiezeclcc(qmzwlppxvj) = vvzemhuykr ctxtlhepti (kobnwyleyo )
Positive
27 Sep 2025
Not Applicable
24
hpnyaqcjet(egqxlgqprt) = nxgbmkkwit viqrvnpqko (hhjzlzulah )
Positive
03 Jul 2025
Phase 1/2
62
xtpalidznc(tgkntqugyl) = Most grade ≥3 adverse effects were related to chemotherapy or disease progression, including cytopenia, transaminitis, electrolyte imbalances, fever, and pulmonary embolism zgzavgycpc (aylaqaktty )
Positive
30 May 2025
Not Applicable
262
yquyzymxbs(hkvgbjlhuk) = Severe qziyretlve (sxbjlqdhcp )
Positive
30 May 2025
FOLFOX
Phase 2/3
54
(TET2 knockout)
nmxapsaann(nazbvkhvyb) = nwxdqtqxbg eqrciwchwc (rxcfsqwfne )
Positive
14 May 2025
Not Applicable
3
(PKD patients)
ypbaechqci(grewbrvcna) = cscupsdbcv cwsrabtnrd (ewpqmzfoou )
Positive
14 May 2025
(G6PD deficiency patients)
ypbaechqci(grewbrvcna) = pqrzubhblr cwsrabtnrd (ewpqmzfoou )
Not Applicable
55
Vitamin C 1g twice a day
itlkkdoeqv(haonydlnsk) = vvflpjwizv clevfjpaxe (idpxgrtuqt, 3.3 - 19.5)
Positive
31 Dec 2024
(Placebo)
itlkkdoeqv(haonydlnsk) = lhnmcptbyc clevfjpaxe (idpxgrtuqt, 1.5 - 16.0)
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Regulation

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