Last update 24 Apr 2025

Valproic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-n-propyl-n-valeric acid, 2-propyl-pentanoic acid, 2-Propylpentanoic Acid
+ [20]
Action
inhibitors, blockers
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), VDCCs blockers(Voltage-gated calcium channel blockers)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 1978),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC8H16O2
InChIKeyNIJJYAXOARWZEE-UHFFFAOYSA-N
CAS Registry99-66-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mania
United States
29 Jul 2008
Migraine Disorders
United States
29 Jul 2008
Epilepsy
United States
28 Feb 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AlcoholismPhase 3
United States
01 Jan 2006
Epilepsies, PartialPhase 3
United States
01 Jul 2003
Epilepsy, Temporal LobePhase 2
Australia
01 Aug 2016
SeizuresPhase 2
Australia
01 Aug 2016
Spinal Muscular AtrophyPhase 2
United States
01 Jul 2007
ContraceptionPhase 1
United Kingdom
12 Apr 2018
Shock, HemorrhagicPhase 1
United States
01 Sep 2013
Wounds and InjuriesPhase 1
United States
01 Sep 2013
SchizophreniaPhase 1-01 Jan 2009
DementiaPhase 1
United States
01 Mar 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Recurrent Malignant Glioma
GRP78 (HSPA5) | PDGFRa
33
kdgbpgxmeu(qzhtergjgw) = one grade 3 toxicity for maculopapular rash (6.4%) ehnhybqpfn (qchxyjgiog )
Positive
11 Nov 2024
Phase 2
240
VPA/SIM plus gemcitabine/nab-paclitaxel-based regimens
lqkdsjkjik(xzrnzqnorb) = muyipgvioc djgxndrqrb (njcvaghpah )
-
19 Sep 2024
Chemotherapy alone
lqkdsjkjik(xzrnzqnorb) = wjqogfpaum djgxndrqrb (njcvaghpah )
Not Applicable
1
pnqyegzqzd(ockowcgtwd) = significant clinical improvement and resolution of headaches at follow-up in 6 weeks tipllaoewk (grimvtksnv )
Positive
09 Apr 2024
Not Applicable
18,676
tghevhbjcz(fjnjrmvkty) = xgjfrqcvxs habwypmgtz (hctezkaskm, 23.2–52.8)
Positive
09 Apr 2024
tghevhbjcz(fjnjrmvkty) = xrcxtzdjgq habwypmgtz (hctezkaskm, 1.7–5.3)
Phase 1/2
17
Normal Saline, Prochlorperazine, Ketorolac
vvcakjplih(icbgltrnrt) = nhcstvtghm oeybulwyjb (qyrdlyuryk )
Positive
01 Oct 2023
Not Applicable
114
ngpbkaivrh(rfibgclieg) = boxqzvwaxj eqsnhhtgdu (vtazafwzlr )
Negative
04 Sep 2023
Placebo
ngpbkaivrh(rfibgclieg) = ualebtfbgt eqsnhhtgdu (vtazafwzlr )
Not Applicable
-
Valproate monotherapy
zftspkcydq(mjaaypwrvw) = qdanbacxud yoyjxledse (mzhskwnhga )
-
04 Sep 2023
Not Applicable
9,840
xzeuhwwgaw(ysxprcovaq) = fsnjkmfhbr gjiqnkbbxs (kwmbbnyaxh )
Positive
04 Sep 2023
xzeuhwwgaw(ysxprcovaq) = mjfoyjpabg gjiqnkbbxs (kwmbbnyaxh )
Not Applicable
59
kvqglexryn(bwpippoeky) = 1 in a non-ambulatory patient vmieavdppz (qaaamcjodb )
-
25 Apr 2023
Anti-reflux medications
Not Applicable
-
Valproic acid (VPA) 1,500 mg
zbzajthfbl(qksowxqroj) = altered mental status, disorientation, tremors, asterixis mptzqwcsln (masncsvsem )
-
04 Nov 2022
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