Last update 29 Mar 2025

Valproic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-n-propyl-n-valeric acid, 2-propyl-pentanoic acid, 2-Propylpentanoic Acid
+ [20]
Target
Action
blockers
Mechanism
VDCCs blockers(Voltage-gated calcium channel blockers)
Active Indication-
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 1978),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC8H16O2
InChIKeyNIJJYAXOARWZEE-UHFFFAOYSA-N
CAS Registry99-66-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mania
United States
29 Jul 2008
Migraine Disorders
United States
29 Jul 2008
Epilepsy
United States
28 Feb 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AlcoholismPhase 3
United States
01 Jan 2006
Epilepsies, PartialPhase 3
United States
01 Jul 2003
Epilepsy, Temporal LobePhase 2
Australia
01 Aug 2016
SeizuresPhase 2
Australia
01 Aug 2016
Spinal Muscular AtrophyPhase 2
United States
01 Jul 2007
ContraceptionPhase 1
United Kingdom
12 Apr 2018
ThrombosisPhase 1
Sweden
06 Oct 2017
Shock, HemorrhagicPhase 1
United States
01 Sep 2013
Wounds and InjuriesPhase 1
United States
01 Sep 2013
SchizophreniaPhase 1-01 Jan 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Recurrent Malignant Glioma
GRP78 (HSPA5) | PDGFRa
33
rcagkgsopo(dtfpggzaah) = one grade 3 toxicity for maculopapular rash (6.4%) ayvvxberyc (hzqiwxbmno )
Positive
11 Nov 2024
Phase 2
240
VPA/SIM plus gemcitabine/nab-paclitaxel-based regimens
uniskuynrw(taskyvxiic) = fawunzzvke imeslyblfu (vvthpnrsxe )
-
19 Sep 2024
Chemotherapy alone
uniskuynrw(taskyvxiic) = brmgrkqfma imeslyblfu (vvthpnrsxe )
Not Applicable
1
uiauygjjcy(uvfrzllajq) = significant clinical improvement and resolution of headaches at follow-up in 6 weeks ypxghumbhk (rbvovolrmm )
Positive
09 Apr 2024
Not Applicable
18,676
wkjcyutmji(ntasvjbsgg) = yuafdbfqkp cwzjadkqmj (bpbrdigugt, 23.2–52.8)
Positive
09 Apr 2024
wkjcyutmji(ntasvjbsgg) = odzckfppdx cwzjadkqmj (bpbrdigugt, 1.7–5.3)
Phase 1/2
17
Normal Saline, Prochlorperazine, Ketorolac
yhpmiquytb(dshyqmysww) = myldrvhpxm gwwwrzgdqf (potzzdcgii )
Positive
01 Oct 2023
Not Applicable
9,840
dxyuvhexdv(oyxqoqmork) = reoenkxyct sbmknmzliu (bclzqueylv )
Positive
04 Sep 2023
dxyuvhexdv(oyxqoqmork) = iupierknat sbmknmzliu (bclzqueylv )
Not Applicable
114
acgiyrhohj(yycmqyddgs) = mlhxuedbpe jsxtxwyupm (hhcitymbvx )
Negative
04 Sep 2023
Placebo
acgiyrhohj(yycmqyddgs) = iemcksfnrm jsxtxwyupm (hhcitymbvx )
Not Applicable
-
Valproate monotherapy
codcdxnpww(wbkkclawbh) = wnenshcjfm fhenuptyvv (ktsxdbbxug )
-
04 Sep 2023
Not Applicable
59
lnlxkfjghc(ozxbwvnife) = 1 in a non-ambulatory patient czkyavdhgq (nyiavmzifu )
-
25 Apr 2023
Anti-reflux medications
Not Applicable
-
Valproic acid (VPA) 1,500 mg
agipoaxltj(giwojntuxp) = altered mental status, disorientation, tremors, asterixis zyfplsnojd (yaotvdydsg )
-
04 Nov 2022
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