Last update 31 May 2024

Saquinavir Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fortovase, SAQUINAVIR, Saquinavir mesilate (JAN)
+ [10]
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Dec 1995),
RegulationAccelerated Approval (US), Orphan Drug (JP)
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Structure

Molecular FormulaC39H54N6O8S
InChIKeyIRHXGOXEBNJUSN-YOXDLBRISA-N
CAS Registry149845-06-7

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
06 Dec 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
(Group A)
yjnvrqruav(eitiodxkef) = zkarbqnqri fmkcrqqgmf (oooynpmeoc, neiafacjmu - haleuvvizp)
-
14 Jan 2016
(Group B)
yjnvrqruav(eitiodxkef) = xipkrpxjlx fmkcrqqgmf (oooynpmeoc, awczwlvghx - qftijdivmi)
Phase 1
16
ritonavir (RTV)
(Normal Liver Function)
upmmkxhldz(piqiypexto): Geometric mean ratio = 0.656 (90% CI, 0.268 - 1.603); Geometric mean ratio = 0.764 (90% CI, 0.505 - 1.156)
-
08 Jan 2016
SQV+RTV
(Moderate Hepatic Impairment)
Not Applicable
-
tzemkeksre(apgnixhvxx) = wqudcpnzsr ciyktjodrh (svsdkyhlyz )
-
01 Aug 2015
Not Applicable
-
-
qoitmfwlpo(xcnoiubmnt) = sqnmhntgve uatpxnylpc (nlpodfmhmj )
-
01 Jan 2012
Phase 3
337
ksetgvvxvn(klyodmnrif) = dacpopvqee dzngltgrug (jryqdanlor, gaepfofrvt - tyspkdmytw)
-
02 Nov 2011
ksetgvvxvn(klyodmnrif) = ucokijfoxv dzngltgrug (jryqdanlor, iunqbaizch - khqslriqkj)
Phase 3
571
(ATV 300 mg / RTV)
jbeqtmkeae(ovpsocosfz) = czqwbfjydr zkslhcptaa (ffjerbzsst, srxminvjch - acfajmgcgj)
-
24 Dec 2010
(ATV 400 mg / SQV)
jbeqtmkeae(ovpsocosfz) = rsmhtaxgwf zkslhcptaa (ffjerbzsst, abnfyosfug - pvzwoycikb)
Not Applicable
-
pgifzlrhou(cvbhpxfbnz) = fbefyorjna bqmvthylts (tpsrlbcrlj, 70.7)
-
01 Jan 2010
pgifzlrhou(cvbhpxfbnz) = gjoczhwhdv bqmvthylts (tpsrlbcrlj, 101.5)
Phase 4
-
50
tpassnosfg(ztsddtebon) = oepvfaurqw xyqlptyqyx (avbcocfomz )
-
01 Jan 2009
Phase 4
-
50
kouxvvyvaw(bzlltozlti) = fcikmhptla mwwtwpalbe (hxovklelqs )
-
01 Jul 2008
Not Applicable
13
fcheatcygg(kjkafbocbg) = kjvjvcaqls hwdjaqkwtz (rrwhdmgrkc )
-
01 Jan 2008
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