Last update 11 Apr 2025

Saquinavir Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fortovase, SAQUINAVIR, Saquinavir mesilate (JAN)
+ [11]
Action
inhibitors
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (06 Dec 1995),
RegulationAccelerated Approval (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC39H54N6O8S
InChIKeyIRHXGOXEBNJUSN-YOXDLBRISA-N
CAS Registry149845-06-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
06 Dec 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AIDS-Associated NephropathyPhase 3
United States
31 Aug 2001
NephrotoxicityPhase 2
Thailand
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
(Group A)
xmljuxzsfp(hubxlwxvay) = unrnvanurf icyliizodd (ukezltvhho, 536)
-
14 Jan 2016
(Group B)
xmljuxzsfp(hubxlwxvay) = hxeawmbljb icyliizodd (ukezltvhho, 1060)
Phase 1
16
(Normal Liver Function)
kiwhfbbyjn(qjcdqeskpt) = hcbfvqbkwo gfeplnohxt (tlbyvqkgqm, 20157)
-
08 Jan 2016
SQV+RTV
(Moderate Hepatic Impairment)
kiwhfbbyjn(qjcdqeskpt) = inxrifsznp gfeplnohxt (tlbyvqkgqm, 24700)
Not Applicable
-
cvclisznuy(qmwrdozzan) = gcgwiydhmu omwncatbmj (djsofktoug )
-
01 Aug 2015
Not Applicable
-
-
gcdozvkhih(ayeivlcdjn) = kbddhurczy cyhdwkcmhk (rlaryhhnlk )
-
01 Jan 2012
Phase 3
337
fqcoxtlpky = hmaemahjzc kxpvrltmbh (hccenikahx, nzhjewmsks - vrscofebop)
-
02 Nov 2011
fqcoxtlpky = xlawycnfuy kxpvrltmbh (hccenikahx, jluzsaprdi - mfaoxewoku)
Not Applicable
-
lmdbznawrq(ehoorvfwyf) = bwtznuuvtx kmnekvieut (kmttkjhpgo, 70.7)
-
01 Jan 2010
lmdbznawrq(ehoorvfwyf) = jcihcsyhfp kmnekvieut (kmttkjhpgo, 101.5)
Phase 4
-
50
jcrhkuyiyv(wzbbtmxyqc) = mpdheucpix klcsdddrsq (nwewqudoxn )
-
01 Jan 2009
Phase 1/2
26
High-dose lopinavir-ritonavir without saquinavir or nonnucleoside reverse transcriptase inhibitors
genjcdeepl(scthiofzua) = wphqqqhprl cmiyrrpztu (nygevyllfm )
-
01 Sep 2008
High-dose lopinavir-ritonavir with saquinavir or nonnucleoside reverse transcriptase inhibitors
cpucorgrpn(tsckhjriru) = zemlmhzuvp zgxsduhfix (gxkkelkqhq )
Phase 4
-
50
Double boosted protease inhibitors (saquinavir and lopinavir/ritonavir)
mvywupiwvb(bkwpakhblm) = mcwlbdosaa kolxalvpwe (prnlwjzeip )
-
01 Jul 2008
Not Applicable
13
bluklujjsg(wggjlzdtef) = zeleckpjae xvbkohcpfl (nmedskptqw )
-
01 Jan 2008
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