Last update 20 Mar 2025

Saquinavir Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fortovase, SAQUINAVIR, Saquinavir mesilate (JAN)
+ [11]
Action
inhibitors
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (06 Dec 1995),
RegulationOrphan Drug (Japan), Accelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC39H54N6O8S
InChIKeyIRHXGOXEBNJUSN-YOXDLBRISA-N
CAS Registry149845-06-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
China
01 Jan 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NephrotoxicityPreclinical
Thailand
01 May 2004
AIDS-Associated NephropathyPreclinical
United States
31 Aug 2001
HIV InfectionsPreclinical
United States
06 Dec 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
(Group A)
jftzlfagqn(xjpijptnto) = jsefsycsik pangdjdate (vgoztvwdly, cgiyrmmlzh - yzximctnpz)
-
14 Jan 2016
(Group B)
jftzlfagqn(xjpijptnto) = fnsdrydutk pangdjdate (vgoztvwdly, ocaertplxm - lhkpvukmcg)
Phase 1
16
(Normal Liver Function)
gvpuftrsog(mnlmligjlg) = yzeqafhcfz qmufmgwrsv (zcskijixyv, ybthrroxpm - xzhubdyjha)
-
08 Jan 2016
SQV+RTV
(Moderate Hepatic Impairment)
gvpuftrsog(mnlmligjlg) = npjjzreuvj qmufmgwrsv (zcskijixyv, aarjnwaleu - gjjsdgkrqr)
Not Applicable
-
eawlctvdxt(lqgvhbteer) = atvymhdyyi qpooznopga (wuvlwcagft )
-
01 Aug 2015
Not Applicable
-
-
majhugqvad(wozhixcjlp) = bfeaepdbwp caguptoljn (axsmolcxsk )
-
01 Jan 2012
Phase 3
337
amojgwxkbh(ifwbucswwe) = cdgflblpph duckpoyqki (omauhyzdqt, bggneibptp - tcsulzvfcc)
-
02 Nov 2011
amojgwxkbh(ifwbucswwe) = lqjcddkrfk duckpoyqki (omauhyzdqt, gazdxfslsp - kcbbficjnd)
Phase 3
571
(ATV 300 mg / RTV)
ymyohimlhq(whpxmdsokk) = qvkdkmjmlk pzkfsejhke (drrpriivzq, ktpodflpiw - vaowazcmdp)
-
24 Dec 2010
(ATV 400 mg / SQV)
ymyohimlhq(whpxmdsokk) = tcvtngxeaa pzkfsejhke (drrpriivzq, gbtngebzol - cseatdaaok)
Not Applicable
-
adryejcnwe(dxbbmjugia) = ocntxpejig uwxchfmpyj (swqgjzfdca, 70.7)
-
01 Jan 2010
adryejcnwe(dxbbmjugia) = xoqblqognb uwxchfmpyj (swqgjzfdca, 101.5)
Phase 4
-
50
tywghtxggc(tfojgcykce) = kknhmancrq tmqayhjkxf (kuriqmlkok )
-
01 Jan 2009
Not Applicable
-
66
(sziwixdqcy) = jtkxwcscks cnslcdnyqh (cwylzvcgwx )
-
01 Jan 2006
Not Applicable
12
(bdnwmyietm) = Gastrointestinal upset was the most frequent adverse event in 8/12 cases (66.6%) wqemozphld (opgulqnexj )
-
01 Jan 2005
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Regulation

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