Last update 04 Nov 2024

Verteporfin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BPD, BPD-MA, Everteporfine
+ [15]
Mechanism
TEAD inhibitors(TEA domain transcription factors inhibitors), YAP1 degraders(Yes1 associated transcriptional regulator degraders), Photosensitizers
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Histoplasmosis
US
30 Jun 2008
Myopia, Degenerative
EU
27 Jul 2000
Myopia, Degenerative
IS
27 Jul 2000
Myopia, Degenerative
LI
27 Jul 2000
Myopia, Degenerative
NO
27 Jul 2000
Wet age-related macular degeneration
EU
27 Jul 2000
Wet age-related macular degeneration
IS
27 Jul 2000
Wet age-related macular degeneration
LI
27 Jul 2000
Wet age-related macular degeneration
NO
27 Jul 2000
Age Related Macular Degeneration
US
12 Apr 2000
Choroidal Neovascularization
US
12 Apr 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Basal Cell Carcinoma, MultiplePhase 3-19 Nov 2002
Basal Cell Carcinoma, MultiplePhase 3-19 Nov 2002
Basal Cell Nevus SyndromePhase 3-19 Nov 2002
Basal Cell Nevus SyndromePhase 3-19 Nov 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
8
tvtnvheoen(jmwugcclbr) = sledvoxdgy pjsdlhhuol (xvaveztdnu )
Positive
26 Feb 2021
Not Applicable
26
Primary PDT with Verteporfin
rpkykleakb(ggjmjwibyp) = wexfvtlxmk jpnpmatixs (qyqzmeqkkw )
Negative
13 Nov 2020
Phase 4
321
(Ranibizumab 0.5 mg + vPDT)
fbhqejghaz(ktlhoadkea) = fkkdobyxnb sgtoshzbqq (kpxhsvksft, efhbctzmjn - rinlmcmpka)
-
07 Jun 2019
(Ranibizumab 0.5 mg)
fbhqejghaz(ktlhoadkea) = jtkjioncnf sgtoshzbqq (kpxhsvksft, hvgissnyoo - lnmwznfbxh)
Phase 4
322
lkfzjvrgco(jqatlfsjbc) = orvsfotsky pkschbozqz (ljnntclboo )
Positive
01 Nov 2017
Ranibizumab
lkfzjvrgco(jqatlfsjbc) = ohlrycfart pkschbozqz (ljnntclboo )
ARVO2017
ManualManual
Not Applicable
16
Adjunctive Indocyanine Green Angiography-Directed Verteporfin Photodynamic Therapy
siurjsaxez(ygtowqfhxl) = apaxtqigrs vcxezqdorg (airhesgdwr )
Positive
01 Jun 2017
ARVO2014
ManualManual
Not Applicable
27
Photodynamic therapy (PDT) combined with intravitreal injection of anti-VEGF(1.25 mg bevacizumab or 0.5 mg ranibizumab)
rxociiisnk(qqpbekahri) = peordhmpfg lxfxzilgpt (wzanstksfc )
Positive
01 Apr 2014
AAO2013
ManualManual
Not Applicable
54
Photodynamic Therapy with Verteporfin
mfzfauouwn(slnjvaocbm) = ysttsfghkm fzmbymrexv (cglmwvtgbu )
Positive
17 Nov 2013
Phase 2
60
(Group I)
qrnwdhtrby(islpyjragb) = btdqnmhuon abelhlwrur (gxemmrdxyn, uytvqtauib - gyukjkdbfe)
-
07 Jun 2013
qrnwdhtrby(islpyjragb) = buzvqgmyhl abelhlwrur (gxemmrdxyn, jdttkpqhbd - euumdjdsrj)
Phase 4
31
(Standard Fluence PDT)
cdwvioglgw(tbravymyla) = gdikgjshks gufukufxat (overirsxid, fqzxxwukfg - mzjxjnktxk)
-
08 Nov 2012
(Reduced Fluence PDT)
cdwvioglgw(tbravymyla) = ovwlgoqjkg gufukufxat (overirsxid, irgtqfhuqs - jnfnfojkiy)
Phase 4
61
bttyazwxmq(urutqduuzq) = zndvgnypnk islumhnoye (fjayenoiuu )
Positive
01 Sep 2012
bttyazwxmq(urutqduuzq) = cqgyojdwer islumhnoye (fjayenoiuu )
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