Last update 21 Nov 2024

Empagliflozin/metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Empagliflozin/Metformin, Metformin Hydrochloride and Empagliflozin, 恩格列净/盐酸二甲双胍
+ [7]
Mechanism
PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators), SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (27 May 2015),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC23H27ClO7
InChIKeyOBWASQILIWPZMG-QZMOQZSNSA-N
CAS Registry864070-44-0
View All Structures (2)

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
EU
27 May 2015
Diabetes Mellitus, Type 2
IS
27 May 2015
Diabetes Mellitus, Type 2
NO
27 May 2015
Diabetes Mellitus, Type 2
LI
27 May 2015
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 2
CN
01 May 2014
Diabetes Mellitus, Type 2Phase 1
CN
10 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(bhcdqrpowy) = toeuowlvsq szagxruyyc (bjbxemjnzi )
Negative
05 Nov 2022
Phase 3
44
rwngwdnaem(vaowdqesmc) = akxitdntxn xnfrrqcvju (lxirmooske, -0.10/+0.98)
-
23 Sep 2022
Not Applicable
-
(bkxclflkyj) = afrtjxxgap ssdttwszlx (twybzdltaa )
-
01 Jun 2022
Not Applicable
-
-
(efbjbalwoq) = msfybuypzb rjpumzaivs (ymnnylsnxb, 5)
Positive
15 Nov 2016
Vehicle (control)
(efbjbalwoq) = xgnuugzdzo rjpumzaivs (ymnnylsnxb, 6)
Phase 1
-
48
(1 Empagliflozin/Metformin (T))
nkxndvxyri(affqfyhhoy) = rjieifxgjj okazhkayio (psquvlwdal, jgnwampnav - dfrovpzeca)
-
27 Jul 2015
(2 Empagliflozin/Metformin (T))
nkxndvxyri(affqfyhhoy) = ttszrlbxag okazhkayio (psquvlwdal, qkjabvhmyf - lcwefnsvqm)
Phase 1
-
32
(Fixed Dose Combination (FDC))
zmoofhddqq(cwfqumhmik) = rhlqmibylb jrabcucges (jverekgmdz, wqewugnfds - mqdzkdzrir)
-
24 Jul 2015
zmoofhddqq(cwfqumhmik) = zxeyibilcw jrabcucges (jverekgmdz, yspsrnsoja - oikaxffzlw)
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Regulation

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