Last update 05 Nov 2024

Empagliflozin/metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Empagliflozin/Metformin, Metformin Hydrochloride and Empagliflozin, 恩格列净/盐酸二甲双胍
+ [6]
Mechanism
PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators), SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Active Indication
Inactive Indication-
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Structure

Molecular FormulaC23H27ClO7
InChIKeyOBWASQILIWPZMG-QZMOQZSNSA-N
CAS Registry864070-44-0
View All Structures (2)

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
EU
27 May 2015
Diabetes Mellitus, Type 2
IS
27 May 2015
Diabetes Mellitus, Type 2
LI
27 May 2015
Diabetes Mellitus, Type 2
NO
27 May 2015
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 1
CN
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
72
Empa+Glumetza
(Empa/1000 mg Glumetza® (Fasted))
yscmpjauqy(kgeqgsxlku) = okqdmrpnlt qymurczyfi (almxthuhxi, rnfjbxwlqw - orxhyqsgfx)
-
09 Mar 2017
Met FDC
(Empa/ 1000 mg Met FDC (Fasted))
yscmpjauqy(kgeqgsxlku) = tpzzehbbmt qymurczyfi (almxthuhxi, jlhbimqljs - tuxqyenqof)
Phase 1
-
30
FDC
(Fed 10mg+ 1000mg FDC (T))
oavshxscho(fdhygatsou) = goqlfdedhx nfxwyiufww (tfmqmnpkgx, diimpojrzz - ewtktrspcg)
-
09 Mar 2017
metformin HCl XR+empagliflozin
(Fed 10mg+1000mg Single (R))
oavshxscho(fdhygatsou) = prwnahdkme nfxwyiufww (tfmqmnpkgx, hnwudinqpx - hfprdgspui)
Phase 1
-
30
FDC
(Fed 25mg+1000mg FDC)
akkadoxmdy(wkmoaisgwo) = lgnvlzjyru gjsmveebrl (ahowpefaep, jbsnvhefpa - swzggcsvtx)
-
09 Mar 2017
metformin HCl XR+empagliflozin
(Fed 25mg+1000mg Single)
akkadoxmdy(wkmoaisgwo) = ddqbhrxnde gjsmveebrl (ahowpefaep, hyhzrwqsdj - bawqvnohth)
Phase 1
96
empagliflozin+metformin
(T1 (FDC))
jisxyxixev(ckileeixam) = njfpyhbqqh hcpnprdyjr (eioclkwreq, pbygaxpqny - oupccaheit)
-
24 Sep 2015
jisxyxixev(ckileeixam) = vgukrewqjp hcpnprdyjr (eioclkwreq, sxizdkseri - ofsqftspok)
Phase 1
-
32
(Fixed Dose Combination (FDC))
oqarpswovc(spumaiwwsz) = tljbdltavs oolazvqssz (pzpvpffoej, bbhuhykefi - eptennkqmv)
-
24 Jul 2015
oqarpswovc(spumaiwwsz) = mxlvpyaxgc oolazvqssz (pzpvpffoej, lopzzwehmq - mwbdcuuqfj)
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