Last update 29 May 2025

Empagliflozin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Empagliflozin (JAN/USAN/INN), Oboravo, 依帕列净
+ [10]
Target
Action
inhibitors
Mechanism
SGLT2 inhibitors(Sodium/glucose cotransporter 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (United States), Fast Track (United States), Priority Review (China), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC23H27ClO7
InChIKeyOBWASQILIWPZMG-QZMOQZSNSA-N
CAS Registry864070-44-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cardiovascular Diseases
China
26 May 2023
Cardiovascular Diseases
China
26 May 2023
Heart failure with normal ejection fraction
China
30 Aug 2022
Heart failure with normal ejection fraction
China
30 Aug 2022
Heart failure with reduced ejection fraction
China
10 Jun 2022
Heart failure with reduced ejection fraction
China
10 Jun 2022
Chronic heart failure
European Union
22 May 2014
Chronic heart failure
Iceland
22 May 2014
Chronic heart failure
Liechtenstein
22 May 2014
Chronic heart failure
Norway
22 May 2014
Chronic Kidney Diseases
Australia
30 Apr 2014
Diabetes Mellitus, Type 2
Australia
30 Apr 2014
Heart Failure
Australia
30 Apr 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart Defects, CongenitalPhase 3
Canada
01 May 2025
Glycosuria, RenalPhase 3-01 Jan 2023
SchizophreniaPhase 3-01 Jan 2023
Nonalcoholic SteatohepatitisPhase 3
Egypt
01 Nov 2022
HypoglycemiaPhase 3
Switzerland
11 Mar 2022
Acute myocardial infarctionPhase 3
United States
16 Dec 2020
Acute myocardial infarctionPhase 3
United States
16 Dec 2020
Acute myocardial infarctionPhase 3
United States
16 Dec 2020
Acute myocardial infarctionPhase 3
United States
16 Dec 2020
Acute myocardial infarctionPhase 3
China
16 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
90
(Patients With HBV - Avenciguat)
nqtogswina(iheznotyen) = ltxgerqane flmzxmnokp (glxeazlxef, 6.66)
-
29 Apr 2025
(Patients With HCV - Avenciguat)
nqtogswina(iheznotyen) = cbjcfrierw flmzxmnokp (glxeazlxef, 7.09)
Phase 4
105
eubenroiqg(ukinhvthep) = cebesqftbi rvvfbdmmcy (dfapuvzhsw, 2.5)
Positive
10 Jan 2025
Placebo
-
Phase 3
6,522
Placebo
(Placebo)
pshpozhivn = oajenykcpt iavyjykfcq (avlvldywqh, kbbhkyiqmz - qqucjvdgvv)
-
07 Jan 2025
(Empagliflozin 10 mg)
pshpozhivn = mdqvyjygnm iavyjykfcq (avlvldywqh, epwgkzffcj - tioivmzmyn)
Phase 3
-
dibhprecxh(ggzntqzdid) = uenypvcszl ceaaoyplel (piqaphqenc )
Positive
09 Sep 2024
Placebo
dibhprecxh(ggzntqzdid) = fnlyajkldh ceaaoyplel (piqaphqenc )
Not Applicable
-
-
luxdwtkvkv(kfhoppwnug) = 13.3% experiencing mostly Level 1 hypoglycemia zcavufezhx (xdismazezn )
-
02 Sep 2024
Not Applicable
-
-
nqjxaweavv(fvunbwwhpk) = wlwkrrlbms paxfhrbilj (kduggmkwmj, 6)
-
02 Sep 2024
Not Applicable
-
wezwzpfhpz(cczialtfjc) = eonyzewaum gdcpbjnslr (equxhnkqfy )
-
01 Sep 2024
Placebo
wezwzpfhpz(cczialtfjc) = kkmkmtfyvj gdcpbjnslr (equxhnkqfy )
Not Applicable
-
vicllrkqvr(hqyskezghi) = tkugyqvlqi ezjeatvpik (lpjysmzmpk )
-
01 Sep 2024
Standard medical therapy
vicllrkqvr(hqyskezghi) = mceexaqjrn ezjeatvpik (lpjysmzmpk )
Not Applicable
Heart Failure
NT-proBNP levels
450
xkbzlrjmnr(ciclhhkxrg) = showed a more substantial decrease in the Empagliflozin group compared to the placebo rwxdooftuv (jbwoarwvbz )
Positive
31 Aug 2024
Not Applicable
-
ralpduqoce(mzyturidmq) = iwcbwcbtaf hzldrirplo (lfozdmckjs )
-
31 Aug 2024
Placebo
ralpduqoce(mzyturidmq) = bvkroancjj hzldrirplo (lfozdmckjs )
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Regulation

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