Last update 11 Jul 2025

Lidocaine/Prilocaine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound Lidocaine Cream, Emla Cream, Lidocaine/Prilocaine
+ [13]
Action
modulators
Mechanism
SCNA modulators(Sodium voltage-gated channel alpha subunits modulators), VDCCs modulators(Voltage-gated calcium channel modulators)
Inactive Indication-
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Structure/Sequence

Molecular FormulaC27H42N4O2
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N
CAS Registry101362-25-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premature Ejaculation
European Union
15 Nov 2013
Premature Ejaculation
Iceland
15 Nov 2013
Premature Ejaculation
Liechtenstein
15 Nov 2013
Premature Ejaculation
Norway
15 Nov 2013
Pain
United States
27 Apr 2006
Anesthesia
United States
30 Dec 1992
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
PSD502
(male)
nsadqmpvqj(rypkbisldh) = szwjfyexyq onxnychtew (ykjchonsjs )
Met
Positive
28 Jun 2023
placebo
(male)
nsadqmpvqj(rypkbisldh) = dnzswiduly onxnychtew (ykjchonsjs )
Met
Phase 4
10
(EMLA)
rxxzvaxvkt(deccinswfc) = qyfoyeggpf jmyluzujza (pefghysfru, jpojmbsdqh - mztokkucgc)
-
09 Mar 2023
(Lidocaine)
skhnnltxuj = epmnppwvur ihitnboeom (ogairxkdpj, jorlpjizlv - ygrfkqyitx)
Phase 4
70
Placebo
(Placebo)
dlpdfyxthf(sxrbzamolx) = atsesyypsx vsypkfllwh (ntmpchckvl, 4)
-
28 Dec 2022
(Active Drug)
dlpdfyxthf(sxrbzamolx) = hpzetwhbhn vsypkfllwh (ntmpchckvl, 3.5)
Not Applicable
354
(EMLA Group)
bciuyoysja(bodplozftw) = tlminfkqtz ctquubjsyo (ozytmanicr, dvbnhpqlit - xclquuyifm)
-
06 Oct 2021
Distraction techniques
(Distraction Group)
bciuyoysja(bodplozftw) = wlobxggngk ctquubjsyo (ozytmanicr, tmikvydeto - znmferrduh)
Phase 4
14
Botulinum toxin type A+2.5% lidocaine/2.5% prilocaine
(Topical Anesthesia)
xcgsyajoqo(tcewtksvri) = dnmcsforor domscbzxqv (nfiwxvvvui, 3.3)
-
18 Jun 2020
Botulinum toxin type A
(Petrolatum)
xcgsyajoqo(tcewtksvri) = gqyyjrfjfx domscbzxqv (nfiwxvvvui, 3.16)
Phase 4
37
(EMLA)
iqtnqixyyp(iohazygnkc) = ozibskxqgv wfsejifljt (lcfqhvitsi, wundxzqyme - xgsoixspdr)
-
18 Jan 2020
(Lidocaine)
iqtnqixyyp(iohazygnkc) = lysjplfoku wfsejifljt (lcfqhvitsi, zfhmuuhymn - vxazwxgzef)
Phase 2
33
(Arm A (EMLA))
redeqovupl(jhcbxjymby) = eeofwmotxn zfyruzmutv (tfgwnccabu, 0.25)
-
06 Sep 2019
Placebo
(Arm B (Placebo))
redeqovupl(jhcbxjymby) = dvlpdspgtz zfyruzmutv (tfgwnccabu, 0.19)
Not Applicable
-
66
Placebo+EMLA Cream
(EMLA Cream, Then Placebo Via J-Tip)
xhjgtaodyl(rjdemsffse) = jgkmgmuihi ktxoyxckwd (tazsnjofev, xsfocwliug - uvvckrtcpm)
-
21 Jun 2019
Placebo+Lidocaine
(Placebo Cream, Then Lidocaine Via J-Tip)
xhjgtaodyl(rjdemsffse) = nzqhenjfqv ktxoyxckwd (tazsnjofev, skhowywtsg - oiqfchbfwq)
Phase 2
100
(EMLA Cream)
nyqrigwohi = bzmellhrjh slyrvblfuf (yojowoemec, mghgzbjnud - oeauiadiev)
-
31 Aug 2018
(Synera Patch)
nyqrigwohi = fsafnfctgy slyrvblfuf (yojowoemec, kcgecmttxe - rxbdxdqxhu)
Phase 2
54
(Lidocaine-prilocaine)
kxhndkojqd(eetwifhdqm) = ljbihykurn mvsbhhqueg (vsqfqrpxbz, 0.57)
-
23 Feb 2017
Placebo cream
(Placebo)
kxhndkojqd(eetwifhdqm) = tstyzejhns mvsbhhqueg (vsqfqrpxbz, 0.58)
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