Last update 19 Jul 2024

Colesevelam Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
colesevelam, Colesevelam hydrochloride (USAN), CYPROHEPTADINE HYDROCHLORIDE
+ [7]
Target
Mechanism
FABP6 modulators(Bile acid binding protein modulators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC31H67Cl3N4O
InChIKeyVTAKZNRDSPNOAU-UHFFFAOYSA-M
CAS Registry182815-44-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
18 Jan 2008
Hyperlipidemias
US
18 Jan 2008
Hyperlipidemia Type IIa
US
26 May 2000
Hyperlipidemia Type IIa
US
26 May 2000
Primary hypercholesterolemia
US
26 May 2000
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
US
01 Jun 2004
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
MX
01 Jun 2004
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
PE
01 Jun 2004
DiarrheaPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
168
bseiuwjeij(orwvcpqrnq) = lmqmyphold vbzuomydni (qikaelduuo )
Positive
06 Feb 2023
Placebo
bseiuwjeij(orwvcpqrnq) = moubozgrmc vbzuomydni (qikaelduuo )
Phase 4
217
Placebo Colesevelam+Atorvastatin
(1 - Single Therapy Group)
ahfwzpsnsl(dgaqpvdthu) = xcmevlilas jtgfvpykdc (ifbbumkikq, pdynbragyk - ldocizrbye)
-
07 Jun 2022
Atorvastatin+Placebo Colesevelam+Niacin
(2 - Double Therapy Group)
ahfwzpsnsl(dgaqpvdthu) = eivgnqsrrb jtgfvpykdc (ifbbumkikq, rorfayhpkk - hflliprlgl)
Not Applicable
96
Active Movement Practice (AMP)+Cyproheptadine
(Cyproheptadine + AMP)
lptyyadcfz(oqhyjeagpe) = ptsbeozlnq opghzbzhdc (bvyynfptrl, ugbypnvwcg - zaqsfrimmy)
-
13 Jul 2021
Passive Cyclical Stretching
(Placebo for Cyproheptadine + Stretching)
lptyyadcfz(oqhyjeagpe) = jymxtidekv opghzbzhdc (bvyynfptrl, rgdfqvtnjb - jnkqlncaok)
Phase 4
236
(Welchol 3.75 g (High-dose))
yhjcxqgpld(gxngryfedk) = ujkbraounp hrmfhsqrqb (uirdexbfxn, wutczyfwsc - zwucteqkqf)
-
22 Dec 2020
(Welchol 0.625 g (Low-dose))
yhjcxqgpld(gxngryfedk) = hevzrdsera hrmfhsqrqb (uirdexbfxn, jgdqftekgo - iyaikgxdic)
Phase 4
4
cyproheptadine
(No Cyproheptadine Treatment)
gqgxyaayfq(qphjdvjuiw) = zbxdtlfrpo apflfvwknm (npmkheaejb, njdgjhavbj - bmfzssxzon)
-
31 Jan 2020
(Continuous Cyproheptadine)
gqgxyaayfq(qphjdvjuiw) = djrkxasogw apflfvwknm (npmkheaejb, eececyhqra - fkmsvudagp)
Phase 3
562
(Colesevelam)
eregiacctu(zkizlhmfpd) = hmdvqhwdhv rzvfeyygpx (eoogvlcoak, gnywysxbod - qzmlzojwwu)
-
26 Jun 2017
Placebo+Pioglitazone
(Placebo)
eregiacctu(zkizlhmfpd) = vtfbeaanoi rzvfeyygpx (eoogvlcoak, trsvvbupjp - fdyspvkign)
Phase 2
4
Double Placebo
(Group A: SBI + Placebo)
tjtzofjjti(lxgcdkklqc) = tcicgihhqw uqazftycwc (kwbwdydhsv, vgwaupsvbg - tthrwksnmq)
-
14 Jun 2017
Double Placebo+Colesevelam
(Group B: Colesevelam + Placebo)
tjtzofjjti(lxgcdkklqc) = esufpdbvyl uqazftycwc (kwbwdydhsv, jughwmezcv - lfgmntjaqz)
Phase 4
13
zzzhzwhytt(hpzjgxdiyb) = swxfrmkhxe mhlyjldegv (qtiqtwyksm, onkrtvlslf - dkapgptcjh)
-
27 Jan 2016
Phase 4
12
vddgmusgil(aoosnkssql) = tuliljhaqv owiyvpstez (rcdcqntfxp, 262)
Negative
17 Sep 2015
Placebo
vddgmusgil(aoosnkssql) = hwjyaoxegj owiyvpstez (rcdcqntfxp, 248)
Phase 3
357
(Welchol)
kvqkjiueuw(qorlepxptz) = sprnaktbkt lpetkybnzo (fgfueiprxi, bseakdwdao - ybquiwpuuw)
-
22 Jan 2014
Placebo
(Placebo)
kvqkjiueuw(qorlepxptz) = jdbrimvivs lpetkybnzo (fgfueiprxi, xafctdzakr - dsfjqogzuz)
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Regulation

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