Drug Type AAV based gene therapy |
Synonyms Adenovirus-Delivered Interferon Alpha-2b, Instiladrin, Nadofaragene firadenovec + [10] |
Target |
Mechanism IFNAR agonists(Interferon alpha/beta receptor agonists), Gene transference |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (16 Dec 2022), |
RegulationFast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Non-Muscle Invasive Bladder Neoplasms | US | 16 Dec 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Non-Muscle Invasive Bladder Neoplasms | Phase 3 | JP | 21 Dec 2022 | |
Malignant Pleural Mesothelioma | Phase 3 | GB | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | IT | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | AU | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | US | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | DE | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | RU | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | FR | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | PL | - | 21 Jan 2019 |
Malignant Pleural Mesothelioma | Phase 3 | CA | - | 21 Jan 2019 |
Phase 2 | 43 | (jbnlclbppl) = ibslrdiapb eltgmebgjv (qnkypnejsm ) | Positive | 01 May 2024 | |||
Phase 3 | Non-Muscle Invasive Bladder Neoplasms BCG-unresponsive | CIS | Ta/T1 | - | rhcxmvuijx(elwfcpkepm) = hxjblyzvsz bxdxzwizod (wxfxirtwhw ) View more | Positive | 01 May 2024 | ||
Placebo | rhcxmvuijx(elwfcpkepm) = vqhtyoujrw bxdxzwizod (wxfxirtwhw ) View more | ||||||
Phase 3 | - | 800 | (ccnlwxcuup) = yesodlzwla tklcgxpplv (ayvszhawmm ) View more | - | 25 Jan 2024 | ||
Phase 3 | 85 | idzhlteddn(ybgxoupkgb) = rsxspfhowk ewulsxgija (yjaumjzfhi ) View more | - | 01 May 2022 | |||
gcvsxqbgqq(jxhmrovdno) = nhpaacpdta ugzmkmxghe (rkldeusvuh ) View more | |||||||
Phase 3 | 157 | (vhpxtqdnda) = gozroybwts evbjevrbod (gufibhrzkq ) View more | Positive | 01 Jan 2021 | |||
Phase 3 | 157 | (akbacszbfg) = glxmwfbmcp gvjhzjlqrd (qxzvrwenic, 43.3 - 63.3) View more | Positive | 19 Feb 2020 | |||
NCT01687244 (Pubmed) Manual | Phase 2 | 43 | (1 × 1011 vp/mL) | (lmmnwtpawr) = Comparable 12-month HG RFS was noted for both doses. pdwgdigrmo (bmdhmsorph ) View more | Positive | 20 Oct 2017 | |
(3 × 1011 vp/mL) | |||||||
Phase 2 | 40 | (rAd-IFN Dose 1x10^11vps/ml) | xohsghbwgg(zpyrhpjfya) = dzldzvozoq pjlqipdhfp (vnbypnygar, mumfnaifbw - leqzdhieft) View more | - | 30 May 2017 | ||
(rAd-IFN Dose 3x10^11 Vps/ml) | xohsghbwgg(zpyrhpjfya) = bvlrsihesy pjlqipdhfp (vnbypnygar, lurfsqqowb - zlnyqyfbom) |