Last update 01 Nov 2024

Nadofaragene firadenovec-vncg

Overview

Basic Info

Drug Type
AAV based gene therapy
Synonyms
Adenovirus-Delivered Interferon Alpha-2b, Instiladrin, Nadofaragene firadenovec
+ [9]
Target
Mechanism
IFNAR agonists(Interferon alpha/beta receptor agonists), Gene transference
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Orphan Drug (US), Priority Review (US), Fast Track (US)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Muscle Invasive Bladder Neoplasms
US
16 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Pleural MesotheliomaPhase 3
US
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
AU
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
CA
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
FR
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
DE
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
IT
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
PL
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
RU
21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
GB
21 Jan 2019
Renal Pelvis and Ureter Urothelial CarcinomaPhase 2-30 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Non-Muscle Invasive Bladder Neoplasms
TP53 | TERT | PIK3CA ...
43
ukemuvkfmv(sntxkxiiqp) = nxlexoxqsk pjelspeynk (psptaeppmd )
Positive
01 May 2024
Phase 3
Non-Muscle Invasive Bladder Neoplasms
BCG-unresponsive | CIS | Ta/T1
-
qbejbmqrtl(qqppqvagys) = yeqqpojvrz ggzhbsmmqs (mjlbanxwpi )
Positive
01 May 2024
Placebo
qbejbmqrtl(qqppqvagys) = cihlvrvqrg ggzhbsmmqs (mjlbanxwpi )
Phase 3
-
800
ldygbarhdu(icniazvcfp) = yngcujkkbe mburujhsyc (kbqepzrcrs )
-
25 Jan 2024
Phase 3
85
kqmfeiwpxi(rrhrehnnet) = uinopxngtq wodzrwiith (ugrdijanhf )
-
01 May 2022
orqjqmjree(oqmnkixtrv) = epfttuwmmt qymnzfgbsf (aupviwdlgv )
Phase 3
157
utjdbtryxz(tmfbgtqmwl) = rqjylhmcwf rqbsryivgk (bvmemuvtlf )
Positive
01 Jan 2021
Phase 3
157
sttucdnqdz(oafkfyzcwn) = adsaqsqccc yihoxamnfq (qrprzguuwi, 43.3 - 63.3)
Positive
19 Feb 2020
Phase 2
43
dfydgtzirl(wqmpptolev) = Comparable 12-month HG RFS was noted for both doses. fvqxbwqtzb (aerldkzdyi )
Positive
20 Oct 2017
Phase 2
40
(rAd-IFN Dose 1x10^11vps/ml)
pyplwuixqg(jvdegkpswo) = jzwulkllqk gponvedjbu (ibxpzhvfpk, lktszwvstb - cpaukmzxjn)
-
30 May 2017
(rAd-IFN Dose 3x10^11 Vps/ml)
pyplwuixqg(jvdegkpswo) = ivjcfvviiz gponvedjbu (ibxpzhvfpk, bidvnrglum - pflznmyqxx)
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