Drug Type AAV based gene therapy |
Synonyms Adenovirus-Delivered Interferon Alpha-2b, Instiladrin, Nadofaragene firadenovec + [9] |
Target |
Mechanism IFNAR agonists(Interferon alpha/beta receptor agonists), Gene transference |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (16 Dec 2022), |
RegulationBreakthrough Therapy (US), Orphan Drug (US), Priority Review (US), Fast Track (US) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Non-Muscle Invasive Bladder Neoplasms | US | 16 Dec 2022 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Malignant Pleural Mesothelioma | Phase 3 | US | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | AU | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | CA | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | FR | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | DE | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | IT | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | PL | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | RU | 21 Jan 2019 | |
Malignant Pleural Mesothelioma | Phase 3 | GB | 21 Jan 2019 | |
Renal Pelvis and Ureter Urothelial Carcinoma | Phase 2 | - | 30 Nov 2024 |
Phase 2 | 43 | ukemuvkfmv(sntxkxiiqp) = nxlexoxqsk pjelspeynk (psptaeppmd ) | Positive | 01 May 2024 | |||
Phase 3 | Non-Muscle Invasive Bladder Neoplasms BCG-unresponsive | CIS | Ta/T1 | - | qbejbmqrtl(qqppqvagys) = yeqqpojvrz ggzhbsmmqs (mjlbanxwpi ) View more | Positive | 01 May 2024 | ||
Placebo | qbejbmqrtl(qqppqvagys) = cihlvrvqrg ggzhbsmmqs (mjlbanxwpi ) View more | ||||||
Phase 3 | - | 800 | ldygbarhdu(icniazvcfp) = yngcujkkbe mburujhsyc (kbqepzrcrs ) View more | - | 25 Jan 2024 | ||
Phase 3 | 85 | kqmfeiwpxi(rrhrehnnet) = uinopxngtq wodzrwiith (ugrdijanhf ) View more | - | 01 May 2022 | |||
orqjqmjree(oqmnkixtrv) = epfttuwmmt qymnzfgbsf (aupviwdlgv ) View more | |||||||
Phase 3 | 157 | utjdbtryxz(tmfbgtqmwl) = rqjylhmcwf rqbsryivgk (bvmemuvtlf ) View more | Positive | 01 Jan 2021 | |||
Phase 3 | 157 | sttucdnqdz(oafkfyzcwn) = adsaqsqccc yihoxamnfq (qrprzguuwi, 43.3 - 63.3) View more | Positive | 19 Feb 2020 | |||
NCT01687244 (Pubmed) Manual | Phase 2 | 43 | (1 × 1011 vp/mL) | dfydgtzirl(wqmpptolev) = Comparable 12-month HG RFS was noted for both doses. fvqxbwqtzb (aerldkzdyi ) View more | Positive | 20 Oct 2017 | |
(3 × 1011 vp/mL) | |||||||
Phase 2 | 40 | (rAd-IFN Dose 1x10^11vps/ml) | pyplwuixqg(jvdegkpswo) = jzwulkllqk gponvedjbu (ibxpzhvfpk, lktszwvstb - cpaukmzxjn) View more | - | 30 May 2017 | ||
(rAd-IFN Dose 3x10^11 Vps/ml) | pyplwuixqg(jvdegkpswo) = ivjcfvviiz gponvedjbu (ibxpzhvfpk, bidvnrglum - pflznmyqxx) |