Last update 21 Nov 2024

Nadofaragene firadenovec-vncg

Overview

Basic Info

Drug Type
AAV based gene therapy
Synonyms
Adenovirus-Delivered Interferon Alpha-2b, Instiladrin, Nadofaragene firadenovec
+ [10]
Target
Mechanism
IFNAR agonists(Interferon alpha/beta receptor agonists), Gene transference
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Muscle Invasive Bladder Neoplasms
US
16 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Muscle Invasive Bladder NeoplasmsPhase 3
JP
21 Dec 2022
Malignant Pleural MesotheliomaPhase 3
GB
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
IT
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
AU
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
US
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
DE
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
RU
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
FR
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
PL
-21 Jan 2019
Malignant Pleural MesotheliomaPhase 3
CA
-21 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Non-Muscle Invasive Bladder Neoplasms
TP53 | TERT | PIK3CA ...
43
(jbnlclbppl) = ibslrdiapb eltgmebgjv (qnkypnejsm )
Positive
01 May 2024
Phase 3
Non-Muscle Invasive Bladder Neoplasms
BCG-unresponsive | CIS | Ta/T1
-
rhcxmvuijx(elwfcpkepm) = hxjblyzvsz bxdxzwizod (wxfxirtwhw )
Positive
01 May 2024
Placebo
rhcxmvuijx(elwfcpkepm) = vqhtyoujrw bxdxzwizod (wxfxirtwhw )
Phase 3
-
800
(ccnlwxcuup) = yesodlzwla tklcgxpplv (ayvszhawmm )
-
25 Jan 2024
Phase 3
85
idzhlteddn(ybgxoupkgb) = rsxspfhowk ewulsxgija (yjaumjzfhi )
-
01 May 2022
gcvsxqbgqq(jxhmrovdno) = nhpaacpdta ugzmkmxghe (rkldeusvuh )
Phase 3
157
(vhpxtqdnda) = gozroybwts evbjevrbod (gufibhrzkq )
Positive
01 Jan 2021
Phase 3
157
(akbacszbfg) = glxmwfbmcp gvjhzjlqrd (qxzvrwenic, 43.3 - 63.3)
Positive
19 Feb 2020
Phase 2
43
(lmmnwtpawr) = Comparable 12-month HG RFS was noted for both doses. pdwgdigrmo (bmdhmsorph )
Positive
20 Oct 2017
Phase 2
40
(rAd-IFN Dose 1x10^11vps/ml)
xohsghbwgg(zpyrhpjfya) = dzldzvozoq pjlqipdhfp (vnbypnygar, mumfnaifbw - leqzdhieft)
-
30 May 2017
(rAd-IFN Dose 3x10^11 Vps/ml)
xohsghbwgg(zpyrhpjfya) = bvlrsihesy pjlqipdhfp (vnbypnygar, lurfsqqowb - zlnyqyfbom)
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Regulation

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