Drug Type Bispecific antibody |
Synonyms Recombinant Humanized PDL1/CTLA-4 Bispecific Domain Antibody Fc Fusion Protein, 重组人源化PD-L1/CTLA4双特异性单域抗体Fc融合蛋白 + [1] |
Target |
Action inhibitors |
Mechanism CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors), PDL1 inhibitors(Programmed death-ligand 1 inhibitors) |
Therapeutic Areas |
Originator Organization |
Active Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationSpecial Review Project (China), Orphan Drug (United States) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
HER2 positive Gastrooesophageal junction cancer | Phase 3 | China | 27 Oct 2022 | |
Advanced Pancreatic Ductal Adenocarcinoma | Phase 3 | China | 20 Jan 2022 | |
Squamous non-small cell lung cancer | Phase 3 | China | 14 Sep 2020 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 1 | China | 11 Oct 2021 | |
thymic carcinoma | Phase 1 | China | 02 Dec 2020 | |
Advanced Lung Non-Small Cell Squamous Carcinoma | Preclinical | China | 14 Sep 2020 | |
Advanced Esophageal Squamous Cell Carcinoma | Preclinical | China | 21 Jun 2019 | |
Metastatic Esophageal Squamous Cell Carcinoma | Preclinical | China | 21 Jun 2019 | |
Unresectable Esophageal Squamous Cell Carcinoma | Preclinical | China | 21 Jun 2019 | |
Triple Negative Breast Cancer | Preclinical | China | 30 May 2019 |
NCT04542837 (Pubmed) Manual | Phase 2 | 55 | (jhdioxtenu) = lfudwkfltg mizgxeeduo (htxzwhkmud, 31.97 - 59.45) View more | Positive | 07 Feb 2025 | ||
Phase 2 | 85 | (xaevfbbeqv) = pcwgoxiahj tfsnjruals (pwbhynxrur, 38.8 - 69.6) View more | Positive | 12 Dec 2024 | |||
(xaevfbbeqv) = dtrpeqwryr tfsnjruals (pwbhynxrur, 38.4 - 88.2) View more | |||||||
Phase 3 | Pancreatic Ductal Adenocarcinoma First line | - | KN046+白蛋白紫杉醇+吉西他滨 | (xsptobqhjy) = 未达到预设的统计学终点 kgistbkmdf (vqgkrsahuw ) Not Met | Negative | 28 May 2024 | |
安慰剂+白蛋白紫杉醇+吉西他滨 | |||||||
Phase 2 | 4 | atgurabwnv(eqeciqlynt) = bzexrdxbre yubzubautc (skgvmgogmi, kihanzpgip - rsflvxhpnr) View more | - | 16 Apr 2024 | |||
Phase 2 | metastatic non-small cell lung cancer First line | - | KN046+chemotherapy | (mgvekwvvkx) = zgmvwcpgis vtqoqcppps (yozsfvchet ) View more | Positive | 19 Mar 2024 | |
NCT03872791 (Pubmed) Manual | Phase 2 | 25 | (wrolofrwfz) = xluiucxbyv mppxxfavvy (bwhuwjsuhx, 24.4 - 65.1) View more | Positive | 03 Feb 2024 | ||
(PD-L1 positive) | (gyazrxgdbs) = fgxtjatyfl ereohfidjv (widickqsct ) View more | ||||||
Phase 1/2 | 31 | (bqlghfozox) = yfjowyfvnm ugzmvjjnny (vexyoraoev, 0.1 - 16.7) View more | Positive | 23 Oct 2023 | |||
Phase 2 | 22 | (vrmvaqurqu) = fozjhzgjvy ewjabldldo (dtawepaxwe ) View more | Positive | 23 Oct 2023 | |||
Phase 2 | metastatic non-small cell lung cancer EGFR L858R | EGFR Exon 19 Deletion | 26 | (ijmnpnrnrh) = fpuizwftfz qqwxaswaiy (etiuymtfgb, 11.6 - 47.8) View more | Positive | 23 Oct 2023 | ||
Phase 2 | thymic carcinoma PD-L1 Expression | 46 | (yuhkjajwwl) = xitqgfwepq ekqgajopoz (dgwpjsxquc, 6.8 - 30.7) View more | Positive | 21 Oct 2023 | ||
(PD-L1-positive) | (yuhkjajwwl) = klyvkpvvvu ekqgajopoz (dgwpjsxquc ) View more |