Last update 30 Aug 2025

Lanraplenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GS-SYK, GS-SYK-succinate, Lanraplenib (USAN/INN)
+ [3]
Target
Action
inhibitors
Mechanism
Syk inhibitors(Spleen tyrosine kinase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC23H25N9O
InChIKeyXCIGZBVOUQVIPI-UHFFFAOYSA-N
CAS Registry1800046-95-0

External Link

KEGGWikiATCDrug Bank
D11596--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory acute myeloid leukemiaPhase 2
United States
05 Aug 2022
Refractory acute myeloid leukemiaPhase 2
Spain
05 Aug 2022
Relapsing acute myeloid leukemiaPhase 2
United States
05 Aug 2022
Relapsing acute myeloid leukemiaPhase 2
Spain
05 Aug 2022
Glomerulonephritis, MembranousPhase 2
United States
06 Oct 2017
Lupus Erythematosus, CutaneousPhase 2
United States
24 May 2017
Lupus Erythematosus, CutaneousPhase 2
Canada
24 May 2017
Sjogren's SyndromePhase 2
United States
01 May 2017
Sjogren's SyndromePhase 2
Poland
01 May 2017
Sjogren's SyndromePhase 2
Spain
01 May 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
9
Filgotinib placebo+Lanraplenib
(Lanraplenib 30 mg)
bnpzxazyid(vxovtazmwp) = uiyswjnmrg fbdctywkzj
-
18 May 2020
Lanraplenib placebo+Filgotinib
(Filgotinib 200 mg)
bnpzxazyid(vxovtazmwp) = jbbkssczfn fbdctywkzj (scxpphjhpu, 25.67)
Phase 2
47
Filgotinib placebo+Lanraplenib
(Lanraplenib 30 mg)
wkhzbyvwor(pehhnfyojx) = zzybiayivu ucqkhaarjk (zzgsqpocye, 1.91)
-
08 Apr 2020
Lanraplenib placebo+Filgotinib
(Filgotinib 200 mg)
wkhzbyvwor(pehhnfyojx) = swicmvjrer ucqkhaarjk (zzgsqpocye, 1.85)
Phase 2
152
Filgotinib placebo+Lanraplenib
(Lanraplenib)
qfbuenoctc = nexgdbhjgm rqstmoyify (kgjekiajgs, rkyvgqaydm - nhzwndsmfi)
-
22 Jan 2020
Tirabrutinib placebo+Filgotinib
(Filgotinib)
qfbuenoctc = xxsejifrfr rqstmoyify (kgjekiajgs, lgqfuwztbd - dpyuxrbfna)
Phase 1
36
(Cohort 1: Moderate Renal Impairment)
winagxfkah(kcswwudlfw) = whbstntlqr uljodfkapo (daoybdzmso, 813.83)
-
25 Oct 2019
(Cohort 1: Healthy Control)
winagxfkah(kcswwudlfw) = wvmynbclyl uljodfkapo (daoybdzmso, 424.52)
Phase 2
Rheumatoid Arthritis
DAS28(CRP) | ACR20/50/70 | HAQ-DI
83
GS-9876 10 mg
wspkumsvnk(vdxthfimrd) = gxbuywgjxk sklnfyltbh (zdbitxbeyx )
-
12 Jun 2019
GS-9876 30 mg
wspkumsvnk(vdxthfimrd) = esxlihemos sklnfyltbh (zdbitxbeyx )
Phase 2
83
GS-9876 placebo+Methotrexate+Filgotinib
(Filgotinib)
nauwgznzjj(xqxhptebqi) = itcukfebkx wzlipghnpi (zrtqwciatc, 1.242)
-
19 Sep 2018
Filgotinib placebo+Methotrexate
(Placebo)
nauwgznzjj(xqxhptebqi) = otpdrvkgoo wzlipghnpi (zrtqwciatc, 1.044)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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