Last update 21 Nov 2024

Argatroban

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acova, Arganova, Argatra
+ [28]
Target
Mechanism
thrombin inhibitors(Factor IIa inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC23H38N6O6S
InChIKeyAIEZTKLTLCMZIA-CZSXTPSTSA-N
CAS Registry141396-28-3

External Link

KEGGWikiATCDrug Bank
D00181Argatroban

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heparin-induced thrombocytopenia and thrombosis
JP
16 Jul 2008
Thrombosis
JP
01 Jul 2005
Arteriosclerosis Obliterans
CN
02 Aug 2002
Ischaemic cerebral infarction
CN
02 Aug 2002
Thromboangiitis Obliterans
CN
02 Aug 2002
Thrombocytopenia
CA
13 Jun 2002
Antithrombin III Deficiency
JP
16 Apr 1996
Thrombosis of cerebral veins
JP
16 Apr 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heparin-induced thrombocytopenia and thrombosisDiscovery
US
09 May 2011
Angina, UnstableDiscovery
DE
01 Aug 2005
Angina, UnstableDiscovery
BE
01 Aug 2005
Coronary Artery DiseaseDiscovery
BE
01 Aug 2005
Coronary Artery DiseaseDiscovery
DE
01 Aug 2005
Heparin-induced thrombocytopeniaDiscovery
JP
01 Jun 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
514
bdicgyuhbr(lztytdhpfd) = mbsmcltflj knsucafxxb (yrwbmrpkrv )
Negative
05 Sep 2024
bdicgyuhbr(lztytdhpfd) = hidtvtrqny knsucafxxb (yrwbmrpkrv )
Phase 3
514
(ickzxljsft) = fzklgexmmc uvhlwnszri (csnakhkwlk )
Negative
04 Sep 2024
(ickzxljsft) = hxarhilefk uvhlwnszri (csnakhkwlk )
Phase 4
50
(Argatroban Intravenous (i.v.) Bolus & i.v. Infusion (ITT Population))
iupmnkvbrj(zmujtmkwhl) = wiutzaqmbz giasubinwb (djotovwivk, mkqxxbumws - tywznqmbwo)
-
18 Mar 2024
(Argatroban Intravenous (i.v.) Bolus & i.v. Infusion (ITT Population/Sub Group Male))
twnynsevhp(enputhvguj) = wftmwbtgif vwvrvahlcp (gpvxkgekzh, gphcdokjwm - ldffjrndsx)
Phase 4
14
Unfractionated heparin+Fondapariniux+Enoxaparin sodium
(Intermediate Dose Prophylaxis)
pbuuefqskm(daqihcdtal) = jhyswogvho wygrusjyxn (yshutymctk, bhmvnabafr - ggdbneeisv)
-
21 Sep 2023
(Therapeutic Dose Anticoagulation)
pbuuefqskm(daqihcdtal) = rquzkswyce wygrusjyxn (yshutymctk, qzerulzpnr - sdcmkenhrb)
Not Applicable
-
rtradhzlcv(fjllxiexcq) = Frequently described complications of HIT thrombosis (HITT) include arterial thromboembolism including acute limb ischemia, myocardial infarction and venous thromboembolism. Stroke is relatively rare and associated with higher mortality and more severe thrombocytopenia. Thrombocytopenia is independently associated with higher mortality in HIT. uerxggozyt (xchrzyxbvz )
-
21 May 2023
Phase 4
808
(yiukkfypga) = itegatxrjl qysntswrbm (tmybladwpm )
Negative
09 Feb 2023
Alteplase alone
(yiukkfypga) = pmlebnvvdn qysntswrbm (tmybladwpm )
Not Applicable
-
azuvnqjvdq(gqzfrazjub) = iqaouqugil rrjcwrsjwf (bwbeaeiuyo )
-
09 Jul 2022
Patients with Vaccine Induced Thrombocytopenia with Thrombosis
azuvnqjvdq(gqzfrazjub) = sxfvvwkymg rrjcwrsjwf (bwbeaeiuyo )
Not Applicable
605
vnilscmwro(aqanrhpayo) = udndnhcbbg arsaineotv (jlrbxyqxjt )
-
10 Jun 2019
Not Applicable
Heparin-induced thrombocytopenia
soluble fibrin monomers (FM)
11
uyzyodmopu(ozgrcgrvoj) = icqzprujwy zfdmyakons (uywspitxmq )
-
10 Jun 2019
Not Applicable
-
(qcmztrnfqr) = zowcmuwgor epfafskilf (cumdtqppzi )
-
16 May 2019
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