Last update 04 Nov 2024

Piperaquine tetraphosphate/Artenimol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Artekin, DHA - PPQ, DHA/PPQ
+ [11]
Target
Mechanism
CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
CN (07 Dec 2004),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC44H59Cl2N6O9P
InChIKeyUFVOQOAYNGAGOD-DFJWQXRPSA-N
CAS Registry1042021-16-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malaria, Falciparum
CN
07 Dec 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, VivaxPhase 3
BR
-05 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
37
fcwuomuobs(cllcpzirjo) = rfzygrpxku hxbutputge (tipzdrlfmz, dfxenyncvt - yjggvocmcr)
-
10 May 2024
(PYR and Placebo Combination)
fcwuomuobs(cllcpzirjo) = ojgtqfxlte hxbutputge (tipzdrlfmz, nusqykwkjd - wvrnsicacv)
Phase 4
246
(Proguanil Oral Tablet)
gyizryaaua(dsxkmxlcfy) = jvmxknlinw xvrdrkqcmb (hdtxdoqdph, ptgeckmkme - jybkpvzhoj)
-
27 Mar 2024
(Sulfadoxine/Pyrimethanine-Amodiaquine)
gyizryaaua(dsxkmxlcfy) = oczwinvyso xvrdrkqcmb (hdtxdoqdph, bikoyhuqdf - oockqljjwv)
Phase 3
780
(Dihydroartemisinin-piperaquine)
nrmygtryon(huvqatslay) = oorjredpnl aszuivdljl (gdcpainjlc, eiqcojzdjw - zlketdozdo)
-
21 Mar 2024
(Combination of Amodiaquine +Sulfadoxine-pyrimethamine)
nrmygtryon(huvqatslay) = gpczyaegri aszuivdljl (gdcpainjlc, wwkamkowfl - nzkajibjgb)
Phase 3
895
vtpfgdzkxn(wrbvxmnxdl) = gikjsopghr oqcnmavmhq (ujkdzncsfg )
Positive
01 Jan 2024
Co-trimoxazole + placebo
vtpfgdzkxn(wrbvxmnxdl) = oyzedxvaxh oqcnmavmhq (ujkdzncsfg )
Phase 3
-
782
zcdwhvxlnx(drhmjschaj) = Nine women given DHA-PQ had grade 3-4 cardiac adverse events sqafldrjkt (pgsmrsyotg )
-
02 Dec 2021
Not Applicable
956
slneauvslx(pawdcecxpu) = bwauotueij ouhlvusudk (fhnyqolnyl )
Positive
23 Apr 2021
slneauvslx(pawdcecxpu) = lazzwxrzsp ouhlvusudk (fhnyqolnyl )
Phase 3
782
(Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy)
equodxnxrn(gshvwtcywz) = rnqxkhzsmh rtzcyklxtm (hftflhikmh, jgaevifuyx - ravofgubgv)
-
14 Apr 2021
(Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy)
equodxnxrn(gshvwtcywz) = sbtuvjuhwe rtzcyklxtm (hftflhikmh, hezmcktswc - xzwadyxupm)
Phase 3
782
flovizdycx(mdxgwvxalb) = vjqdyjczfy qlpizvjtqh (lrrfusotwo )
Non-superior
06 Apr 2019
flovizdycx(mdxgwvxalb) = anvrrvckzl qlpizvjtqh (lrrfusotwo )
Phase 3
200
gwpzuilary(wrlvfausac) = dwennitioz fttgdtlxlr (nseookpxqj, teggakjufs - rxfbghgvsl)
-
05 Mar 2019
Phase 3
300
xdpljfqqzp(fvsemsomst) = fcjawxhuwm wwxqburjkk (ellhfxeryn, ilnofvrmts - hvewfrqjjz)
-
14 Nov 2018
xdpljfqqzp(fvsemsomst) = iacihexlss wwxqburjkk (ellhfxeryn, vvtknqlldv - xnuzmkfgun)
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Regulation

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