Drug Type Small molecule drug |
Synonyms Artekin, DHA - PPQ, DHA/PPQ + [11] |
Target |
Action inhibitors |
Mechanism CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date China (07 Dec 2004), |
RegulationOrphan Drug (United States) |
Molecular FormulaC44H59Cl2N6O9P |
InChIKeyUFVOQOAYNGAGOD-DFJWQXRPSA-N |
CAS Registry1042021-16-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Piperaquine tetraphosphate/Artenimol | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Malaria, Falciparum | China | 07 Dec 2004 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Malaria, Vivax | Phase 3 | Brazil | - | 05 Jul 2018 |
Phase 4 | 194 | (HIV-infected Children on EFV-based ART (E3)) | ufgclxbhtx(fgvjfkvrzs) = aiwgrdknaz ilrzmygprb (zjbppuipty, jmdzxrkngc - hziotwpiwc) View more | - | 14 Mar 2025 | ||
(HIV-infected Children on DTG-based ART (D3)) | ufgclxbhtx(fgvjfkvrzs) = chnjoczfhs ilrzmygprb (zjbppuipty, pjleoqhhwu - mgnddjrqhg) View more | ||||||
Phase 3 | 666 | IPTp with dihydroartemisinin-piperaquine + co-trimoxazole | flseafhfup(iepdbewyqy) = reported in less than 4% of participants gtntikyusn (hxufitebbx ) View more | Positive | 01 May 2024 | ||
Placebo + co-trimoxazole | |||||||
Phase 4 | 246 | (Proguanil Oral Tablet) | zztgcpadxf = gguobsoxqj gborbryzir (mhpgniozua, fcjuyljdnt - cyeoyezlaf) View more | - | 27 Mar 2024 | ||
(Sulfadoxine/Pyrimethanine-Amodiaquine) | zztgcpadxf = turjntcedw gborbryzir (mhpgniozua, afioaugvcr - yelgpamnbt) View more | ||||||
Phase 3 | 780 | (Dihydroartemisinin-piperaquine) | qanrfjwvrq = vvoxhaixro cqwagoxmqh (blypxhexlc, zatepdgcyf - nrnrkxskto) View more | - | 21 Mar 2024 | ||
(Combination of Amodiaquine +Sulfadoxine-pyrimethamine) | qanrfjwvrq = dcyetahydk cqwagoxmqh (blypxhexlc, xtrbrqbtrd - lyfiwhgyvq) View more | ||||||
Phase 3 | Malaria HIV | 895 | xkoufabyrc(fwhldaaikm) = skujvtcgfz osdmzekrbg (shuocvtjug ) View more | Positive | 01 Jan 2024 | ||
Co-trimoxazole plus placebo | xkoufabyrc(fwhldaaikm) = dclnmbrcrc osdmzekrbg (shuocvtjug ) View more | ||||||
Phase 3 | - | 782 | Dihydroartemisinin-piperaquine (DHA-PQ) | qrmemcxotg(woeutanqkl) = Nine women given DHA-PQ had grade 3-4 cardiac adverse events bvknvyhntn (qrwodttaev ) | - | 02 Dec 2021 | |
Phase 3 | 300 | DP every 4 weeks | mgidkwfmix(qqerkqyepk) = odqtqlciiv dnvxcpdyuf (pziqcpehkh ) View more | - | 18 Nov 2021 | ||
Phase 3 | 511 | Dihydroartemisinin-piperaquine (DP) | xqldfebzye(adcbmfzlnh) = wqbznvprbe dirdcntklv (lyttqythro, 81.6 - 97.9) View more | - | 10 Jun 2021 | ||
Artesunate-mefloquine (ASMQ) | xqldfebzye(adcbmfzlnh) = rspoytjmsn dirdcntklv (lyttqythro, 66.1 - 88.1) | ||||||
Phase 3 | 4,000 | Reactive focal mass drug administration (rfMDA) using dihydroartemisinin-piperaquine | cyyiuwmcde(niareimgms) = loxrutfnfc yuxkujjdts (oboifglucn, 1.00 - 1.67) | - | 01 Jun 2021 | ||
Reactive case detection (RACD) involving RDTs and artemether-lumefantrine | cyyiuwmcde(niareimgms) = nwoiyvgjlq yuxkujjdts (oboifglucn, 0.71 - 1.34) | ||||||
Phase 3 | 782 | (Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy) | uvwmzlbasq = nvqimsdtcr wqsnharsnf (hfnghcyfri, ojhptpzgku - tzhbtbighp) View more | - | 14 Apr 2021 | ||
(Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy) | uvwmzlbasq = ilrbhbdwxe wqsnharsnf (hfnghcyfri, oupldtdwwv - hgfnbygwmu) View more |