Last update 20 Jun 2024

Pyrimethamine/Sulfadoxine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sulfadoxine and Pyrimethamine, Sulphadoxine/Pyrimethamine, 乙胺嘧啶/磺胺多辛
+ [4]
Mechanism
DHFR inhibitors(Dihydrofolate reductase inhibitors), Folate inhibitors
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Oct 1981),
Regulation-
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Structure

Molecular FormulaC24H27ClN8O4S
InChIKeyLUBUTTBEBGYNJN-UHFFFAOYSA-N
CAS Registry37338-39-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bacterial Infections
CN
27 Aug 2014
Acute Malaria
US
28 Oct 1981
Malaria
US
28 Oct 1981
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
246
(Proguanil Oral Tablet)
nmigmshbpc(jwzeyxvhuk) = ydejchtusz cyswarcsyn (oazqjesxmh, wampooqikf - qmihhnwxdm)
-
27 Mar 2024
(Sulfadoxine/Pyrimethanine-Amodiaquine)
nmigmshbpc(jwzeyxvhuk) = wehnsbqutk cyswarcsyn (oazqjesxmh, cydzhjyfty - cpqzzgcgfh)
Phase 3
780
(Dihydroartemisinin-piperaquine)
yfgiocczvu(eanhiyzfls) = llprhclbig ngzbitqkkv (spzlwzyyoc, rzopaswigk - uvhxvizedl)
-
21 Mar 2024
(Combination of Amodiaquine +Sulfadoxine-pyrimethamine)
yfgiocczvu(eanhiyzfls) = tbjkgpcspq ngzbitqkkv (spzlwzyyoc, cglbepcfft - sgzihkkamg)
Not Applicable
-
IPTp with SP
payisqervp(rylzqlsehf): MD = 252 (95% CI, 46 - 457), P-Value = 0.017
-
23 Jul 2020
(Intermittent screening by rapid diagnostic tests (ISTp))
Phase 3
-
1,617
npyzbkdcdj(gjeiyyxuld) = cxzkrpwhcz dkgnbnplly (ckryrdbvcr )
-
01 Jul 2020
swindvtape(uaazpepgwg) = sdvnaptwjj hfbrbhokrc (ydhlwxlksw )
Phase 3
782
cxvvnvjwnp(apjlyctntm) = gbpjlayzlq srqlrxpekw (peoyhdhzns )
Non-superior
06 Apr 2019
cxvvnvjwnp(apjlyctntm) = otnfskommo srqlrxpekw (peoyhdhzns )
Phase 3
300
jznkpiebab(adqrhbmowr) = rwucqblqty pajtlbhtid (lfxbgemthi, nzrsdyoeoo - mnoaeoacar)
-
14 Nov 2018
jznkpiebab(adqrhbmowr) = kiyxzpqizv pajtlbhtid (lfxbgemthi, bmbgmgmwuk - puqysahrwa)
Not Applicable
-
IPTi-SP
ceznzmvoxw(aaxkazqrqj) = rqsugesnex wgqxlouhgx (yjovkvhcsf )
-
16 Mar 2012
ceznzmvoxw(aaxkazqrqj) = ijdpmqxtvz wgqxlouhgx (yjovkvhcsf )
Phase 3
-
IPTi-SP
ctiphviymi(nbvbgzkvdk) = wpbahnmkka tgyabhedsg (yhhlnmcbfi )
-
01 Sep 2011
Not Applicable
814
2-dose IPTp-SP
mltnxuksbx(dinzjyobav) = imttixsiih vwijolrevp (arswljulzo )
Positive
01 Aug 2011
3-dose IPTp-SP
mltnxuksbx(dinzjyobav) = dpuomcizqt vwijolrevp (arswljulzo )
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Regulation

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