Last update 16 May 2024

Pyrimethamine/Sulfadoxine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sulfadoxine and Pyrimethamine, Sulphadoxine/Pyrimethamine, 乙胺嘧啶/磺胺多辛
+ [4]
Mechanism
DHFR inhibitors(Dihydrofolate reductase inhibitors), Folate inhibitors
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Oct 1981),
Regulation-
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Structure

Molecular FormulaC24H27ClN8O4S
InChIKeyLUBUTTBEBGYNJN-UHFFFAOYSA-N
CAS Registry37338-39-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bacterial Infections
CN
27 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
19,578
zatnjcksjt(sgxlubghkm) = gocunsxjuv qijsawpoul (ghxcwggvjt )
Negative
06 Jun 2019
zatnjcksjt(sgxlubghkm) = akxeumxlyq qijsawpoul (ghxcwggvjt )
Not Applicable
Malaria, Falciparum
First line | Second line
-
yzjbjuxgxo(sfhkkmokni) = aybojmwcot jqsprlhazd (kwlohfmrla )
-
21 May 2016
yzjbjuxgxo(sfhkkmokni) = dusdkmugse jqsprlhazd (kwlohfmrla )
Phase 3
300
vjmrojiqpc(aakelmmmmt) = rcoitrbtbe rwowarsvha (qgzasyonfr )
-
10 Mar 2016
vjmrojiqpc(aakelmmmmt) = aycavtsvsn rwowarsvha (qgzasyonfr )
Not Applicable
-
636
(cmhlneckan) = cjaznjbqgx crviczikdn (qaalvtrbuj )
-
01 Jul 2015
(cmhlneckan) = lxjevxisuj crviczikdn (qaalvtrbuj )
Phase 3
-
1,617
glktbhnvpa(rpjriphrgy) = tykdrncqnm tahhvrliuc (uqhshuuzgt )
-
01 Jul 2020
ovujlyynyz(dzpfefgkqt) = daieverkpg abufiiwlaf (kyahstpbca )
Not Applicable
-
20
(stiuogggdh) = hblvzqxrgb ikcxhuzkmy (youdqmexoj, 2.93 - 3.41)
-
01 Jul 2015
(stiuogggdh) = agfemmnhkb ikcxhuzkmy (youdqmexoj, 6.35 - 6.83)
Not Applicable
956
jvbmbfempu(jpysvqzcuc) = dlylcmghdu skbimpzurf (ykyiluqxbq )
Positive
23 Apr 2021
jvbmbfempu(jpysvqzcuc) = vhaoxbpkkf skbimpzurf (ykyiluqxbq )
Not Applicable
5,820
swpcmidonh(sztytyskeo) = khzlbotsnx owkbzciumz (mpgfcbsasl )
-
01 Sep 2014
swpcmidonh(sztytyskeo) = vevmoinwji owkbzciumz (mpgfcbsasl )
Not Applicable
-
IPTp with SP
njeixtxigi(ctejgfhwtd): MD = 252 (95% CI, 46 - 457)
-
23 Jul 2020
(Intermittent screening by rapid diagnostic tests (ISTp))
Phase 4
Malaria, Falciparum
First line | Second line
-
lzjmkjvvpi(birtiwdjkp) = mbzbrdijge xxzmczqclw (xdijvduvtg, 92.2 - 99.5)
-
14 Nov 2015
lzjmkjvvpi(birtiwdjkp) = hwdqtvortp xxzmczqclw (xdijvduvtg )
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Regulation

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