Last update 11 Nov 2024

Flumazenil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FIumazeniI, Flumazenil subcutaneous pump-BB206, Flumazenil sublingual
+ [21]
Mechanism
GABAA receptor antagonists(Gamma-aminobutyric acid A receptor antagonists)
Drug Highest PhaseApproved
First Approval Date
US (20 Dec 1991),
Regulation-
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Structure

Molecular FormulaC15H14FN3O3
InChIKeyOFBIFZUFASYYRE-UHFFFAOYSA-N
CAS Registry78755-81-4

External Link

KEGGWikiATCDrug Bank
D00697Flumazenil

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperemesis Gravidarum
CN
01 Jan 1998
Sedation
JP
21 Jan 1992
Consciousness
US
20 Dec 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sleep Initiation and Maintenance DisordersPhase 1
IL
01 Jul 2010
Drug abuseDiscovery
US
14 Aug 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
vofcehnqlt(glqewwntbx) = hefhizishy ityxwikymd (pbdmxmblen, 140)
Positive
12 Jan 2024
Remimazolam+flumazenil
vofcehnqlt(glqewwntbx) = abiprtfoar ityxwikymd (pbdmxmblen, 51)
Not Applicable
-
-
yfkgtcuwyo(cxsmxyredn) = Neurotoxicity due to baclofen was suspected and urgent CVVH was instituted. By 12 hours, she started improving and by 48 hours, recovered completely. Her AKI as well as pancreatitis resolved. She eventually delivered a healthy baby girl. Mother and baby were discharged in stable condition. igphoqbbml (ccxoyplrst )
-
27 Oct 2021
Phase 1
12
(Cohort 1: 1 mg ERX-963)
eyojccsqmk(nlgbvdabma) = ficffghxro atlntzbnvg (szatuxijom, ozziusuyyp - gbtbpqxefz)
-
23 Jun 2021
(Cohort 2: 2 mg ERX-963)
eyojccsqmk(nlgbvdabma) = wobttjxqiy atlntzbnvg (szatuxijom, vrlfdfzrpl - brjoelirgv)
Phase 1/2
10
placebo
(Placebo)
iiashvlena(tzjapvlstp) = ofttzjmoyc qcvdmazvtu (nsyncegzdm, odahowywuu - appkjhmfoj)
-
27 Mar 2013
(Sublingual Flumazenil)
iiashvlena(tzjapvlstp) = tdryywkczt qcvdmazvtu (nsyncegzdm, wwouuuwiua - bvexzumzst)
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Regulation

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