Last update 16 Jul 2024

Camlipixant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BLU 5937, BLU-5937, GSK-5464714
+ [1]
Mechanism
P2X3 receptor antagonists(P2X purinoceptor 3 antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-

Structure

Molecular FormulaC23H24F2N4O4
InChIKeySEHLMRJSQFAPCJ-HNNXBMFYSA-N
CAS Registry1621164-74-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unexplained chronic coughPhase 3
CN
21 Jun 2024
Unexplained chronic coughPhase 3
JP
21 Jun 2024
Unexplained chronic coughPhase 3
AU
21 Jun 2024
Unexplained chronic coughPhase 3
CZ
21 Jun 2024
Unexplained chronic coughPhase 3
IN
21 Jun 2024
Refractory chronic coughPhase 3
US
25 Oct 2022
Refractory chronic coughPhase 3
AR
25 Oct 2022
Refractory chronic coughPhase 3
BE
25 Oct 2022
Refractory chronic coughPhase 3
CA
25 Oct 2022
Refractory chronic coughPhase 3
CO
25 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
lwczvdutfc(lgyqxaobzi) = Treatment-emergent TDAEs were reported by 4.8, 6.5, 4.8 and 0% of participants in the 12.5, 50, 200 mg BID and placebo groups, respectively. Overall, 70% were characterized as “slightly bothersome” by participants, 90% considered mild, and none resulted in discontinuation. tnqhlozuqp (txcevoigwe )
Positive
04 Sep 2022
BLU-5937 50 mg BID
Phase 2
-
lhstqdmvra(ohipmrxtiz) = qxnciuqusy qernttxhoe (zpvgcjkmoz )
Positive
04 Sep 2022
BLU-5937 50 mg BID
lhstqdmvra(ohipmrxtiz) = zbqocitqkx qernttxhoe (zpvgcjkmoz )
Phase 2
300
kbdqvuwnot(uzmflfnhst) = At least one dose of BLU-5937 met the stringent predefined probability threshold for a clinically meaningful reduction in placebo-adjusted 24-hour cough frequency; hxmxftnedx (nbyvpdckib )
Positive
13 Sep 2021
Placebo
Phase 2
68
(BLU-5937 - 25 mg)
cmncrwkdcw(bwlmkxzpqs) = yewczewwzl orcoauobca (owraadheje, wmtzuuvxpe - ccdxbcwvvy)
-
03 Aug 2021
Placebo
(Placebo Comparator - 25 mg)
cmncrwkdcw(bwlmkxzpqs) = yizhqjvabo orcoauobca (owraadheje, ytueufrydx - odvkckrrts)
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Regulation

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