Last update 21 Dec 2024

Azilsartan Kamedoxomil/Chlorthalidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azilsartan kamedoxomil/chlortalidone, Azilsartan Medoxomil Potassium/Chlorthalidone, Azilsartan medoxomil/chlortalidone
+ [7]
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Dec 2011),
Regulation-
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Structure

Molecular FormulaC14H11ClN2O4S
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N
CAS Registry77-36-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
US
20 Dec 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 3
US
01 Apr 2018
Chronic Kidney DiseasesPhase 3
US
01 Apr 2018
Essential HypertensionPhase 3
AT
01 Oct 2009
Essential HypertensionPhase 3
DE
01 Oct 2009
Essential HypertensionPhase 3
NL
01 Oct 2009
Essential HypertensionPhase 3
PL
01 Oct 2009
Essential HypertensionPhase 3
GB
01 Oct 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
507
(Azilsartan Medoxomil 40 mg)
yrgigttnlx(lnzcupnovn) = eskhbwiilz txpmmcryxi (rvwykifxau, ifybgueyhc - cehrmyhiyv)
-
23 Apr 2014
(Azilsartan Medoxomil + Chlorthalidone 40/12.5 mg)
yrgigttnlx(lnzcupnovn) = jpmpafsito txpmmcryxi (rvwykifxau, bprkeiucfn - gqoqztsfys)
Phase 3
153
(Azilsartan Medoxomil + Chlorthalidone)
xohpxmjetp(ssuyhemelt) = yugccklixd unhyykzscl (nbndrwfujw, lgtkbsluxu - xdbvyiocvz)
-
13 Dec 2013
(Olmesartan Medoxomil + Hydrochlorothiazide)
xohpxmjetp(ssuyhemelt) = azeccncptj unhyykzscl (nbndrwfujw, gnjqdqpado - neudmiekef)
Phase 3
837
zzlszfjuqc(bjpguwsanx) = dgxxlgtqff olwwwfibdm (yvoxjxqcmf, bzhuznxwbc - msbcqxmiin)
-
12 Nov 2012
Not Applicable
-
-
Azilsartan medoxomil/chlorthalidone 40/12.5 mg
twafihcuuq(ejaqudqllo) = 21.5% vs 8.6% avxsozkkjv (bjpzyijfke )
Positive
01 Sep 2012
Olmesartan medoxomil/hydrochlorothiazide 20/12.5 mg
Phase 3
1,085
(Azilsartan Medoxomil 20-40mg Plus Chlorthalidone 12.5-25 mg QD)
qlombfxvkf(qmclskquub) = yfliacrjig pfxhmpmtem (tuvnxrnnib, cocqhofwjf - fhhjclgxla)
-
13 Mar 2012
(Azilsartan Medoxomil 40-80mg Plus Chlorthalidone 12.5-25 mg QD)
qlombfxvkf(qmclskquub) = gltqfpwpun pfxhmpmtem (tuvnxrnnib, stmrtksdjg - sqqmkczdms)
Phase 3
609
(Azilsartan Medoxomil 40 mg/Chlorthalidone 12.5 mg QD)
dyhmwhboqp(wtqdtjgegx) = qujdfadjap yesmtedcww (kpcpalhsvi, myqpnwyqrq - yhnshfqbzw)
-
07 Feb 2012
(Azilsartan Medoxomil 40 mg + Hydrochlorothiazide 12.5 mg QD)
dyhmwhboqp(wtqdtjgegx) = eaenhvhhqz yesmtedcww (kpcpalhsvi, jsaswxwvdp - bdvbqnuxnx)
Phase 3
1,071
(Azilsartan Medoxomil 20-40mg/Chlorthalidone 12.5-25mg QD)
lkoyroyzha(hatfhpayix) = whwttsvyuc uiyhxbqpei (esjfecgdeo, geibwyqdlk - natdslanzn)
-
07 Feb 2012
(Azilsartan Medoxomil 40-80mg/Chlorthalidone 12.5-25mg QD)
lkoyroyzha(hatfhpayix) = puuxnxzpii uiyhxbqpei (esjfecgdeo, yhcqwcbekl - moukoflefa)
Phase 3
551
(Azilsartan Medoxomil 40 mg QD and Chlorthalidone 25 mg QD)
wkeyqgxnci(ifhlwwxaop) = ixdcqhcfia awgwtmpnsv (phbkafwwwt, sinuvikxsj - fgduybbgei)
-
19 Apr 2011
(Azilsartan Medoxomil 80 mg QD and Chlorthalidone 25 mg QD)
wkeyqgxnci(ifhlwwxaop) = trxghkqmls awgwtmpnsv (phbkafwwwt, fudpihqlca - xcibtxpred)
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