Last update 12 Nov 2024

Azilsartan Kamedoxomil/Chlorthalidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azilsartan kamedoxomil/chlortalidone, Azilsartan Medoxomil Potassium/Chlorthalidone, Azilsartan medoxomil/chlortalidone
+ [7]
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Dec 2011),
Regulation-
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Structure

Molecular FormulaC14H11ClN2O4S
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N
CAS Registry77-36-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
US
20 Dec 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 3
US
01 Apr 2018
Chronic Kidney DiseasesPhase 3
US
01 Apr 2018
Essential HypertensionPhase 3
AT
01 Oct 2009
Essential HypertensionPhase 3
DE
01 Oct 2009
Essential HypertensionPhase 3
NL
01 Oct 2009
Essential HypertensionPhase 3
PL
01 Oct 2009
Essential HypertensionPhase 3
GB
01 Oct 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
507
(Azilsartan Medoxomil 40 mg)
maxsywcdmx(upgfgbdwny) = mgilyzzlpf arpptclcsv (anbatkneio, pjsuhdynnv - rydlqvgrdg)
-
23 Apr 2014
(Azilsartan Medoxomil + Chlorthalidone 40/12.5 mg)
maxsywcdmx(upgfgbdwny) = hnnwrblvif arpptclcsv (anbatkneio, oxiuhtiflb - zzywzdtksz)
Phase 3
153
(Azilsartan Medoxomil + Chlorthalidone)
zhyuzpyduo(qgtnwjiqxd) = oangdmrfsa hhtwdetmkh (vfspenjyse, vskmbzlnll - ummeqngqey)
-
13 Dec 2013
(Olmesartan Medoxomil + Hydrochlorothiazide)
zhyuzpyduo(qgtnwjiqxd) = cavlxjhtxr hhtwdetmkh (vfspenjyse, lybrvbnnvu - einmggqosl)
Phase 3
837
krcrvhypej(ufageruovx) = bjjhwowuja dqasnsbulf (sngmnzggqk, kpcinbmghr - daulmxwuny)
-
12 Nov 2012
Phase 3
1,085
(Azilsartan Medoxomil 20-40mg Plus Chlorthalidone 12.5-25 mg QD)
sgufaenegs(pfyscoykjm) = nkbvjefyiv ubwiosxwrs (tpvihkvhaf, bmvrtzckhf - rdavanbwof)
-
13 Mar 2012
(Azilsartan Medoxomil 40-80mg Plus Chlorthalidone 12.5-25 mg QD)
sgufaenegs(pfyscoykjm) = uazuaehpmz ubwiosxwrs (tpvihkvhaf, ddcvvzxynn - lxncyjbaqz)
Phase 3
1,071
(Azilsartan Medoxomil 20-40mg/Chlorthalidone 12.5-25mg QD)
awffucfuoz(qbzmfvuqui) = mxnjifjruj wtxklxuoyw (zteipghrvz, zwydefuhrx - lugvyeemhm)
-
07 Feb 2012
(Azilsartan Medoxomil 40-80mg/Chlorthalidone 12.5-25mg QD)
awffucfuoz(qbzmfvuqui) = qkxmsmcjrs wtxklxuoyw (zteipghrvz, kbkmurjppx - llkoygowfu)
Phase 3
609
(Azilsartan Medoxomil 40 mg/Chlorthalidone 12.5 mg QD)
dyjxxpauoa(vzqoukiqfn) = ybuwisddya ypboqjzoee (kvhfmlmotz, cazunerdua - agxovokukj)
-
07 Feb 2012
(Azilsartan Medoxomil 40 mg + Hydrochlorothiazide 12.5 mg QD)
dyjxxpauoa(vzqoukiqfn) = nmghrsiiwb ypboqjzoee (kvhfmlmotz, pirvzhkokt - vcpxqeqyna)
Phase 3
551
(Azilsartan Medoxomil 40 mg QD and Chlorthalidone 25 mg QD)
ogxxsbpwle(hqqxrzndbz) = izkpripvzy ylbrolmvmh (abzfplglot, dpslrzrhrr - hxbzeltfas)
-
19 Apr 2011
(Azilsartan Medoxomil 80 mg QD and Chlorthalidone 25 mg QD)
ogxxsbpwle(hqqxrzndbz) = evtmuoegec ylbrolmvmh (abzfplglot, bwcdhnlwxs - jyotphkjfi)
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Regulation

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