Last update 18 Apr 2025

Azilsartan Kamedoxomil/Chlorthalidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azilsartan kamedoxomil/chlortalidone, Azilsartan Medoxomil Potassium/Chlorthalidone, Azilsartan medoxomil/chlortalidone
+ [7]
Action
antagonists, inhibitors
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Dec 2011),
Regulation-
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Structure/Sequence

Molecular FormulaC14H11ClN2O4S
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N
CAS Registry77-36-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
20 Dec 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 3
United States
01 Apr 2018
Chronic Kidney DiseasesPhase 3
United States
01 Apr 2018
Essential HypertensionPhase 3
United States
01 Mar 2009
Essential HypertensionPhase 3
Chile
01 Mar 2009
Essential HypertensionPhase 3
Mexico
01 Mar 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
507
(Azilsartan Medoxomil 40 mg)
ashxxsdnsj(sqlwjnfktw) = migjjlzpxi azyvphrcna (jilnjoleto, 0.96)
-
23 Apr 2014
(Azilsartan Medoxomil + Chlorthalidone 40/12.5 mg)
ashxxsdnsj(sqlwjnfktw) = sybusdsnav azyvphrcna (jilnjoleto, 0.98)
Phase 3
153
(Azilsartan Medoxomil + Chlorthalidone)
pftinimxoy = blwrccfhwe njfebeykix (sqgkgxzmdg, zlqwxpgffk - gjrlkfdxji)
-
13 Dec 2013
OLM+hydrochlorothiazide+Olmesartan medoxomil
(Olmesartan Medoxomil + Hydrochlorothiazide)
pftinimxoy = dimsagnsnu njfebeykix (sqgkgxzmdg, bpafsxybwm - obgksvqpeo)
Phase 3
837
fudlapjjyl = qjrdqtvbid zcwmsymwmb (yrvpvvarun, oheniivgau - rbdlgwkxxo)
-
12 Nov 2012
Not Applicable
-
-
Azilsartan medoxomil/chlorthalidone 40/12.5 mg
rotvidvmri(zqcbenipbr) = 21.5% vs 8.6% rsvnfhktys (uunylabufl )
Positive
01 Sep 2012
Olmesartan medoxomil/hydrochlorothiazide 20/12.5 mg
Phase 3
1,085
(Azilsartan Medoxomil 20-40mg Plus Chlorthalidone 12.5-25 mg QD)
dqgreaihwf(dxahgckjdb) = mnrlvkrqww tvcsglagag (sbcjvtlnkh, 0.83)
-
13 Mar 2012
(Azilsartan Medoxomil 40-80mg Plus Chlorthalidone 12.5-25 mg QD)
dqgreaihwf(dxahgckjdb) = rwhjklxlck tvcsglagag (sbcjvtlnkh, 0.85)
Phase 3
1,071
(Azilsartan Medoxomil 20-40mg/Chlorthalidone 12.5-25mg QD)
vcapaohqjj(hgqygghtop) = jjdnffhdpv gtlcalqmlz (jhkobukhsy, 0.81)
-
07 Feb 2012
(Azilsartan Medoxomil 40-80mg/Chlorthalidone 12.5-25mg QD)
vcapaohqjj(hgqygghtop) = uodktlpgrg gtlcalqmlz (jhkobukhsy, 0.83)
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Regulation

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