Last update 05 Nov 2024

Triolex

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
17α-ethynyl-5-androstene-3β,7β,17β-triol, Bezisterim, HE 3286
+ [4]
Mechanism
ERK inhibitors(ERK subfamily inhibitors), NF-kappa-B-repressing factor inhibitors
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC21H30O3
InChIKeyJJKOQZHWYLMASZ-FJWDNACWSA-N
CAS Registry1001100-69-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3
US
05 Aug 2021
Brain Injuries, TraumaticPhase 2
US
21 Dec 2023
FatiguePhase 2
US
21 Dec 2023
SleepPhase 2
US
21 Dec 2023
Multiple MyelomaPhase 2
US
10 Aug 2022
Prostatic CancerPhase 2
US
10 Aug 2022
Cognitive DysfunctionPhase 2
US
19 Jan 2022
Parkinson DiseasePhase 2
US
04 Jan 2022
Rheumatoid ArthritisPhase 2
US
01 Jul 2008
Diabetes Mellitus, Type 2Phase 2
US
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
23
mephzkitxh(fxmupfokqu) = fezoxznhqb cmnpijgksi (zzrylirtnw, uhlwltrbvu - fwngsivbko)
-
09 Jul 2024
Phase 3
-
zxcqjrnavr(zjliwvjbpn) = bojhixznit bhwbvveysc (ydairryrgo )
Positive
25 Apr 2024
Phase 3
57
placebo
uhdaauvjbr(ufikacaufi) = tdwoileujg paoeuiueob (ibatglyxez )
Positive
29 Nov 2023
uhdaauvjbr(ufikacaufi) = eyzsnkcrhb paoeuiueob (ibatglyxez )
Phase 3
Alzheimer Disease
Amyloid β 42 | Amyloid β 40
322
NE3107 20 mg
gyzekruapi(oojhwnajes) = Statistically significant population changes from baseline were observed for all primary and secondary cognitive and functional assessments measured: ADAS-Cog12, ADCS-CGIC, MMSE, CDR, CDR-SB, ADCOMS, and ADL. jgghhdxerj (rpxiqpvhac )
Positive
25 Oct 2023
MDS2023
ManualManual
Phase 2
39
xmqvvtnvve(eqzoidncdq) = All patients tolerated NE3107 well, and no drug-related adverse events were reported. eputwvkmxg (ngwucjbhkv )
Positive
30 Aug 2023
Phase 2
45
Carbidopa+Levodopa hydrate+HE 3286
wrmwmlbvdi(tgvnmjnbys) = rponxekpaa oznttpotqc (ndyhxctdcr )
Positive
05 Dec 2022
Carbidopa+Levodopa hydrate+Placebo
qpcbirvmbn(athmhsjrpi) = dkhmmjyxjl aggjdjninp (pdsyiwtvlo )
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Clinical Trial

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Approval

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Regulation

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