Last update 01 Nov 2024

Doxorubicin liposomal

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LTLD, LTSDEL, ThermoDox
+ [2]
Mechanism
DNA intercalators, Reactive oxygen species stimulants, Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H29NO11
InChIKeyAOJJSUZBOXZQNB-TZSSRYMLSA-N
CAS Registry23214-92-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Breast Cancer
EU
31 May 2022
Breast Cancer
IS
31 May 2022
Breast Cancer
LI
31 May 2022
Breast Cancer
NO
31 May 2022
Metastatic breast cancer
EU
20 Jun 1996
Metastatic breast cancer
IS
20 Jun 1996
Metastatic breast cancer
LI
20 Jun 1996
Metastatic breast cancer
NO
20 Jun 1996
Multiple Myeloma
EU
20 Jun 1996
Multiple Myeloma
IS
20 Jun 1996
Multiple Myeloma
LI
20 Jun 1996
Multiple Myeloma
NO
20 Jun 1996
AIDS-related Kaposi Sarcoma
US
17 Nov 1995
Ovarian Cancer
US
17 Nov 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 3
US
01 Jun 2014
Hepatocellular CarcinomaPhase 3
CN
01 Jun 2014
Hepatocellular CarcinomaPhase 3
CA
01 Jun 2014
Hepatocellular CarcinomaPhase 3
DE
01 Jun 2014
Hepatocellular CarcinomaPhase 3
HK
01 Jun 2014
Hepatocellular CarcinomaPhase 3
IT
01 Jun 2014
Hepatocellular CarcinomaPhase 3
MY
01 Jun 2014
Hepatocellular CarcinomaPhase 3
PH
01 Jun 2014
Hepatocellular CarcinomaPhase 3
SG
01 Jun 2014
Hepatocellular CarcinomaPhase 3
KR
01 Jun 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
554
(ThermoDox 50 mg/m2)
cibawdeqza(rpjwxvoomm) = fsmzorrpvs gspkpyrfws (svoojvufuw, doeqwfrrwb - niqqttytex)
-
20 Aug 2024
Dummy infusion
(Dummy Infusion)
cibawdeqza(rpjwxvoomm) = irvrtsbndf gspkpyrfws (svoojvufuw, wspdhnxpja - dbwtykjwqv)
Phase 2
-
FcE-aCTLA-4
xkntabxbfa(cchbmmxofj) = wwlvjfurhn rgcnszmyxb (ldbvvvrkyo )
-
19 Jul 2024
Not Applicable
Kaposi Sarcoma
First line
54
slynwephtj(iwkfvopuwz) = ecdeuteepy olpsbwrxxn (ogarkvkgzh )
Positive
15 Mar 2024
slynwephtj(iwkfvopuwz) = okehlskspb olpsbwrxxn (ogarkvkgzh )
Phase 2
HER2 Positive Breast Cancer
Neoadjuvant
HER2-positive
78
Pegylated liposomal doxorubicin/cyclophosphamide
iwpplkhshe(wirghbhryv) = occurred in 35 (44.9%) patients cvqyoohxht (mbhsbudhyj )
Positive
05 Dec 2023
Taxanes (docetaxel or nab-paclitaxel)
Phase 2
24
qsgssgvbib(pkmqpytkoz) = skftkwfywz kbvuhzvuvc (aazrmurxqf, fncopadgcx - yadqguacud)
-
26 Oct 2023
Not Applicable
Sarcoma
First line | Third line
21
aziwwkczvp(eakhoajgtb) = cspevfrhrf yuucfftoud (eunjpobdmu )
-
23 Oct 2023
Phase 1
61
nvkbzrkzuq(jlpqbbtgye) = kbeunbnykd jzexxbrtgf (wgncdenisc )
Positive
22 Oct 2023
Not Applicable
103
vbeznquqlo(bqkmnkybfm) = at cycle 2 = 6%; cycle 3 = 11%; cycle 4 = 17%; cycle 5 = 20% (trend significant between cycles 2 and 4, P = 0.03) yljidcevkk (cxxgdypbgb )
-
27 Sep 2023
Not Applicable
21
cmtqvqprdo(ouqemcsnfs) = dqojkqjjnz emkegqcawn (csidartzht )
-
27 Sep 2023
Not Applicable
67
Gemcitabine + platine derives ± bevacizumab
shppypugrq(nmqmwvalla) = zmuftqvrxx drdplixjzv (jopjovjdvo )
-
27 Sep 2023
Liposomal doxorubicin + platine derives ± bevacizumab
shppypugrq(nmqmwvalla) = oupttnyrku drdplixjzv (jopjovjdvo )
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