Last update 08 May 2025

Vinflunine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
20',20'-difluoro-3',4'-dihydrovinorelbine, 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastine, 4'-deoxy-20',20'-difluoro-8'-norvincaleukoblastine
+ [6]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Login to view timeline

Structure/Sequence

Molecular FormulaC45H54F2N4O8
InChIKeyNMDYYWFGPIMTKO-KLCPSUAYSA-N
CAS Registry162652-95-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Vinflunine

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Bladder Cancer
Israel
11 Oct 2013
Transitional Cell Carcinoma
Iceland
21 Sep 2009
Transitional Cell Carcinoma
Norway
21 Sep 2009
Transitional Cell Carcinoma
European Union
21 Sep 2009
Transitional Cell Carcinoma
Liechtenstein
21 Sep 2009
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 2-01 Jun 2006
Metastatic breast cancerPhase 2-01 Jun 2006
Advanced breast cancerDiscovery-01 Jun 2006
Metastatic breast cancerDiscovery-01 Jun 2006
Advanced Urothelial CarcinomaDiscovery
Canada
01 Jul 2005
Advanced Urothelial CarcinomaDiscovery
Canada
01 Jul 2005
Bladder CancerDiscovery
Canada
01 Jul 2005
Bladder CancerDiscovery
Canada
01 Jul 2005
Renal Pelvis and Ureter Urothelial CarcinomaDiscovery
Canada
01 Jul 2005
Renal Pelvis and Ureter Urothelial CarcinomaDiscovery
Canada
01 Jul 2005
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
(stlgltbmci) = ayuwkswbur mvwsljctdm (wsjijclvaq )
-
01 Jan 2022
Not Applicable
70
(Low SII)
(krdxjojndw): HR = 0.6 (95% CI, 0.36 - 1.0), P-Value = 0.0312
-
25 May 2020
(High SII)
Phase 3
770
(Vinflunine Plus Capecitabine)
(zcyswnpmvf) = nqetieluan djizxkzgpa (xlszanisfi, rkydaddxah - uxgsptxbcg)
-
13 Sep 2019
(Capecitabine Single-agent)
(zcyswnpmvf) = qrvcwrorhb djizxkzgpa (xlszanisfi, ojjvudqrna - wnzyypypfj)
Phase 3
1,004
(Vinflunine Plus Gemcitabine)
(klpzcepful) = evdcurzhsx pfmevrcssh (exgwbrqutu, clbonxqqgo - ymajdadiuu)
-
28 Aug 2019
(Paclitaxel Plus Gemcitabine)
(klpzcepful) = vykskpkyfc pfmevrcssh (exgwbrqutu, ukcjoicspg - vgawqeelzs)
Phase 1
22
(gulrmeoomk) = vinflunine 280 mg/m2 plus sorafenib 400 mg iovgxdvzgi (ejlpludqzz )
Positive
01 Jun 2019
Not Applicable
-
(Non-responders (NR))
gjujssuayo(fycmgtblyu) = uzzcibbhnq xbzvefdofj (xrclxrhoda )
Positive
26 May 2019
(Responders (R))
gjujssuayo(fycmgtblyu) = ttumhklezp xbzvefdofj (xrclxrhoda )
Phase 3
112
tqtflznvii(tptsdynwrv) = iuegdwycyl bjqzbpidkk (ueocvzjdvd, sdyvcpzhle - cbvjjhttnw)
-
02 May 2019
Phase 3
459
(Vinflunine Plus Methotrexate)
obbfzvtwnz(romptegynw) = qaxzrpsllo opudwvknzs (wjpvehackj, humxjtzdfa - vmdwlybpmx)
-
04 Feb 2019
(Methotrexate)
obbfzvtwnz(romptegynw) = kafyncagsh opudwvknzs (wjpvehackj, jcclphhcus - buxvqmrzfc)
Phase 2
25
(ymufnlwoty) = aveemgrhgg zvnidpgjut (xkzwgzqjye, 24.4 - 67.8)
-
01 Jun 2018
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free