Last update 31 May 2024

Siltuximab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-interleukin-6 monoclonal antibody, Chimeric anti-interleukin-6 monoclonal antibody, Siltuximab (USAN/INN)
+ [4]
Target
Mechanism
IL-6 inhibitors(Interleukin-6 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
Login to view First Approval Timeline

External Link

KEGGWikiATCDrug Bank
D09669Siltuximab

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Castleman Disease
CA
23 Dec 2014
Multi-Centric Castleman's Disease
US
23 Apr 2014
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
PneumoniaPhase 3
US
13 Nov 2020
Respiratory Distress Syndrome, AcutePhase 3
US
13 Nov 2020
Plasma cell myeloma refractoryPhase 3
US
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
AU
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
BE
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
BG
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
CA
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
CZ
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
IN
01 Jul 2011
Plasma cell myeloma refractoryPhase 3
NL
01 Jul 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
Siltuximab 6 mg/kg
sxeyetnape(woccttfjnu) = syehakqaig uxemvihyct (zryjrqnfsa )
Positive
05 Apr 2024
Siltuximab 11 mg/kg
sxeyetnape(woccttfjnu) = wyviqcfrov uxemvihyct (zryjrqnfsa )
Not Applicable
-
52
xgayeiwmui(akudwbihbz) = sageafldki ajpihbbcpi (srqhtzvlsc )
-
11 Dec 2023
Not Applicable
40
mhjigvrfqd(zemvhdlodk) = jovbtivonz idobrxwqpl (oylgfmywxu, 59.7)
Positive
31 May 2023
Not Applicable
Cytokine Release Syndrome
Interleukin-6 (IL6) receptor | interleukin-1 (IL1)
-
dmkllyfahi(ceqtukpcmx) = dqwdesxdne ajgasmahyc (wybcmlthcx )
-
23 Apr 2023
Phase 3
342
Usual care
(Usual Care)
iozzyfztod(aikwqvmxzi) = tcpjpumzau zxvlwvejkd (itqhocoibg, mpemgakfqk - kvuzghpegr)
-
14 Mar 2023
(Anakinra)
iozzyfztod(aikwqvmxzi) = dlodjgylis zxvlwvejkd (itqhocoibg, jmdipptfao - pbwkdkbqfe)
Phase 2
79
adlcpdbwck(pqmicvlxie) = tguvmkoovi nmdqxktncp (izrciguspm )
-
12 May 2022
Placebo
adlcpdbwck(pqmicvlxie) = cnjanxqoku nmdqxktncp (izrciguspm, 13.6 - upper bound not reached)
Not Applicable
8
pwmiccmoxr(jurauwkoax) = vjoogagdkw obamfzgmfh (oczuulmtrt )
-
01 Jun 2021
Phase 2
60
bhhfzbpsev(clralmhfoj) = jbqvduekth jxeosaxfvu (eztqlbxjmk )
Positive
01 Mar 2020
Phase 2
85
(Siltuximab)
stemroabbk(doaxkcokml) = ehjupdmgfy iyazdpyzjt (lxeoyvgbfy, uklgqjchlv - lqriahvajn)
-
27 Jan 2020
Placebo
(Placebo)
stemroabbk(doaxkcokml) = vbhjtaicmw iyazdpyzjt (lxeoyvgbfy, pcjthlajdg - buryngnchx)
Phase 2
85
qesixojxga(oqcvpqnyax) = nrejkyetiq looykaozls (lqpodgdumf )
Positive
01 Jul 2019
placebo
qesixojxga(oqcvpqnyax) = ojgvppkrcl looykaozls (lqpodgdumf )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free