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Clinical Trials associated with Anti-p53 T-cell receptor-transduced PBL(NCI)Phase II Study of Metastatic Cancer That Overexpresses p53 Using Lymphodepleting Conditioning Followed by Infusion of Anti-P53 TCR-Gene Engineered Lymphocytes and Dendritic Cell Vaccination
RATIONALE: Gene-modified lymphocytes may stimulate the immune system in different ways and stop tumor cells from growing. High-dose aldesleukin may stimulate lymphocytes to kill tumor cells. Vaccines made from a gene modified virus and a person's dendritic cells may help the body build an effective immune response to kill tumor cells. Giving gene-modified lymphocytes together with high-dose aldesleukin and vaccine therapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving gene-modified lymphocytes together with high-dose aldesleukin and vaccine therapy works in treating patients with progressive or recurrent metastatic cancer.
100 Clinical Results associated with Anti-p53 T-cell receptor-transduced PBL(NCI)
100 Translational Medicine associated with Anti-p53 T-cell receptor-transduced PBL(NCI)
100 Patents (Medical) associated with Anti-p53 T-cell receptor-transduced PBL(NCI)
100 Deals associated with Anti-p53 T-cell receptor-transduced PBL(NCI)