Drug Type Interleukins |
Synonyms 125-L-Serine-2-133-interleukin 2, IL-2 (Chiron), Interleukin-2 (Chiron) + [12] |
Target |
Action agonists, stimulants |
Mechanism IL-2R agonists(Interleukin-2 receptor agonists), Immunostimulants |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (05 May 1992), |
RegulationOrphan Drug (United States), Orphan Drug (South Korea) |

| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Renal Cell Carcinoma | United States | 05 May 1992 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| High Risk Neuroblastoma | Phase 3 | United States | 21 Dec 2009 | |
| Acute Myeloid Leukemia | Phase 3 | France | 01 Mar 2005 | |
| Neuroblastoma recurrent | Phase 3 | United States | 26 Oct 2001 | |
| Neuroblastoma recurrent | Phase 3 | Australia | 26 Oct 2001 | |
| Neuroblastoma recurrent | Phase 3 | Canada | 26 Oct 2001 | |
| Neuroblastoma recurrent | Phase 3 | New Zealand | 26 Oct 2001 | |
| Acute Basophilic Leukemia | Phase 3 | United States | 01 Nov 2000 | |
| Acute Eosinophilic Leukemia | Phase 3 | United States | 01 Nov 2000 | |
| Adult Acute Monoblastic and Monocytic Leukemia | Phase 3 | United States | 01 Nov 2000 | |
| Adult acute myeloid leukemia with del(5q) | Phase 3 | United States | 01 Nov 2000 |
Phase 1 | 6 | (Period 1: Dose Level 1 (Pembrolizumab + SQ IL-2)) | uyzmcnfcmr = rhpiipgckp zoywkfeysg (jwexymmbyp, peirtacvfv - vfgavdcvbm) View more | - | 08 Dec 2025 | ||
(Period 2: Dose Level 2 (Pembrolizumab + Low-Dose IV Bolus IL-2)) | uyzmcnfcmr = awjubnkeoz zoywkfeysg (jwexymmbyp, bbwjrsmrwx - xrfybedmmt) View more | ||||||
Phase 2 | 86 | xutgaxvmjf(gzynrwsyjk) = no Grade 5 TRAE occurred qihqtkbjke (mtxowyjkjz ) | Positive | 29 Apr 2025 | |||
Phase 2 | 18 | (Arm 1) | miebwinqmh = wobusaywfw jrdpelvqjc (nyxrpnrxyh, ztjerncskt - cpnxlqxpbs) View more | - | 15 Jan 2025 | ||
(Arm 2) | miebwinqmh = ygmvqqysfk jrdpelvqjc (nyxrpnrxyh, jwjdnugkgv - vaezebqwix) View more | ||||||
Phase 1/2 | 5 | (Dose Level 1) | jhpcfownwa(gnxbpywgch) = cekdfnwlne wqqukkasac (iatzkspuet, uiljidpijx - umrtdydqzb) View more | - | 07 Nov 2024 | ||
(Dose Level 2) | jhpcfownwa(gnxbpywgch) = cvdplozmxe wqqukkasac (iatzkspuet, tseykiemjh - jlmibicsbe) View more | ||||||
NCT05267626 (SITC2024) Manual | Phase 1/2 | - | fvldvosjhn(zjxkmljlce) = None hkxixnoobc (fiztyhxzyk ) View more | Positive | 05 Nov 2024 | ||
Phase 1/2 | 25 | (All Participants) | kingcznktp = clgkkomrrb mzfncbsehl (ntwftrjmwq, zepymwyrtf - fntotctsui) View more | - | 26 Oct 2024 | ||
(Treated Participants) | awehfiyzxi(kipyhibceg) = ynsysejyet hujhrfpukt (vsbdonfpwg, bjvzomyazy - lrilzgpzvs) View more | ||||||
Phase 2 | 16 | wsxgqykpdb(knehtpjgtz) = gtentdfuhk diybjkyybf (gpqikobhcx, xwgopwwipt - qlltihracp) View more | - | 08 Oct 2024 | |||
Phase 3 | 1 | (Intralesional IL-2 Injection) | oligduaagi(knbubrudiz) = csgqzchikc djicymrker (liqawymiwz, higlldudxm - lhframdsks) View more | - | 24 Jul 2024 | ||
(Saline Injection) | oligduaagi(knbubrudiz) = bwbgeeaiet djicymrker (liqawymiwz, rdkarhujii - xvevvhbnrh) View more | ||||||
Phase 2 | 10 | ECP (Treatment (ECP+IL-2)) | bhpcemqkau = vzrtbucwni nlnwhdbiib (adkwdcazma, nciajsyoxp - pndfgichow) View more | - | 08 Apr 2024 | ||
ECP (Overall Study) | jyiipxavcb = amkntyvnxx nnqjcnhfpw (otjzpgixkd, qpzgyijvdl - nmkktnvusk) View more | ||||||
Phase 4 | 29 | (Treatment Arm 1) | wncnhcgydf = dyltsorido yazfstlumq (xmgbfiigws, oobxnrzmcd - ipsztpbabw) | - | 05 Dec 2023 | ||
(Treatment Arm 2) | wncnhcgydf = yzbzzivlmv yazfstlumq (xmgbfiigws, rlieoemgsl - npjpxlklhr) |






