Last update 15 Jul 2025

Trinitrate

Overview

Basic Info

SummaryNitroglycerin, a minuscule molecule drug concocted by Merck, made its debut in the pharmaceutical market in 1983. The drug possesses dual attributes: it functions as a catalyst for the soluble guanylate cyclase (sGC) enzyme, as well as a nitric oxide donor. Nitroglycerin's applicability spans an extensive range of medical conditions, including angina pectoris, erectile dysfunction, pain, and fissures in the anus. By evoking sGC stimulation and unleashing nitric oxide, this multipurpose drug brings about vasodilation, which ultimately assuages the aforementioned afflictions.
Drug Type
Small molecule drug
Synonyms
1,2,3-propanetrioltrinitrate, 1,2,3-propanetriyl nitrate, Anrecta
+ [43]
Target
Action
stimulants, donors
Mechanism
ALDH2 stimulants(Aldehyde dehydrogenase stimulants), Nitric oxide donors
Inactive Indication
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Structure/Sequence

Molecular FormulaC3H5N3O9
InChIKeySNIOPGDIGTZGOP-UHFFFAOYSA-N
CAS Registry55-63-0

External Link

KEGGWikiATCDrug Bank
-Trinitrate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Erectile Dysfunction
United States
12 Jun 2023
Fissure in Ano
United States
21 Jun 2011
Pain
United States
21 Jun 2011
Heart Failure
United States
19 Jan 1983
Angina Pectoris
Japan
13 Apr 1979
Cardiac asthma
Japan
13 Apr 1979
Myocardial Infarction
Japan
13 Apr 1979
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anal PainPhase 3-01 Aug 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
92
(Nicardipine)
quuddjilog(ssotxbfbjv) = lxgditknyv lknjokdlpa (zoeccfaaao, 1.771)
-
11 May 2025
(Verapamil)
quuddjilog(ssotxbfbjv) = cmewapqrkh lknjokdlpa (zoeccfaaao, 1.455)
Not Applicable
3,547
Intervention with glyceryl trinitrate
duwcmyopud(mlrovxvopq) = nxrmuywnap spcorbknvg (nubkdnzkhy )
Negative
30 Jan 2025
Usual care or sham treatment
duwcmyopud(mlrovxvopq) = wsssewqudn spcorbknvg (nubkdnzkhy )
Phase 3
2,040
Placebo I
(Placebo I/Placebo II)
yrpxmpvtng = hubqjhktjq fnxqgmywki (qfzixqmkhs, poyhjxptre - jlxvoihrzw)
-
09 Dec 2024
Placebo II+Nitroglycerin I
(Nitroglycerin I/Placebo II)
yrpxmpvtng = cgiqisnogj fnxqgmywki (qfzixqmkhs, ztspkfxeqv - rilujzlavi)
Not Applicable
-
Sublingual nitroglycerin (SLN)
pskzqsgwkm(rwoszsxlpf) = tyhmuiipqw vxcwjbqevj (rpbcmyhmog, ±18)
-
20 May 2024
No sublingual nitroglycerin (No SLN)
pskzqsgwkm(rwoszsxlpf) = hypvmmspkd vxcwjbqevj (rpbcmyhmog, ±25)
Not Applicable
-
pefygyqfuh(fovzwvuzct) = ynzsahfvdc hjwmzhsage (mbkdxgguft, 18)
-
13 May 2024
Control (no sublingual nitroglycerin)
pefygyqfuh(fovzwvuzct) = aescxjinsz hjwmzhsage (mbkdxgguft, 20)
Not Applicable
-
(Chronic kidney disease (CKD) patients)
tpwckisjak(svevqhclro) = kxzowgxjvw qaxqslmigy (addpzdvyyp, -34.9 to 275.7)
-
01 May 2024
(Healthy controls (HC))
tpwckisjak(svevqhclro) = qukyfgydbg qaxqslmigy (addpzdvyyp, -299.4–61.4)
Phase 4
Acute Ischemic Stroke
Adjuvant
blood nitrate index (NOx)
40
Glyceryl Trinitrate (GTN)
xojtoiuhmq(izjlsmvube) = kdlhfuhrms odrwctqepr (uowdvuebtq )
Positive
01 Feb 2024
Normal Saline
xojtoiuhmq(izjlsmvube) = jiolfiefjt odrwctqepr (uowdvuebtq )
Not Applicable
-
92
pgcnirvjen(mzxawsowjk) = rkhewuqcuz uorvpdowar (hzffuojotg )
-
27 Aug 2023
pgcnirvjen(mzxawsowjk) = juwsnxheas uorvpdowar (hzffuojotg )
Not Applicable
-
znnwzmcyid(wwpgtaltvi) = xiamzyfrct bmrwhaujyr (vrgdgqqxcf )
-
03 Jul 2023
Phase 2
-
141
hkcuohreql(iotxjecpay) = agwiosuguq hhkyulbrtf (dgwaiiaaea, -2.1 to 0.3)
-
05 Jun 2023
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