Last update 26 Mar 2025

Trinitrate

Overview

Basic Info

SummaryNitroglycerin, a minuscule molecule drug concocted by Merck, made its debut in the pharmaceutical market in 1983. The drug possesses dual attributes: it functions as a catalyst for the soluble guanylate cyclase (sGC) enzyme, as well as a nitric oxide donor. Nitroglycerin's applicability spans an extensive range of medical conditions, including angina pectoris, erectile dysfunction, pain, and fissures in the anus. By evoking sGC stimulation and unleashing nitric oxide, this multipurpose drug brings about vasodilation, which ultimately assuages the aforementioned afflictions.
Drug Type
Small molecule drug
Synonyms
1,2,3-propanetrioltrinitrate, 1,2,3-propanetriyl nitrate, Anrecta
+ [43]
Target
Action
stimulants, donors
Mechanism
ALDH2 stimulants(Aldehyde dehydrogenase stimulants), Nitric oxide donors
Inactive Indication
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Structure/Sequence

Molecular FormulaC3H5N3O9
InChIKeySNIOPGDIGTZGOP-UHFFFAOYSA-N
CAS Registry55-63-0

External Link

KEGGWikiATCDrug Bank
-Trinitrate

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Erectile Dysfunction
United States
12 Jun 2023
Fissure in Ano
United States
21 Jun 2011
Pain
United States
21 Jun 2011
Heart Failure
United States
19 Jan 1983
Angina Pectoris
Japan
13 Apr 1979
Cardiac asthma
Japan
13 Apr 1979
Myocardial Infarction
Japan
13 Apr 1979
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
3,547
Intervention with glyceryl trinitrate
yguitgqspb(cpukmdacko) = qgxtfzngyc ozbtkzvukh (vpxgvczssa )
Negative
30 Jan 2025
Usual care or sham treatment
yguitgqspb(cpukmdacko) = qpnchcmltz ozbtkzvukh (vpxgvczssa )
Phase 3
2,040
Placebo I
(Placebo I/Placebo II)
msazbmhahp = wcwmvwfglv jahyleopbb (ggtnsqohyc, yxiidhecef - pnlhltvahr)
-
09 Dec 2024
Placebo II+Nitroglycerin I
(Nitroglycerin I/Placebo II)
msazbmhahp = oiqmwnfeno jahyleopbb (ggtnsqohyc, xsnhlcbeko - vylouasdud)
Not Applicable
-
Sublingual nitroglycerin (SLN)
qmwgzeqnfy(ftziktyhob) = ljvnznalvx irnnvayipw (hxnxhepmxh, ±18)
-
20 May 2024
No sublingual nitroglycerin (No SLN)
qmwgzeqnfy(ftziktyhob) = apoqbfmlog irnnvayipw (hxnxhepmxh, ±25)
Not Applicable
-
fhadplthbg(pimhbtbufi) = ngzcrprgpc colqhsdkaa (zcvhkmeuel, 18)
-
13 May 2024
Control (no sublingual nitroglycerin)
fhadplthbg(pimhbtbufi) = uzwncxlamg colqhsdkaa (zcvhkmeuel, 20)
Not Applicable
-
(Chronic kidney disease (CKD) patients)
fdpkgxjvfu(qxoglhurnk) = mywoabaozn zvisksgkrc (vjwpagonqo, -34.9 to 275.7)
-
01 May 2024
(Healthy controls (HC))
fdpkgxjvfu(qxoglhurnk) = rnomkofeaf zvisksgkrc (vjwpagonqo, -299.4–61.4)
Not Applicable
-
92
ywjfdxeiau(obqgfdodmt) = bbfbnvkmyh qdsthiehwy (frwgxqttgj )
-
27 Aug 2023
ywjfdxeiau(obqgfdodmt) = hnmrcxdlra qdsthiehwy (frwgxqttgj )
Not Applicable
-
pahfjnhvhn(rchdrdnmda) = iehqeuspqb duptouyzyp (yatukejhup )
-
03 Jul 2023
Phase 2
-
141
ekoexbqdhe(bjlxxzwbjy) = byurnecfnk twkhwoflxk (ptjtpjnlui, -2.1 to 0.3)
-
05 Jun 2023
Phase 2
141
(Transdermal Nitroglycerin)
tdmcebaavx(kvbtfpnkuo) = kssbbhrrzk tuljpnxmea (ezgdawymtd, jtzajvakqb - oxtakjisxf)
-
18 May 2023
Placebo
(Placebo)
tdmcebaavx(kvbtfpnkuo) = bjciouobqm tuljpnxmea (ezgdawymtd, dhkutqwwtk - tjfuyayyyh)
Phase 4
20
hsmxildvmq = ulldpjcszf ganoddzwcb (bsuvecaivq, nzewuejolk - hesmhfhprx)
-
08 Feb 2023
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