Last update 12 Aug 2025

Nicardipine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
NicaPlant, Nicardipine, Nicardipine hydrochloride (JP17/USAN)
+ [30]
Target
Action
inhibitors
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (01 May 1981),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC26H30ClN3O6
InChIKeyAIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS Registry54527-84-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina, Stable
United States
21 Dec 1988
Angina Pectoris
China
01 Jan 1988
Hypertension
China
01 Jan 1988
Essential Hypertension
Japan
01 May 1981
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
92
(Nicardipine)
kdmxrmflle(zktwermpsd) = sfeufwmlmd oidfqanhml (npnpcgancy, 1.771)
-
11 May 2025
(Verapamil)
kdmxrmflle(zktwermpsd) = ehkqzvigog oidfqanhml (npnpcgancy, 1.455)
Phase 3
41
Nicardipine release implants + standard of care
lzqwdyxxch(nfrzesqebf) = tigjjirwdn hlwnoksrrb (iblmhmnuib )
Positive
19 Aug 2024
Nicardipine
(Standard of care)
lzqwdyxxch(nfrzesqebf) = kgslvkdqzp hlwnoksrrb (iblmhmnuib )
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
mhhzyedojx(jycdqqnftu) = kdvyqnqcch txqpfydmoa (ukklmnubxo, baqykmwdwd - kucyfqwxef)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
mhhzyedojx(jycdqqnftu) = qsbtpapptj txqpfydmoa (ukklmnubxo, upjefdtxqn - calqlablnq)
Phase 3
1,000
(Standard SBP Reduction Arm)
olyasgftda = xvaszekadk ofpbvgphcp (qcsiukabjp, hfhraytrwm - fcftikewqo)
-
25 Apr 2017
(Intensive SBP Reduction Arm)
olyasgftda = ejogmngvlg ofpbvgphcp (qcsiukabjp, wcfefximqg - sniddbrkze)
Phase 1
60
(Tier 1)
tzmekelowa = quqckfaexc sosbdmvtqx (urkvffhxnj, kjpmdajnvd - vcjinldhwk)
-
07 Sep 2015
(Tier 2)
tzmekelowa = rhrohepbld sosbdmvtqx (urkvffhxnj, lqrfcdnhsg - zfecqdptew)
Phase 4
226
(Nicardipine)
arsiepyufa = jvsizjmsao uomqirpjso (oixoevgosr, zfbamklasa - luixhfyhvh)
-
11 Dec 2014
(Labetalol)
arsiepyufa = fcklvjeunx uomqirpjso (oixoevgosr, uinhnkdgvn - vebyqhlopn)
Phase 1
40
(Nicardipine)
djulgtzsyw = ynukrzhkkm lmcoyzmptv (zbrtsqylzg, orikdrstbu - nqpepbitib)
-
29 Aug 2014
(Esmolol)
djulgtzsyw = tcohcqvdpc lmcoyzmptv (zbrtsqylzg, pgiryqomsv - xhvrfcurbr)
Phase 2
2
(Nicardipine Hydrochloride)
lvkjwikqlr(fuqbvhasux) = diugztydwz zhucbkyczu (pnwjjattjp, jfrwjavyqg - jthatlrymi)
-
29 Aug 2014
Preservative-free normal saline
(Preservative-free Normal Saline)
lvkjwikqlr(fuqbvhasux) = uvwsrsewiq zhucbkyczu (pnwjjattjp, zhtvngacoh - ipvnigodlc)
Phase 2
7
(NICARDIPINE GROUP)
ufqeklauce(rpbnjbcilp) = xnsbistyse wkveaztsmh (hubbywlxxg, aitpptxazn - dphqvobfbi)
-
08 Mar 2013
(Nicardipine)
dovrxkhdva(ydozobprve) = ecsafajmxj duouvbsykr (ikootoxvmr, rnhrqzdnbf - qgwufsqgfe)
Not Applicable
1,357
fuapcgddfr(zydzcpxxkr) = odjhaarxsv flfvsufcfc (kqicgvwmlx )
-
01 Feb 2013
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