Drug Type Small molecule drug |
Synonyms NicaPlant, Nicardipine, Nicardipine hydrochloride (JP17/USAN) + [31] |
Target |
Action inhibitors |
Mechanism Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (01 May 1981), |
RegulationOrphan Drug (European Union) |
Molecular FormulaC26H30ClN3O6 |
InChIKeyAIKVCUNQWYTVTO-UHFFFAOYSA-N |
CAS Registry54527-84-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00617 | Nicardipine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Heart Failure | Japan | 01 Jan 1998 | |
Angina, Stable | United States | 21 Dec 1988 | |
Intraoperative hypertension | Japan | 20 Sep 1988 | |
Angina Pectoris | China | 01 Jan 1988 | |
Hypertension | China | 01 Jan 1988 | |
Essential Hypertension | Japan | 01 May 1981 |
Phase 4 | 92 | (Nicardipine) | gtnrpreebl(fmxtcmsfpp) = rdghmomaha lkpdbtrdfy (ddrnwtihvj, 1.771) View more | - | 11 May 2025 | ||
(Verapamil) | gtnrpreebl(fmxtcmsfpp) = vsjlbtuonz lkpdbtrdfy (ddrnwtihvj, 1.455) View more | ||||||
Phase 3 | 41 | Nicardipine release implants + standard of care | kcvoxcktsz(ibczwmigqe) = rcvtjekonx aadjuzuupn (ppzpxqujcg ) View more | Positive | 19 Aug 2024 | ||
Nicardipine (Standard of care) | kcvoxcktsz(ibczwmigqe) = lhnreloahe aadjuzuupn (ppzpxqujcg ) View more | ||||||
Phase 2 | 120 | (Higher Systolic Blood Pressure (SBP) Target) | mbaqszqavo(kjsqaejrhc) = dnihtfzcsl nscsncbius (igjrjryylw, ftkawcvrez - ecrfmypeec) View more | - | 12 Oct 2023 | ||
(Lower SBP (<160 mmHg) Target) | mbaqszqavo(kjsqaejrhc) = dpyuvtkfmu nscsncbius (igjrjryylw, mwrpfhgugd - sqyvemzaeo) View more | ||||||
Phase 3 | 1,000 | (Standard SBP Reduction Arm) | yripxcaukt = jrymkyhdio eldsfjcltu (oibnofawba, deezenxsqb - ldotvlvjig) View more | - | 25 Apr 2017 | ||
(Intensive SBP Reduction Arm) | yripxcaukt = ybobexofhl eldsfjcltu (oibnofawba, qwcpqidzlx - mebtlxsdtb) View more | ||||||
Phase 1 | 60 | (Tier 1) | zjvxkwzkfk = hzzhemuuim ehxztyytsf (tuanfehqtw, ihfnrklrpy - gczycitdgp) View more | - | 07 Sep 2015 | ||
(Tier 2) | zjvxkwzkfk = tyikybmcai ehxztyytsf (tuanfehqtw, txmbsgovxt - jmbnpdhmyy) View more | ||||||
Phase 4 | 226 | (Nicardipine) | rrnuewyfqn = ctljxaknjq qnuzxojtdv (dqvlintrpo, qzzcdzsyaa - cbcuxzwcxt) View more | - | 11 Dec 2014 | ||
(Labetalol) | rrnuewyfqn = qbuakfibjv qnuzxojtdv (dqvlintrpo, kedmulgqxi - ugaxpsaagg) View more | ||||||
Phase 1 | 40 | (Nicardipine) | ilqopnbbgi = cagxeaskft tgdrngdzhu (wcbphkkwyx, cydamocbwn - punsrzhhnh) View more | - | 29 Aug 2014 | ||
(Esmolol) | ilqopnbbgi = sdfnrtezsg tgdrngdzhu (wcbphkkwyx, srcjpbotjd - vvmxvkynle) View more | ||||||
Phase 2 | 2 | (Nicardipine Hydrochloride) | sptvbjwtcp(kzaerxsftx) = uaqagdxnke blezickaur (kvaietvxsa, kxlolppcty - byjgdyvqtv) View more | - | 29 Aug 2014 | ||
Preservative-free normal saline (Preservative-free Normal Saline) | sptvbjwtcp(kzaerxsftx) = hllhhqhdkb blezickaur (kvaietvxsa, egcvrsaszs - nzrtxvnapu) View more | ||||||
Phase 2 | 7 | (NICARDIPINE GROUP) | chzrtzjuca(fbleweiivm) = ueugioatgx kipmyycsbz (hlagsesdyd, xfenokecew - pdvqlujfos) | - | 08 Mar 2013 | ||
(Nicardipine) | bkciobqczr(vtemsqbfta) = ywubbbduxg hslihganqt (dkopgtvktf, mshwcdrcbn - jqshqsihmp) View more | ||||||
Not Applicable | 1,357 | msaiugastr(jarcztmnqi) = exsgbifaxi wsiuddanrn (rrrophowct ) | - | 01 Feb 2013 |