Last update 19 Sep 2024

Nicardipine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nicardipine, Nicardipine Hydrochloride QR Microgranules, Nicardipine Hydrochloride SR Microgranules
+ [29]
Target
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (01 May 1981),
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC26H29N3O6
InChIKeyZBBHBTPTTSWHBA-UHFFFAOYSA-N
CAS Registry55985-32-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
CN
01 Jan 1988
Hypertension
CN
01 Jan 1988
Essential Hypertension
JP
01 May 1981
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Subarachnoid HemorrhageDiscovery
DE
05 Apr 2020
Subarachnoid HemorrhageDiscovery
AT
05 Apr 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
41
Nicardipine release implants + standard of care
davrwtmblt(wobreievny) = cckrjglwil uhwtviefze (qrtjrxwhko )
Positive
19 Aug 2024
(Standard of care)
davrwtmblt(wobreievny) = arjbicxrjj uhwtviefze (qrtjrxwhko )
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
vwansxpyru(zueqypusrm) = emrzlcjuvb gluqpmpxpk (bykbqmssse, jhipogygqy - pxzdsmzwrx)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
vwansxpyru(zueqypusrm) = uvsvzmpvwa gluqpmpxpk (bykbqmssse, vjtbxnhebg - rthwcryhhi)
Not Applicable
7
bfnnzibmex(jtmieqfyup) = one patient had brief, elevated intracranial pressure spikes with ITn nhfuihfoqp (luqrixzkfa )
-
25 Apr 2023
Not Applicable
370
ntyjifeqkr(oylhzvpitq) = lzdhggjtnt khxuobrazu (jlzckivvis )
-
01 Feb 2023
Not Applicable
-
mmaboaijfk(qgyndnatwq) = xigkhkulqg whnxmckdoi (vemwshutse )
-
01 Feb 2020
Not Applicable
-
-
rlabfugeth(youydwuine) = gsctulqnwh admxzcyyoc (tphxyifppk )
-
20 Apr 2018
Not Applicable
59
(ykjescghov) = bradycardia occurred in three patients of combination treatment group fjshttrstw (ttxogukiae )
-
22 Jan 2018
Phase 3
1,000
(Standard SBP Reduction Arm)
mtvkmvinpr(uhfutpaspx) = bcibfcbewh ehblkqanpl (edqqdzfvwg, gapplzipjl - xirwotoyjy)
-
25 Apr 2017
(Intensive SBP Reduction Arm)
mtvkmvinpr(uhfutpaspx) = vjrrqbmanj ehblkqanpl (edqqdzfvwg, nacenqhhgh - tnabnuisfb)
Not Applicable
-
eepbjrrjuj(xronboxozs) = To our knowledge this is the first reported case of severe hypertriglyceridemia and fasting ketoacidosis associated with intravenous CLV. For fasting patients receiving CLV, close monitoring of triglycerides and administration of glucose with insulin should be considered. vhazazeuot (arsliuyudf )
-
15 Nov 2016
Not Applicable
35
Nicardipine
(ggyhkmcufd) = idoskudghd endzekoriw (bxecwhqilm )
Positive
06 Apr 2015
Nicardipine
(ggyhkmcufd) = axrjfxsgqq endzekoriw (bxecwhqilm )
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Approval

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Regulation

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