Last update 30 Aug 2025

Nicardipine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
NicaPlant, Nicardipine, Nicardipine hydrochloride (JP17/USAN)
+ [31]
Target
Action
inhibitors
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (01 May 1981),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC26H30ClN3O6
InChIKeyAIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS Registry54527-84-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
Japan
01 Jan 1998
Angina, Stable
United States
21 Dec 1988
Intraoperative hypertension
Japan
20 Sep 1988
Angina Pectoris
China
01 Jan 1988
Hypertension
China
01 Jan 1988
Essential Hypertension
Japan
01 May 1981
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
92
(Nicardipine)
gtnrpreebl(fmxtcmsfpp) = rdghmomaha lkpdbtrdfy (ddrnwtihvj, 1.771)
-
11 May 2025
(Verapamil)
gtnrpreebl(fmxtcmsfpp) = vsjlbtuonz lkpdbtrdfy (ddrnwtihvj, 1.455)
Phase 3
41
Nicardipine release implants + standard of care
kcvoxcktsz(ibczwmigqe) = rcvtjekonx aadjuzuupn (ppzpxqujcg )
Positive
19 Aug 2024
Nicardipine
(Standard of care)
kcvoxcktsz(ibczwmigqe) = lhnreloahe aadjuzuupn (ppzpxqujcg )
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
mbaqszqavo(kjsqaejrhc) = dnihtfzcsl nscsncbius (igjrjryylw, ftkawcvrez - ecrfmypeec)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
mbaqszqavo(kjsqaejrhc) = dpyuvtkfmu nscsncbius (igjrjryylw, mwrpfhgugd - sqyvemzaeo)
Phase 3
1,000
(Standard SBP Reduction Arm)
yripxcaukt = jrymkyhdio eldsfjcltu (oibnofawba, deezenxsqb - ldotvlvjig)
-
25 Apr 2017
(Intensive SBP Reduction Arm)
yripxcaukt = ybobexofhl eldsfjcltu (oibnofawba, qwcpqidzlx - mebtlxsdtb)
Phase 1
60
(Tier 1)
zjvxkwzkfk = hzzhemuuim ehxztyytsf (tuanfehqtw, ihfnrklrpy - gczycitdgp)
-
07 Sep 2015
(Tier 2)
zjvxkwzkfk = tyikybmcai ehxztyytsf (tuanfehqtw, txmbsgovxt - jmbnpdhmyy)
Phase 4
226
(Nicardipine)
rrnuewyfqn = ctljxaknjq qnuzxojtdv (dqvlintrpo, qzzcdzsyaa - cbcuxzwcxt)
-
11 Dec 2014
(Labetalol)
rrnuewyfqn = qbuakfibjv qnuzxojtdv (dqvlintrpo, kedmulgqxi - ugaxpsaagg)
Phase 1
40
(Nicardipine)
ilqopnbbgi = cagxeaskft tgdrngdzhu (wcbphkkwyx, cydamocbwn - punsrzhhnh)
-
29 Aug 2014
(Esmolol)
ilqopnbbgi = sdfnrtezsg tgdrngdzhu (wcbphkkwyx, srcjpbotjd - vvmxvkynle)
Phase 2
2
(Nicardipine Hydrochloride)
sptvbjwtcp(kzaerxsftx) = uaqagdxnke blezickaur (kvaietvxsa, kxlolppcty - byjgdyvqtv)
-
29 Aug 2014
Preservative-free normal saline
(Preservative-free Normal Saline)
sptvbjwtcp(kzaerxsftx) = hllhhqhdkb blezickaur (kvaietvxsa, egcvrsaszs - nzrtxvnapu)
Phase 2
7
(NICARDIPINE GROUP)
chzrtzjuca(fbleweiivm) = ueugioatgx kipmyycsbz (hlagsesdyd, xfenokecew - pdvqlujfos)
-
08 Mar 2013
(Nicardipine)
bkciobqczr(vtemsqbfta) = ywubbbduxg hslihganqt (dkopgtvktf, mshwcdrcbn - jqshqsihmp)
Not Applicable
1,357
msaiugastr(jarcztmnqi) = exsgbifaxi wsiuddanrn (rrrophowct )
-
01 Feb 2013
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