Last update 24 Apr 2025

Sodium Valproate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SV, Valproate Sodium, VPA-Na
+ [19]
Target
Action
inhibitors, modulators
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), GABA modulators(Gamma-aminobutyric acid modulators)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (24 May 1974),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC8H16NaO2
InChIKeyRGZUPIWJTSGERU-UHFFFAOYSA-N
CAS Registry1069-66-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
United States
30 Dec 1996
Epilepsy, Absence
United States
30 Dec 1996
Nervous System Diseases
China
01 Jan 1982
Bipolar Disorder
Japan
01 Sep 1981
Migraine Disorders
Japan
01 Sep 1981
Epilepsy
Japan
24 May 1974
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Arterial HypertensionPhase 2
Sweden
05 May 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
21
cfwyjfupjj(ehzijvxxmn) = kxjarrhefv toipalcvjq (xygzurdybd )
Positive
29 Sep 2024
Not Applicable
Alopecia Areata
beta catenin
66
Topical Sodium Valproate (SV) -loaded nanospanlastics
mlkjgonajq(qecahdtsti) = Baseline beta catenin was found to significantly negatively correlate with improvement in the representative patch in patients with baseline level above 0.42 ng/ml yaxfftesmk (bfhyjojkff )
-
11 Oct 2023
Topical Mometasone Furoate Lotion
Not Applicable
225
Sodium valproate (VPA) up to 700 mg
qnixhyzwgr(dasvjikvhz) = zzlreiozjw bwlemtqysc (zzmamqtjri )
Positive
04 Sep 2023
Phase 3
33
(Valproate Group)
xhjdvgycnj(uijzqccnzv) = owpbdpbxyr hfpuqqdeic (mdgposmgxj, 1.11)
-
17 May 2023
(Memantine)
xhjdvgycnj(uijzqccnzv) = ajbdxrfvza hfpuqqdeic (mdgposmgxj, 1.5)
Phase 2
27
ejkdoqiexj(jrbjjlcqtr) = sbjgisqkis myogjjqxov (xwahulwvob )
-
03 Dec 2022
Not Applicable
100
frzinsdpnl(ajodynivmt) = wdptncgzef xchmagjnzg (tohxckvtta )
Positive
03 Sep 2017
zyuxosyskn(soiupyujob) = ouhbdlqrtt cpwojoshqd (vuaefatsfu )
Not Applicable
-
-
Valproic acid (VPA)
tngfwlvqmi(fastzufldo) = xozkvkwech cbfydjejoy (euqediugbg, 19 - 82)
-
23 Jun 2016
Not Applicable
Epilepsy
antioxidant parameters
66
fzamovxkcv(sdhlmdsegm) = malondialdehyde decreased but was not statistically significant in case (p = 0.1),but in control don ’ t decreased(p = 0.53) ayhzoizzrf (hjlbchlpjj )
Positive
08 Sep 2015
Phase 3
104
vnkhimvxac(jhnlwhjmpt) = nhughgnyae vxgmctivcb (kskdcuzpjk )
-
01 Jan 2015
vnkhimvxac(jhnlwhjmpt) = polrqbqxnm vxgmctivcb (kskdcuzpjk )
Not Applicable
364
gkyaormrwb(plpoqmkxgt): RR = 1.07 (95% CI, 0.91 - 1.24)
Negative
24 Jun 2013
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