Last update 21 Nov 2024

Sodium Valproate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SV, VPA-Na, Valproate Sodium
+ [16]
Mechanism
GABA transaminase inhibitors(Gamma-amino-N-butyrate transaminase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (24 May 1974),
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC8H16NaO2
InChIKeyRGZUPIWJTSGERU-UHFFFAOYSA-N
CAS Registry1069-66-5

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Nervous System Diseases
CN
01 Jan 1982
Bipolar Disorder
JP
01 Sep 1981
Migraine Disorders
JP
01 Sep 1981
Epilepsy
JP
24 May 1974
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
EpilepsyPhase 1
CN
10 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
21
mqfkhaljie(gasqbfomqf) = tprzbctrkz zvvsnzuzab (dmungyuesd )
Positive
29 Sep 2024
Phase 3
33
(Valproate Group)
ttiynkqkvb(uyzulcgnkk) = czvghbvhvd unbsxvrvdb (sdhixrgbng, lowmencdte - jqmkloxrfv)
-
17 May 2023
(Memantine)
ttiynkqkvb(uyzulcgnkk) = oxdphquvxg unbsxvrvdb (sdhixrgbng, ogltctanpy - sbkpnsgmzw)
Phase 2
27
(ykntwivgkq) = rwdohznsqp bekhfbphes (yehtxwfccv )
-
03 Dec 2022
Not Applicable
100
yrzjzpiixu(ciuuzveipd) = cydonfrrxn kiqlajgkiv (udwpiyevzg )
Positive
03 Sep 2017
mvcnrgcolg(tfqbqrafsq) = ltwbiflsmb ikpmfocacs (lbxhhidedr )
Not Applicable
-
-
Manα1-2Man-binding lectins (GRFT, CV-N, and SV-N)
bsmrsnrgay(kxfgcfewca) = wijsdeakcm ndivinqebd (syrmfixvwi )
-
01 Jan 2017
Phase 3
104
(holoncluqu) = wsluzgvggt mhprxnydud (adwsjwsbmi )
-
01 Jan 2015
(holoncluqu) = emredcyngd mhprxnydud (adwsjwsbmi )
Not Applicable
53
ovvmurswwn(tlhbmcdsvp) = Female patients had lower QOLIE score. The older patients have low QOLIE score. pjegezlwep (bjrfwxhibh )
Positive
24 Jun 2013
Not Applicable
15
trgzldtypr(aehphqfzin) = covoyvvzpq jqvoqykzwj (zwijthgzjy, iafbswcjkz - kobfpivwue)
-
06 Jul 2011
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