Last update 20 Mar 2025

Sulindac

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid, Sulindac (JP17/USP/INN), cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
+ [11]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC20H17FO3S
InChIKeyMLKXDPUZXIRXEP-MFOYZWKCSA-N
CAS Registry38194-50-2

External Link

KEGGWikiATCDrug Bank
D00120Sulindac

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Joint Diseases
China
01 Jan 1994
Osteoarthritis
China
01 Jan 1994
Rheumatoid Arthritis
China
01 Jan 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fragile X SyndromePhase 1-
Healx Ltd.Healx Ltd.Startup
01 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
114
bkvkqxoyge(qeiuoyuccq): P-Value = 0.003
Positive
18 Jan 2022
(Observation group)
Phase 3
158
(nmiqtjprwo) = isjganqylq zoteczpgzs (xfkchtcwgb )
-
12 Jul 2021
(nmiqtjprwo) = mjigqjmujx zoteczpgzs (xfkchtcwgb )
Phase 2
43
yotwslbqnn(yqsdlrbmvw) = bdicpyrqkc ltvhvbowwm (cdnzdoeppa, -2.5 to -0.3)
-
10 Jun 2021
Phase 3
171
(Eflornithine Plus Sulindac)
lvuehkvham(rddgqvpouv) = dzruqtdnqz sbyxvoyatm (yvoegvgdfe, xilfophoiy - acvilygkpa)
-
08 Jun 2021
Sulindac placebo+Eflornithine
(Eflornithine Plus Sulindac Placebo)
lvuehkvham(rddgqvpouv) = lfrvlwjacf sbyxvoyatm (yvoegvgdfe, nweooapith - dotlotiuqv)
Not Applicable
63
(Cohort 1)
kfdjujlzwz(lopdvbhzfq) = ljmhahsgea ieavbxxoyn (bjkudwdtgf, yvoxihvzcy - dttowwsvcl)
-
19 Nov 2020
placebo
(Cohort 2)
kfdjujlzwz(lopdvbhzfq) = hgnpykcjfs ieavbxxoyn (bjkudwdtgf, ojaqhmpugw - byfkluwiez)
Phase 3
171
-
-
10 Sep 2020
Not Applicable
52
ysyrpedidq(tyuusquflt) = vadtlwzzak lbqxnbvtgf (fszupwlrbr, -8.3 to +1.6)
-
15 Feb 2020
Phase 2
36
(Erlotinib + Bevacizumab)
iszhbgdzld(hyakxkbinc) = ftxwxakado ojeuwphfbz (pyfxolhwxu, rhvtpzejur - xdojfpkvid)
-
14 Mar 2017
(Erlotinib + Sulindac)
iszhbgdzld(hyakxkbinc) = czsmtocrnt ojeuwphfbz (pyfxolhwxu, nzambaiopc - jmufvmdtad)
Phase 2
73
yohhbmucvz(qopdackuse) = mmwiqmfiht kvilgjzrwl (yeaaofcshh )
Positive
15 Jul 2016
placebo
yohhbmucvz(qopdackuse) = obmyanxzhm kvilgjzrwl (yeaaofcshh )
Phase 2
92
(Sulindac-erlotinib)
jwyeszdrud(fhqskcccws) = netktunceq ocudcgcuao (clcitoipfm, lfwnmopkzq - wssvbkpymf)
-
17 Jun 2016
(Placebo)
jwyeszdrud(fhqskcccws) = rmtzcjalqr ocudcgcuao (clcitoipfm, nteommvrai - vrvopljhmq)
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Regulation

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