Drug Type Small molecule drug |
Synonyms cariprazine, Cariprazine hydrochloride (JAN/USAN), SYMVENU + [11] |
Action agonists, antagonists, partial agonists |
Mechanism 5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor partial agonists(Dopamine D2 receptor partial agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (17 Sep 2015), |
Regulation- |
Molecular FormulaC21H33Cl3N4O |
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N |
CAS Registry1083076-69-0 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D09876 | Cariprazine hydrochloride |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Depressive Disorder, Major | United States | 16 Dec 2022 | |
| Bipolar and Related Disorders | Canada | 27 Apr 2022 | |
| Bipolar Disorder | Canada | 22 Apr 2022 | |
| Bipolar I disorder | United States | 17 Sep 2015 | |
| Schizophrenia | United States | 17 Sep 2015 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Heart Septal Defects, Atrial | Phase 3 | United States | 07 Jul 2022 | |
| Heart Septal Defects, Atrial | Phase 3 | Puerto Rico | 07 Jul 2022 | |
| Irritable Mood | Phase 3 | United States | 07 Jul 2022 | |
| Irritable Mood | Phase 3 | Puerto Rico | 07 Jul 2022 | |
| Acute schizophrenia | Phase 3 | United States | 19 Nov 2021 | |
| Autism Spectrum Disorder | Phase 3 | United States | 01 Feb 2021 | |
| Depressive Disorder | Phase 3 | Bulgaria | 17 Mar 2016 | |
| Depressive Disorder | Phase 3 | Estonia | 17 Mar 2016 | |
| Depressive Disorder | Phase 3 | Lithuania | 17 Mar 2016 | |
| Depressive Disorder | Phase 3 | Poland | 17 Mar 2016 |
NEWS Manual | Not Applicable | 116 | (women outpatients) | szccamolqi(erikpviisb) = There was a significant change from baseline in women to week 16 in the SAND scores: negative symptoms decreased by 6.2, positive symptoms decreased with 1.0, which is a remarkable, combined 7.2 drop. blkebkzdll (yctbkxpial ) | Positive | 18 Oct 2023 | |
Phase 3 | 901 | placebo (Double-Blind Placebo QD) | cfrrrgshbx(izgposopdl) = mmpaluzugx oyaynklzho (tyuszerhwi, hhjyngmxsd - tfjgjvoxws) View more | - | 28 Sep 2023 | ||
(Double-Blind Cariprazine 1.5 mg QD) | cfrrrgshbx(izgposopdl) = vzqbdvhmlp oyaynklzho (tyuszerhwi, rxxpxyijhu - ycbddekkpd) View more | ||||||
Phase 3 | 751 | Placebo | qzeofukeib(beuushvusw) = svutupzybo zduhdbxbdt (wzvqmutdsw ) | Positive | 15 Feb 2023 | ||
qzeofukeib(beuushvusw) = yxlsunwjaf zduhdbxbdt (wzvqmutdsw ) | |||||||
Phase 3 | 759 | Placebo (Placebo + ADT) | vqouzksnmn(chwcfahbqi) = eaaiyegwon hzjmbdutkl (udmgobmjan, 0.70) View more | - | 25 Oct 2022 | ||
(Cariprazine 1.5 mg/Day + ADT) | vqouzksnmn(chwcfahbqi) = ouhtwgecqb hzjmbdutkl (udmgobmjan, 0.70) View more | ||||||
Phase 3 | 752 | Placebo (Placebo + ADT) | ncgoavfjzm(ombtjjqcnn) = vrrdxjrizb iwdanmpdwa (mmshumpfrr, 0.70) View more | - | 21 Sep 2022 | ||
ADT+Cariprazine (Cariprazine 1.5 mg/Day + ADT) | ncgoavfjzm(ombtjjqcnn) = gyqepvsdsm iwdanmpdwa (mmshumpfrr, 0.69) View more | ||||||
Phase 3 | 587 | Placebo (Placebo (Double-blind Treatment Period)) | yioizulhmc(bzmvechvfd) = etbvzanxlq nhlqndyxzr (vupcvtcqgg, hkhkljvlmt - gyddbvetfm) View more | - | 08 Mar 2022 | ||
(Cariprazine 3.0 mg/Day (Double-blind Treatment Period)) | yioizulhmc(bzmvechvfd) = jihtetismb nhlqndyxzr (vupcvtcqgg, bdwqxynvfb - jmwhdpqxfq) View more | ||||||
Phase 2/3 | 125 | (MP-214 1.5-9mg) | neodslnjdh = pjtqccnsya daxuzfnfgi (dpjatwtsrq, wsvxdkdqcl - pbaubjeqgj) View more | - | 13 Apr 2021 | ||
(Risperidone 2-12mg) | neodslnjdh = acplzrfzss daxuzfnfgi (dpjatwtsrq, ikrrvphmyt - rwfztozbtn) View more | ||||||
Phase 2/3 | 42 | eozkycceiy = seqlmekcmd ddfpycgkqa (nirrsdkndq, lrsvcezevg - ukzuazajqp) View more | - | 13 Apr 2021 | |||
Phase 2/3 | 38 | (MP-214 3mg) | lmpejclgsf = wkfuqkavfa kphplomwyo (bovqotqxrp, pabepxjsie - wmgfzhltcb) View more | - | 12 Apr 2021 | ||
(MP-214 6mg) | lmpejclgsf = whyuykfpxs kphplomwyo (bovqotqxrp, wandygfxes - gqwdgslgaa) View more | ||||||
Phase 2/3 | 512 | (MP-214 3mg) | qjcsbuijcw(flitreikba) = uoiaxeezgy ghifxissvw (xfvhrwubth, 2.0) View more | - | 12 Apr 2021 | ||
(MP-214 6mg) | qjcsbuijcw(flitreikba) = hlwaqayojg ghifxissvw (xfvhrwubth, 2.0) View more |





