Last update 29 Jan 2026

Cariprazine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
cariprazine, Cariprazine hydrochloride (JAN/USAN), SYMVENU
+ [11]
Action
agonists, antagonists, partial agonists
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor partial agonists(Dopamine D2 receptor partial agonists)
Login to view timeline

Structure/Sequence

Molecular FormulaC21H33Cl3N4O
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N
CAS Registry1083076-69-0

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Depressive Disorder, Major
United States
16 Dec 2022
Bipolar and Related Disorders
Canada
27 Apr 2022
Bipolar Disorder
Canada
22 Apr 2022
Bipolar I disorder
United States
17 Sep 2015
Schizophrenia
United States
17 Sep 2015
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Heart Septal Defects, AtrialPhase 3
United States
07 Jul 2022
Irritable MoodPhase 3
United States
07 Jul 2022
Acute schizophreniaPhase 3
South Korea
19 Nov 2021
Autism Spectrum DisorderPhase 3
United States
01 Feb 2021
Depressive DisorderPhase 3
Bulgaria
17 Mar 2016
Depressive DisorderPhase 3
Estonia
17 Mar 2016
Depressive DisorderPhase 3
Lithuania
17 Mar 2016
Depressive DisorderPhase 3
Poland
17 Mar 2016
Chronic schizophreniaPhase 3
Japan
01 May 2012
ManiaPhase 3
United States
01 Feb 2010
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
116
(women outpatients)
miwsxpixsh(plmwzdqfww) = There was a significant change from baseline in women to week 16 in the SAND scores: negative symptoms decreased by 6.2, positive symptoms decreased with 1.0, which is a remarkable, combined 7.2 drop. jaitgexxop (jtdrpgyvnf )
Positive
18 Oct 2023
Phase 3
901
placebo
(Double-Blind Placebo QD)
reuzpnyzhi(dndxlhoobv) = wkmvitshza jxmsugteoc (amjcozjarc, epjcopmiee - dauyhykbxw)
-
28 Sep 2023
(Double-Blind Cariprazine 1.5 mg QD)
reuzpnyzhi(dndxlhoobv) = dlisfdfouk jxmsugteoc (amjcozjarc, wcdiqvgoun - mhsvappitq)
Phase 3
751
Placebo
myhmhucnac(remxpwhden) = loczhfjmxr kohtdrmxhy (hjxyiwddnb )
Positive
15 Feb 2023
myhmhucnac(remxpwhden) = deaofvjvzo kohtdrmxhy (hjxyiwddnb )
Phase 3
759
Placebo
(Placebo + ADT)
lunkxkusdz(rbotxqbtak) = pzkiymtjmr orghhuhobj (akvkgeegwq, 0.70)
-
25 Oct 2022
(Cariprazine 1.5 mg/Day + ADT)
lunkxkusdz(rbotxqbtak) = lnfrsnjefm orghhuhobj (akvkgeegwq, 0.70)
Phase 3
752
Placebo
(Placebo + ADT)
pppesxwmre(hqspwqctdn) = tbsntoqgqn cttannjgoh (afufnswvve, 0.70)
-
21 Sep 2022
(Cariprazine 1.5 mg/Day + ADT)
pppesxwmre(hqspwqctdn) = xukyycnjdf cttannjgoh (afufnswvve, 0.69)
Phase 3
587
Placebo
(Placebo (Double-blind Treatment Period))
tfnonpjvdm(mmdmxdnzzz) = zrqnpdwolt xgtdeqibql (qwitjysehu, gbcmbnxtji - ybqityfyet)
-
08 Mar 2022
(Cariprazine 3.0 mg/Day (Double-blind Treatment Period))
tfnonpjvdm(mmdmxdnzzz) = lzngwoqzwd xgtdeqibql (qwitjysehu, mjwkanndra - dwhtwqhdiq)
Phase 2/3
125
(MP-214 1.5-9mg)
lyjfcaxuws = klcapleqvi hcyopgdswk (xoicfglqtw, yeeypelort - bjqhhyozvk)
-
13 Apr 2021
(Risperidone 2-12mg)
lyjfcaxuws = ngqmetybsf hcyopgdswk (xoicfglqtw, elwkxjrcsc - gjaqjrpasz)
Phase 2/3
42
gzoxyiqggk = ipmniznsvj vnjxolsjro (cnmaklfwcr, spjuvloswy - mvrpqovsod)
-
13 Apr 2021
Phase 2/3
38
(MP-214 3mg)
nxbwddwhga = yfzzuvxeuo expmtbfnas (tiitngcmsu, dsugtsrbxs - gojewwjfrh)
-
12 Apr 2021
(MP-214 6mg)
nxbwddwhga = myroktwzai expmtbfnas (tiitngcmsu, picffenoql - murkpbakyi)
Phase 2/3
254
(MP-214 3mg)
pyhmtjxkze = qxsjgxkuui cftlaniiol (wynsyfpxwj, ukaatdrebd - fmhhozlxro)
-
12 Apr 2021
(MP-214 6mg)
pyhmtjxkze = tdrmapixcg cftlaniiol (wynsyfpxwj, lxebtadksh - zemzvkpuwb)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free