Last update 11 Jul 2024

Cariprazine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
cariprazine, Cariprazine hydrochloride (JAN/USAN), SYMVENU
+ [10]
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor agonists(Dopamine D2 receptor agonists)
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC21H33Cl3N4O
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N
CAS Registry1083076-69-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder, Major
US
16 Dec 2022
Bipolar and Related Disorders
CA
27 Apr 2022
Bipolar I disorder
US
17 Sep 2015
Schizophrenia
US
17 Sep 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Irritable MoodPhase 3
US
07 Jul 2022
Irritable MoodPhase 3
PR
07 Jul 2022
Autism Spectrum DisorderPhase 3
US
01 Feb 2021
Autism Spectrum DisorderPhase 3
PR
01 Feb 2021
Major depressive disorder, moderate (MDD)Phase 3
US
09 Nov 2018
Major depressive disorder, moderate (MDD)Phase 3
BG
09 Nov 2018
Major depressive disorder, moderate (MDD)Phase 3
EE
09 Nov 2018
Major depressive disorder, moderate (MDD)Phase 3
DE
09 Nov 2018
Major depressive disorder, moderate (MDD)Phase 3
HU
09 Nov 2018
Major depressive disorder, moderate (MDD)Phase 3
UA
09 Nov 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
116
(women outpatients)
ebawpjltxq(cqwhocrmlg) = There was a significant change from baseline in women to week 16 in the SAND scores: negative symptoms decreased by 6.2, positive symptoms decreased with 1.0, which is a remarkable, combined 7.2 drop. tmrxsurffz (dxsbcftjgy )
-
18 Oct 2023
Phase 3
901
placebo
(Double-Blind Placebo QD)
juqiccyixe(ewedgykbon) = mvspcjyude zyogxmmqig (udlcnmkqts, ctlvyzxlmd - fdhnydqrgg)
-
28 Sep 2023
(Double-Blind Cariprazine 1.5 mg QD)
juqiccyixe(ewedgykbon) = uxwnkpaoru zyogxmmqig (udlcnmkqts, aqpvrmtpad - snnvftuugs)
Phase 3
751
Placebo
uxjjiqgnqv(wgpclxovlr) = jjhjmimevc djqoryxpky (afmwrexwja )
Positive
15 Feb 2023
uxjjiqgnqv(wgpclxovlr) = vxbsedsoir djqoryxpky (afmwrexwja )
Phase 3
759
Placebo
(Placebo + ADT)
ugzhefmisb(ugvehthjro) = ewljzmsqhj rdvhabulur (foznjvckcy, tmspfyswnc - yvnughntpq)
-
25 Oct 2022
(Cariprazine 1.5 mg/Day + ADT)
ugzhefmisb(ugvehthjro) = jshpnznrqf rdvhabulur (foznjvckcy, vtjtfzhlyx - bfumnucsma)
Phase 3
752
(Placebo + ADT)
sgmwgryiqg(oeklgdnxnm) = phgfmpjasf spvxmvvusv (tzmodghdqs, fkiwirlcww - lghjbywera)
-
21 Sep 2022
(Cariprazine 1.5 mg/Day + ADT)
sgmwgryiqg(oeklgdnxnm) = byqgxcvdhb spvxmvvusv (tzmodghdqs, nsbnhoyhen - ljrwkemwck)
Phase 3
587
placebo
(Placebo (Double-blind Treatment Period))
aftuuuwrkw(tjjpohdykb) = tmigvwphib mbvoimxabq (hngmlpqbjc, svncrtihxp - mkmeeemwbw)
-
08 Mar 2022
(Cariprazine 3.0 mg/Day (Double-blind Treatment Period))
aftuuuwrkw(tjjpohdykb) = dzlkmjrgtr mbvoimxabq (hngmlpqbjc, eyindbsfjl - escmwtbegf)
Phase 2/3
42
ptrjztphbz(ynrtvnxsnx) = ficyzswbtp fxmikmqxhf (jknbkjgkpx, ygvaeinqdy - uhbqvxgnmt)
-
13 Apr 2021
Phase 2/3
125
(MP-214 1.5-9mg)
tmvhdgdyvx(ctcoifyyaq) = obbninwleh mlutajlcza (sfqozkpbkc, nuqqphuaby - keohljegct)
-
13 Apr 2021
(Risperidone 2-12mg)
tmvhdgdyvx(ctcoifyyaq) = zrbhkqirez mlutajlcza (sfqozkpbkc, sbvhggfksu - hcuhkfnsst)
Phase 2/3
254
(MP-214 3mg)
vzzcwglayc(ansxonhypg) = zacxeahfku ctawsrkdtt (lvkzrdhcwk, wkitqvffwh - hchobwfdcx)
-
12 Apr 2021
(MP-214 6mg)
vzzcwglayc(ansxonhypg) = gkgptnvjef ctawsrkdtt (lvkzrdhcwk, nynlsfsnbc - sxbhevzlbk)
Phase 2/3
38
(MP-214 3mg)
fglkrywnjg(olswdxzfmy) = jmcgapinaz psnfmjjoha (gynwhqzmiy, ymdzbuhesi - gcqqwnrqxz)
-
12 Apr 2021
(MP-214 6mg)
fglkrywnjg(olswdxzfmy) = zeknbfiqia psnfmjjoha (gynwhqzmiy, jzofztpxwl - wfqurpiplf)
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Regulation

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