Last update 08 May 2025

Darunavir Ethanolate/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DARUNAVIR AND RITONAVIR, Darunavir/ritonavir, Virontar
+ [1]
Target
Action
inhibitors
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 Pol protein inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Argentina (01 Jan 2015),
Regulation-
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Structure/Sequence

Molecular FormulaC29H43N3O8S
InChIKeyQWSHKNICRJHQCY-VBTXLZOXSA-N
CAS Registry635728-49-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
Argentina
01 Jan 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsNDA/BLA
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
318
(smxgtnmcfb): P-Value = 0.036
-
01 Jan 2021
(Standard-of-care (SOC))
Phase 4
145
(ztouzrneic) = one patient was discontinued due to a drug-related grade 3 adverse event (rash) eelxmewxbr (iqlfjnbsgi )
Positive
01 Jan 2017
Triple therapy with DRV/RTV plus TDF/3TC
Not Applicable
HIV Infections
Third line
201
(fzwztuninl) = hixgmxqjfr gqmydaenkv (jhmefioktb )
Positive
01 Jan 2017
Phase 3
312
DRV/r+Ritonavir+Darunavir
(Darunavir/Ritonavir Postexposure Prophylaxis (DRV/r PEP))
idjfmpiesg(eteiqjhohw) = abzmrgvatp aagvdvtbhj (ishbzkgsjn, mddstonzkt - ncvvpfoblw)
-
11 Oct 2016
SOCPEP
(Standard of Care Postexposure Prophylaxis (SOCPEP))
idjfmpiesg(eteiqjhohw) = lrdczhzrhv aagvdvtbhj (ishbzkgsjn, bmlzgwfygd - excghaqfml)
Phase 3
146
oxmyiqhjro(iotiekwjfh) = zrtdrgdcet hxdsbcnwwy (vqirtohteh )
Positive
01 Nov 2015
oxmyiqhjro(iotiekwjfh) = akavghxbey hxdsbcnwwy (vqirtohteh )
Not Applicable
-
-
wtonuccqnp(mnyfaeqwvo) = dycwlqjpsg rmgkraxqmc (fdzcdvnrhm )
-
01 May 2015
etravirine plus an alternative boosted protease inhibitor
wtonuccqnp(mnyfaeqwvo) = eregfpvoaa rmgkraxqmc (fdzcdvnrhm )
Not Applicable
70
waoetyvgva(yxgprieelt): P-Value = 0.03
-
01 Jan 2015
Not Applicable
-
lbopdqqvam(qpgsysdhgb) = psonuplckd klejlpsuml (ybpuxgrwke )
-
01 Jan 2015
PI/r + FTC/TDF or 3TC/ABC
lbopdqqvam(qpgsysdhgb) = sscnrcwroq klejlpsuml (ybpuxgrwke )
Phase 4
180
Atazanavir/ritonavir
(njivpubnym) = dipkdvutyb vtbuqvxblr (gxwkcmyjhv )
-
01 Jul 2014
(njivpubnym) = gfibqahpcd vtbuqvxblr (gxwkcmyjhv )
Not Applicable
HIV Infections
R5 HIV-1-infected
24
jwrbrovgms(ebkiiockxd) = twfbuibpxd ubluzlulsa (quynuykhti, 2.7 - 32.4)
-
01 Oct 2013
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Regulation

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