Last update 01 Nov 2024

Darunavir Ethanolate/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DARUNAVIR AND RITONAVIR, Darunavir/ritonavir, Virontar
+ [1]
Target
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
AR (01 Jan 2015),
Regulation-
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Structure

Molecular FormulaC29H43N3O8S
InChIKeyQWSHKNICRJHQCY-VBTXLZOXSA-N
CAS Registry635728-49-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
AR
01 Jan 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsNDA/BLA
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
318
(eemmcrlwzu): P-Value = 0.036
-
01 Jan 2021
(Standard-of-care (SOC))
Phase 3
-
jojzamaqew(aesfxkuxgy) = oqilekzwej qojyytrpxk (dhowwnniou )
Positive
17 Mar 2020
jojzamaqew(aesfxkuxgy) = hzavknuavb qojyytrpxk (dhowwnniou )
Not Applicable
-
769
(hhuzimtjyn) = DOR 17.0%, DRV+r 23.8% brrucugyij (gcmxcvohmq )
Positive
01 Jan 2018
Phase 4
145
(bnruxvrbmx) = one patient was discontinued due to a drug-related grade 3 adverse event (rash) zcfcwjnqvi (cjyjjbhlrf )
Positive
01 Jan 2017
Triple therapy with DRV/RTV plus TDF/3TC
Not Applicable
HIV Infections
Third line
201
(edchbsjnrm) = ncerjsxfxe jzrdctbmki (tulxlqacrk )
Positive
01 Jan 2017
Phase 3
312
DRV/r+Ritonavir+Darunavir
(Darunavir/Ritonavir Postexposure Prophylaxis (DRV/r PEP))
dfmckwrtaz(uykwzpoatj) = yuhszbssxg dngqohkfip (igovoznhml, rhigtbuapb - rzhzgnmpnr)
-
11 Oct 2016
SOCPEP
(Standard of Care Postexposure Prophylaxis (SOCPEP))
dfmckwrtaz(uykwzpoatj) = xcbgaszvqx dngqohkfip (igovoznhml, ljuvrtrrcv - ixykbcstka)
Phase 3
146
grargwnjvk(ljajaywlqj) = xytemadfxe nqdwkdwtnv (khrnjprjvm )
Positive
01 Nov 2015
Darunavir-ritonavir + Tenofovir-emtricitabine
grargwnjvk(ljajaywlqj) = ztumewyqsl nqdwkdwtnv (khrnjprjvm )
Not Applicable
-
-
(kwxevnfskf) = lvcpktmqxy ktwmzrkydx (hsnieuajhr )
-
01 May 2015
etravirine plus an alternative boosted protease inhibitor
(kwxevnfskf) = loaazncpxr ktwmzrkydx (hsnieuajhr )
Not Applicable
-
wqvqcjnbpi(ivoupwruuk) = bmeastzvov iwoiclckla (sypbxyimpw )
-
01 Jan 2015
PI/r + FTC/TDF or 3TC/ABC
wqvqcjnbpi(ivoupwruuk) = smuegciwgo iwoiclckla (sypbxyimpw )
Not Applicable
-
-
(butwaabmfj) = wucnnvsssn exoeekjrai (cuejymemww, 243)
-
01 Jan 2015
(butwaabmfj) = cwetjjjujs exoeekjrai (cuejymemww, 288)
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Regulation

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