Last update 01 Nov 2024

Pimicotinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationPRIME (EU), Fast Track (US), Orphan Drug (EU), Breakthrough Therapy (EU)
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Structure

Molecular FormulaC22H24N6O3
InChIKeyNXFPMDWYDKHFMM-UHFFFAOYSA-N
CAS Registry2253123-16-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pigmented Villonodular SynovitisPhase 3
CA
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
NL
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
US
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
CN
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
ES
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
PL
27 Apr 2023
Pigmented Villonodular SynovitisPhase 3
IT
27 Apr 2023
Pancreatic CancerPhase 2
CN
17 Oct 2023
Chronic graft-versus-host diseasePhase 2
CN
30 May 2023
Triple Negative Breast CancerPhase 1
US
02 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
56
(rnktoxrsqf) = meevojgcfj vmselouljv (idokncsxui )
Positive
03 Nov 2023
(rnktoxrsqf) = vowyokxrwu vmselouljv (idokncsxui )
Phase 1
49
(hvmcolemun) = include LDH increase (75.5%), CPK increase (67.3%), α-HBDH increase (63.3%), AST increase (42.9%), amylase increase (26.5%), ALT increase (24.5%), pruritus (20.4%) and rash (20.4%) gdpzwdclwd (wrwskibzmv )
Positive
26 May 2023
Phase 1
27
(zeoomcbddr) = The majority of treatment-period adverse events (treatment-period adverse events) were grade 1 or grade 2 events. No cases of color change or severe liver injury were reported. nsogvikjhi (wfbejmbkmf )
Positive
15 Nov 2022
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Core Patent

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Clinical Trial

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Approval

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Regulation

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