The purpose of this study is to test the effectiveness of a drug called temsirolimus in combination with a drug called perifosine in treating brain tumors that have continued to grow after previous treatment. Temsirolimus is an intravenous drug approved by the FDA for treatment of other cancers (kidney cancer, certain types of lymphoma) but not for brain tumors. Perifosine is a pill that has not been approved by the FDA which blocks a messenger that tells cancer cells to grow. Research suggests that combined treatment with both drugs is better than either alone, and that it is reasonably safe.

Start Date08 Dec 2014

Sponsor / Collaborator

Columbia University

[+2]

JPRN-jRCT2080222238

/ Unknown statusPhase 2

Phase II trial of YHI-1003 monotherapy in patients with advanced or relapsed gynecologic cancer

Start Date27 Sep 2013

Sponsor / Collaborator

Yakult Honsha Co., Ltd.

JPRN-JapicCTI-132287

/ Unknown statusPhase 2

Phase II trial of YHI-1003 monotherapy in patients with advanced or relapsed gynecologic cancer

Start Date01 Jun 2013

Sponsor / Collaborator

Yakult Honsha Co., Ltd.

100 Clinical Results associated with Perifosine

100 Translational Medicine associated with Perifosine

100 Patents (Medical) associated with Perifosine

572

Literatures (Medical) associated with Perifosine

28 Jan 2025·LANGMUIR

Unraveling Cholesterol-Dependent Interactions of Alkylphospholipids with Supported Lipid Bilayers

Article

Author: Sut, Tun Naw ; Molla, Abebual ; Jackman, Joshua A.

Alkylphospholipids are single-chain lipid amphiphiles that possess clinically relevant biological activities driven by membrane-destabilizing interactions. Subtle variations in alkylphospholipid structure can lead to significant differences in their biological effects, yet corresponding membrane interactions remain underexplored. Herein, we employed the quartz crystal microbalance-dissipation (QCM-D) technique to characterize the real-time membrane interactions of three alkylphospholipids-edelfosine, miltefosine, and perifosine-on supported lipid bilayers with varying cholesterol fractions. Our findings reveal that the tested alkylphospholipids had distinct membrane-interaction profiles: (1) edelfosine exhibited irreversible binding and caused weak membrane disruption; (2) miltefosine caused major disruption by affecting membrane packing; and (3) perifosine exhibited reversible binding while triggering structural rearrangements and modest disruption. Overall, alkylphospholipid micelles showed greater activity than monomers, and higher membrane cholesterol fractions resulted in more extensive disruption, highlighting the interplay between membrane stiffness and responsiveness. These results provide biophysical evidence that different alkylphospholipids have distinct membrane-interaction behaviors that align well with reported biological activities. Our supported lipid bilayer approach offers a valuable platform for designing and assessing alkylphospholipids with tailored membrane-interaction profiles.

22 Jan 2025·JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Signaling Transduction Network Elucidation of ACE 2 Regulating Apostichopus japonicus Autolysis by Using Integrative TMT Proteomics and Transcriptomics

Article

Author: Sun, Jinghe ; Yang, Jingfeng ; Li, Yimeng ; Wang, Xiaoyan ; Yan, Tingting

This study aims to reveal the transduction signaling network that triggers sea cucumber (Apostichopus japonicus) autolysis. The tandem mass tag (TMT) proteomics and transcriptomic techniques were used to analyze expression differences between inhibited and activated sea cucumber autolysis. Flow cytometry was used to identify apoptosis. Western blotting and RT-PCR verified the signaling pathway. The results showed that the angiotensin-converting enzyme 2 (ACE 2) activator (diminazene, DIZE) maintained the health of A. japonicus. The ACE 2 inhibitor (captopril, Capt) accelerated the autolysis. Based on the multiomics analysis, the ACE 2 activator activated the downstream NF-κB pathway to prevent the sea cucumber apoptosis. The Capt activated apoptosis initiation. Apoptosis occurred through the regulation of TNF and PI3K-Akt signaling pathways, which downregulate NF-κB. Akt was identified as an intermediate signaling protein downstream of ACE 2 that regulates autolysis in A. japonicus. Compared to A. japonicus in the ultraviolet-irradiated and Capt groups, the Akt inhibitor (perifosine, KRX) significantly reduced the expression of the PI3K-Akt and NF-κB pathways, thereby inhibiting the autolysis process. Additionally, DIZE attenuated ROS levels, thereby inhibiting the autolysis of A. japonicus. This study provides better insight into the autolysis mechanism of A. japonicus.

01 Jan 2025·Biomolecules & Therapeutics

Low-Dose Perifosine, a Phase II Phospholipid Akt Inhibitor, Selectively Sensitizes Drug-Resistant ABCB1-Overexpressing Cancer Cells

Article

Author: Lee, Haeun ; Park, Jae Hyeon ; Yoon, Sungpil ; Shin, Joo Kyung ; Zheng, Tian ; Kim, Hyung Sik

We identified drugs or mechanisms targeting ABCB1 (or P-glycoprotein; P-gp)-overexpressing drug-resistant cancer populations, given that these cells play a key role in tumor recurrence. Specifically, we searched for Akt inhibitors that could increase cytotoxicity in P-gp-overexpressing drug-resistant cancer cells. We performed cytotoxicity assays using five cell lines: 1. MCF-7/ADR, 2. KBV20C cancer cells (P-gp overexpression, vincristine [VIC] resistance, and GSK690693-resistance), 3. MCF-7, 4. normal HaCaT cells (non-P-gp-overexpressing, VIC-sensitive, and GSK690693-sensitive), and 5. MDA-MB-231 cancer cells (non-P-gp overexpression, relatively VIC-resistance, and GSK690693-sensitive). Herein, we found that low-dose perifosine markedly and selectively sensitizes both MCF-7/ADR and KBV20C drug-resistant cancer cells exhibiting P-gp overexpression. Compared with other Akt inhibitors (AZD5363, BKM120, and GSK690693), low-dose perifosine specifically sensitized P-gp-overexpressing resistant MCF-7/ADR cancer cells. Conversely, Akt inhibitors (other than perifosine) could enhance sensitization effects in drugsensitive MCF-7 and HaCaT cells. Considering that perifosine has both an alkyl-phospholipid structure and is an allosteric inhibitor for membrane-localizing Akt-targeting, we examined structurally and functionally similar Akt inhibitors (miltefosine and MK-2206). However, we found that these inhibitors were non-specific, suggesting that the specificity of perifosine in P-gp-overexpressing resistant cancer cells is unrelated to phospholipid localizing membranes or allosteric inhibition. Furthermore, we examined the molecular mechanism of low-dose perifosine in drug-resistant MCF-7/ADR cancer cells. MCF-7/ADR cells exhibited increased apoptosis via G2 arrest and autophagy induction. However, no increase in P-gp-inhibitory activity was observed in drug-resistant MCF-7/ADR cancer cells. Single low-dose perifosine treatment exerted a sensitization effect similar to co-treatment with VIC in P-gp-overexpressing drug-resistant MCF-7/ADR cancer cells, suggesting that single treatment with low-dose perifosine is a more powerful tool against P-gp-overexpressing drug-resistant cancer cells. These findings could contribute to its clinical use as a first-line treatment, explicitly targeting P-gp-overexpressing resistant cancer populations in heterogeneous tumor populations. Therefore, perifosine may be valuable in delaying or reducing cancer recurrence by targeting P-gp-overexpressing drug-resistant cancer cells.

News (Medical) associated with Perifosine

09 Oct 2023

·synapse.patsnap.com

Analysis on the Clinical Research Progress of Akt inhibitors

Akt, also known as protein kinase B, is a crucial enzyme that plays a significant role in various cellular processes within the human body. It is a key mediator of cell survival, growth, and metabolism. Akt is involved in regulating multiple signaling pathways, including those related to cell proliferation, apoptosis, and glucose metabolism. It promotes cell survival by inhibiting apoptosis and stimulating cell growth and proliferation. Akt also regulates glucose metabolism by promoting glucose uptake and utilization. Dysregulation of Akt signaling has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Understanding the role of Akt is essential for developing targeted therapies in the pharmaceutical industry. Akt Competitive LandscapeAccording to Patsnap Synapse, as of 27 Sep 2023, there are a total of 73 Akt drugs worldwide, from 103 organizations, covering 96 indications, and conducting 409 clinical trials. 👇Please click on the picture link below for free registration or login directly if you have freemium accounts, you can browse the latest research progress on drugs , indications, organizations, clinical trials, clinical results, and drug patents related to this target. Based on the analysis of the data, AstraZeneca PLC, Roche Holding AG, and Otsuka Holdings Co., Ltd. are the companies growing fastest under the current target Akt. AstraZeneca PLC has the highest stage of development with drugs in multiple phases. Several drugs under the target Akt have been approved for relevant indications, including breast cancer, prostatic cancer, neoplasms, ovarian cancer, colorectal cancer, and lung cancer. Small molecule drugs and synthetic peptides are progressing rapidly under this target. China is showing progress in the development of drugs under the target Akt, with drugs in phase 3 and preclinical stages. The competitive landscape for target Akt is dynamic, with multiple companies and countries actively involved in research and development. The future development of target Akt is expected to continue with a focus on advancing drugs through clinical trials and expanding indications for approved drugs. Key drug：Ipatasertib DihydrochlorideIpatasertib Dihydrochloride is a small molecule drug that targets Akt, a protein involved in cell survival and growth. It has shown potential therapeutic benefits in various therapeutic areas including neoplasms, urogenital diseases, digestive system disorders, endocrinology and metabolic disease, other diseases, and skin and musculoskeletal diseases. In terms of active indications, Ipatasertib Dihydrochloride has demonstrated efficacy in treating breast cancer, castration-resistant prostatic cancer, prostatic cancer, solid tumors, ovarian cancer, stomach cancer, gastrointestinal neoplasms, etc. This wide range of indications suggests its potential as a versatile treatment option for different types of cancers. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. The drug was developed by Array BioPharma, Inc., a pharmaceutical company specializing in the discovery, development, and commercialization of targeted small molecule drugs. It has reached phase 3 globally, which is the highest phase of clinical development. Phase 3 trials are the final stage of clinical testing before seeking regulatory approval, indicating that Ipatasertib Dihydrochloride has progressed significantly in its development process. Furthermore, Ipatasertib Dihydrochloride has been designated as an orphan drug, which means it is intended to treat rare diseases or conditions that affect a small number of patients. This regulatory status provides certain incentives and benefits to the drug developer, such as market exclusivity and financial incentives, to encourage the development of treatments for rare diseases. In summary, Ipatasertib Dihydrochloride is a small molecule drug developed by Array BioPharma, Inc. that targets Akt. It has shown promise in treating various types of cancers and has reached the advanced stage of phase 3 clinical trials globally. Its designation as an orphan drug highlights its potential to address unmet medical needs in rare diseases. PerifosinePerifosine is a small molecule drug that is being developed by AEterna Zentaris GmbH. It is designed to target Akt, a protein that plays a role in cell survival and proliferation. The drug is currently in phase 3 of clinical trials, which is the final stage before seeking regulatory approval. Perifosine has shown potential in treating a range of therapeutic areas, including neoplasms (abnormal growth of cells), nervous system diseases, urogenital diseases, and digestive system disorders. Specifically, it has demonstrated efficacy in treating colorectal cancer, female urogenital diseases, and glioma, a type of brain tumor. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. One notable aspect of Perifosine is its designation as an orphan drug. Orphan drugs are medications developed to treat rare diseases or conditions that affect a small number of patients. This designation provides certain incentives and benefits to the drug developer, such as extended market exclusivity and financial support for clinical trials. The fact that Perifosine has reached phase 3 of clinical trials indicates that it has shown promising results in earlier stages of testing. Phase 3 trials involve a larger number of participants and aim to further evaluate the drug's safety and effectiveness. If the results continue to be positive, AEterna Zentaris GmbH may seek regulatory approval to bring Perifosine to market. In summary, Perifosine is a small molecule drug developed by AEterna Zentaris GmbH that targets Akt. It has shown potential in treating neoplasms, nervous system diseases, urogenital diseases, and digestive system disorders. The drug is currently in phase 3 of clinical trials and has demonstrated efficacy in treating colorectal cancer, female urogenital diseases, and glioma. Its designation as an orphan drug provides certain benefits and incentives to the developer.

03 Apr 2012

·www.biospace.com

Keryx Biopharmaceuticals, AEterna Zentaris Colorectal Cancer Drug Fails Trial

NEW YORK, April 2, 2012 /PRNewswire/ -- Keryx Biopharmaceuticals, Inc. (NASDAQ: KERX) reported today that the Phase 3 "X-PECT" (Xeloda® + Perifosine Evaluation in Colorectal cancer Treatment) clinical trial evaluating perifosine (KRX-0401) + capecitabine (Xeloda) in patients with refractory advanced colorectal cancer did not meet the primary endpoint of improving overall survival versus capecitabine + placebo. This Phase 3 trial was conducted pursuant to a Special Protocol Assessment (SPA) agreement with the FDA. 468 patients at sixty-five U.S. sites participated in this study. Ron Bentsur, Chief Executive Officer of Keryx, stated, "We are all extremely disappointed with the results of the study. We thank the investigators who participated in what we believe was a well-run study, despite the outcome. We will evaluate whether our Phase 3 study of Perifosine in relapsed/refractory multiple myeloma will continue as planned." Mr. Bentsur commented further, "With approximately $31 million in cash as of March 31, 2012, and a well-controlled burn rate, we plan to focus our resources on the pending completion of the Zerenex (ferric citrate) long-term Phase 3 study for end stage renal disease (ESRD) patients with hyperphosphatemia, expected in the fourth quarter of 2012, and the New Drug Application (NDA) filing for Zerenex which will hopefully follow shortly thereafter." KRX-0401 (perifosine) is in-licensed by Keryx from AeternaZentaris Inc. in the United States, Canada and Mexico. Keryx will host a conference call today, April 2, 2012, at 8:00am EDT. In order to participate in the conference call, please call 1-877-869-3847 (U.S.), 1-201-689-8261 (outside the U.S.), call-in ID: KERYX. The audio recording of the conference call will be available for replay at , for a period of 15 days after the call. ABOUT KERYX BIOPHARMACEUTICALS, INC. Keryx Biopharmaceuticals is focused on the acquisition, development and commercialization of medically important pharmaceutical products for the treatment of renal disease and cancer. Keryx is developing Zerenex (ferric citrate), an oral, ferric iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. The Phase 3 clinical program of Zerenex for the treatment of hyperphosphatemia (elevated phosphate levels) in patients with end-stage renal disease is being conducted pursuant to an SPA agreement with the FDA. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and potentially also affects a number of other key signal transduction pathways. KRX-0401 is currently in Phase 3 clinical development for multiple myeloma, being conducted pursuant to an SPA agreement with the FDA, and in Phase 1 and 2 clinical development for several other tumor types. Keryx is headquartered in New York City. Cautionary Statement Some of the statements included in this press release, particularly those anticipating future clinical trials and business prospects for Zerenex (ferric citrate) and KRX-0401 (perifosine) may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results to differ materially are the following: if, upon final analysis, it is determined that all trials of KRX-0401 should be terminated, our ability to successfully adjust our strategy and reduce our operating expenses relating to KRX-0401 clinical trials in order to properly support the trials of Zerenex; our ability to successfully and cost-effectively complete clinical trials for Zerenex and KRX-0401; the risk that the data (both safety and efficacy) from the ongoing Phase 3 trials will not coincide with the data analyses from previous clinical trials reported by the Company; and other risk factors identified from time to time in our reports filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. This press release and prior releases are available at . The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. KERYX CONTACT: Lauren Fischer Director Investor Relations Keryx Biopharmaceuticals, Inc. Tel: 212.531.5965 E-mail: lfischer@keryx.com SOURCE Keryx Biopharmaceuticals, Inc.

CollaborateFirst in ClassAcquisition

29 Apr 2011

·www.biospace.com

Keryx Biopharmaceuticals Announces Positive Final Data from Zerenex Short-Term Phase 3 Study

NEW YORK, April 28, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals (Nasdaq:KERX - News) today announced the final dataset from the Phase 3 short-term clinical trial of Zerenex™ (ferric citrate) for the treatment of hyperphosphatemia in end-stage renal disease patients on dialysis. The Zerenex data was presented earlier today at the National Kidney Foundation Spring Clinical Meetings being held in Las Vegas, Nevada, in an oral presentation by David S. Goldfarb, M.D., Clinical Chief of Nephrology, NYU Langone Medical Center, Professor of Medicine & Physiology, NYU School of Medicine. On November 30, 2010, the Company issued a press release announcing positive top-line results from this Phase 3 short-term study. Phase 3 short-term study design This Phase 3 study was a multicenter, randomized, open-label trial with a two-week washout period, following which patients were randomized 1:1:1 to receive a fixed dose of Zerenex of either 1 gram, 6 grams or 8 grams per day for a treatment period of 28 days. Zerenex was administered using a 1 gram oral caplet formulation, hence, the fixed-dose arms of 1 gram, 6 grams and 8 grams per day represent 1, 6 and 8 pills per day, respectively. One hundred fifty-one dialysis patients were enrolled into the study. The Intent-to-Treat (ITT) group included 146 patients, representing all patients who took at least one dose of Zerenex and provided a Baseline (at the end of washout) and at least one post-Baseline efficacy assessment. Efficacy assessments were taken weekly starting at Baseline and subsequently at days 7, 14, 21 and 28. EFFICACY DATA ANALYSES The primary endpoint of the study was to determine whether there was a dose response in the change in serum phosphorus from Baseline to Day 28 in the ITT group, using a regression analysis to evaluate this objective. The study met the primary endpoint, with the regression analysis indicating a highly statistically significant dose response (p Additional highlights from Dr. Goldfarb's presentation on Zerenex are as follows: * Statistically significant dose response increase in serum bicarbonate suggests potential to address metabolic acidosis * Statistically significant dose response reduction in calcium x phosphorus product * Modest upward trends in Ferritin and TSAT in 6 grams/day and 8 grams/day dose groups further supports theory that Zerenex could reduce the need for intravenous iron and erythropoiesis-stimulating agent (ESA) use * Zerenex appeared to be safe and well-tolerated in the study * GI adverse events were mostly mild and transient in nature * No SAEs were deemed to be drug-related by the Data Safety Monitoring Committee Dr. Goldfarb concluded that Zerenex has the potential to become a viable alternative to the currently approved phosphate binders used to treat ESRD patients. Ron Bentsur, Chief Executive Officer of Keryx, stated, "We are encouraged by the final efficacy and safety data from the Phase 3 short term study presented earlier today, which confirm the top-line data previously reported." Mr. Bentsur continued, "We thank Dr. Goldfarb for his time and effort in preparing for and delivering this morning's presentation." In accordance with the Company's Special Protocol Assessment (SPA) agreement with the FDA, the Phase 3 clinical program for Zerenex consists of two clinical studies, the completed short-term study, and a long-term safety and efficacy study that is currently ongoing. About Keryx Biopharmaceuticals, Inc. Keryx Biopharmaceuticals is focused on the acquisition, development and commercialization of medically important pharmaceutical products for the treatment of cancer and renal disease. Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and also affects a number of other key signal transduction pathways, including the JNK pathway, all of which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 has demonstrated both safety and clinical efficacy in several tumor types, both as a single agent and in combination with approved therapies. KRX-0401 is currently in Phase 3 clinical development for both refractory advanced colorectal cancer and multiple myeloma, and in Phase 1 and 2 clinical development for several other tumor types. Each of the KRX-0401 Phase 3 studies is being conducted under a Special Protocol Assessment (SPA) agreement with the FDA. Keryx is also developing Zerenex (ferric citrate), an oral, ferric iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. The Phase 3 clinical program of Zerenex for the treatment for hyperphosphatemia (elevated phosphate levels) in patients with end-stage renal disease on dialysis is being conducted pursuant to an SPA agreement with the FDA. Keryx is headquartered in New York City. Cautionary Statement Some of the statements included in this press release, particularly those anticipating future clinical trials and business prospects for Zerenex™ (ferric citrate) may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results to differ materially are the following: our ability, and our Japanese partner's ability, to successfully and cost-effectively complete clinical trials for Zerenex (ferric citrate); uncertainties related to the regulatory process; and other risk factors identified from time to time in our reports filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. This press release and prior releases are available at The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. KERYX CONTACT: Lauren Fischer Director - Investor Relations Keryx Biopharmaceuticals, Inc. Tel: 212.531.5965 E-mail: lfischer@keryx.com

CollaborateFirst in ClassAcquisition

100 Deals associated with Perifosine

External Link

KEGG	Wiki	ATC	Drug Bank
-	Perifosine	-	DB06641

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Refractory Colorectal Carcinoma	Phase 3	United States	Æterna Zentaris, Inc.	01 Apr 2010
Multiple Myeloma	Phase 3	United States	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Canada	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Czechia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Ireland	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Israel	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Russia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Slovakia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	South Korea	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Spain	Æterna Zentaris, Inc.	01 Dec 2009

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00590954 (CTgov)	Phase 2	Recurrent Malignant Glioma	32	Perifosine	qnzqyayzic(ihftxegmon) = fpkquctwcp mtodncodqn (yjwrqvhwbv, xjfqrhhizl - clxhyredzs) View more	-	19 Oct 2020
NCT01002248 (Pubmed) Manual	Phase 3	Multiple Myeloma	135	bortezomib+perifosine	rtmrmzdevr(xsuoxajwlo) = usucxuvcle olzxskurzk (smvwjreqjv, 16.0 - 45.4) View more	Negative	06 Apr 2020
NCT01002248 (Pubmed) Manual	Phase 3	Multiple Myeloma	135	bortezomib+Placebo	rtmrmzdevr(xsuoxajwlo) = hsoesdywhy olzxskurzk (smvwjreqjv, 18.3 - 50.1) View more	Negative	06 Apr 2020
NCT00590954 (Pubmed \| J Neurooncol) Manual	Phase 2	Recurrent Glioblastoma	30	Perifosine	zucettzfjy(zeacsiqlwg) = lcnmlxjcop omlasrcjzp (lfykluybrh, 1.08 - 1.84) View more	Negative	01 Sep 2019
NCT00776867 (Pubmed \| Int J Cancer) Manual	Phase 1	High Risk Neuroblastoma	27	perifosine	ujfzvsqjsq(brpphrgjtq) = etzwndzdxo bsxowecldi (cfcyoanurm ) View more	Positive	15 Jan 2017
NCT01051557 (CTgov)	Phase 1/2	Gliosarcoma \| Glioblastoma \| Diffuse Astrocytoma ... View more	36	Laboratory Biomarker Analysis+Perifosine+Temsirolimus	wnggdjmrrj = tddigxqjog ocnmbgaxll (lcvitxlghh, ensusowqyl - lgirpaokyv)	-	18 Apr 2016
NCT00058214 (CTgov)	Phase 2	Recurrent Prostate Carcinoma \| Castration-Resistant Prostatic Cancer \| Adenocarcinoma of prostate	25	laboratory biomarker analysis+perifosine	nvsegyrcfp = qfmmmjghiv hxpoosgiid (loshnffllg, harmscrhrn - oqxzgfwjpw) View more	-	23 Feb 2015
NCT00873457 (CTgov)	Phase 2	Recurrent Chronic Lymphoid Leukemia \| Small Lymphocytic Lymphoma	16	perifosine	kwniibxxan = ocosizaztd zcmxmqexwm (tihwahdwgy, mtuqgiwydn - vglhewherc) View more	-	24 Jan 2013
Pubmed \| Br J Haematol	Phase 1	Multiple Myeloma phospho-Akt	-	Perifosine-lenalidomide-dexamethasone	ntiikqqokj(magecgowux) = yzddrgmneg eakvwmruxc (ltrkyrdhds ) View more	Positive	01 Aug 2012
NCT01097018 (X-PECT, ASCO 12012 \| ASCO 22012) Manual	Phase 3	Metastatic Colorectal Carcinoma	468	Capecitabine+perifosine	grhymwwoye(gqyxowlrmo) = jckhreauya afccnxfmxq (bkxrzijlgl ) View more	Negative	20 Jun 2012
NCT01097018 (X-PECT, ASCO 12012 \| ASCO 22012) Manual	Phase 3	Metastatic Colorectal Carcinoma	468	Capecitabine+placebo	grhymwwoye(gqyxowlrmo) = qvvxgcgsuf afccnxfmxq (bkxrzijlgl ) View more	Negative	20 Jun 2012
NCT00422656 (CTgov)	Phase 2	Waldenstrom Macroglobulinemia	37	Perifosine	fdaiscfzbo = pffmabyfdo hdvdwrxpzo (rwpqmxskcd, lginpdqfhw - uaqnbmrrpd) View more	-	16 Feb 2012

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