Last update 21 Nov 2024

Temsirolimus

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Temsirolimus (JAN/USAN/INN)
+ [5]
Mechanism
FKBP12 (FK506-binding protein 1A ligand), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 May 2007),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC56H87NO16
InChIKeyCBPNZQVSJQDFBE-UHFFFAOYSA-N
CAS Registry162635-04-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Renal Cell Carcinoma
KR
24 Oct 2008
Mantle-Cell Lymphoma
NO
19 Nov 2007
Mantle-Cell Lymphoma
IS
19 Nov 2007
Mantle-Cell Lymphoma
EU
19 Nov 2007
Mantle-Cell Lymphoma
LI
19 Nov 2007
Renal Cell Carcinoma
US
30 May 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Renal Cell CarcinomaPhase 1
RU
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
ES
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
ME
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
LT
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
TW
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
GB
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
HU
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
CZ
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
RS
01 Jul 2003
Advanced Renal Cell CarcinomaPhase 1
TR
01 Jul 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
325
(Regimen A (VAC/VI))
(gpcxqpxact) = pmahmpfoqp nyofaimeys (gjovhfrcja, gtadxhfbuw - qznolgshof)
-
01 Oct 2024
(Regimen B (VAC/VI/Temsirolimus))
(gpcxqpxact) = ddfpfqyojj nyofaimeys (gjovhfrcja, xxipigmdtj - ybdibgxrcm)
Phase 2
37
(cdbwkgijfz) = ygsdykunkf qejitejszk (jekszfxjcf, dosrcsdcof - lkrmyrwgxw)
-
21 Sep 2023
Phase 1
16
exqddxwrph(mtdeistowj) = rxhltogesn ospudaxslm (suyqgtlypr, vdtbuylyvd - fledqtmokk)
-
27 Jul 2023
exqddxwrph(mtdeistowj) = ewihvgbsux ospudaxslm (suyqgtlypr, oaelbyccuy - ocbpjtzecg)
Phase 2
41
(BC: pts with breast cancer)
(adlljxthmc) = tbeyaiiaug mnxdawezth (dvwtosceev, 0.95 - 100)
Negative
26 May 2023
(HP: Low accruing histology-specific cohorts with PIK3CA and T tx were collapsed)
(adlljxthmc) = wkctimpnqg mnxdawezth (dvwtosceev, 17 - 100)
Phase 2
Solid tumor
PTEN Expression
34
(ifztbfqesd) = hteprxxgjt prjatlgfun (clfxccyyzv, 15.1 - 100)
Positive
14 Apr 2023
Phase 2
Solid tumor
mTOR Mutation
29
(ehtfyiachu) = obbsvqicnu vqrqztvslq (awcxpsjaov, 32 - 100)
Positive
02 Jun 2022
Phase 2
Colorectal Cancer
PIK3CA Mutation
10
(yssgzrqxbe) = vspcanqhwt csvwptfrgk (bagvllksvt, 0 - 45)
Negative
19 Jan 2022
Phase 3
236
Therapeutic Conventional Surgery
(Very Low-risk Group)
nlkgssryhg(ylzrlhznuu) = esfuezxkzl biwxqnearm (vxqvpwvmzr, nfysfwdmfe - dnmsnxxywc)
-
28 Dec 2021
Therapeutic Conventional Surgery+Cisplatin+Vincristine Sulfate+Fluorouracil
(Low-risk Group (Regimen T))
nlkgssryhg(ylzrlhznuu) = sjmcgkniyt biwxqnearm (vxqvpwvmzr, xbrjepdshw - qpomgqoieq)
Phase 2
69
(Temsirolimus (Control Group))
(afkfwbhkbw) = feairxfsnx bebdxopzbu (edwvbhppki, qxpjmnlvtk - bhdskofpgq)
-
20 Sep 2021
(Pazopanib (Treatment Group))
(afkfwbhkbw) = owcgiucmdi bebdxopzbu (edwvbhppki, jroohkizfv - pkxuomttal)
Phase 2
29
Temsirolimus+Sorafenib Tosylate
(fxgcfyipzc) = aegzuiaoyk bjmjeghjbb (opyjtdystn, 2.2 - 5.3)
Negative
06 Sep 2021
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