Delving into the Latest Updates on Diatrizoate Sodium/Meglumin diatrizoate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Gastroview, Gastrografin

Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Contrast agents

Inactive Indication-

Originator Organization

G&E Healthcare Co., Ltd.

Active Organization

G&E Healthcare Co., Ltd.Bracco Diagnostics, Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (02 Aug 1955),

Contrast agents

Regulation-

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Structure/Sequence

Molecular FormulaC18H26I3N3O9

InChIKeyMIKKOBKEXMRYFQ-WZTVWXICSA-N

CAS Registry131-49-7

View All Structures (2)

Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team.
The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO.
This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.

Start Date01 Jan 2024

Sponsor / Collaborator

University of California, Los Angeles

NCT05726097

/ CompletedPhase 3

Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure

The study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.

Start Date01 Feb 2023

Sponsor / Collaborator

Region Skåne Holding AB

[+2]

ACTRN12620000710921

/ RecruitingNot ApplicableIIT

A Phase 2 study of efficacy: The validation of Gastrografin measurement in postsurgical samples following low anterior resection when the rectal tube is flushed with Gastrografin

Start Date18 Aug 2020

Sponsor / Collaborator-

100 Clinical Results associated with Diatrizoate Sodium/Meglumin diatrizoate

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100 Translational Medicine associated with Diatrizoate Sodium/Meglumin diatrizoate

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100 Patents (Medical) associated with Diatrizoate Sodium/Meglumin diatrizoate

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442

Literatures (Medical) associated with Diatrizoate Sodium/Meglumin diatrizoate

01 Jan 2025·Radiology Case Reports

Complicated meconium ileus in a male neonate with cystic fibrosis: Case report

Article

Author: Abilkassem, Rachid ; Agadr, Aomar ; Sellouti, Mohamed

In about 10%-15% of instances, meconium ileus (MI) is the first sign of cystic fibrosis (CF). If a newborn exhibits signs of intestinal obstruction and does not pass meconium within a short period of time after birth, MI is suspected. The cystic fibrosis transmembrane conductance regulator gene (CFTR), which is found on chromosome 7q31, is mutated in CF patients. A premature baby, 5 days old, with clinical signs that were typical of MI. These attempts failed in spite of conservative therapies, such as rectal injection of gastrografin. An ileostomy was made and meconium was manually evacuated after an exploratory laparotomy revealed the presence of a typical MI. At ≥1300 µg/L (reference value ≤1000 µg/L), immunoreactive trypsinogen (IRT) levels were increased, which prompted the start of oral pancreatic enzyme replacement treatment. Discharge at 65 days of age included referrals to primary care and a specialized CF clinic. The baby has since shown normal growth and development. This case highlights the rapid onset of CF in a premature infant with complex MI as the initial clinical presentation.

01 Dec 2024·Journal of Surgical Research

“The Itsy-Bitsy Water Bead Went Down the Baby's Mouth. Will Drinking Gastrografin Help to Flush It Out?”

Article

Author: Ciullo, Sean ; Francis, Andrew ; Zhang, Bobby ; Prey, Beau ; Pumiglia, Luke ; Williams, James ; Barlow, Meade ; Horton, John

INTRODUCTIONForeign body ingestion is a common occurrence in the pediatric population. Superabsorbent polymers (i.e., water beads [WB]), such as Orbeez, are brightly colored spheres, can expand up to 100x their original size and are marketed as toys for kids. Ingested WB may lead to a bowel obstruction and typically require surgical removal.METHODSFully expanded WBs (N = 15) were placed into 1 of the 3 solutions: water (N = 5), gastrografin (N = 5), or 1:1 mixture of gg and water (N = 5), with serial diameter measurements obtained at 1, 4, 8, and 24 h. Additionally, fully expanded WBs were placed into succus containing post mortem porcine small bowel and mixed with gastrografin (N = 10) or nothing (N = 10), with diameters measured prior to placement and at 4 h.RESULTSAt all time points, the mean WB diameter of the gastrografin arm was significantly smaller than the other two arms (P < 0.01). WBs submerged in gastrografin saw a 58% reduction in diameter at 4 h compared to 45% reduction in the 1:1 mixture and a 2% growth in water (P < 0.01). When placed into small bowel containing gastrografin, the mean WB diameter decreased by 47% at 4 h versus 37% in the control arm (P < 0.01).CONCLUSIONSGastrografin significantly reduced the size of WB in both the in-vitro and ex-vivo post mortem animal study; and it may offer a nonsurgical option for the management of water bead ingestion. Studies assessing the clinical efficacy of a gastrografin nonoperative management strategy are needed.

01 Dec 2024·Internal Medicine

Successful Gastrografin Vermifugation for <i>Taenia saginata</i>-associated Appendicitis

Article

Author: Umekawa, Yasuhiro ; Kobayashi, Keigo

In Japan, public health improvements have lessened parasitic infections, but increased global travel has introduced new disease risks. We report the case a Japanese man who had previously resided in Vietnam, who experienced appendicitis and the presence of segments in his stool. Gastrografin led to the expulsion of Taenia saginata, as confirmed by scolex identification. Remarkably, the appendicitis symptoms subsided after deworming. This case underscores the importance of considering cestode infections in the differential diagnosis of appendicitis, particularly for patients with relevant travel histories, and highlights the evolving challenges in global health and the significance of acquiring detailed patient histories.

100 Deals associated with Diatrizoate Sodium/Meglumin diatrizoate

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Contrast agents	CN	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01440712 (Pubmed \| World J Surg)	Phase 4	Postoperative ileus	-	Gastrografin	dollsudjcz(razqatpooi) = jfnuusuklg opldbumadf (dyxnynzftk, 6.51 - 11.68)	Negative	01 Jan 2016
				Placebo	dollsudjcz(razqatpooi) = fyqvdfnjsl opldbumadf (dyxnynzftk, 6.96 - 10.29)
UEGW2015	Not Applicable	-	-	Prep2 (2L PEG + Ascorbate + low dose NaP + gastrografin)	pswjfonztw(uivzrgxqad) = dlsskdpnnc lrvyhghtaa (yxrwfsexlc ) View more	-	01 Oct 2015
NCT01515696 (CTgov)	Phase 4	Meconium Ileus	96	Gastrografin (Gastrografin)	irovlhuriu(cxutvivryp) = hsjasozvdh gvdrfvdieu (bkscqkoyyp, jnijjxkicd - jazutntfeg) View more	-	18 Jul 2014
				sterile water (Sterile Water)	irovlhuriu(cxutvivryp) = phwcuikatk gvdrfvdieu (bkscqkoyyp, tdtspqhqwq - recokghvmq) View more