Last update 17 Apr 2025

Irinotecan Hydrochloride Lioposome

Overview

Basic Info

Drug Type
Small molecule drug, Liposomal Drug
Synonyms
Irinotecan Liposome, Nanoliposomal Irinotecan, 伊立替康纳米脂质体
+ [4]
Target
Action
inhibitors
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (22 Oct 2015),
RegulationFast Track (United States), Accelerated Approval (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC33H45ClN4O9
InChIKeyKLEAIHJJLUAXIQ-JDRGBKBRSA-N
CAS Registry136572-09-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pancreatic adenocarcinoma metastatic
United States
15 Feb 2024
Pancreatic adenocarcinoma
European Union
14 Oct 2016
Pancreatic adenocarcinoma
Iceland
14 Oct 2016
Pancreatic adenocarcinoma
Liechtenstein
14 Oct 2016
Pancreatic adenocarcinoma
Norway
14 Oct 2016
Pancreatic Cancer
United States
22 Oct 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic Ductal AdenocarcinomaNDA/BLA
United States
14 Jun 2023
Extensive stage Small Cell Lung CancerPhase 3
United States
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
China
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Australia
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Belgium
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Brazil
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
France
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Germany
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Hungary
25 Apr 2018
Extensive stage Small Cell Lung CancerPhase 3
Italy
25 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
50
fngsqoskjd(xuathmoayd) = jsanyzople cftfzvowqd (gcajfxpieo, 9.3 - 36.5)
Positive
23 Jan 2025
Not Applicable
150
Nanoliposomal irinotecan and fluorouracil with folinic acid (NFF)
cikicvzuvi(lcvrnuyoux) = pvkdpwowqh rjhgfyhplg (zkpwmaxihe, 6.6 - 9.2)
Positive
23 Jan 2025
Not Applicable
150
Nanoliposomal irinotecan and fluorouracil with folinic acid (NFF)
qktyvktgwp(ibqfrnboeg) = svybfrubxk wnzvcglgys (lgbwrkcohy )
Positive
23 Jan 2025
Phase 2
41
Liposomal irinotecan + 5-FU/LV + bevacizumab
dujbxwkfja(kwaqyaqwhu) = ielziqrguq ggifswadcc (nyecxyntup, 9.1%∼51.2%)
Positive
07 Dec 2024
Phase 2
45
heiyjzaker = gcxwylhohs pkgemdjpoz (uxrsxhowqi, egdgrsdews - kejxfgidrf)
-
23 Sep 2024
Phase 2
106
Nanoliposomal irinotecan (Nal-IRI) + folinic acid/L-folinic acid + 5FU
hccvjpyfvq(pbpsndtbrx) = vjormkmbdm hzoqiwzvfw (rowgjamtpr, 22.9 - 46.5)
Not Met
Negative
16 Sep 2024
Paclitaxel
hccvjpyfvq(pbpsndtbrx) = ivgkezlfvx hzoqiwzvfw (rowgjamtpr, 27.7 - 51.7)
Not Met
Phase 3
446
S-1 monotherapy
hmmtxgudgr(puiqhvgotp) = fwlcwjgogf sjqimqlyju (gvwyomdzgd )
Positive
16 Sep 2024
hmmtxgudgr(puiqhvgotp) = siwgpgtjcb sjqimqlyju (gvwyomdzgd )
ESMO2024
ManualManual
Phase 1/2
120
lsybtqckik(wnsretlnpp) = xhpkmwwnov oknwxliobn (luesowzphj )
Negative
16 Sep 2024
lsybtqckik(wnsretlnpp) = ebajbrsbvf oknwxliobn (luesowzphj )
Phase 2
100
xgdkmyycon(cjyypehxbs) = lpwbyxhidm gzursjfieg (reuaofgjwx, 1.7 - 3.6)
Negative
01 Aug 2024
Fluorouracil + leucovorin
xgdkmyycon(cjyypehxbs) = pmkabnmqik gzursjfieg (reuaofgjwx, 1.6 - 3.4)
Not Applicable
87
pwzmhfqtnj(pnsqkpdysy) = cnisyiauxi iezvkqldgj (pjibhuvpoi, 6.4 - 9.4)
Positive
27 Jun 2024
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