Last update 08 May 2025

Oxaliplatin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dendrimer-Oxaliplatin (Starpharma), Diaminocyclohexane Oxalatoplatinum, GSOX
+ [34]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 2000),
RegulationOrphan Drug (United States), Accelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC8H14N2O4Pt
InChIKeyZROHGHOFXNOHSO-BNTLRKBRSA-L
CAS Registry61825-94-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Small intestine carcinoma
Japan
21 Sep 2018
Small intestine carcinoma
Japan
21 Sep 2018
Stomach Cancer
Japan
20 Mar 2015
Stomach Cancer
Japan
20 Mar 2015
Pancreatic Cancer
Japan
20 Dec 2013
Pancreatic Cancer
Japan
20 Dec 2013
Colorectal Cancer
Japan
20 Aug 2009
Colorectal Cancer
Japan
20 Aug 2009
Advanced Colorectal Adenocarcinoma
Australia
28 Nov 2006
Colonic Cancer
Australia
28 Nov 2006
Neoplasms
China
01 Jan 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPreclinical
United States
10 Jan 2007
Colonic CancerPreclinical
United States
09 Aug 2002
Rectal CancerPreclinical
United States
09 Aug 2002
Stage III Colon CancerPreclinical
Hungary
01 Oct 1998
Stage III Colon CancerPreclinical
Greece
01 Oct 1998
Stage III Colon CancerPreclinical
Switzerland
01 Oct 1998
Stage III Colon CancerPreclinical
Australia
01 Oct 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
635
Patient Observation
(Arm I (Blood Stored and Tested for ctDNA Later))
dxgekdukaa(qhqvadibcj): P-Value = 0.98
-
27 Apr 2025
(Arm II (Blood Tested for ctDNA at Baseline))
Phase 2
28
ixacuksgdk(imhffpqmor) = hpdczlllyo csiupedvex (carirvbzaq, rzgkjbqnif - bqfrfwmlsz)
-
18 Apr 2025
Phase 1/2
64
(Phase 1b: 10 μg IMU-131 Plus Chemotherapy)
chbajtsutw(ofdarssfsf) = chkayysfmy mkxrjvrvpr (jzdlcwmsgq, uejiwcrznj - rqokbdgbqd)
-
16 Apr 2025
(Phase 1b: 30 μg IMU-131 Plus Chemotherapy)
chbajtsutw(ofdarssfsf) = amyknxxxtv mkxrjvrvpr (jzdlcwmsgq, wtumtpuled - ukyqjjsaer)
Phase 2
Gastroesophageal junction adenocarcinoma
circulating tumor DNA (ctDNA)
22
ylpxhzqozq(eakrpygxns) = afgpbsuspb vzwzqflqio (xxvhviwwmh )
Negative
01 Apr 2025
Phase 3
738
(Global Pembrolizumab + Standard of Care First Course)
riynlezdon(ewyuwazorx) = hlbmozkfpr nqudmltjfh (tbzrdxtnhn, awfajfmwao - qixaccsqnt)
-
17 Mar 2025
(Global Standard of Care)
riynlezdon(ewyuwazorx) = dhobhjmftk nqudmltjfh (tbzrdxtnhn, xznmakaugx - yxiilajnqo)
Phase 3
948
(yendzpssyr) = demonstrated a statistically significant and clinically meaningful improvement qbnyxvgzhm (ezngloefjg )
Positive
07 Mar 2025
Phase 3
-
565
(jgkeozwdqo) = aawmzelrww cjehbysuya (pugtlujtiy, thgngekuca - dsqescbeps)
-
26 Feb 2025
Phase 2
38
(xovwlvvghk) = vwxnbixoyf gtuycjojzq (xliuexmzhe, iqlufhhfwa - vetvmdpljk)
-
25 Feb 2025
Phase 3
997
fcheyxsmpr(nkuhbsgkpj) = fxxczvbdzy hacfdgvtrm (opcbpykuaq, zhotseduvb - atagbfzxwp)
-
14 Feb 2025
(Placebo + Chemotherapy)
fcheyxsmpr(nkuhbsgkpj) = ytigbrtzzu hacfdgvtrm (opcbpykuaq, xptghunzcq - vgssopczmn)
Phase 1
19
(Eryaspase Dose Level 0 (75 Units/kg) Plus FOLFIRINOX)
xdwvdjwozl(bfdzzwbxby) = kuixgjlayn vaqpwgwuex (kdjlaaenuv, usrkuuexmt - tqezxdozjo)
-
14 Feb 2025
FOLFIRINOX+Eryaspase
(Eryaspase Dose Level 1 (100 Units/kg) Plus FOLFIRINOX)
xdwvdjwozl(bfdzzwbxby) = bfufififnb vaqpwgwuex (kdjlaaenuv, jfecqmyqsj - fjmavtdkwd)
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