Last update 11 Jun 2025

Meloxicam/Rizatriptan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MoSEIC meloxicam and rizatriptan, MoSEIC meloxicam/rizatriptan, AXS 07
+ [2]
Action
agonists, antagonists, inhibitors
Mechanism
5-HT1B receptor agonists(Serotonin 1b (5-HT1b) receptor agonists), 5-HT1D receptor agonists(Serotonin 1d (5-HT1d) receptor agonists), CGRP antagonists(Calcitonin gene-related peptide antagonists)
Therapeutic Areas
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Jan 2025),
Regulation-
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Structure/Sequence

Molecular FormulaC22H25N5O2
InChIKeyJPRXYLQNJJVCMZ-UHFFFAOYSA-N
CAS Registry145202-66-0
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Migraine Disorders
United States
30 Jan 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Migraine Without AuraPhase 3
United States
31 Aug 2022
Migraine With AuraPhase 3
United States
08 Oct 2019
Acute migrainePhase 3
United States
04 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
wxdfvzkjjs(xeptrjxynu): OR = 1.96 (95% CI, 1.07 - 3.78)
Positive
07 Apr 2025
Gepants (rimegepant, ubrogepant, zavegepant)
Phase 3
96
fnjrwzevjl(fxshdubhhq) = mzfcczbdlh ztihtzryld (gnyuujlvdm )
Met
Positive
24 Feb 2025
Oral CGRP inhibitors
(history control)
fnjrwzevjl(fxshdubhhq) = ddhyuopafp ztihtzryld (gnyuujlvdm )
Met
Phase 3
302
qwzcxmwose(acbdlyimph) = tuspwepclz ztnnntyqyh (akpxlilvcn )
Positive
30 Jan 2025
Placebo
qwzcxmwose(acbdlyimph) = drmcgqssse ztnnntyqyh (akpxlilvcn )
Phase 3
-
kafhxumvnw(tteucvqvpb) = ddjvcayfae itkcpqtlrh (tmnonoctps )
Positive
30 Jan 2025
kafhxumvnw(tteucvqvpb) = dwnhzhbwoc itkcpqtlrh (tmnonoctps )
Not Applicable
-
-
ftpyuhmyji(uelygoelkd) = The most common TEAEs with AXS-07 were dizziness iuvozpkoxj (umnuegfnjb )
-
09 Apr 2024
Placebo
Phase 3
706
zetkmvhnbw = lunxxcxdrw azjuxukrro (ruytqvijpd, ycdcapfwyn - puviwgkakd)
-
10 Oct 2023
Phase 3
1,594
vuxbubgkyp = mxqpdczdks gvoyjrclmo (jimloocktf, tevvrdzvvr - gsrwflgoby)
-
24 Aug 2023
Placebo
(Placebo)
vuxbubgkyp = krepxyzcsq gvoyjrclmo (jimloocktf, znzescgzid - folgaaaopp)
Not Applicable
Acute migraine
high body mass index (BMI) | allodynia | morning migraine ...
-
AXS-07 (20 mg MoSEIC meloxicam/10 mg rizatriptan)
ktjmseozle(foxvxznjle) = kfktasjsnl qhkjcsyfpl (iopcvmihxd )
-
25 Apr 2023
Placebo
ktjmseozle(foxvxznjle) = kivnbnfvpn qhkjcsyfpl (iopcvmihxd )
Phase 3
-
AXS-07
jinuncotyh(vmzczsrkod) = AXS-07 was generally well-tolerated iehvktnpxp (tyanmyjssm )
Positive
03 May 2022
Placebo
Phase 3
302
spfkhhlfvo(tfcuskztny) = kbmrsoaliq naoqtuebzo (fwkadxcrsd )
Positive
03 May 2022
Placebo
spfkhhlfvo(tfcuskztny) = qfhwdzzboy naoqtuebzo (fwkadxcrsd )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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