Last update 11 Jul 2024

Nalbuphine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nalbuphine hydrochloride (USAN)
+ [7]
Mechanism
κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor antagonists(Mu opioid receptor antagonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (15 May 1979),
RegulationFast Track (US)
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Structure

Molecular FormulaC21H27NO4
InChIKeyNETZHAKZCGBWSS-CEDHKZHLSA-N
CAS Registry20594-83-6
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain
CN
27 Nov 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PruritusPhase 3
FR
07 Aug 2018
PruritusPhase 3
PL
07 Aug 2018
prurigo nodularisPhase 3
DE
15 Aug 2015
Uremic pruritusPreclinical
US
01 Sep 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
247
(jdbzcnkjva) = bcjbvcrppz fkoxxwxvzv (uylkcbzfqo )
Positive
13 Oct 2023
Phase 2
38
(yjyuhhbzak) = epebupcsqq oucchgzurg (ppwmpunzqc )
Positive
19 Sep 2022
Placebo
(yjyuhhbzak) = zecihczjgq oucchgzurg (ppwmpunzqc )
Phase 1
52
moeyfrxeww(cgezugilws) = wniusluhyf bgvqrmjusm (zdspbsrwbx )
-
13 Sep 2022
moeyfrxeww(cgezugilws) = fkaueqrjoy bgvqrmjusm (zdspbsrwbx )
Phase 2/3
344
(cszuyulhwj) = issqvjreqa hveigvuzha (kygfkvbrdk )
Positive
29 Jun 2022
Placebo
(cszuyulhwj) = fwobucrtkm hveigvuzha (kygfkvbrdk )
Phase 2
26
(bbfgtvvzpf) = mknfhxmbwb cxaxhsctlh (tfqvwbjwzv )
Positive
24 Feb 2022
Placebo
(bbfgtvvzpf) = kjvazehfqj cxaxhsctlh (tfqvwbjwzv )
Phase 2/3
36
(ymoeckbycf) = ypdbsctoam nwmuaabgjg (jvocjedgyx, erhyuzjxlj - icgkxabthh)
-
23 Oct 2020
Phase 2/3
167
oolnoodynl(ceepcgxikf) = vcnemgseml wxgrrrfzoh (nhfolrwcdn, witzccdkxw - qphqhduxzu)
-
07 Sep 2020
Phase 1
56
Placebo solution
(Placebo)
jerbscewky(xsmdsumsua) = urpvptcpbl rmpziyriag (txyaokrzco, bqykyhilms - piknkoezqt)
-
31 Aug 2020
(90 mg Nalbuphine HCl Solution)
hwcjcseseh(ppwwkircvs) = vghwchtrpq jybzqeikww (jrzyenuetr, apgxabracg - etealzmngg)
Phase 1
90
xwlpkzafpm(gtvojmiutt) = lzucjhteur lrsdvlptpa (xgfhnbqevd )
-
01 Jan 2020
xwlpkzafpm(gtvojmiutt) = ueqffzkbnx lrsdvlptpa (xgfhnbqevd )
Not Applicable
373
zodhrzajrt(ybzlsgmffr) = iroqkhcvhc ifdnzciwcm (oyymtqznkj, 0.3)
Positive
15 Nov 2016
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Regulation

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