Optimization of the Efficacy and Safety of Nalbuphine Combined with Esketamine for Post-Cesarean Analgesia: A Randomized, Double-Blind, Parallel-Controlled Clinical Study

Start Date01 Jul 2025

Sponsor / Collaborator-

NCT06996561

/ Not yet recruitingPhase 2/3IIT

Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management

The goal of this study is to identify the genes as well as their association with Nalbuphine. This will help us identify opioid vulnerability in our population in the postoperative patients and will contribute to overcoming the opioid crisis, resulting in better and safer outcomes.
Research question is:
Is there any association between the underlying genetic variations and the analgesic efficacy of Nalbuphine in postoperative patients? The Research Objectives are
1. To identify the underlying genes in postoperative patients having pain.
2. To find an association between identified genes and nalbuphine clinical efficacy.
Procedure: After the written informed consent adult men and women will be enrolled in the study. On the day of surgery in the preoperative area, a 5 ml blood sample will be drawn before surgery and will be sent to laboratory for analysis. After routine hemodynamic monitoring in the operative room, general anesthesia will be given including nalbuphine. Standard routine anesthesia monitoring will be done and maintained while monitoring heart rate, ECG, NIBP oxygen saturation, ETCO2 and temperature. Incremental analgesia will be provided whenever needed. After extubation and shifting to recovery room the 2nd sample of blood will be taken and will be sent for analysis. Pain score, nausea vomiting, sedation, requirement of analgesia will be assessed till 24 hours postoperatively.

Start Date01 Jul 2025

Sponsor / Collaborator

Ziauddin University

NCT07009808

/ Not yet recruitingNot ApplicableIIT

Effects of Different Doses of Nalbuphine on Anxiety and Depression in Patients Undergoing Ectopic Pregnancy Surgery: A Prospective, Randomized, Controlled Study

This prospective, randomized, controlled study aims to evaluate the impact of different doses of nalbuphine on anxiety and depression in patients undergoing surgery for ectopic pregnancy. Ectopic pregnancy, which occurs in approximately 2% of all pregnancies, often requires surgical intervention, leading to potential psychological distress such as anxiety and depression in affected women. Effective postoperative pain management is essential to enhance recovery and reduce emotional disturbances.
The study will involve 165 eligible patients diagnosed with ectopic pregnancy at Jinjiang District Maternal and Child Health Hospital. Participants will be randomly assigned to three groups, each receiving a different concentration of nalbuphine combined with metoclopramide for postoperative analgesia. The primary outcome will focus on changes in anxiety and depression scores measured on postoperative day three, while secondary outcomes will assess pain levels, the use of patient-controlled analgesia (PCA), the necessity for rescue analgesics, and the occurrence of adverse reactions.
Sample size calculations suggest that at least 165 participants are required to achieve adequate statistical power. Data will be analyzed using SPSS 25.0 software, with results expected to provide insights into the effectiveness of nalbuphine in improving postoperative recovery and mental health in women experiencing ectopic pregnancy. The study has received ethical approval and is funded by the Chengdu Medical Research Projects (No. 2023465, 2022548, and 2023304).

Start Date20 Jun 2025

Sponsor / Collaborator

Chengdu Jinjiang Maternity & Child Health Hospital

100 Clinical Results associated with Nalbuphine Hydrochloride

100 Translational Medicine associated with Nalbuphine Hydrochloride

100 Patents (Medical) associated with Nalbuphine Hydrochloride

1,797

Literatures (Medical) associated with Nalbuphine Hydrochloride

01 Nov 2025·SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

A novel ultrasensitive derivatization-free synchronous fluorescence approach for the simultaneous analysis of propofol and nalbuphine in human plasma and dosage forms: Compliance with greenness and blueness metrics

Article

Author: Magdy, Galal ; El-Maghrabey, Mahmoud ; Mansour, Fotouh R ; Alshehri, Sultan ; Al-Khateeb, Lateefa A ; Radwan, Aya Saad ; El Hamd, Mohamed A ; Alsehli, Bandar R ; Mahdi, Wael A

This study presents a very sensitive and eco-friendly synchronous spectrofluorimetric method for the simultaneous quantification of propofol (PRP) and nalbuphine (NAL) for the first time. The technique used the intrinsic fluorescence characteristics of the two drugs, providing enhanced sensitivity and specificity. The two drugs were assessed simultaneously at 217 nm and 281 nm for PRP and NAL, respectively, with a synchronous wavelength difference (Δλ) of 80 nm. The proposed method was validated according to ICH Q2 (R2) requirements, exhibiting satisfactory accuracy, precision, linearity, and selectivity within the designated concentration ranges. The concentrations exhibited linearity within the ranges of 15.0-300.0 ng/mL and 0.5-16.0 µg/mL, with detection limits of 2.67 ng/mL and 0.15 µg/mL for PRP and NAL, respectively. The developed approach, owing to its great sensitivity, was utilized to assess the examined drugs in human plasma samples. The results demonstrated good bioanalytical applicability, exhibiting high recovery percentages (98.40-101.70) and low relative standard deviation (%RSD) values (<1.66). The proposed method was applied to accurately analyze the cited drugs in their ampoule dosage forms with great selectivity. The MoGAPI and AGREE metricsdemonstrated the method's exceptional eco-friendliness and sustainability. Additionally, the BAGI tool was employed to assess the method's economic viability, applicability, and practicality. The three tools demonstrated the sustainability and feasibility of the developedapproach, as well as its appropriateness for the routine analysis of the examined drugs. The developed method represents the first analytical technique for the concurrent estimation of PRP and NAL without the necessity for toxic reagents, excessive organic solvents, or complicated instruments. The method is derivatization-free and does not require complicated sample treatment or lengthy extraction procedures. The suggested method's excellent sensitivity, simplicity, speed, environmental friendliness, and cost-effectiveness make it appropriate for therapeutic drug monitoring of the studied drugs.

01 Jun 2025·JOURNAL OF CRANIOFACIAL SURGERY

Morphine Versus Nalbuphine as Intra-Articular Medications Following Temporomandibular Joint Arthrocentesis: A Randomized Clinical Trial

Article

Author: Eissa, Ahmed Adel Soliman ; Ghanem, Amr Amin ; El Badawy, Fatma Mostafa ; Abdelhameed, Abdelrahman Mohamed Fahmy ; Bahaa, Moataz

Purpose::

This study aimed at comparing the therapeutic effect of nalbuphine in comparison to morphine after Temporomandibular joint (TMJ) arthrocentesis in patients with anterior disc displacement without reduction (ADDwoR).

Materials and Methods::

Twenty-four female patients diagnosed with ADDwoR. Patients were treated with TMJ arthrocentesis then randomly divided into parallel groups. Group (A) received an intra-articular injection of 2 mL 10 mg morphine and group (B) received an intraarticular injection of 2 mL 10 mg nalbuphine. Each patient was assessed in terms of maximum mouth opening (MMO), lateral excursions and pain according to visual analogue scale (VAS). Follow-up was made at the intervals of 1 week 1 month, 3 months and 6 months.

Results::

A vast improvement was attained in both groups in all assessment variables with a significant value at the end of the follow-up period in comparison to the preoperative assessment values. Yet there was an insignificant difference between both groups regarding the assessment criteria. However insignificant yet the scales tip slightly towards nalbuphine group.

Conclusion::

Nalbuphine is a highly potent and effective analgesic to be administered post TMJ arthrocentesis in patients with closed lock and highly comparable to that of morphine.

01 Jun 2025·International Journal of Surgery

Predicting high-risk factors for postoperative inadequate analgesia and adverse reactions in cesarean delivery surgery: a prospective study

Article

Author: Zhang, Kaiwen ; Jiao, Bo ; Zhou, Zhiqiang ; Sun, Jiaoli ; Liu, Baowen ; Zhang, Guanglei ; Li, Ningbo ; Zhang, Xianwei

Background::

Early identification of high-risk factors for inadequate analgesia and adverse reactions in obstetric patients is critical for improving outcomes. This study developed a machine learning model to predict these factors and optimize anesthesia management in obstetric surgery.

Material and methods::

This prospective study included 763 obstetric patients who underwent elective cesarean delivery between December 2023 and May 2024. A machine-learning model for postoperative analgesia and adverse reactions (MLPIAAR) was constructed using 42 variables categorized into preoperative (18), intraoperative (12), and postoperative (12) factors. Ten algorithms were applied for model development. Model performance was optimized through 10-fold cross-validation and GridSearchCV. Evaluation metrics included receiver operating characteristic, area under the curve, accuracy, and precision. Model interpretability was enhanced using SHapley Additive exPlanations (SHAP). Regression analysis explored PCA compression frequency, consumption, and satisfaction of PCA factors. Validation was performed using predicted values and scatter plots.

Results::

Our study found 24.25% of patients experienced inadequate postoperative analgesia within 24 h. Postoperative nausea also occurred in 23.20% of patients. Simultaneously using dexamethasone and flurbiprofen axetil reduced both risks. However, pregnancy-induced hypertension and intraoperative shivering increased nausea risk. Postoperative vomiting occurred in 11.80% of patients, primarily associated with intravenous PCA type. Hydromorphone PCA showed a higher vomiting incidence than nalbuphine PCA. Intraoperative nausea and vomiting increased postoperative vomiting risk. Patients receiving diclofenac sodium and those with longer surgeries exhibited higher PCA compression frequencies and consumption. Higher preoperative Edinburgh Postnatal Depression Scale scores correlated with increased PCA consumption.

Conclusions::

The MLPIAAR model predicted high-risk factors for inadequate analgesia, nausea, and vomiting in obstetric patients. Dexamethasone and flurbiprofen axetil reduced these risks, while hydromorphone PCA increased vomiting risk compared to nalbuphine PCA. Machine learning and SHAP are valuable for optimizing anesthesia and analgesia management in obstetrics.

112

News (Medical) associated with Nalbuphine Hydrochloride

05 Jun 2025

·www.prnewswire.com

Trevi Therapeutics Announces Closing of $115 Million Underwritten Offering and Full Exercise by Underwriters of Option to Purchase Additional Shares

NEW HAVEN, Conn., June 5, 2025 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC), today announced the closing of its previously announced underwritten public offering of 20,010,000 shares of its common stock at a public offering price of $5.75 per share, which includes 2,610,000 additional shares issued upon the exercise in full by the underwriters of their option to purchase additional shares of common stock in the public offering at the public offering price, less underwriting discounts and commissions. The total proceeds of the public offering were approximately $115.1 million, before deducting underwriting discounts and commissions and expenses payable by Trevi. All of the shares in the offering were sold by Trevi. Morgan Stanley, Leerink Partners, Stifel and Cantor acted as joint book-running managers for the offering. The shares were offered by Trevi pursuant to a shelf registration statement on Form S-3 (File No. 333-273030), which was filed with the Securities and Exchange Commission (SEC) on June 29, 2023, amended on August 11, 2023 and declared effective by the SEC on August 15, 2023. This offering was made only by means of a prospectus supplement and the accompanying prospectus that form a part of the registration statement. The final terms of the offering are disclosed in a final prospectus supplement which has been filed with the SEC. Copies of the final prospectus supplement and the accompanying prospectus may also be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014, or by email at [email protected]; Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, or by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720 or by email at [email protected]; or Cantor Fitzgerald & Co., Attention: Capital Markets, 110 East 59th Street, New York 10022, or by email at [email protected]. This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC). Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), targeting opioid receptors that play a key role in controlling chronic cough. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency. Investor Contact Jonathan Carlson Trevi Therapeutics, Inc. (203) 654 3286 [email protected] Media Contact Rosalia Scampoli 914-815-1465 [email protected] SOURCE Trevi Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

04 Jun 2025

·www.prnewswire.com

Trevi Therapeutics Announces Pricing of $100 Million Underwritten Offering of Common Stock

NEW HAVEN, Conn., June 3, 2025 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC), today announced the pricing of its previously announced underwritten public offering of 17,400,000 shares of its common stock at a public offering price of $5.75 per share, for total proceeds of $100 million, before deducting underwriting discounts and commissions and expenses payable by Trevi. All of the shares in the offering are being sold by Trevi. In addition, Trevi has granted the underwriters a 30-day option to purchase up to 2,610,000 additional shares of its common stock at the public offering price, less underwriting discounts and commissions. The offering is expected to close on or about June 5, 2025, subject to satisfaction of customary closing conditions. Morgan Stanley, Leerink Partners, Stifel and Cantor are acting as joint book-running managers for the offering. The shares are being offered by Trevi pursuant to a shelf registration statement on Form S-3 (File No. 333-273030), which was filed with the Securities and Exchange Commission (SEC) on June 29, 2023, amended on August 11, 2023 and declared effective by the SEC on August 15, 2023. This offering is being made only by means of a prospectus supplement and the accompanying prospectus that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering has been filed with the SEC and is available on the SEC's website located at . The final terms of the offering will be disclosed in a final prospectus supplement to be filed with the SEC. When available, copies of the preliminary prospectus supplement, final prospectus supplement and the accompanying prospectus may also be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014, or by email at [email protected]; Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, or by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720 or by email at [email protected]; or Cantor Fitzgerald & Co., Attention: Capital Markets, 110 East 59th Street, New York 10022, or by email at [email protected]. This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC). Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), targeting opioid receptors that play a key role in controlling chronic cough. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements about the anticipated closing of the public offering and the expected gross proceeds of the offering, among other things, and other statements containing the words "believes," "anticipates," "plans," "expects," "may," and similar expressions. Risks that contribute to the uncertain nature of the forward-looking statements include: uncertainties related to market conditions and whether the conditions for the closing of the public offering will be satisfied, as well as other risks and uncertainties, as well as other risks and uncertainties set forth in the "Risk Factors" section of the preliminary prospectus supplement filed with the SEC on June 2, 2025, in Trevi's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 filed with the SEC, and in any subsequent filings with the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Trevi undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made except as required by law. Investor Contact Jonathan Carlson Trevi Therapeutics, Inc. (203) 654 3286 [email protected] Media Contact Rosalia Scampoli 914-815-1465 [email protected] SOURCE Trevi Therapeutics, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical Study

02 Jun 2025

·www.prnewswire.com

Trevi Therapeutics Announces Proposed Public Offering of Common Stock

NEW HAVEN, Conn., June 2, 2025 /PRNewswire/ -- Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and in patients with refractory chronic cough (RCC), today announced that it has commenced an underwritten public offering of $100,000,000 of shares of its common stock. All of the shares in the offering are being offered by Trevi. In addition, Trevi expects to grant the underwriters a 30-day option to purchase up to an additional $15,000,000 of the shares of its common stock sold in the public offering at the public offering price, less underwriting discounts and commissions. Morgan Stanley, Leerink Partners, Stifel and Cantor are acting as joint book-running managers for the offering. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering. The shares are being offered by Trevi pursuant to a shelf registration statement on Form S-3 (File No. 333-273030), which was filed with the Securities and Exchange Commission (SEC) on June 29, 2023, amended on August 11, 2023 and declared effective by the SEC on August 15, 2023. This offering is being made only by means of a prospectus supplement and the accompanying prospectus that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering is expected to be filed with the SEC and, when filed, copies of the preliminary prospectus supplement relating to and describing the offering may be obtained for free by visiting the SEC's website at . Copies of the preliminary prospectus supplement and the accompanying prospectus may also be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014, or by email at [email protected]; Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, or by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720 or by email at [email protected]; or from Cantor Fitzgerald & Co., Attention: Capital Markets, 110 East 59th Street, New York 10022, or by email at [email protected] final terms of the offering will be disclosed in a final prospectus supplement to be filed with the SEC. This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. About Trevi Therapeutics, Inc. Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF), chronic cough in patients with non-IPF interstitial lung disease (ILD) and in patients with refractory chronic cough (RCC). Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), targeting opioid receptors that play a key role in controlling chronic cough. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements about the anticipated public offering and the expected size of the offering, and other statements containing the words "believes," "anticipates," "plans," "expects," "may," and similar expressions. Risks that contribute to the uncertain nature of the forward-looking statements include: uncertainties related to market conditions and the completion of the public offering on the anticipated terms or at all, as well as other risks and uncertainties, set forth in the "Risk Factors" section of the preliminary prospectus supplement to be filed with the SEC, in Trevi's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 filed with the SEC, and in any subsequent filings with the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Trevi undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made except as required by law. Investor Contact Jonathan Carlson Trevi Therapeutics, Inc. (203) 654 3286 [email protected] Media Contact Rosalia Scampoli 914-815-1465 [email protected] SOURCE Trevi Therapeutics, Inc. 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100 Deals associated with Nalbuphine Hydrochloride

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KEGG	Wiki	ATC	Drug Bank
D00843	Nalbuphine Hydrochloride	N02AF02	DB00844

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Anesthesia	United States	Endo Operations Ltd.	15 May 1979
Pain	United States	Endo Operations Ltd.	15 May 1979

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Analgesia	Phase 3	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	09 Oct 2023
Respiratory Insufficiency	Phase 3	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	30 Aug 2023
prurigo nodularis	Phase 3	United States	Trevi Therapeutics, Inc.	01 Mar 2015
prurigo nodularis	Phase 3	Germany	Trevi Therapeutics, Inc.	01 Mar 2015
prurigo nodularis	Phase 3	Poland	Trevi Therapeutics, Inc.	01 Mar 2015
Pruritus	Phase 3	Germany	Trevi Therapeutics, Inc.	01 Mar 2015
Uremic pruritus	Phase 3	United States	Trevi Therapeutics, Inc.	01 Jun 2014
Uremic pruritus	Phase 3	Poland	Trevi Therapeutics, Inc.	01 Jun 2014
Uremic pruritus	Phase 3	Romania	Trevi Therapeutics, Inc.	01 Jun 2014
Moderate pain	Phase 1	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	31 Aug 2018

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03497975 (PRISM \| PRISM study, CTgov)	Phase 2/3	prurigo nodularis \| Pruritus	353	Nalbuphine ER Tablets (NAL ER)	cpyvdpmmkf = scvcsmwpwl fzkzbbyart (yfixlmnmsn, iyiaofiofl - edldwquuxj) View more	-	24 Jun 2025
				Placebo Tablets+Nalbuphine ER Tablets (Placebo)	cpyvdpmmkf = pbkzayjhde fzkzbbyart (yfixlmnmsn, crizrwlmfg - kbrpawukma) View more
PRNewswire Manual	Not Applicable	Chronic cough	-	Placebo	ydzyjfhftx(lgtkohuzgp) = eofkvfeeon epkaovibwu (agjuqhxiuo ) View more	Positive	03 Dec 2024
				IV Butorphanol 6mg	ydzyjfhftx(lgtkohuzgp) = exjdrmxono epkaovibwu (agjuqhxiuo ) View more
NCT02820051 (CTgov)	Not Applicable	Sedation	102	Transcutaneous CO2 monitor+Midazolam+Lidocaine+nalbuphine (Midazolam)	rpcbhqrfaj(kbbrzcweiw) = hzyysxvwdn nivtsrsjxj (lnwzcrifav, 7.5) View more	-	02 Dec 2024
				Transcutaneous CO2 monitor+propofol+Lidocaine+nalbuphine (Propofol)	rpcbhqrfaj(kbbrzcweiw) = vrvpxjvkrr nivtsrsjxj (lnwzcrifav, 9.6) View more
NCT05041270 (ZU-IRB#:7045-15-8-2021, Pubmed \| BMC Anesthesiol)	Not Applicable	-	69	Bupivacaine + Normal Saline	fdjasozkcg(bigaydzxvk) = ldinziiduv sykjtnlyxo (ohrjxhvnqj ) View more	Positive	06 Dec 2023
				Bupivacaine + Nalbuphine	fdjasozkcg(bigaydzxvk) = gfmjicqgdi sykjtnlyxo (ohrjxhvnqj ) View more
NCT03497975 (PRISM, EADV2023) Manual	Phase 2/3	prurigo nodularis	247	Haduvio	ozoyrvcpst(knankihjeu) = ehuzjmfrtw igdiegiaha (klbbjgndxh ) View more	Positive	13 Oct 2023
ATS2023	Not Applicable	Chronic cough	-	Nalbuphine ER	wswviejoep(djglwpzajd) = 61% of patients treated with nalbuphine ER improved, 21% had no change, and 18% worsened, compared with 18%, 68%, and 14%, respectively, of patients receiving placebo hltchmsmoj (jgrgkpnzsi ) View more	-	21 May 2023
				Placebo
NCT03059511 (Pubmed \| Arch Dis Child)	Phase 1	-	52	Intranasal nalbuphine	thqyskdrle(gkjuwrzyzz) = zlbihfppcy wamvbhmsbo (mxgrtptaet )	-	13 Sep 2022
				Intravenous nalbuphine	thqyskdrle(gkjuwrzyzz) = rsbxgfqwts wamvbhmsbo (mxgrtptaet )
NCT03497975 (PRISM study, EADV2022)	Phase 2/3	prurigo nodularis	-	Oral Nalbuphine Extended-Release 162 mg	jzatfqwyhr(yponjpsbxz) = taslhelqqq zkqjuhewqr (igrfsfjnyl )	Positive	07 Sep 2022
				Placebo	jzatfqwyhr(yponjpsbxz) = gmmibapusj zkqjuhewqr (igrfsfjnyl )
ERS2022	Phase 2	Idiopathic Pulmonary Fibrosis	45	NAL ER 27 mg once daily	afvazqlcir(mssrmddnku) = yylvmmorna bwiyztdkwi (odqgciktds )	Positive	04 Sep 2022
NCT03497975 (PRISM, Corporate Publications) Manual	Phase 2/3	prurigo nodularis	344	Haduvio	igdpilsmdx(uzgqknqrjj) = ewbycbahrw bhurgevnhm (gnpmybwztr ) View more	Positive	29 Jun 2022
				Placebo	igdpilsmdx(uzgqknqrjj) = goobndruob bhurgevnhm (gnpmybwztr ) View more

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