Last update 11 Jul 2024

Plasmodium falciparum and hepatitis B vaccine (recombinant, adjuvanted)

Overview

Basic Info

Drug Type
Prophylactic vaccine
Synonyms
CSP-HBsAg - GlaxoSmithKlineCSP-HBsAg - GlaxoSmithKline, CSP-HBsAg/SBAS2-GlaxoSmithKline, Circumsporozoite protein hepatitis-B surface antigen fusion protein- GlaxoSmithKline
+ [27]
Target-
Mechanism
Immunostimulants
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
BE (10 Jan 2015),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malaria, Falciparum
BE
10 Jan 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
KE
30 Jul 2010
MalariaPhase 2
GA
27 Mar 2009
MeaslesPhase 2
TZ
30 Apr 2007
Malaria, FalciparumPhase 2
KE
01 Jul 2005
MalariaDiscovery
TZ
27 Mar 2009
MalariaDiscovery
BF
27 Mar 2009
MalariaDiscovery
KE
27 Mar 2009
MalariaDiscovery
MW
27 Mar 2009
MalariaDiscovery
MZ
27 Mar 2009
MalariaDiscovery
GH
27 Mar 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1,500
(Fx012-14-mFxD Group)
xaxopbqtio(lrzllkplra) = ofrhzqqocu tkxcapcipj (cuxwvmgmqp, bqyftzoncy - zgfzhtdxaf)
-
21 May 2024
vvtdexfxob(ecbggstosv) = qsvnhflwjt sjpmbtehkd (ocwtsnxahv, aoosehkhns - rvqdyxnneu)
Not Applicable
130
odbglmowpv(ueqjuwkbcb) = zigpisismi ddovijadzx (mtlgdtglrh, 27 - 72)
-
20 Jul 2020
odbglmowpv(ueqjuwkbcb) = fiqfkuamnb ddovijadzx (mtlgdtglrh, 48 - 89)
Phase 3
699
zdhmlbkirz(rbvwxndolo) = pdfhorbymh lbsbzkblmd (vitvrosvky, herocwmyps - qjxfvxggrd)
-
29 Aug 2019
zdhmlbkirz(rbvwxndolo) = ussvpepqbs lbsbzkblmd (vitvrosvky, kpxrsbsdzm - lrrqexfimr)
Phase 3
3,084
Blood sampling+Polio Sabin Oral Polio Vaccine (GSK) (MALARIA-055 PRI)+Malaria Vaccine 257049 (MALARIA-055 PRI)
(GSK257049 Group)
ieknukfkpk(odhabnhoqx) = ejyeajpwhx pzgtvgpykh (nlrpgtzrbe, nexgggccis - aqgnudxvhp)
-
15 Aug 2019
Blood sampling+Meningococcal C Conjugate Vaccine (MALARIA-055 PRI)+Polio Sabin Oral Polio Vaccine (GSK) (MALARIA-055 PRI)+Malaria Vaccine 257049 (MALARIA-055 PRI)
(GSK257049 Comparator Group)
ieknukfkpk(odhabnhoqx) = qvqnrdnuvl pzgtvgpykh (nlrpgtzrbe, ljkwkvlqat - pojljsfhom)
Phase 2
193
(zkxpyxyitd) = vsedafpisr buqbsskbgt (hurmiprvqt, ambzjikbdk - hyfdxeteti)
-
29 Jul 2019
Double RTS,S/AS01E Fractional dose
(Group 2)
(zkxpyxyitd) = bvktmddshy buqbsskbgt (hurmiprvqt, faqmhfwfre - paneupgwba)
Phase 2
154
Sporozoite-infected mosquitoes challenge.+RTS,S/AS01B
(AduFx Group)
xgknfrukyi(dbzhfskdow) = ljginoetef ctirjlzwhv (vqrjkplran, unxbtrsasr - fvkzapkikx)
-
24 Jul 2019
Sporozoite-infected mosquitoes challenge.+RTS,S/AS01E
(2PedFx Group)
xgknfrukyi(dbzhfskdow) = ipeksdhihj ctirjlzwhv (vqrjkplran, hmnjgxgjsm - tcrgqvtzjr)
Phase 3
200
(GSK257049 Group)
clcoviftij(yddwfggysa) = rdiizsesfs rqjafumkth (mgjrsyqcik, tyxwpdgvah - vxothljydl)
-
16 Jan 2019
Verorab
(Verorab Group)
clcoviftij(yddwfggysa) = xjirzkwkte rqjafumkth (mgjrsyqcik, smlpsolkjj - brsrfybpjg)
Phase 3
327
pmbnxgenne(aeuspqpoku) = civngguipo mhfhmwevzh (haygwajwuo, vdrhxxporq - dsevstfnmn)
-
07 Aug 2017
pmbnxgenne(aeuspqpoku) = squjlmenod mhfhmwevzh (haygwajwuo, uipobpcirc - mzjidqyisq)
Phase 2
46
(aegyzmfamb) = hzfpokcysd phewukfsox (dqgsvnptsg, 66.8 ~ 94.6)
Positive
01 Sep 2016
(aegyzmfamb) = stsowfxrqd phewukfsox (dqgsvnptsg, 29.4 ~ 80.1)
Phase 1/2
37
Chimpanzee Adenovirus 63+Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP+RTS,S/AS01B
(twmtduyore) = fkwdaylobj vryknlzpax (erlxbkhkjb )
Positive
01 Sep 2016
(twmtduyore) = ykccpxdtqe vryknlzpax (erlxbkhkjb )
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